30 research outputs found
Femtosecond laser fabrication of LIPSS-based waveplates on metallic surfaces
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/08/2020
- Field of study
A fast and reliable method for the fabrication of polarization modifying devices using femtosecond laser is reported. A setup based on line focusing is used for the generation of LIPSS on stainless steel, processing at different speeds between 0.8 and 2.4 mm/s with constant energy per pulse of 1.4 mJ. SEM and AFM characterizations of the LIPSS show a progressive increase in period as the processing speed increases, while height remains approximately constant in the studied range. Optical characterization of the devices shows an induced change in the polarization of the reflected beam that varies with the processing speed, which allows a controlled fabrication of these devices
Pancreatic metastases from renal cell carcinoma. Postoperative outcome after surgical treatment in a Spanish multicenter study (PANMEKID)
- Author
- Alonso Casado Óscar
- Becerra Massare Antonio
- Blanco Fernández Gerardo
- Blas Juan Luis
- Burdío Fernando
- Castell Gómez José
- Cornejo Marian
- Diez Valladares Luis
- Domingo del Pozo Carlos
- Estevan Estevan Rafael
- Fabregat Prous Joan
- Fondevila Campo Constantino
- García Plaza Gabriel
- González Serrano Carmen
- Gutierrez Calvo Alberto
- Gómez Bravo Miguel Ángel
- Jaén Torrejimeno Isabel
- Jiménez Garrido Manuel
- Jover José María
- López Andújar Rafael
- López Baena José Ángel
- López Ben Santiago
- López Guerra Diego
- Martín Pérez Elena
- Martínez Insfran Luis Alberto
- Marín Ortega Héctor
- Muñoz Bellvís Luis
- Muñoz Forner Elena
- Ochando Cerdan Federico
- Pando Elizabeth
- Pardo Sánchez Fernando
- Pereira Fernando
- Prieto Calvo Mikel
- Pérez Alonso Alejandro J.
- Ramia José M.
- Rebollar Saenz José
- Rodriguez López Mario
- Rodríguez Sanjuan Juan Carlos
- Rojas Holguín Adela
- Rotellar Sastre Fernando
- Salinas Gómez Javier
- Sanjuanbenito Alfonso
- Secanella Medayo Luís
- Senra del Rio Paula
- Serrablo Requejo Alejandro
- Solar García Lorena
- Suárez Muñoz Miguel Ángel
- Sánchez Cabús Santiago
- Sánchez Turrión Víctor
- Sánchez Belinda
- Publication venue
- 'Elsevier BV'
- Publication date
- 11/08/2021
- Field of study
Background: Renal Cell Carcinoma (RCC) occasionally spreads to the pancreas. The purpose of our study is to evaluate the short and long-term results of a multicenter series in order to determine the effect of surgical treatment on the prognosis of these patients. Methods: Multicenter retrospective study of patients undergoing surgery for RCC pancreatic metastases, from January 2010 to May 2020. Variables related to the primary tumor, demographics, clinical characteristics of metastasis, location in the pancreas, type of pancreatic resection performed and data on short and long-term evolution after pancreatic resection were collected. Results: The study included 116 patients. The mean time between nephrectomy and pancreatic metastases' resection was 87.35 months (ICR: 1.51-332.55). Distal pancreatectomy was the most performed technique employed (50 %). Postoperative morbidity was observed in 60.9 % of cases (Clavien-Dindo greater than IIIa in 14 %). The median follow-up time was 43 months (13-78). Overall survival (OS) rates at 1, 3, and 5 years were 96 %, 88 %, and 83 %, respectively. The disease-free survival (DFS) rate at 1, 3, and 5 years was 73 %, 49 %, and 35 %, respectively. Significant prognostic factors of relapse were a disease free interval of less than 10 years (2.05 [1.13-3.72], p 0.02) and a history of previous extrapancreatic metastasis (2.44 [1.22-4.86], p 0.01). Conclusions: Pancreatic resection if metastatic RCC is found in the pancreas is warranted to achieve higher overall survival and disease-free survival, even if extrapancreatic metastases were previously removed. The existence of intrapancreatic multifocal compromise does not always warrant the performance of a total pancreatectomy in order to improve survival. (C) 2021 The Authors. Published by Elsevier Ltd
