4,201 research outputs found
Single-parameter non-adiabatic quantized charge pumping
Controlled charge pumping in an AlGaAs/GaAs gated nanowire by
single-parameter modulation is studied experimentally and theoretically.
Transfer of integral multiples of the elementary charge per modulation cycle is
clearly demonstrated. A simple theoretical model shows that such a quantized
current can be generated via loading and unloading of a dynamic quasi-bound
state. It demonstrates that non-adiabatic blockade of unwanted tunnel events
can obliterate the requirement of having at least two phase-shifted periodic
signals to realize quantized pumping. The simple configuration without multiple
pumping signals might find wide application in metrological experiments and
quantum electronics.Comment: 4 pages, 4 figure
The Role of a Hot Gas Environment on the Evolution of Galaxies
Most spiral galaxies are found in galaxy groups with low velocity
dispersions; most E/S0 galaxies are found in galaxy groups with relatively high
velocity dispersions. The mass of the hot gas we can observe in the E/S0 groups
via their thermal X-ray emission is, on average, as much as the baryonic mass
of the galaxies in these groups. By comparison, galaxy clusters have as much or
more hot gas than stellar mass. Hot gas in S-rich groups, however, is of low
enough temperature for its X-ray emission to suffer heavy absorption due to
Galactic HI and related observational effects, and hence is hard to detect. We
postulate that such lower temperature hot gas does exist in low velocity
dispersion, S-rich groups, and explore the consequences of this assumption. For
a wide range of metallicity and density, hot gas in S-rich groups can cool in
far less than a Hubble time. If such gas exists and can cool, especially when
interacting with HI in existing galaxies, then it can help link together a
number of disparate observations, both Galactic and extragalactic, that are
otherwise difficult to understand.Comment: 16 pages with one figure. ApJ Letters, in pres
A Causal Order for Spacetimes with Lorentzian Metrics: Proof of Compactness of the Space of Causal Curves
We recast the tools of ``global causal analysis'' in accord with an approach
to the subject animated by two distinctive features: a thoroughgoing reliance
on order-theoretic concepts, and a utilization of the Vietoris topology for the
space of closed subsets of a compact set. We are led to work with a new causal
relation which we call , and in terms of it we formulate extended
definitions of concepts like causal curve and global hyperbolicity. In
particular we prove that, in a spacetime \M which is free of causal cycles,
one may define a causal curve simply as a compact connected subset of \M
which is linearly ordered by . Our definitions all make sense for
arbitrary metrics (and even for certain metrics which fail to be
invertible in places). Using this feature, we prove for a general metric,
the familiar theorem that the space of causal curves between any two compact
subsets of a globally hyperbolic spacetime is compact. We feel that our
approach, in addition to yielding a more general theorem, simplifies and
clarifies the reasoning involved. Our results have application in a recent
positive energy theorem, and may also prove useful in the study of topology
change. We have tried to make our treatment self-contained by including proofs
of all the facts we use which are not widely available in reference works on
topology and differential geometry.Comment: Two small revisions to accomodate errors brought to our attention by
R.S. Garcia. No change to chief results. 33 page
Spectral evolution of non-thermal electron distributions in intense radiation fields
(abridged) Models of many astrophysical gamma-ray sources assume they contain
a homogeneous distribution of electrons that are injected as a power-law in
energy and evolve by interacting with radiation fields, magnetic fields and
particles in the source and by escaping. This problem is particularly
complicated if the radiation fields have higher energy density than the
magnetic field and are sufficiently energetic that inverse Compton scattering
is not limited to the Thomson regime. We present a simple, time-dependent,
semi-analytical solution of the electron kinetic equation that treats both
continuous and impulsive injection, cooling via synchrotron and inverse Compton
radiation, (taking into account Klein-Nishina effects) and energy dependent
particle escape. The kinetic equation for an arbitrary, time-dependent source
function is solved by the method of Laplace transformations. Using an
approximate expression for the energy loss rate that takes into account
synchrotron and inverse Compton losses including Klein-Nishina effects for
scattering off an isotropic photon field with either a power-law or black-body
distribution, we find explicit expressions for the cooling time and escape
probability of individual electrons. This enables the full, time-dependent
solution to be reduced to a single quadrature. From the electron distribution,
we then construct the time-dependent, multi-wavelength emission spectrum. We
compare our solutions with several limiting cases and discuss the general
appearance and temporal behaviour of spectral features (i.e., cooling breaks,
bumps etc.). As a specific example, we model the broad-band energy spectrum of
the open stellar association Westerlund-2 at different times of its evolution,
and compare it with observations.Comment: 14 pages, 8 figures, acccepted for publication in A&
Optimising use of electronic health records to describe the presentation of rheumatoid arthritis in primary care: a strategy for developing code lists
Background
Research using electronic health records (EHRs) relies heavily on coded clinical data. Due to variation in coding practices, it can be difficult to aggregate the codes for a condition in order to define cases. This paper describes a methodology to develop âindicator markersâ found in patients with early rheumatoid arthritis (RA); these are a broader range of codes which may allow a probabilistic case definition to use in cases where no diagnostic code is yet recorded.
