Clinical epidemiology and case fatality due to antimicrobial resistance in Germany: a systematic review and meta-analysis, 1 January 2010 to 31 December 2021

Background Antimicrobial resistance (AMR) is of public health concern worldwide. Aim We aimed to summarise the German AMR situation for clinicians and microbiologists. Methods We conducted a systematic review and meta-analysis of 60 published studies and data from the German Antibiotic-Resistance-Surveillance (ARS). Primary outcomes were AMR proportions in bacterial isolates from infected patients in Germany (2016–2021) and the case fatality rates (2010–2021). Random and fixed (common) effect models were used to calculate pooled proportions and pooled case fatality odds ratios, respectively. Results The pooled proportion of meticillin resistance in Staphylococcus aureus infections (MRSA) was 7.9% with a declining trend between 2014 and 2020 (odds ratio (OR) = 0.89; 95% CI: 0.886–0.891; p  70%) across studies reporting resistance proportions. Conclusion Continuous efforts in AMR surveillance and infection prevention and control as well as antibiotic stewardship are needed to limit the spread of AMR in Germany.Peer Reviewe

Personality maturation around the world:A cross-cultural examination of Social-Investment Theory

During early adulthood, individuals from different cultures across the world tend to become more agreeable, more conscientious, and less neurotic. Two leading theories offer different explanations for these pervasive age trends: Five-factor theory proposes that personality maturation is largely determined by genetic factors, whereas social-investment theory proposes that personality maturation in early adulthood is largely the result of normative life transitions to adult roles. In the research reported here, we conducted the first systematic cross-cultural test of these theories using data from a large Internet-based sample of young adults from 62 nations (N = 884,328). We found strong evidence for universal personality maturation from early to middle adulthood, yet there were significant cultural differences in age effects on personality traits. Consistent with social-investment theory, results showed that cultures with an earlier onset of adult-role responsibilities were marked by earlier personality maturation. Keywords: personality development, Big Five, social investment, culture, adult development, cross-cultural differences, personalit

Trajectories of temperament from late childhood through adolescence and associations with anxiety and depression in young adulthood

Anxiety and depression are pervasive and pernicious mental health problems for young adults. Developmental trajectories of adolescent temperament (Effortful Control, Negative Emotionality, and Positive Emotionality) may help us predict who will experience anxiety/depression during young adulthood. The present study used longitudinal data from a large, community sample of Mexican-origin youth ( N = 674) to examine how temperament develops across adolescence (age 10–16) and whether the developmental trajectories of temperament are associated with anxiety/depression during young adulthood (ages 19 and 21). Results indicate that Effortful Control, Negatively Emotionality, and the Affiliation facet of Positive Emotionality tend to decrease across adolescence, whereas Surgency tends to increase. Smaller decreases in Effortful Control and greater increases in Positive Emotionality across adolescence were associated with fewer anxiety/depression symptoms during young adulthood, whereas smaller decreases in Negative Emotionality were associated with more anxiety/depression symptoms later on. Thus, temperament development serves as both a protective factor (Effortful Control, Positive Emotionality) and a risk factor (Negative Emotionality) for later anxiety/depression in Mexican-origin youth

Personality traits below facets:The consensual validity, longitudinal stability, heritability, and utility of personality nuances

Mõttus R, Kandler C, Bleidorn W, Riemann R, McCrae RR. Personality Traits Below Facets: The Consensual Validity, Longitudinal Stability, Heritability, and Utility of Personality Nuances. Journal of Personality and Social Psychology. 2016;112(3):474-490

Longitudinal Experience-Wide Association Studies-A Framework for Studying Personality Change

The importance of personality for predicting life outcomes in the domains of love, work, and health is well established, as is evidence that personality traits, while relatively stable, can change. However, little is known about the sources and processes that drive changes in personality traits and how such changes might impact important life outcomes. In this paper, we make the case that the research paradigms and methodological approaches commonly used in personality psychology need to be revised to advance our understanding of the sources and processes of personality change. We proposeLongitudinal Experience-Wide Association Studiesas a framework for studying personality change that can address the limitations of current methods, and we discuss strategies for overcoming some of the challenges associated withLongitudinal Experience-Wide Association Studies.Peer reviewe