Repeated pancreatic resection for pancreatic metastases from renal cell Carcinoma: A Spanish multicenter study (PANMEKID)
- Author
- Alonso-casado Óscar
- Becerra-massare Antonio
- Blanco-fernández Gerardo
- Blas Juan Luis
- Burdío Fernando
- Castell-gómez José
- Cornejo Marian
- Diez-valladares Luis
- Estevan-estevan Rafael
- Fabregat-prous Joan
- Fondevila-campo Constantino
- García-plaza Gabriel
- Garrido Manuel Jiménez
- González-serrano Carmen
- Gutierrez-calvo Alberto
- Gómez-bravo Miguel Ángel
- Jaén-torrejimeno Isabel
- Jover José María
- López-andújar Rafael
- López-baena José Ángel
- López-ben Santiago
- López-guerra Diego
- Martín-pérez Elena
- Martínez-insfran Luis Alberto
- Marín-ortega Héctor
- Muñoz-bellvís Luis
- Muñoz-forner Elena
- Ochando-cerdan Federico
- Pando Elizabeth
- Pardo-sánchez Fernando
- Pereira Fernando
- Pozo Carlos Domingo-del
- Prieto-calvo Mikel
- Pérez-alonso Alejandro J.
- Ramia José M.
- Rebollar-saenz José
- Rio Paula Senra-del
- Rodriguez-lópez Mario
- Rodríguez-sanjuan Juan Carlos
- Rojas-holguín Adela
- Rotellar-sastre Fernando
- Salinas-gómez Javier
- Sanjuanbenito Alfonso
- Secanella-medayo Luís
- Serrablo-requejo Alejandro
- Solar-garcía Lorena
- Suárez-muñoz Miguel Ángel
- Sánchez Belinda
- Sánchez-cabús Santiago
- Turrión Víctor Sánchez
- Publication venue
- Elsevier BV
- Publication date
- 13/06/2024
- Field of study
Background and objectives: Recurrent isolated pancreatic metastasis from Renal Cell Carcinoma (RCC) after pancreatic resection is rare. The purpose of our study is to describe a series of cases of relapse of pancreatic metastasis from renal cancer in the pancreatic remnant and its surgical treatment with a repeated pancreatic resection, and to analyse the results of both overall and disease -free survival. Methods: Multicenter retrospective study of patients undergoing pancreatic resection for RCC pancreatic metastases, from January 2010 to May 2020. Patients were grouped into two groups depending on whether they received a single pancreatic resection (SPS) or iterative pancreatic resection. Data on short and long-term outcome after pancreatic resection were collected. Results: The study included 131 pancreatic resections performed in 116 patients. Thus, iterative pancreatic surgery (IPS) was performed in 15 patients. The mean length of time between the first pancreatic surgery and the second was 48.9 months (95 % CI: 22.2-56.9). There were no differences in the rate of postoperative complications. The DFS rates at 1, 3 and 5 years were 86 %, 78 % and 78 % vs 75 %, 50 % and 37 % in the IPS and SPS group respectively (p = 0.179). OS rates at 1, 3, 5 and 7 years were 100 %, 100 %, 100 % and 75 % in the IPS group vs 95 %, 85 %, 80 % and 68 % in the SPS group (p = 0.895). Conclusion: Repeated pancreatic resection in case of relapse of pancreatic metastasis of RCC in the pancreatic remnant is justified, since it achieves OS results similar to those obtained after the first resection
Evolution of the use of corticosteroids for the treatment of hospitalised COVID-19 patients in Spain between March and November 2020: SEMI-COVID national registry
- Author
- Abad M.D.C.B.