Methods
We examined EHRs of 5,843 patients in the General Practice Research Database, aged â„30y, with a first coded diagnosis of RA between 2005 and 2008. Lists of indicator markers for RA were developed initially by panels of clinicians drawing up code-lists and then modified based on scrutiny of available data. The prevalence of indicator markers, and their temporal relationship to RA codes, was examined in patients from 3y before to 14d after recorded RA diagnosis.
Findings
Indicator markers were common throughout EHRs of RA patients, with 83.5% having 2 or more markers. 34% of patients received a disease-specific prescription before RA was coded; 42% had a referral to rheumatology, and 63% had a test for rheumatoid factor. 65% had at least one joint symptom or sign recorded and in 44% this was at least 6-months before recorded RA diagnosis.
Conclusion
Indicator markers of RA may be valuable for case definition in cases which do not yet have a diagnostic code. The clinical diagnosis of RA is likely to occur some months before it is coded, shown by markers frequently occurring â„6 months before recorded diagnosis. It is difficult to differentiate delay in diagnosis from delay in recording. Information concealed in free text may be required for the accurate identification of patients and to assess the quality of care in general practice
The IL-15 cytokine system provides growth and survival signals in hodgkin lymphoma and enhances the inflammatory phenotype of HRS cells
Impacts of warming and elevated CO\u3csub\u3e2\u3c/sub\u3e on a semi-arid grassland are non-additive, shift with precipitation, and reverse over time
It is unclear how elevated CO2 (eCO2) and the corresponding shifts in temperature and precipitation will interact to impact ecosystems over time. During a 7-year experiment in a semi-arid grassland, the response of plant biomass to eCO2 and warming was largely regulated by interannual precipitation, while the response of plant community composition was more sensitive to experiment duration. The combined effects of eCO2 and warming on aboveground plant biomass were less positive in âwetâ growing seasons, but total plant biomass was consistently stimulated by ~ 25% due to unique, supra-additive responses of roots. Independent of precipitation, the combined effects of eCO2 and warming on C3 graminoids became increasingly positive and supraadditive over time, reversing an initial shift toward C4 grasses. Soil resources also responded dynamically and non-additively to eCO2 and warming, shaping the plant responses. Our results suggest grasslands are poised for drastic changes in function and highlight the need for long-term, factorial experiments
Spatially resolved X-ray spectroscopy and modeling of the nonthermal emission of the PWN in G0.9+0.1
We performed a spatially resolved spectral X-ray study of the pulsar wind
nebula (PWN) in the supernova remnant G0.9+0.1. Furthermore we modeled its
nonthermal emission in the X-ray and very high energy (VHE, E > 100 GeV)
gamma-ray regime. Using Chandra ACIS-S3 data, we investigated the east-west
dependence of the spectral properties of G0.9+0.1 by calculating hardness
ratios. We analyzed the EPIC-MOS and EPIC-pn data of two on-axis observations
of the XMM-Newton telescope and extracted spectra of four annulus-shaped
regions, centered on the region of brightest emission of the source. A radially
symmetric leptonic model was applied in order to reproduce the observed X-ray
emission of the inner part of the PWN. Using the optimized model parameter
values obtained from the X-ray analysis, we then compared the modeled inverse
Compton (IC) radiation with the published H.E.S.S. gamma-ray data. The spectral
index within the four annuli increases with growing distance to the pulsar,
whereas the surface brightness drops. With the adopted model we are able to
reproduce the characteristics of the X-ray spectra. The model results for the
VHE gamma radiation, however, strongly deviate from the H.E.S.S. data.Comment: 8 pages, 7 figures, accepted for publication in Astronomy &
Astrophysic
A depression before a bump in the highest energy cosmic ray spectrum
We re-examine the interaction of ultra high energy nuclei with the microwave
background radiation. We find that the giant dipole resonance leaves a new
signature in the differential energy spectrum of iron sources located around 3
Mpc: A depression before the bump which is followed by the expected cutoff.Comment: revisited version, 5 pages RevTex, 5 figure
Fission Hindrance in hot 216Th: Evaporation Residue Measurements
The fusion evaporation-residue cross section for 32S+184W has been measured
at beam energies of E_beam = 165, 174, 185, 196, 205, 215, 225, 236, 246,and
257 MeV using the ATLAS Fragment Mass Analyzer. The data are compared with
Statistical Model calculations and it is found that a nuclear dissipation
strength, which increases with excitation energy, is required to reproduce the
excitation function. A comparison with previously published data show that the
dissipation strength depends strongly on the shell structure of the nuclear
system.Comment: 15 pages 9 figure
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