Reciprocal Associations between Parenting Challenges and Parents' Personality Development in Young and Middle Adulthood

Having children affects many aspects of people's lives. However, it remains unclear to what degree the challenges that come along with having children are associated with parents' personality development. We addressed this question in two studies by investigating the relationship between parenting challenges and personality development in mothers of newborns (Study 1, N = 556) and the reciprocal associations between (mastering) parenting challenges and personality development in parents of adolescents (Study 2, N = 548 mothers and 460 fathers). In Study 1, we found the stress of having a newborn baby to be associated with declines in maternal Agreeableness, Conscientiousness, and Emotional Stability. Parenting challenges were also related to personality development in parents of adolescent children in Study 2, with parent–child conflict being reciprocally associated with decreases in Conscientiousness and Emotional Stability. Mastering parenting challenges in the form of high parenting self-efficacy, on the other hand, was found to be associated with increases in Agreeableness, Conscientiousness, and Emotional Stability, and vice versa. In sum, our results suggest that mastering the challenges associated with the social role of parenthood is one of the mechanisms underlying personality development in young and middle adulthood

Author Correction: A consensus-based transparency checklist.

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Annelid phylogeny and the status of Sipuncula and Echiura

BACKGROUND: Annelida comprises an ancient and ecologically important animal phylum with over 16,500 described species and members are the dominant macrofauna of the deep sea. Traditionally, two major groups are distinguished: Clitellata (including earthworms, leeches) and "Polychaeta" (mostly marine worms). Recent analyses of molecular data suggest that Annelida may include other taxa once considered separate phyla (i.e., Echiura, and Sipuncula) and that Clitellata are derived annelids, thus rendering "Polychaeta" paraphyletic; however, this contradicts classification schemes of annelids developed from recent analyses of morphological characters. Given that deep-level evolutionary relationships of Annelida are poorly understood, we have analyzed comprehensive datasets based on nuclear and mitochondrial genes, and have applied rigorous testing of alternative hypotheses so that we can move towards the robust reconstruction of annelid history needed to interpret animal body plan evolution. RESULTS: Sipuncula, Echiura, Siboglinidae, and Clitellata are all nested within polychaete annelids according to phylogenetic analyses of three nuclear genes (18S rRNA, 28S rRNA, EF1α; 4552 nucleotide positions analyzed) for 81 taxa, and 11 nuclear and mitochondrial genes for 10 taxa (additional: 12S rRNA, 16S rRNA, ATP8, COX1-3, CYTB, NAD6; 11,454 nucleotide positions analyzed). For the first time, these findings are substantiated using approximately unbiased tests and non-scaled bootstrap probability tests that compare alternative hypotheses. For echiurans, the polychaete group Capitellidae is corroborated as the sister taxon; while the exact placement of Sipuncula within Annelida is still uncertain, our analyses suggest an affiliation with terebellimorphs. Siboglinids are in a clade with other sabellimorphs, and clitellates fall within a polychaete clade with aeolosomatids as their possible sister group. None of our analyses support the major polychaete clades reflected in the current classification scheme of annelids, and hypothesis testing significantly rejects monophyly of Scolecida, Palpata, Canalipalpata, and Aciculata. CONCLUSION: Using multiple genes and explicit hypothesis testing, we show that Echiura, Siboglinidae, and Clitellata are derived annelids with polychaete sister taxa, and that Sipuncula should be included within annelids. The traditional composition of Annelida greatly underestimates the morphological diversity of this group, and inclusion of Sipuncula and Echiura implies that patterns of segmentation within annelids have been evolutionarily labile. Relationships within Annelida based on our analyses of multiple genes challenge the current classification scheme, and some alternative hypotheses are provided