- Abanedes C.I.S.
- Aizpuru E.M.F.
- Alcalá J.N.
- Alegría J.G.
- Amezua C.H.
- Amodeo Oblitas C.M.
- Andreu M.D.M.G.
- Antúnez M.G.
- Arenzana C.B.
- Aseguinolaza M.G.
- Ayala-Gutiérrez M.M.
- Ayuso B.
- Bailón M.M.
- Balaz D.
- Bandera V.A.
- Beamonte E.D.C.
- Beato R.A.
- Benbunan C.C.
- Bengoa G.D.
- Bermejo C.L.
- Bermúdez M.
- Blanco A.L.
- Bueso T.S.
- Buonaiuto V.A.
- Caleya J.F.L.
- Calvo C.M.
- Campo B.M.
- Candalija A.C.
- Capitán C.F.
- Carmona J.M.
- Carracedo E.F.
- Carrasco A.G.
- Carrillo R.
- Carvajal M.C.C.
- Casado L.P.
- Casanova P.C.
- Casas L.A.
- Casas-Rojo J.-M.
- Castro S.M.
- Cañas C.A.
- Cebrián M.B.
- Chamorro L.M.T.
- Christophel A.T.F.-T.
- Clotet N.C.
- Corbella X.
- Corral J.B.
- Corral-Gudino L.
- Cruz A.F.
- Cuchillo J.B.
- Cánovas J.S.
- De Blas P.A.
- De La Calle G.M.
- De La Chica M.N.
- De Luque C.M.C.
- De Oña Á.A.
- De Pedro I.P.
- De Santos S.
- De Windt F.
- Del Pino J.L.
- Delgado C.M.
- Do Rego A.T.
- Elías A.E.C.
- Escalante M.D.M.
- Escudero S.C.
- Estrada A.D.B.
- Etayo M.Z.
- Fernandez-Bravo I.G.
- Fernandez-Castelao S.
- Fernández A.M.
- Fernández F.A.
- Fernández M.S.
- Fernández P.C.
- Fernández-Garcés M.
- Fernández-Llamazares G.S.
- Fonseca J.B.
- Fontan P.M.P.
- Fontán P.M.P.
- Frías M.C.
- Galeano Valle F.
- Galvañ V.G.
- Garcia A.
- Garcia M.V.V.
- García A.T.
- García C.A.
- García García G.M.
- García J.G.
- García S.L.
- Gil C.R.H.
- Godoy R.M.
- Gonzalo J.L.
- Gonzalo L.A.
- Grela A.G.
- Guerrero M.B.
- Guillan E.M.P.
- Gurjian A.A.
- Gutiérrez J.C.M.
- Gómez A.E.
- Gómez C.R.
- Gómez J.A.
- Hernández A.L.
- Hernández C.D.
- Hernández M.J.J.
- Homs N.
- Hontañón V.
- Huelgas R.G.
- Huerta L.J.
- Hurtado Oliver J.A.
- Ibáñez L.J.
- Iglesias M.F.G.
- Iscar C.O.
- Jansen-Chaparro S.
- Jenaro M.M.F.-M.
- Jimeno V.M.
- Jiménez P.D.
- Jiménez-García N.
- Klepzig J.L.G.
- Lahoz C.
- Laorden C.J.
- Ledesma S.M.
- Leoni M.E.G.
- Lezaun C.G.
- Llorente B.P.
- Lora-Tamayo J.
- Lorenzo-Hernández E.
- López C.M.O.
- López I.B.
- López M.M.M.
- López M.N.
- López R.B.
- López-Carmona M.D.
- Macías M.T.
- Manau J.V.
- Manglano J.D.
- Manuel E.C.
- Martínez D.L.
- Martínez J.M.H.
- Martínez L.F.C.
- Martínez M.L.T.
- Martínez R.F.-M.
- Mayoral M.V.
- Mendo C.L.
- Mera I.F.
