Completeness and Nonclassicality of Coherent States for Generalized Oscillator Algebras

The purposes of this work are (1) to show that the appropriate generalizations of the oscillator algebra permit the construction of a wide set of nonlinear coherent states in unified form; and (2) to clarify the likely contradiction between the nonclassical properties of such nonlinear coherent states and the possibility of finding a classical analog for them since they are P-represented by a delta function. In (1) we prove that a class of nonlinear coherent states can be constructed to satisfy a closure relation that is expressed uniquely in terms of the Meijer G-function. This property automatically defines the delta distribution as the P-representation of such states. Then, in principle, there must be a classical analog for them. Among other examples, we construct a family of nonlinear coherent states for a representation of the su(1,1) Lie algebra that is realized as a deformation of the oscillator algebra. In (2), we use a beam splitter to show that the nonlinear coherent states exhibit properties like anti-bunching that prohibit a classical description for them. We also show that these states lack second order coherence. That is, although the P-representation of the nonlinear coherent states is a delta function, they are not full coherent. Therefore, the systems associated with the generalized oscillator algebras cannot be considered `classical' in the context of the quantum theory of optical coherence.Comment: 26 pages, 10 figures, minor changes, misprints correcte

Interplay between Riccati, Ermakov and Schroedinger equations to produce complex-valued potentials with real energy spectrum

Nonlinear Riccati and Ermakov equations are combined to pair the energy spectrum of two different quantum systems via the Darboux method. One of the systems is assumed Hermitian, exactly solvable, with discrete energies in its spectrum. The other system is characterized by a complex-valued potential that inherits all the energies of the former one, and includes an additional real eigenvalue in its discrete spectrum. If such eigenvalue coincides with any discrete energy (or it is located between two discrete energies) of the initial system, its presence produces no singularities in the complex-valued potential. Non-Hermitian systems with spectrum that includes all the energies of either Morse or trigonometric Poeschl-Teller potentials are introduced as concrete examples.Comment: 21 pages, 12 figure

Relationship between rain and groundwater in the hydrogeological sectors of the South Basin of Ciego de Ávila

Abstract: Introduction: Groundwater constitutes the main source of water in the province of Ciego de Ávila, Cuba; especially in agriculture, which occupies the main economic line, however the overexploitation of aquifers in the southern basin of the province puts the sustainability of this important resource at risk, which is renewed through the natural recharge of rainfall. Objective: To determine the relationship between precipitation and groundwater levels in the hydrogeological sectors CA-II-2 and CA-II-3 of the Ciego de Ávila South Basin, which can constitute a way for the efficient use of water for irrigation purposes in this area of ​​great agricultural importance. Methodology: In the development of the research, different methodologies were used: selection of the most representative rain gauges, calculation of effective precipitation, determination of accumulated monthly and annual rainfall; as well as the annual rainfall of the wet and dry periods, completion of rainfall series by the linear regression method, use of the HidroEsta 2 program to obtain the mean hiperanual rainfall and the historical mean levels, absolute minimum and maximum of all the selected wells. The mean rainfall of the area of ​​the sectors was determined with the Isohyet method and the charts of hiperanual limnigrams were constructed using the BARHIS software. Results: The investigation showed that the average rainfall in the area is 1303.6 mm, higher than the historical average for the province. The water levels in the aquifer range between 0.84 and 12.98 m; where 7.21 m is the absolute average value. The year 1988 had great variations in rainfall, levels and the exploitation of groundwater. This study suggests the need to take measures that contribute to the rational use of groundwater in this overexploited basin due to the intensive use of water resources in agricultural irrigation. Conclusions: The study carried out was able to verify that the average rainfall in the area is 1303.6 mm, higher than the historical average for the province. The water levels in the aquifer range between 0.84 and 12.98 m, with absolute averages of 6.52 and 7.21 m respectively. The year 1988 presented high variability in rainfall, underground levels and the exploitation of groundwater.Abstract: Introduction: Groundwater constitutes the main source of water in the province of Ciego de Ávila, Cuba; especially in agriculture, which occupies the main economic line, however the overexploitation of aquifers in the southern basin of the province puts the sustainability of this important resource at risk, which is renewed through the natural recharge of rainfall. Objective: To determine the relationship between precipitation and groundwater levels in the hydrogeological sectors CA-II-2 and CA-II-3 of the Ciego de Ávila South Basin, which can constitute a way for the efficient use of water for irrigation purposes in this area of ​​great agricultural importance. Methodology: In the development of the research, different methodologies were used: selection of the most representative rain gauges, calculation of effective precipitation, determination of accumulated monthly and annual rainfall; as well as the annual rainfall of the wet and dry periods, completion of rainfall series by the linear regression method, use of the HidroEsta 2 program to obtain the mean hiperanual rainfall and the historical mean levels, absolute minimum and maximum of all the selected wells. The mean rainfall of the area of ​​the sectors was determined with the Isohyet method and the charts of hiperanual limnigrams were constructed using the BARHIS software. Results: The investigation showed that the average rainfall in the area is 1303.6 mm, higher than the historical average for the province. The water levels in the aquifer range between 0.84 and 12.98 m; where 7.21 m is the absolute average value. The year 1988 had great variations in rainfall, levels and the exploitation of groundwater. This study suggests the need to take measures that contribute to the rational use of groundwater in this overexploited basin due to the intensive use of water resources in agricultural irrigation. Conclusions: The study carried out was able to verify that the average rainfall in the area is 1303.6 mm, higher than the historical average for the province. The water levels in the aquifer range between 0.84 and 12.98 m, with absolute averages of 6.52 and 7.21 m respectively. The year 1988 presented high variability in rainfall, underground levels and the exploitation of groundwater

