Efectividad de un programa en comprensión lectora con modalidad tutorial, para alumnos de bajo nivel de desarrollo comprensivo en quinto año básico del Colegio Cristiano Los Pinos

Tesis (Magíster en Desarrollo Curricular y Proyectos Educativos)La presente investigación se titula “Efectividad de un Programa en Comprensión Lectora con Modalidad Tutorial, para alumnos de bajo nivel de desarrollo comprensivo en Quinto Año Básico del Colegio Cristiano Los Pinos”, cuyo propósito es verificar si esta intervención a través de este programa con modalidad tutorial mejorará los niveles de comprensión lectora en alumnos descendidos. Para sustentar esta investigación se definieron dos temáticas relevantes, siendo éstas: Comprensión Lectora y Modalidad Tutorial. Entendiendo la comprensión Lectora como una interacción que posee el lector con el texto quien otorga significado a partir de sus experiencias y conocimientos previos, en un contexto determinado. Y la modalidad Tutorial, como una acción de parte del docente tutor, quien acompaña, guía, orienta, anima, aconseja, enseña, en forma personalizada a alumnos en situación vulnerable tanto en lo académico como en lo socioafectivo. En esta investigación se utilizó una metodología de diseño cuasiexperimental de pre y post prueba con grupo control, de enfoque cuantitativo. En relación a la muestra se trabajó con niños y niñas de Quinto Año Básico, con bajo nivel de comprensión lectora. El instrumento utilizado para medir nivel de comprensión tanto al inicio como después de la intervención, fue la Prueba de Comprensión Lectora de Complejidad Lingüística Progresiva Forma A y Forma B. Quinto Nivel. Finalmente los resultados obtenidos evidenciaron una diferencia significativa entre el pre y post experimental, a favor de este último con un 0,05 de error. No dándose esta diferencia en pre y post control

Covenant Christian Academy - Civil Design

The Covenant Christian Academy Civil Design team has partnered with Covenant Christian Academy (CCA) in Harrisburg, Pennsylvania to improve the utilization and safety of the facilities at the rear of the main building. The team worked with David Sonju, Headmaster at CCA and client representative for the school, to achieve two major goals for this project. The first goal was to redesign the rear parking lot to create a grass recreation area while integrating the remaining paved area into an improved student drop-off/turn-around. The design considered stormwater run-off and drainage, including conversion of impervious area to pervious area. The second goal was to design a portico/covered walkway structure that connects the rear entrance of the main building to the entrance of the Fine Arts Building. The design incorporates a combined straight and curvilinear steel-frame support structure, and a truss roof support system with steel decking. The team will provide its design work to CCA and their design consultant, H. Edward Black and Associates, Ltd., to finalize the required construction drawings and obtain professional approvals to build the project.https://mosaic.messiah.edu/engr2020/1019/thumbnail.jp

Dissertatio medica inauguralis de amenorrhoea

Cui melius consacrem primitias meorum in Medicina studiorum, quam tibi, amice spectatissime, qui me primus docuisti de rebus medicis cogitare, quique, dum, te ciuce, in medendi scientiam incumbebam tau tum operre, cura plus quam paterna posuisti in me principiis hujus professionis imbuendo? Si gratia in pectore meo natura lateret, tua erga me beneficia non potuerunt non eam excitare, et ad maturitatem perducere. Tibi igitur, ob admirationem simul turae in arte medendi perititiae simul multorum prrestantium vitre virtutum, hocce opusculum grati animi, propter beneficia innumera quae in me contulisti, atque amicitiam in quam me nullo tuo commodo recepisti, tenue testimonium, volo sacrum. Vale

Potassium is a trigger for conformational change in the fusion spike of an enveloped RNA virus

Many enveloped viruses enter cells through the endocytic network, from which they must subsequently escape through fusion of viral and endosomal membranes. This membrane fusion is mediated by virus-encoded spikes that respond to the dynamic endosomal environment, which triggers conformational changes in the spikes that initiate the fusion process. Several fusion triggers have been identified and include pH, membrane composition, and endosome-resident proteins, and these cues dictate when and where viral fusion occurs. We recently reported that infection with an enveloped bunyavirus requires elevated potassium ion concentrations [K⁺], controlled by cellular K⁺ channels, that are encountered during viral transit through maturing endosomes. Here we reveal the molecular basis for the K⁺ requirement of bunyaviruses through the first direct visualization of a member of the Nairoviridae family, namely Hazara virus (HAZV), using cryo-EM. Using cryo-electron tomography, we observed HAZV spike glycoproteins within infectious HAZV particles exposed to both high and low [K⁺], which showed that exposure to K⁺ alone results in dramatic changes to the ultrastructural architecture of the virion surface. In low [K⁺], the spikes adopted a compact conformation arranged in locally ordered arrays, whereas, following exposure to high [K⁺], the spikes became extended, and spike–membrane interactions were observed. Viruses exposed to high [K⁺] also displayed enhanced infectivity, thus identifying K⁺ as a newly defined trigger that helps promote viral infection. Finally, we confirmed that K⁺ channel blockers are inhibitory to HAZV infection, highlighting the potential of K⁺ channels as anti-bunyavirus targets