- Molina S.C.
- Montero A.
- Montes J.T.
- Mora-Luján J.M.
- Morejón J.B.
- Moreno A.D.C.
- Moreno M.C.
- Mozo A.N.
- Murgui R.M.
- Muriel C.C.
- Muñoz B.G.
- Muñoz E.C.
- Muñoz J.A.
- Míguez A.M.
- Narciso C.G.S.
- Nohales C.M.
- Nuñez M.P.
- Núñez-Cortés J.M.
- Ocaña P.G.
- Olleros C.L.
- Ortega L.O.
- Palacios L.C.
- Pampyn M.P.
- Pedroche C.D.
- Peláez E.P.
- Peralta E.E.D.
- Perpiña B.O.
- Pineda-Cantero A.
- Prieto J.M.M.
- Prieto M.M.
- Purificación A.S.
- Pérez S.C.
- Pérez V.E.
- Pérez-Belmonte L.M.
- Quintana F.B.
- Quirantes P.L.
- Ramos J.C.
- Reyne A.G.
- Rhyman N.
- Ricci M.
- Rivera N.A.
- Robles E.M.
- Rodriguez V.N.
- Rodríguez-Mancheño A.L.
- Romero F.N.
- Romero M.A.F.
- Royo Trallero L.E.
- Rubio-Rivas M.
- Ruiz D.P.
- Ruiz S.P.
- Ruperto L.R.
- Saavedra M.O.F.
- Saldaña A.M.
- Samaniego N.T.
- Sampalo A.L.
- Sanz M.T.M.
- Sanz M.T.P.
- Sevilla J.J.M.
- Sierra J.O.
- Simon R.D.
- Simón M.A.Q.
- Suárez A.M.Á.
- Sánchez S.P.
- Tabares Y.U.
- Tejido S.C.
- Torre R.S.
- Troncoso J.Á.
- Veganzones L.I.
- Vergés C.D.
- Vidal A.D.
- Vieitez A.C.
- Vilan L.D.
- Villarreal G.
- Virto A.P.
- Wikman-Jorgensen P.E.
- Yeguas I.A.
- Zapico A.M.
- Publication venue
- 'MDPI AG'
- Publication date
- 01/01/2021
- Field of study
Objectives: Since the results of the RECOVERY trial, WHO recommendations about the use of corticosteroids (CTs) in COVID-19 have changed. The aim of the study is to analyse the evolutive use of CTs in Spain during the pandemic to assess the potential influence of new recommendations. Material and methods: A retrospective, descriptive, and observational study was conducted on adults hospitalised due to COVID-19 in Spain who were included in the SEMI-COVID- 19 Registry from March to November 2020. Results: CTs were used in 6053 (36.21%) of the included patients. The patients were older (mean (SD)) (69.6 (14.6) vs. 66.0 (16.8) years; p < 0.001), with hypertension (57.0% vs. 47.7%; p < 0.001), obesity (26.4% vs. 19.3%; p < 0.0001), and multimorbidity prevalence (20.6% vs. 16.1%; p < 0.001). These patients had higher values (mean (95% CI)) of C-reactive protein (CRP) (86 (32.7-160) vs. 49.3 (16-109) mg/dL; p < 0.001), ferritin (791 (393-1534) vs. 470 (236- 996) µg/dL; p < 0.001), D dimer (750 (430-1400) vs. 617 (345-1180) µg/dL; p < 0.001), and lower Sp02/Fi02 (266 (91.1) vs. 301 (101); p < 0.001). Since June 2020, there was an increment in the use of CTs (March vs. September; p < 0.001). Overall, 20% did not receive steroids, and 40% received less than 200 mg accumulated prednisone equivalent dose (APED). Severe patients are treated with higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%. Conclusions: Patients with greater comorbidity, severity, and inflammatory markers were those treated with CTs. In severe patients, there is a trend towards the use of higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
- Author
- 14 | COVIDSurg COllabOratIVe Tzovaras G. (General University Hospital of Larissa)
- Aawsaj Y.