Relationship between rain and groundwater in the hydrogeological sectors of the South Basin of Ciego de Ávila

Abstract: Introduction: Groundwater constitutes the main source of water in the province of Ciego de Ávila, Cuba; especially in agriculture, which occupies the main economic line, however the overexploitation of aquifers in the southern basin of the province puts the sustainability of this important resource at risk, which is renewed through the natural recharge of rainfall. Objective: To determine the relationship between precipitation and groundwater levels in the hydrogeological sectors CA-II-2 and CA-II-3 of the Ciego de Ávila South Basin, which can constitute a way for the efficient use of water for irrigation purposes in this area of ​​great agricultural importance. Methodology: In the development of the research, different methodologies were used: selection of the most representative rain gauges, calculation of effective precipitation, determination of accumulated monthly and annual rainfall; as well as the annual rainfall of the wet and dry periods, completion of rainfall series by the linear regression method, use of the HidroEsta 2 program to obtain the mean hiperanual rainfall and the historical mean levels, absolute minimum and maximum of all the selected wells. The mean rainfall of the area of ​​the sectors was determined with the Isohyet method and the charts of hiperanual limnigrams were constructed using the BARHIS software. Results: The investigation showed that the average rainfall in the area is 1303.6 mm, higher than the historical average for the province. The water levels in the aquifer range between 0.84 and 12.98 m; where 7.21 m is the absolute average value. The year 1988 had great variations in rainfall, levels and the exploitation of groundwater. This study suggests the need to take measures that contribute to the rational use of groundwater in this overexploited basin due to the intensive use of water resources in agricultural irrigation. Conclusions: The study carried out was able to verify that the average rainfall in the area is 1303.6 mm, higher than the historical average for the province. The water levels in the aquifer range between 0.84 and 12.98 m, with absolute averages of 6.52 and 7.21 m respectively. The year 1988 presented high variability in rainfall, underground levels and the exploitation of groundwater.Abstract: Introduction: Groundwater constitutes the main source of water in the province of Ciego de Ávila, Cuba; especially in agriculture, which occupies the main economic line, however the overexploitation of aquifers in the southern basin of the province puts the sustainability of this important resource at risk, which is renewed through the natural recharge of rainfall. Objective: To determine the relationship between precipitation and groundwater levels in the hydrogeological sectors CA-II-2 and CA-II-3 of the Ciego de Ávila South Basin, which can constitute a way for the efficient use of water for irrigation purposes in this area of ​​great agricultural importance. Methodology: In the development of the research, different methodologies were used: selection of the most representative rain gauges, calculation of effective precipitation, determination of accumulated monthly and annual rainfall; as well as the annual rainfall of the wet and dry periods, completion of rainfall series by the linear regression method, use of the HidroEsta 2 program to obtain the mean hiperanual rainfall and the historical mean levels, absolute minimum and maximum of all the selected wells. The mean rainfall of the area of ​​the sectors was determined with the Isohyet method and the charts of hiperanual limnigrams were constructed using the BARHIS software. Results: The investigation showed that the average rainfall in the area is 1303.6 mm, higher than the historical average for the province. The water levels in the aquifer range between 0.84 and 12.98 m; where 7.21 m is the absolute average value. The year 1988 had great variations in rainfall, levels and the exploitation of groundwater. This study suggests the need to take measures that contribute to the rational use of groundwater in this overexploited basin due to the intensive use of water resources in agricultural irrigation. Conclusions: The study carried out was able to verify that the average rainfall in the area is 1303.6 mm, higher than the historical average for the province. The water levels in the aquifer range between 0.84 and 12.98 m, with absolute averages of 6.52 and 7.21 m respectively. The year 1988 presented high variability in rainfall, underground levels and the exploitation of groundwater

