1,731 research outputs found
LHCb Alignment Strategy
In this note, we review the alignment strategy for the LHCb detector. We discuss the internal alignment stategy for each subdetector and the alignment of each of the subdetectors relative to one another
Improved performance of the LHCb Outer Tracker in LHC Run 2
The LHCb Outer Tracker is a gaseous detector covering an area of with 12 double layers of straw tubes. The performance of the detector is
presented based on data of the LHC Run 2 running period from 2015 and 2016.
Occupancies and operational experience for data collected in , pPb and
PbPb collisions are described. An updated study of the ageing effects is
presented showing no signs of gain deterioration or other radiation damage
effects. In addition several improvements with respect to LHC Run 1 data taking
are introduced. A novel real-time calibration of the time-alignment of the
detector and the alignment of the single monolayers composing detector modules
are presented, improving the drift-time and position resolution of the detector
by 20\%. Finally, a potential use of the improved resolution for the timing of
charged tracks is described, showing the possibility to identify low-momentum
hadrons with their time-of-flight.Comment: 29 pages, 20 figures, minor changes to match the published versio
Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression
Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1 expression in subcutaneous and intracranial mouse glioma models induced endothelial Wnt/β-catenin signaling and led to diminished tumor growth, reduced vascular density, and normalized vessels with increased mural cell attachment. These findings were corroborated in GL261 glioma cells intracranially transplanted in mice expressing dominant-active β-catenin specifically in the endothelium. Enforced endothelial β-catenin signaling restored BBB characteristics, whereas inhibition by Dkk1 (Dickkopf-1) had opposing effects. By overactivating the Wnt pathway, we induced the Wnt/β-catenin–Dll4/Notch signaling cascade in tumor endothelia, blocking an angiogenic and favoring a quiescent vascular phenotype, indicated by induction of stalk cell genes. We show that β-catenin transcriptional activity directly regulated endothelial expression of platelet-derived growth factor B (PDGF-B), leading to mural cell recruitment thereby contributing to vascular quiescence and barrier function. We propose that reinforced Wnt/β-catenin signaling leads to inhibition of angiogenesis with normalized and less permeable vessels, which might prove to be a valuable therapeutic target for antiangiogenic and edema glioma therapy
Measurement of Angular Distributions and R= sigma_L/sigma_T in Diffractive Electroproduction of rho^0 Mesons
Production and decay angular distributions were extracted from measurements
of exclusive electroproduction of the rho^0(770) meson over a range in the
virtual photon negative four-momentum squared 0.5< Q^2 <4 GeV^2 and the
photon-nucleon invariant mass range 3.8< W <6.5 GeV. The experiment was
performed with the HERMES spectrometer, using a longitudinally polarized
positron beam and a ^3He gas target internal to the HERA e^{+-} storage ring.
The event sample combines rho^0 mesons produced incoherently off individual
nucleons and coherently off the nucleus as a whole. The distributions in one
production angle and two angles describing the rho^0 -> pi+ pi- decay yielded
measurements of eight elements of the spin-density matrix, including one that
had not been measured before. The results are consistent with the dominance of
helicity-conserving amplitudes and natural parity exchange. The improved
precision achieved at 47 GeV,
reveals evidence for an energy dependence in the ratio R of the longitudinal to
transverse cross sections at constant Q^2.Comment: 15 pages, 15 embedded figures, LaTeX for SVJour(epj) document class
Revision: Fig. 15 corrected, recent data added to Figs. 10,12,14,15; minor
changes to tex
Observation of a Single-Spin Azimuthal Asymmetry in Semi-Inclusive Pion Electro-Production
Single-spin asymmetries for semi-inclusive pion production in deep-inelastic
scattering have been measured for the first time. A significant target-spin
asymmetry of the distribution in the azimuthal angle phi of the pion relative
to the lepton scattering plane was observed for pi+ electro-production on a
longitudinally polarized hydrogen target. The corresponding analyzing power in
the sin(phi) moment of the cross section is 0.022 +/- 0.005 +/- 0.003. This
result can be interpreted as the effect of terms in the cross section involving
chiral-odd spin distribution functions in combination with a time-reversal-odd
fragmentation function that is sensitive to the transverse polarization of the
