Exploiting coastal altimetry to improve the surface circulation scheme over the central Mediterranean Sea

This work is the first study exploiting along track altimetry data to observe and monitor coastal ocean features over the transition area between the western and eastern Mediterranean Basins. The relative performances of both the AVISO and the X‐TRACK research regional altimetric data sets are compared using in situ observations. Both products are cross validated with tide gauge records. The altimeter‐derived geostrophic velocities are also compared with observations from a moored Acoustic Doppler Current Profiler. Results indicate the good potential of satellite altimetry to retrieve dynamic features over the area. However, X‐TRACK shows a more homogenous data coverage than AVISO, with longer time series in the 50 km coastal band. The seasonal evolution of the surface circulation is therefore analyzed by conjointly using X‐TRACK data and remotely sensed sea surface temperature observations. This combined data set clearly depicts different current regimes and bifurcations, which allows us to propose a new seasonal circulation scheme for the central Mediterranean. The analysis shows variations of the path and temporal behavior of the main circulation features: the Atlantic Tunisian Current, the Atlantic Ionian Stream, the Atlantic Libyan Current, and the Sidra Gyre. The resulting bifurcating veins of these currents are also discussed, and a new current branch is observed for the first time

Revisiting the tropical Atlantic western boundary circulation from a 25-year time series of satellite altimetry data

Geostrophic currents derived from altimetry are used to investigate the surface circulation in the Western Tropical Atlantic over the 1998&ndash;2017 period. Using six horizontal sections defined to capture the current branches of the study area, we investigate their respective variations at both seasonal and interannual time-scales as well as the spatial distribution of these variations. Our results show that the central branch of the South Equatorial Current, the North Brazil Current component located south of the equator, the Guyana Current and the northern branch of the South Equatorial Current at 42&deg; W have similar annual cycles, with maxima/minima during boreal winter-spring/October&ndash;November. In contrast, the seasonal cycles of the North Brazil Current branch located between the equator and 7&ndash;8&deg; N, the North Brazil Current retroflected branch and the North Equatorial Countercurrent show maxima/minima during boreal fall/May. West of 42&deg; W, an eastward current is observed between 0&deg;&ndash;2&deg; N, identified as the equatorial extension of the retroflected branch of the North Brazil Current. It is part of a large cyclonic circulation observed between 0&deg;&ndash;6&deg; N and 35&deg;&ndash;45&deg; W during boreal spring. The North Equatorial Countercurrent shows a two-core structure during the second half of the year, when we also observe the two regions where the North Brazil Current retroflects. The latter can be related to the wind stress curl seasonal changes. At interannual scales, depending on which side of the equator, the North Brazil Current exhibits two opposite scenarios related to the tropical Atlantic Meridional Mode phases. The interannual variability of the North Equatorial Countercurrent and of the northern branch of the South Equatorial Current (in terms of both strength and/or latitudinal shift) at 42&deg; W are also associated to the Atlantic Meridional Mode, while they are associated to the zonal mode phases at 32&deg; W.</p

Coastal sea level anomalies and associated trends from Jason satellite altimetry over 2002–2018

Climate-related sea level changes in the world coastal zones result from the superposition of the global mean rise due to ocean warming and land ice melt, regional changes caused by non-uniform ocean thermal expansion and salinity changes, and by the solid Earth response to current water mass redistribution and associated gravity change, plus small-scale coastal processes (e.g., shelf currents, wind & waves changes, fresh water input from rivers, etc.). So far, satellite altimetry has provided global gridded sea level time series up to 10–15 km to the coast only, preventing estimation of sea level changes very close to the coast. Here we present a 16-year-long (June 2002 to May 2018), high-resolution (20-Hz), along-track sea level dataset at monthly interval, together with associated sea level trends, at 429 coastal sites in six regions (Northeast Atlantic, Mediterranean Sea, Western Africa, North Indian Ocean, Southeast Asia and Australia). This new coastal sea level product is based on complete reprocessing of raw radar altimetry waveforms from the Jason-1, Jason-2 and Jason-3 missions

Sea level along the world’s coastlines can be measured by a network of virtual altimetry stations