Plan de marketing y nivel de ventas de la empresa corporación Vimoda S.A.C, Lima, 2015

La investigación tiene por objetivo “determinar la relación entre el plan de marketing y las ventas en la empresa Corporación Vimoda SAC, 2015”. Se tuvo como objetivo organizacional, incrementar el nivel de ventas (generar ingresos) implementando un plan de marketing para obtener mayor rentabilidad. Dentro del plan de marketing, se analizó el mercado, segmentándolo entre la competencia y los puntos clave de mercadotécnica, lo cual ayudó a conseguir resultados esperados debido a la cantidad de recursos que tiene la empresa: tales como monitoreo, nivel de ventas, penetración del mercado, entre otros. La información sugiere que las empresas desarrollen un plan de análisis interno y externo para obtener la mayor cantidad de estrategias utilizadas. Este plan encaja en la realidad y presupuesto de la organización, como se encuentra en la etapa de ejecución, revisión, comprobación y definición de estrategias que se encuentran enfocados a conocimientos más amplios.The objective of the research is "To determine the relationship between the marketing plan and sales in the company Corporación Vimoda SAC, 2015". The organizational objective was to increase the level of sales (generate income) by implementing a marketing plan to obtain greater profitability. Within the marketing plan, the market was analyzed, segmenting it between the competition and the key marketing points, which helped to achieve expected results due to the amount of resources that the company has: such as monitoring, sales level, penetration of the market. market, among others. The information suggests that companies develop an internal and external analysis plan to obtain the greatest number of strategies used. This plan fits into the reality and budget of the organization, as it is in the stage of execution, review, verification and definition of strategies that are focused on broader knowledge

Investigación en tecnologías de inteligencia ambiental para la salud del futuro

El concepto de Inteligencia Ambiental que fue desarrollado en el documento ISTAG presenta una visión de la Sociedad de la Información futura enfatizando en la proximidad al usuario, eficiencia y soporte a servicios distribuidos, potenciación del usuario y en la facilidad de interacción humana con el entorno

SOX2 Expression and Transcriptional Activity Identifies a Subpopulation of Cancer Stem Cells in Sarcoma with Prognostic Implications