- Abad Gurumeta A.
- Abad-Motos A.
- Abate E.
- Abbott D.
- Abdalla M.
- Abdeldayem H.
- Abdelkader Salama I.
- Abdelkarim M.
- Abdur-Rahman L.
- Abel M. K.
- Aboelkassem Ibrahim A.
- Abou Chaar M. K.
- Abreu da Silva A.
- Abubakar A.
- Acebes García F.
- Achalandabaso Boira M. Sales Mallafré R. (Hospital Universitari de Tarragona Joan XXIII)
- Acher A.
- Acrich E.
- Adamina M.
- Aderombi A.
- Adeyeye A.
- Adiamah A.
- Afonso J.
- Agapov M.
- Agnes A.
- Agostini C.
- Agresta F.
- Aguado H. (Hellín Hospital)
- Aguilar Gonzalez M. Talukder S. (West Suffolk Hospital)
- Ahmed Z.
- Ahmeidat A.
- Ahn J. H.
- Aiken T.
- Aimé A.
- Akalin M.
- Akaydin E.
- Akhtar M. A.
- Akhter Rahman M. M.
- Akin E.
- Al Awwad S.
- Al Habes H.
- Al Maadany F. S. (Al-Jalaa Hospital)
- Al- Khayal K.
- Al- Najjar H.
- Al-Habsi R.
- Al-Masri M.
- Al-Mohammad A.
- Alaa S.
- AlAamer O.
- Aladeojebi A.
- Alam F.
- Alawneh F. (King Hussein Cancer Center). Libya: Alkadeeki G.
- Albertsmeier M.
- Alcaide Matas F.
- Aldokali N.
- Alemanno G.
- Alfieri S.
- Alghamdi M.
- Alhamed A.
- Alharthi M.
- Alhassan N.
- Ali M.
- Ali S.
- Aliyeva Z.
- Aljiffry M.
- Alma Mater Studiorum University of Bologna)
- Almeida A. C.
- Almeida J. I.
- Almeida-Reis R.
- Alnumani T. (King Fahad 16 | COVIDSurg COllabOratIVe General Hospital)
- Alobeed O.
- Alonso de la Fuente N. Jimenez Toscano M. (Hospital del Mar)
- Alonso Poza A.
- Alonso- Lamberti L.
- Alqannas M.
- Alselaim N. (King Saud Bin Abdulaziz University for Health Sciences
- Alshammari S.
- Alsharif F.
- Altintoprak F.
- Alvarez E.
- Alyami M.
- Alzamanan M.
- Amaral M. J.
- Amin Sahid N.
- Amira G.
- Amorim E.
- Anania G.
- Anastasi A.
- Andrade R.
- Angelou D.
- Annamalai S.
- Annessi V.
- Antic A.
- Antonopoulou M. I.
- Anula R.
- Aou Sassari)
- Aprile A.
- Argentina: Alurralde C.
- Arican C.
- Arikan A. E.
- Arkadopoulos N.
- Armao T.
- Armatura G.
- Arminio A.
- Arrowsmith L. Campbell W. (Causeway Hospital)
- Asaad P.
- Ashcroft J.
- Ashmore C.
- Ashoush F.
- Askari A.
- Asqalan A.
- Athanasakis E.
- Athanasiou A.
- Atherton R.
- Attia D.
- Avci E. K.
- Aversano A.
- Ayasra F.
- Ayasra Y.
- Aydin C.
- Ayorinde J.
- Aytac E.
- Ayub B.
- Ayubi A.
- Ayyaz M. (Services Hospital Lahore)
- Azam M.
- Azamat İ. F.
- Azevedo P.
- Babar M. S.
- Baca B.
- Badra R.
- Baena Sanfeliu E.
- Bagraith K.
- Baiao J. M.
- Baig M.
- Baili E.
- Bailón M.
- Bajomo O.