For nearly 30 years, space-based radar altimetry has been routinely measuring changes in sea level at global and regional scales. But this technique designed for the open ocean does not provide reliable sea level data within 20 km to the coast, mostly due to land contamination within the radar echo in the vicinity of the coast. This problem can now be overcome through dedicated reprocessing, allowing the retrieval of valid sea level data in the 0-20 km band from the coast, and then the access to novel information on sea level change in the world coastal zones. Here we present sea level anomalies and associated coastal sea level trends at 756 altimetry-based virtual coastal stations located along the coasts of North and South America, Northeast Atlantic, Mediterranean Sea, Africa, North Indian Ocean, Asia and Australia. This new dataset, derived from the reprocessing of high-resolution (300 m) along-track altimetry data from the Jason-1, 2 and 3 missions from January 2002 to December 2019, allows the analysis of the decadal evolution of coastal sea level and fills the coastal gap where sparse sea level information is currently available

Towards comprehensive observing and modeling systems for monitoring and predicting regional to coastal sea level

A major challenge for managing impacts and implementing effective mitigation measures and adaptation strategies for coastal zones affected by future sea level (SL) rise is our limited capacity to predict SL change at the coast on relevant spatial and temporal scales. Predicting coastal SL requires the ability to monitor and simulate a multitude of physical processes affecting SL, from local effects of wind waves and river runoff to remote influences of the large-scale ocean circulation on the coast. Here we assess our current understanding of the causes of coastal SL variability on monthly to multi-decadal timescales, including geodetic, oceanographic and atmospheric aspects of the problem, and review available observing systems informing on coastal SL. We also review the ability of existing models and data assimilation systems to estimate coastal SL variations and of atmosphere-ocean global coupled models and related regional downscaling efforts to project future SL changes. We discuss (1) observational gaps and uncertainties, and priorities for the development of an optimal and integrated coastal SL observing system, (2) strategies for advancing model capabilities in forecasting short-term processes and projecting long-term changes affecting coastal SL, and (3) possible future developments of sea level services enabling better connection of scientists and user communities and facilitating assessment and decision making for adaptation to future coastal SL change.RP was funded by NASA grant NNH16CT00C. CD was supported by the Australian Research Council (FT130101532 and DP 160103130), the Scientific Committee on Oceanic Research (SCOR) Working Group 148, funded by national SCOR committees and a grant to SCOR from the U.S. National Science Foundation (Grant OCE-1546580), and the Intergovernmental Oceanographic Commission of UNESCO/International Oceanographic Data and Information Exchange (IOC/IODE) IQuOD Steering Group. SJ was supported by the Natural Environmental Research Council under Grant Agreement No. NE/P01517/1 and by the EPSRC NEWTON Fund Sustainable Deltas Programme, Grant Number EP/R024537/1. RvdW received funding from NWO, Grant 866.13.001. WH was supported by NASA (NNX17AI63G and NNX17AH25G). CL was supported by NASA Grant NNH16CT01C. This work is a contribution to the PIRATE project funded by CNES (to TP). PT was supported by the NOAA Research Global Ocean Monitoring and Observing Program through its sponsorship of UHSLC (NA16NMF4320058). JS was supported by EU contract 730030 (call H2020-EO-2016, “CEASELESS”). JW was supported by EU Horizon 2020 Grant 633211, Atlantos

Multiple Myeloma Treatment in Real-world Clinical Practice : Results of a Prospective, Multinational, Noninterventional Study