fragmenting quark.Comment: 5 pages of RevTex, 3 ps figures, 2 table
SEU Robustness, Total Dose Radiation Hardness and Analogue Performance of the Beetle Chip
The Beetle is a 128 channel readout chip for silicon strip detectors in LHCb. In addition to the pipelined readout path known from the RD20 architecture which can be used either in analogue or binary mode, the Beetle features an additional prompt binary readout path, used for the LHCb pile-up veto counters and a triple-redundant layout of the control logic. It is manufactured in commercial 0.25 µm CMOS technology using radiation hard design techniques. In addition to a total dose irradiation with X-rays, an SEU irradiation test with 65 MeV protons was performed with Beetle1.3. The results of this test are presented together with new results from the Beetle versions 1.3, 1.4 and 1.5, which were submitted in the Beetle ER engineering run in May 2004
Measurement of the Spin Asymmetry in the Photoproduction of Pairs of High-pT Hadrons at HERMES
We present a measurement of the longitudinal spin asymmetry A_|| in
photoproduction of pairs of hadrons with high transverse momentum p_T. Data
were accumulated by the HERMES experiment using a 27.5 GeV polarized positron
beam and a polarized hydrogen target internal to the HERA storage ring. For
h+h- pairs with p_T^h_1 > 1.5 GeV/c and p_T^h_2 > 1.0 GeV/c, the measured
asymmetry is A_|| = -0.28 +/- 0.12 (stat.) +/- 0.02 (syst.). This negative
value is in contrast to the positive asymmetries typically measured in deep
inelastic scattering from protons, and is interpreted to arise from a positive
gluon polarization.Comment: 5 pages (latex), 4 figures (eps
A Study of Time-Dependent CP-Violating Asymmetries and Flavor Oscillations in Neutral B Decays at the Upsilon(4S)
We present a measurement of time-dependent CP-violating asymmetries in
neutral B meson decays collected with the BABAR detector at the PEP-II
asymmetric-energy B Factory at the Stanford Linear Accelerator Center. The data
sample consists of 29.7 recorded at the
resonance and 3.9 off-resonance. One of the neutral B mesons,
which are produced in pairs at the , is fully reconstructed in
the CP decay modes , , , () and , or in flavor-eigenstate
modes involving and (). The flavor of the other neutral B meson is tagged at the time of
its decay, mainly with the charge of identified leptons and kaons. The proper
time elapsed between the decays is determined by measuring the distance between
the decay vertices. A maximum-likelihood fit to this flavor eigenstate sample
finds . The value of the asymmetry amplitude is determined from
a simultaneous maximum-likelihood fit to the time-difference distribution of
the flavor-eigenstate sample and about 642 tagged decays in the
CP-eigenstate modes. We find , demonstrating that CP violation exists in the neutral B meson
system. (abridged)Comment: 58 pages, 35 figures, submitted to Physical Review
Beam-Induced Nuclear Depolarisation in a Gaseous Polarised Hydrogen Target
Spin-polarised atomic hydrogen is used as a gaseous polarised proton target
in high energy and nuclear physics experiments operating with internal beams in
storage rings. When such beams are intense and bunched, this type of target can
be depolarised by a resonant interaction with the transient magnetic field
generated by the beam bunches. This effect has been studied with the HERA
positron beam in the HERMES experiment at DESY. Resonances have been observed
and a simple analytic model has been used to explain their shape and position.
Operating conditions for the experiment have been found where there is no
significant target depolarisation due to this effect.Comment: REVTEX, 6 pages, 5 figure
Measurement of Longitudinal Spin Transfer to Lambda Hyperons in Deep-Inelastic Lepton Scattering
Spin transfer in deep-inelastic Lambda electroproduction has been studied
with the HERMES detector using the 27.6 GeV polarized positron beam in the HERA
storage ring. For an average fractional energy transfer = 0.45, the
longitudinal spin transfer from the virtual photon to the Lambda has been
extracted. The spin transfer along the Lambda momentum direction is found to be
0.11 +/- 0.17 (stat) +/- 0.03 (sys); similar values are found for other
possible choices for the longitudinal spin direction of the Lambda. This result
is the most precise value obtained to date from deep-inelastic scattering with
charged lepton beams, and is sensitive to polarized up quark fragmentation to
hyperon states. The experimental result is found to be in general agreement
with various models of the Lambda spin content, and is consistent with the
assumption of helicity conservation in the fragmentation process.Comment: 8 pages, 3 figures; new version has an expanded discussion and small
format change
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