Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Estudios de la relacion estructura-funcion en DNA polimerasa DNA-dependiente del bacteriofago #phi#29

Centro de Informacion y Documentacion Cientifica (CINDOC). C/Joaquin Costa, 22. 28002 Madrid. SPAIN / CINDOC - Centro de Informaciòn y Documentaciòn CientìficaSIGLEESSpai

The effect of rapamycin on bovine oocyte maturation success and metaphase telomere length maintenance

Dr P. Kordowitzki was supported by KNOW consortium (Poland MS&HE, Decision No. 05-1/KNOW2/2015) and by a special statutory fund of DRI&P IAR&FR PAS in OlsztynMaternal aging-associated reduction of oocyte viability is a common feature in mammals, but more research is needed to counteract this process. In women, the first aging phenotype appears with a decline in reproductive function, and the follicle number gradually decreases from menarche to menopause. Cows can be used as a model of early human embryonic development and reproductive aging because both species share a very high degree of similarity during follicle selection, cleavage, and blastocyst formation. Recently, it has been proposed that the main driver of aging is the mammalian target of rapamycin (mTOR) signaling rather than reactive oxygen species. Based on these observations, the study aimed to investigate for the first time the possible role of rapamycin on oocyte maturation, embryonic development, and telomere length in the bovine species, as a target for future strategies for female infertility caused by advanced maternal age. The 1nm rapamycin in vitro treatment showed the best results for maturation rates (95.21±4.18%) of oocytes and was considered for further experiments. In conclusion, rapamycin influenced maturation rates of oocytes in a concentration-dependent manner. Our results also suggest a possible link between mTOR, telomere maintenance, and bovine blastocyst formation.S

The genetics of prenatal survival of pigs and rabbits: a review

International audienc

Evaluation of educational quality in hybrid teaching methods in undergraduate training projects. qualitative phase

En busca de una gestión orientada a la calidad y la transparencia en la educación superior, el presente proyecto tenía como objetivo primordial: • Diseñar un modelo de valoración de la calidad del servicio educativo en metodologías de enseñanza híbrida en pregrado que comprenda la percepción de los estudiantes, PDI y PAS. La consecución de este objetivo resolverá los siguientes problemas: • Falta de un modelo que permita evaluar la calidad de la educación considerando las particularidades de las metodologías de enseñanza híbrida. • Ausencia de un modelo de valoración de la calidad de la educación superior que integre la percepción de los estudiantes, PDI y PAS. • La necesidad de promover la cultura de la calidad educativa mediante un modelo que permita identificar aspectos negativos a mejorar en el servicio educativo, así como puntos fuertes a explotar de cara a tener una ventaja competitiva. • La carencia de un modelo de valoración de la calidad que presente resultados que permitan al SGIC, una correcta gestión de cara a los procesos de seguimiento y renovación de la acreditación. • La necesidad de un modelo de evaluación de la calidad que presente resultados comparables en términos de calidad a nivel de titulación, nivel de enseñanza y de facultad.In search of a management oriented towards quality and transparency in higher education, the present project had as its primary objective: • Design a model for assessing the quality of the educational service in hybrid teaching methodologies in undergraduates that includes the perception of students, PDI and PAS. The achievement of this objective will solve the following problems: • Lack of a model that allows evaluating the quality of education considering the particularities of hybrid teaching methodologies. • Absence of a model for assessing the quality of higher education that integrates the perception of students, PDI and PAS. • The need to promote the culture of educational quality through a model that allows the identification of negative aspects to improve in the educational service, as well as strong points to exploit in order to have a competitive advantage. • The lack of a quality assessment model that presents results that allow the SGIC to correctly manage the accreditation follow-up and renewal processes. • The need for a quality assessment model that presents comparable results in terms of quality at the degree, teaching and faculty level.Fac. de Comercio y TurismoFALSEUniversidad Complutense de Madridsubmitte

Guia de pràctica clínica sobre el maneig i tractament d’úlceres d’extremitats inferiors

Úlceres; Extremitats inferiors; Cures; EpidemiologiaÚlceras; Extremidades inferiores; Curas; EpidemiologíaUlcers; Lower extremities; Cures; EpidemiologyLes úlceres cròniques en les extremitats inferiors són un problema de salut amb importants repercussions socioeconòmiques a causa de la seva llarga evolució. Pot minvar la qualitat de vida del pacient i propiciar l’absentisme laboral, i constitueix un gran repte per als professionals sanitaris. L'objectiu d'aquest document és oferir al professional un coneixement actualitzat sobre les millors actuacions preventives i curatives en el maneig i tractament de les úlceres d’extremitat inferior. També facilitar informació sobre mesures diagnòstiques i terapèutiques per a cada situació clínica, per poder millorar la qualitat i eficiència de les cures proporcionades des d'una perspectiva holística i individualitzada