Funding Information: The authors would like to thank all patients and their families and all the EMMOS investigators for their valuable contributions to the study. The authors would like to acknowledge Robert Olie for his significant contribution to the EMMOS study. Writing support during the development of our report was provided by Laura Mulcahy and Catherine Crookes of FireKite, an Ashfield company, a part of UDG Healthcare plc, which was funded by Millennium Pharmaceuticals, Inc, and Janssen Global Services, LLC. The EMMOS study was supported by research funding from Janssen Pharmaceutical NV and Millennium Pharmaceuticals, Inc. Funding Information: The authors would like to thank all patients and their families and all the EMMOS investigators for their valuable contributions to the study. The authors would like to acknowledge Robert Olie for his significant contribution to the EMMOS study. Writing support during the development of our report was provided by Laura Mulcahy and Catherine Crookes of FireKite, an Ashfield company, a part of UDG Healthcare plc, which was funded by Millennium Pharmaceuticals, Inc, and Janssen Global Services, LLC. The EMMOS study was supported by research funding from Janssen Pharmaceutical NV and Millennium Pharmaceuticals, Inc. Funding Information: M.M. has received personal fees from Janssen, Celgene, Amgen, Bristol-Myers Squibb, Sanofi, Novartis, and Takeda and grants from Janssen and Sanofi during the conduct of the study. E.T. has received grants from Janssen and personal fees from Janssen and Takeda during the conduct of the study, and grants from Amgen, Celgene/Genesis, personal fees from Amgen, Celgene/Genesis, Bristol-Myers Squibb, Novartis, and Glaxo-Smith Kline outside the submitted work. M.V.M. has received personal fees from Janssen, Celgene, Amgen, and Takeda outside the submitted work. M.C. reports honoraria from Janssen, outside the submitted work. M. B. reports grants from Janssen Cilag during the conduct of the study. M.D. has received honoraria for participation on advisory boards for Janssen, Celgene, Takeda, Amgen, and Novartis. H.S. has received honoraria from Janssen-Cilag, Celgene, Amgen, Bristol-Myers Squibb, Novartis, and Takeda outside the submitted work. V.P. reports personal fees from Janssen during the conduct of the study and grants, personal fees, and nonfinancial support from Amgen, grants and personal fees from Sanofi, and personal fees from Takeda outside the submitted work. W.W. has received personal fees and grants from Amgen, Celgene, Novartis, Roche, Takeda, Gilead, and Janssen and nonfinancial support from Roche outside the submitted work. J.S. reports grants and nonfinancial support from Janssen Pharmaceutical during the conduct of the study. V.L. reports funding from Janssen Global Services LLC during the conduct of the study and study support from Janssen-Cilag and Pharmion outside the submitted work. A.P. reports employment and shareholding of Janssen (Johnson & Johnson) during the conduct of the study. C.C. reports employment at Janssen-Cilag during the conduct of the study. C.F. reports employment at Janssen Research and Development during the conduct of the study. F.T.B. reports employment at Janssen-Cilag during the conduct of the study. The remaining authors have stated that they have no conflicts of interest. Publisher Copyright: © 2018 The AuthorsMultiple myeloma (MM) remains an incurable disease, with little information available on its management in real-world clinical practice. The results of the present prospective, noninterventional observational study revealed great diversity in the treatment regimens used to treat MM. Our results also provide data to inform health economic, pharmacoepidemiologic, and outcomes research, providing a framework for the design of protocols to improve the outcomes of patients with MM. Background: The present prospective, multinational, noninterventional study aimed to document and describe real-world treatment regimens and disease progression in multiple myeloma (MM) patients. Patients and Methods: Adult patients initiating any new MM therapy from October 2010 to October 2012 were eligible. A multistage patient/site recruitment model was applied to minimize the selection bias; enrollment was stratified by country, region, and practice type. The patient medical and disease features, treatment history, and remission status were recorded at baseline, and prospective data on treatment, efficacy, and safety were collected electronically every 3 months. Results: A total of 2358 patients were enrolled. Of these patients, 775 and 1583 did and did not undergo stem cell transplantation (SCT) at any time during treatment, respectively. Of the patients in the SCT and non-SCT groups, 49%, 21%, 14%, and 15% and 57%, 20%, 12% and 10% were enrolled at treatment line 1, 2, 3, and ≥ 4, respectively. In the SCT and non-SCT groups, 45% and 54% of the patients had received bortezomib-based therapy without thalidomide/lenalidomide, 12% and 18% had received thalidomide/lenalidomide-based therapy without bortezomib, and 30% and 4% had received bortezomib plus thalidomide/lenalidomide-based therapy as frontline treatment, respectively. The corresponding proportions of SCT and non-SCT patients in lines 2, 3, and ≥ 4 were 45% and 37%, 30% and 37%, and 12% and 3%, 33% and 27%, 35% and 32%, and 8% and 2%, and 27% and 27%, 27% and 23%, and 6% and 4%, respectively. In the SCT and non-SCT patients, the overall response rate was 86% to 97% and 64% to 85% in line 1, 74% to 78% and 59% to 68% in line 2, 55% to 83% and 48% to 60% in line 3, and 49% to 65% and 36% and 45% in line 4, respectively, for regimens that included bortezomib and/or thalidomide/lenalidomide. Conclusion: The results of our prospective study have revealed great diversity in the treatment regimens used to manage MM in real-life practice. This diversity was linked to factors such as novel agent accessibility and evolving treatment recommendations. Our results provide insight into associated clinical benefits.publishersversionPeer reviewe

Separation of quasi-semiannual Rossby waves from the eastern boundary of the Indian Ocean.