Stemness in sarcomas is coordinated by the expression of pluripotency factors, like SOX2, in cancer stem cells (CSC). The role of SOX2 in tumor initiation and progression has been well characterized in osteosarcoma. However, the pro-tumorigenic features of SOX2 have been scarcely investigated in other sarcoma subtypes. Here, we show that SOX2 depletion dramatically reduced the ability of undifferentiated pleomorphic sarcoma (UPS) cells to form tumorspheres and to initiate tumor growth. Conversely, SOX2 overexpression resulted in increased in vivo tumorigenicity. Moreover, using a reporter system (SORE6) which allows to monitor viable cells expressing SOX2 and/or OCT4, we found that SORE6+ cells were significantly more tumorigenic than the SORE6- subpopulation. In agreement with this findings, SOX2 expression in sarcoma patients was associated to tumor grade, differentiation, invasive potential and lower patient survival. Finally, we studied the effect of a panel of anti-tumor drugs on the SORE6+ cells of the UPS model and patient-derived chondrosarcoma lines. We found that the mithramycin analogue EC-8042 was the most efficient in reducing SORE6+ cells in vitro and in vivo. Overall, this study demonstrates that SOX2 is a pro-tumorigenic factor with prognostic potential in sarcoma. Moreover, SORE6 transcriptional activity is a bona fide CSC marker in sarcoma and constitutes an excellent biomarker for evaluating the efficacy of anti-tumor treatments on CSC subpopulations.This work was supported by the Agencia Estatal de Investigación (AEI) [MINECO/Fondo Europeo de Desarrollo Regional (FEDER) (SAF-2016-75286-R to R.R.), ISC III/FEDER (Miguel Servet Program CPII16/00049 to R.R., Sara Borrell Program CD16/00103 to S.T.M. and PI16/00280 and PI19/00560 to J.M.G-P) and Consorcio CIBERONC CB16/12/00390)] and the Plan de Ciencia Tecnología e Innovación del Principado de Asturias/FEDER (IDI/2018/155) to J.P.R and Predoctoral Fellowship Severo Ochoa (BP-17-108) to O.E.S

Machine detector interface for the e+e−e^+e^- future circular collider

The international Future Circular Collider (FCC) study aims at a design of $pp$, $e^+e^-$, $ep$ colliders to be built in a new 100 km tunnel in the Geneva region. The $e^+e^-$ collider (FCC-ee) has a centre of mass energy range between 90 (Z-pole) and 375 GeV (tt_bar). To reach such unprecedented energies and luminosities, the design of the interaction region is crucial. The crab-waist collision scheme has been chosen for the design and it will be compatible with all beam energies. In this paper we will describe the machine detector interface layout including the solenoid compensation scheme. We will describe how this layout fulfills all the requirements set by the parameters table and by the physical constraints. We will summarize the studies of the impact of the synchrotron radiation, the analysis of trapped modes and of the backgrounds induced by single beam and luminosity effects giving an estimate of the losses in the interaction region and in the detector.Comment: 6 pages, 7 figures, 62th ICFA ABDW on High Luminosity Circular $e^+e^-$ Colliders, eeFACT2018, Hong Kong, Chin

Short- and Long-Term Prognosis of Patients With Takotsubo Syndrome Based on Different Triggers: Importance of the Physical Nature

Background Takotsubo syndrome (TTS) is an acute reversible heart condition initially believed to represent a benign pathology attributable to its self-limiting clinical course; however, little is known about its prognosis based on different triggers. This study compared short- and long-term outcomes between TTS based on different triggers, focusing on various physical triggering events. Methods and Results We analyzed patients with a definitive TTS diagnosis recruited for the Spanish National Registry on TTS (RETAKO [Registry on Takotsubo Syndrome]). Short- and long-term outcomes were compared between different groups according to triggering factors. A total of 939 patients were included. An emotional trigger was detected in 340 patients (36.2%), a physical trigger in 293 patients (31.2%), and none could be identified in 306 patients (32.6%). The main physical triggers observed were infections (30.7%), followed by surgical procedures (22.5%), physical activities (18.4%), episodes of severe hypoxia (18.4%), and neurological events (9.9%). TTS triggered by physical factors showed higher mortality in the short and long term, and within this group, patients whose physical trigger was hypoxia were those who had a worse prognosis, in addition to being triggered by physical factors, including age >70 years, diabetes mellitus, left ventricular eyection fraction <30% and shock on admission, and increased long-term mortality risk. Conclusions TTS triggered by physical factors could present a worse prognosis in terms of mortality. Under the TTS label, there could be as yet undiscovered very different clinical profiles, whose differentiation could lead to individual better management, and therefore the perception of TTS as having a benign prognosis should be generally ruled out