- Baker A.
- Baker O.
- Bakmaz B.
- Balabel M.
- Balasubramaniam D.
- Baldari L.
- Baldi C.
- Baldini E.
- Bali R.
- Balik E.
- Ballabio M.
- Ballouhey Q.
- Baloyiannis I.
- Bandara G. B. K. D.
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- Baptista V. H.
- Barisic G.
- Baron R. D.
- Barrat B.
- Barrett J.
- Barrios O.
- Barry C.
- Bartalucci B.
- Bartolini I.
- Basendowah M.
- Bashir Y.
- Bass G. A.
- Bates H.
- Batistotti P.
- Baxevanidou K.
- Baía C.
- Beamish A.
- Beatson K.
- Becker R. Jonescheit J. (Heilig-Geist Hospital Bensheim)
- Beech N.
- Bekheit M.
- Belia F.
- Bellacci A.
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- Bello J.
- Bellora P.
- Belluco C.
- Beltrán de Heredia J.
- Belvedere A.
- Benavides Buleje J. A.
- Benkabbou A.
- Bergamini C.
- Bergeat D. Merdrignac A. (CHU Rennes – General Surgery)
- Bernante P.
- Bernasconi M.
- Berselli M.
- Bertolani E.
- Beyer K.
- Bhalla A.
- Bhangu A.
- Bhangu Aneel
- Bhasin S.
- Bhat M. A.
- Bhatti M. I.
- Bianchini M.
- Bianco F.
- Bianco F. (ASST Papa Giovanni XXIII – Bergamo)
- Bigelow B. (Johns Hopkins Hospital)
- Bilgin I. A.
- Bin Nasser A.
- Bin Traiki T.
- Biondi A.
- Bisagni P.
- Bisset C. Moug S. J. (Royal Alexandra Hospital)
- Blackwell L.
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- Bodla A. S.
- Boeck M.
- Boeker C.
- Bonci E.
- Bond-Smith G.
- Bondurri A.
- Bong C. Gundara J. (Logan Hospital)
- Boni L.
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- Borges F.
- Borges N.
- Borghi F.
- Borroni G.
- Bouchagier K.
- Bouche P. A. Tzedakis S. (Hôpital Cochin – APHP)
- Bouliaris K.
- Boulton A. J. (Good Hope Hospital)
- Boutall A.
- Boutros M.
- Bowman S. Guerra G. R. (Queen Elizabeth II Jubilee Hospital)
- Boyce R.
- Boyd-Carson H.
- Bozkurt E.
- Bozkurt M. A.
- Brachini G.
- Bravo Infante R.
- Brewer H.
- Brito da Silva F.
- Brixton G.
- Brocklehurst M.
- Brown B.
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- Brunt A.
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- Bueno Cañones A. D.
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- Butt U. I.
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- Cagigal Ortega E. P.
- Cagigas Fernandez C.
- Caiado A.
- Caiña Ruiz R.
- Cakmak G.
- Calabrò M.
- Calvo Espino P. Guillamot Ruano P. (Hospital Universitario de Móstoles)
- Camacho C.
- Caminsky N. G.
- Campagnaro T.
- Campus Benjamin Franklin)
- Canas-Martinez A.
- Cano A.
- Cano-Valderrama O.
- Canonico G.
- Canotilho R.
- Cantalejo Diaz M.
- Capelli P.
- Capezzuoli L.
- Capitan- Morales L.
- Capolupo G. T. Mazzotta E. (Policlinico Universitario Campus Bio Medico of Rome)
- Caram E. L.
- Carbone F.
- Carcoforo P.
- Cardoso N.
- Cardoso P.
- Carrano F. M.
- Carrasco Prats M.
- Carvello M. M.
- Casati M.
- Casiraghi T.
- Cassinotti E. (Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico di Milano)
- Castellammare di Stabia)
- Castro Ruiz C.
- Cato L. D.