Epigenetic mediation of AKT1 rs1130233's Effect on delta-9-tetrahydrocannabinol-induced medial temporal function during fear processing

High doses of delta-9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis, have been shown to have anxiogenic effects. Additionally, THC effects have been shown to be modulated by genotype, including the single nucleotide polymorphism (SNP) rs1130233 at the protein kinase AKT1 gene, a key component of the dopamine signalling cascade. As such, it is likely that epigenetic methylation around this SNP may affect AKT gene expression, which may in turn impact on the acute effects of THC on brain function. We investigated the genetic (AKT1 rs1130233) and epigenetic modulation of brain function during fear processing in a 2-session, double-blind, cross-over, randomized placebo-controlled THC administration, in 36 healthy males. Fear processing was assessed using an emotion (fear processing) paradigm, under functional magnetic resonance imaging (fMRI). Complete genetic and fMRI data were available for 34 participants. THC caused an increase in anxiety and transient psychotomimetic symptoms and para-hippocampal gyrus/amygdala activation. Number of A alleles at the AKT1 rs1130233 SNP, and percentage methylation at the CpG11-12 site, were independently associated with a greater effect of THC on activation in a network of brain regions including left and right parahippocampal gyri, respectively. AKT1 rs1130233 moderation of the THC effect on left parahippocampal activation persisted after covarying for methylation percentage, and was partially mediated in sections of the left parahippocampal gyrus/hippocampus by methylation percentage. These results may offer an example of how genetic and epigenetic variations influence the psychotomimetic and neurofunctional effects of THC

Pupil Size in Spider Eyes Is Linked to Post-Ecdysal Lens Growth

In this study we describe a distinctive pigment ring that appears in spider eyes after ecdysis and successively decreases in size in the days thereafter. Although pigment stops in spider eyes are well known, size variability is, to our knowledge, reported here for the first time. Representative species from three families (Ctenidae, Sparassidae and Lycosidae) are investigated and, for one of these species (Cupiennius salei, Ctenidae), the progressive increase in pupil diameter is monitored. In this species the pupil occupies only a fourth of the total projected lens surface after ecdysis and reaches its final size after approximately ten days. MicroCT images suggest that the decrease of the pigment ring is linked to the growth of the corneal lens after ecdysis. The pigment rings might improve vision in the immature eye by shielding light rays that would otherwise enter the eye via peripheral regions of the cornea, beside the growing crystalline lens

A Predator from East Africa that Chooses Malaria Vectors as Preferred Prey

BACKGROUND: All vectors of human malaria, a disease responsible for more than one million deaths per year, are female mosquitoes from the genus Anopheles. Evarcha culicivora is an East African jumping spider (Salticidae) that feeds indirectly on vertebrate blood by selecting blood-carrying female mosquitoes as preferred prey. METHODOLOGY/PRINCIPAL FINDINGS: By testing with motionless lures made from mounting dead insects in lifelike posture on cork discs, we show that E. culicivora selects Anopheles mosquitoes in preference to other mosquitoes and that this predator can identify Anopheles by static appearance alone. Tests using active (grooming) virtual mosquitoes rendered in 3-D animation show that Anopheles' characteristic resting posture is an important prey-choice cue for E. culicivora. Expression of the spider's preference for Anopheles varies with the spider's size, varies with its prior feeding condition and is independent of the spider gaining a blood meal. CONCLUSIONS/SIGNIFICANCE: This is the first experimental study to show that a predator of any type actively chooses Anopheles as preferred prey, suggesting that specialized predators having a role in the biological control of disease vectors is a realistic possibility

Altered Relationship between Cortisol Response to Social Stress and Mediotemporal Function during Fear Processing in People at Clinical High Risk for Psychosis: A Preliminary Report

Evidence suggests that people at Clinical High Risk for Psychosis (CHR) have a blunted cortisol response to stress and altered mediotemporal activation during fear processing, which may be neuroendocrine–neuronal signatures of maladaptive threat responses. However, whether these facets are associated with each other and how this relationship is affected by cannabidiol treatment is unknown. We examined the relationship between cortisol response to social stress and mediotemporal function during fear processing in healthy people and in CHR patients. In exploratory analyses, we investigated whether treatment with cannabidiol in CHR individuals could normalise any putative alterations in cortisol-mediotemporal coupling. 33 CHR patients were randomised to 600 mg cannabidiol or placebo treatment. Healthy controls (n = 19) did not receive any drug. Mediotemporal function was assessed using a fearful face-processing functional magnetic resonance imaging paradigm. Serum cortisol and anxiety were measured immediately following the Trier Social Stress Test. The relationship between cortisol and mediotemporal blood-oxygen-level-dependent haemodynamic response was investigated using linear regression. In healthy controls, there was a significant negative relationship between cortisol and parahippocampal activation (p = 0.023), such that the higher the cortisol levels induced by social stress, the lower the parahippocampal activation (greater deactivation) during fear processing. This relationship differed significantly between the control and placebo groups (p = 0.033), but not between the placebo and cannabidiol groups (p = 0.67). Our preliminary findings suggest that the parahippocampal response to fear processing may be associated with the neuroendocrine (cortisol) response to experimentally induced social stress, and that this relationship may be altered in patients at clinical high risk for psychosis.</p