International audienceWestward propagating features, identified as semiannual Rossby waves, have been observed in the southern subtropical Indian Ocean between 20S and 35S. A previous study based on ERS satellite scatterometer wind stress data in this region has shown that the Rossby waves were not forced by local Ekman pumping in the ocean interior nor by local variations in wind stress near the Australian coast. In the present study, we investigate a third possible source, in the form of remotely forced semiannual coastal waves propagating along the Australian coast. Altimetric and tide gauge data show consistent semiannual anomalies along the northwestern and western coast, with a phase lag between the northernmost station and about 25S, producing a poleward phase speed of ∼0.4 m s-1. South of the critical latitude for semiannual Rossby wave radiation at 27S, we still observe a significant sea level signal along the coast at the semiannual frequency that appears nearly in phase between the stations. Semiannual sea level anomalies lead the semiannual wind forcing by about one month, confirming that the signal is not locally forced. These semiannual coastal variations are in phase with the offshore radiation of Rossby waves observed between 20S and 35S. We suggest that, south of the critical latitude of 27S, the observed coastal wave signal could interact with the poleward coastal Leeuwin Current and that this wave-current interaction could stimulate nonlinear instabilities of this density-driven current and may be a key mechanism for the Rossby wave radiation in the subtropical Indian Ocean

Using high sampling rate (10/20 Hz) altimeter data for the observation of coastal surface currents: A case study over the northwestern Mediterranean Sea

International audienceSatellite altimetry, measuring sea surface heights (SSHs), has unique capabilities to provide information about the ocean dynamics. In this paper, the skill of the original full rate (10/20 Hz) measurements, relative to conventional 1-Hz data, is evaluated in the context of coastal studies in the Northwestern Mediterranean Sea. The performance and the question of the measurement noise are quantified through a comparison with different tide gauge sea level time series. By applying a specific processing, closer than 30 km to the land, the number of valid data is higher for the 10/20-Hz than for the 1-Hz observations: + 4.5% for T/P, + 10.3 for Jason-1 and + 13% for Jason-2. By filtering higher sampling rate measurements (using a 30-km cut-off low-pass Lanczos filter), we can obtain the same level of sea level accuracy as we would using the classical 1-Hz altimeter data. The gain in near-shore data results in a better observation of the Liguro-Provençal-Catalan Current. The seasonal evolution of the currents derived from 20-Hz data is globally consistent with patterns derived from the corresponding 1-Hz observations. But the use of higher frequency altimeter measurements allows us to observe the variability of the regional flow closer to the coast (~ 10-15 km from land)

Loop Current Eddies as a Possible Cause of the Rapid Sea Level Rise in the Gulf of Mexico

International audienceThe Gulf of Mexico (GOM), with its densely populated coastline, is one of the world's most vulnerable regions to climate change and sea level (SL) rise. Over the last three decades, various works have been conducted to assess coastal SL trends around the basin using tide gauge stations, separately from studies dealing with regional dynamical processes. Using altimetry, Argo, and eddy atlas products over the period from January 1993 to December 2020, we have analyzed the regional SL variations in the area to define their characteristics and explore their possible dynamical causes. We observe a mean GIA‐corrected SL rise rate of 4.81 ± 0.85 mm yr −1 , which is 25% higher than that of the adjacent Caribbean Sea and 44% higher than that of the global ocean. This result highlights the singular SL evolution in the GOM over the 28‐year study period. Over 2010–2020, the SL trend in the GOM has even accelerated, along with a strong warming of the upper‐layer (0.58 ± 0.17°C), which explains ∼60% of the SL rise rate through the thermosteric effect. Finally, the heat input estimates emphasize the role of the Loop Current eddies as a major contributor to the recent acceleration of SL rise due to upper‐layer warming