- Cayetano Paniagua L. Gómez Fernández L. (Consorci Sanitari de Terrassa)
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- Cervellera M.
- Cervera I.
- Chan E.
- Chan E.
- Chand M.
- Charalabopoulos A.
- Chase T.
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- Chavarrias N.
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- Chessa A.
- Cheung L. K.
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- Choolani Bhojwani E.
- Choudhry A.
- Chowdhury A.
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- Choynowski M.
- Christidis P.
- Christoforidis D.
- Chrysos E.
- Chumbinho B.
- Chung E.
- Cianflocca D.
- Cicerchia P. M.
- Cintas Catena J.
- Ciofic E.
- Cirillo B.
- Cirocchi N.
- Claro M.
- Clifford R.
- Clinical Centre of Serbia)
- Coccolini F.
- Cocozza E.
- Coffey J. C.
- Colao García L.
- Collera P.
- Colletti G.
- Colombari R. C.
- Colombo F.
- Confalonieri M.
- Connelly T. M.
- Conti L.
- Conti L.
- Contis I.
- Corbellini C.
- Corless K.
- Correa Bonito A.
- Correia A. M.
- Correia de Sá T.
- Corrigan M.
- Corte Real J.
- Cortés Guiral D.
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- Rutegård M. (Umea University Hospital). Switzerland: Arigoni M.
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- Ryan M. (University Hospital Waterford/University College Cork). Italy: Macina S. (ASST Mantua)
- Ryan É. (University Hospital Galway)
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- Río Lafuente F. D.
- Saad M. M.
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- Sasia D.
- Saudí S. (Hospital Universitario Miguel Servet)
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- Sauvat F. (CHU Réunion). Romania: Bezede C.
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- Sayyed R. (Patel Hospital)
- Scabini S.
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- Sechenov Medical State University)
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- Seymour Z. (Ysbyty Gwynedd). USA: Haynes A.
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- Yüksel E. (Kocaeli University Teaching Hospital)
- Zafar S. N. (University of Wisconsin)
- Zakaria A. D.
- Zakaria Z. (School of Medical Sciences and Hospital
- Zambon M. (Policlinico Umberto I Sapienza University of Rome)
- Zanus G. (Ca’ Foncello Treviso – DISCOG – Università di Padova)
- Zegarac M. (Institute for Oncology and Radiology of Serbia)
- Zelić M. (University Hospital Center Rijeka)
- Zengin A. K. (Istanbul Universty – Cerrahpaşa Medical Faculty)
- Zerbib P. (CHU Lille)
- Zervas K.
- Zese M. (Santa Maria degli Angeli Hospital ULSS 5 – Adria)
- Zhang H. (Concord Repatriation General Hospital)
- Zizzo M. (Azienda Unità Sanitaria Locale – IRCCS di Reggio Emilia)
- Zografos C. (Laiko University Hospital)
- Zorrilla Ortúzar J. (Hospital General Universitario Gregorio Marañón)
- Zourntou S. (General Hospital of Larissa ‘Koutlimpaneio and Triantafylleio’)
- Zubaidi A. M. (King Saud University). Serbia: Aleksić L.
- Ângelo M.
- Çelebi F.
- Çolak E.
- Öfner D. (Medical University of Innsbruck)
- Öhlberger L.
- Özçelık M. F.
- Öğücü H.
- Überrück L.
- Ćoza I.
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-Gómez E
- Alessandri C
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- Alizadeh J
- Almacellas E
- Almasan A
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- Alonso GD
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- Altieri DC
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- Alzaharna MM
- Amadio M
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- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
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- Zuryn S
- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Intraperitoneal drain placement and outcomes after elective colorectal surgery: international matched, prospective, cohort study
- Author
- Aba M
- Abdellatif M
- Abdelmahmoud S
- Abu Hassan F
- Acil C
- Adarkwah P
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- Afzal A
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- Akintunde A
- Akkaya YM
- Akram J
- Aktas MK
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- Aktaş A
- Akula Y
- Al Nassrallah M
- Al-Habsi R
- Alam F
- Albino V
- Alfadhel S
- Ali T
- Alicata F
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- Yüksel E
- Zabiyaka M
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- Zafer F
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- Zahid M
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- Ziolkowska K
- Zografos G
- Zonta S
- Çetin B
- Ölmez M
- Özbalcı GS
- Özen D
- Özen D
- Öztürk OU
- Čustović S
- Štefanová H
- Ευσταθίου Η
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2022
- Field of study
Despite current guidelines, intraperitoneal drain placement after elective colorectal surgery remains widespread. Drains were not associated with earlier detection of intraperitoneal collections, but were associated with prolonged hospital stay and increased risk of surgical-site infections.Background Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice. Methods COMPASS (COMPlicAted intra-abdominal collectionS after colorectal Surgery) was a prospective, international, cohort study which enrolled consecutive adults undergoing elective colorectal surgery (February to March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included: rate and time to diagnosis of postoperative intraperitoneal collections; rate of surgical site infections (SSIs); time to discharge; and 30-day major postoperative complications (Clavien-Dindo grade at least III). After propensity score matching, multivariable logistic regression and Cox proportional hazards regression were used to estimate the independent association of the secondary outcomes with drain placement. Results Overall, 1805 patients from 22 countries were included (798 women, 44.2 per cent; median age 67.0 years). The drain insertion rate was 51.9 per cent (937 patients). After matching, drains were not associated with reduced rates (odds ratio (OR) 1.33, 95 per cent c.i. 0.79 to 2.23; P = 0.287) or earlier detection (hazard ratio (HR) 0.87, 0.33 to 2.31; P = 0.780) of collections. Although not associated with worse major postoperative complications (OR 1.09, 0.68 to 1.75; P = 0.709), drains were associated with delayed hospital discharge (HR 0.58, 0.52 to 0.66; P < 0.001) and an increased risk of SSIs (OR 2.47, 1.50 to 4.05; P < 0.001). Conclusion Intraperitoneal drain placement after elective colorectal surgery is not associated with earlier detection of postoperative collections, but prolongs hospital stay and increases SSI risk
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
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- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
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- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
565 Optimized Triple and Concomitant Therapy for Helicobacter pylori Eradication: The OPTRICON Study
- Author
- Alain Huerta
- Alfredo J. Lucendo
- Angel Lanas
- Angeles Perez Aisa
- Antonio Lima
- Blas J. Gómez Rodriguez
- Elisa Martin-Noguerol
- Francisco J. Rancel Medina
- Ines Ariño
- Ines Modolell
- Javier Molina-Infante
- Javier P. Gisbert
- Jesus Barrio
- Joaquín Rodríguez-Sánchez
- Jorge Perez-Lasala
- Josep M. Botargues
- Judith Gomez-Camarero
- Judith Millastre
- Maria A. Tejero
- Marta Gracia
- MTeresa Herranz-Bachiller
- Norberto Mañas
- Susana Prados
- Teresa Angueira
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Su1167 European Registry on H. pylori Management (Hp-EuReg): Spanish Detailed Results (Interim Analysis)
- Author
- Adrian G. McNicholl
- Alain Huerta
- Alfredo J. Lucendo
- Angel Lanas
- Angeles Perez Aisa
- Blas J. Gómez Rodriguez
- Cristobal De la Coba
- Ines Modolell
- J. Alcedo
- Javier Molina-Infante
- Javier P. Gisbert
- Jesus Barrio
- Josep M. Botargues
- Judith Millastre
- Julio Ducons
- Luis Bujanda
- Luis Fernandez Salazar
- Luis Rodrigo
- Manuel Castro-Fernandez
- Manuel Domínguez Cajal
- Maria Caldas
- Mercè Barenys
- Miguel A. Montoro
- Pedro Almela
- Pilar Sanchez-Pobre
- Xavier Calvet
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study