Equine digital tendons show breed‐specific differences in their mechanical properties that may relate to athletic ability and predisposition to injury

Background Throughout the ages, human subjects have selected horse breeds for their locomotor capacities. Concurrently, tissue properties may have diversified because of specific requirements of different disciplines. Objectives The aim of this study was to compare the biomechanical properties of tendons with different functions between equine breeds traditionally selected for racing or sport. Study design This study used ex vivo tendons and compared the mechanical properties of the common digital extensor tendon (CDET) and superficial digital flexor tendon (SDFT) between racehorses (Thoroughbred [TB]) and sports horses (Friesian Horse [FH], Warmblood [WB]). Methods The SDFT and CDET of FH (n = 12), WBs (n = 12) and TBs (n = 8) aged 3-12 years were harvested. The cross sectional area (cm(2)), maximal load (N), ultimate strain (%), ultimate stress (MPa) and elastic modulus (MPa) were determined and tested for significant differences between the breeds (P<0.05). Results The SDFT from WB horses had a significantly lower elastic modulus than TB horses and failed at a higher strain and load than both FHs and TBs. The mechanical properties of the CDET did not differ between breeds. In agreement with previous studies, the CDET failed at a higher stress and had a higher elastic modulus than the SDFT and, for the WB group of horses only, failed at a significantly lower strain. Interestingly, the mode of failure differed between breeds, particularly with respect to the FHs. Main limitations The exercise history of horses used in this study was unknown and the age-range was relatively large; both these factors may have influenced the absolute properties reported in this study. Conclusions This study shows for the first time that mechanical properties of the SDFT differ between breeds. These properties are likely to be related to selection for high-speed vs. an extravagant elastic gait and may be an important indicator of performance ability. The is available in Spanish - see Supporting Informatio

Emerging key roles for P2X receptors in the kidney

P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides. Whilst there is a wealth of literature describing a regulatory role of P2 receptors (P2R) in the kidney, there are significantly less data on the regulatory role of P2X receptors (P2XR) compared with that described for metabotropic P2Y. Much of the historical literature describing a role for P2XR in the kidney has focused heavily on the role of P2X1R in the autoregulation of renal blood flow. More recently, however, there has been a plethora of manuscripts providing compelling evidence for additional roles for P2XR in both kidney health and disease. This review summarizes the current evidence for the involvement of P2XR in the regulation of renal tubular and vascular function, and highlights the novel data describing their putative roles in regulating physiological and pathophysiological processes in the kidney

Testing Helioseismic-Holography Inversions for Supergranular Flows Using Synthetic Data

Supergranulation is one of the most visible length scales of solar convection and has been studied extensively by local helioseismology. We use synthetic data computed with the Seismic Propagation through Active Regions and Convection (SPARC) code to test regularized-least squares (RLS) inversions of helioseismic holography measurements for a supergranulation-like flow. The code simulates the acoustic wavefield by solving the linearized three-dimensional Euler equations in Cartesian geometry. We model a single supergranulation cell with a simple, axisymmetric, mass-conserving flow. The use of simulated data provides an opportunity for direct evaluation of the accuracy of measurement and inversion techniques. The RLS technique applied to helioseismic-holography measurements is generally successful in reproducing the structure of the horizontal flow field of the model supergranule cell. The errors are significant in horizontal-flow inversions near the top and bottom of the computational domain as well as in vertical-flow inversions throughout the domain. We show that the errors in the vertical velocity are due largely to cross talk from the horizontal velocity.Comment: 22 pages, 12 figues, accepted for publication in Solar Physic

Can fundamental movement skill mastery be increased via a six week physical activity intervention to have positive effects on physical activity and physical self-perception?

Previous research has suggested a positive relationship between fundamental movement skills (FMS) mastery and physical activity (PA) level. Research conducted on interventions to improve FMS mastery is equivocal and further research is needed.An intervention group of 82 children (35 boys and 47 girls) and a control group of 83 children (42 boys and 41 girls) were recruited from Years 4 and 5 (mean age ± SD = 8.3 ± 0.4 years) of two schools in Central England. The intervention included a combination of circuits and dancing to music. Pre and post intervention tests were conducted. Tests included: subjective assessment of eight FMS; objective measurement of two FMS; four day pedometer step count recording; height and mass for Body Mass Index (BMI); and the completion of Harter et al.'s (1982) self-perception questionnaire.Following a two (pre to post) by two (intervention and control group) mixed-model ANOVA it was highlighted that the intervention group improved mastery in all eight FMS, and increased both daily steps and physical self-perception.It can be concluded that focussing one Physical Education (PE) lesson per week on the development of FMS has had a positive benefit on FMS, PA level and physical self-perception for the children in this study

Final Report of the Commission on Presidential Disability and the Twenty-Fifth Amendment

This Report examines the Twenty-Fifth Amendment to identify potential difficulties in presidential succession and makes recommendations

Biological, physical and morphological factors for the programming of a novel microbial hygromorphic material

The urgency for energy efficient, responsive architectures has propelled smart material development to the forefront of scientific and architectural research. This paper explores biological, physical, and morphological factors influencing the programming of a novel microbial-based smart hybrid material which is responsive to changes in environmental humidity. Hygromorphs respond passively, without energy input, by expanding in high humidity and contracting in low humidity.Bacillus subtilisdevelops environmentally robust, hygromorphic spores which may be harnessed within a bilayer to generate a deflection response with potential for programmability. The bacterial spore-based hygromorph biocomposites (HBCs) were developed and aggregated to enable them to open and close apertures and demonstrate programmable responses to changes in environmental humidity. This study spans many fields including microbiology, materials science, design, fabrication and architectural technology, working at multiple scales from single cells to \u27bench-top\u27 prototype.Exploration of biological factors at cellular and ultracellular levels enabled optimisation of growth and sporulation conditions to biologically preprogramme optimum spore hygromorphic response and yield. Material explorations revealed physical factors influencing biomechanics, preprogramming shape and response complexity through fabrication and inert substrate interactions, to produce a palette of HBCs. Morphological aggregation was designed to harness and scale-up the HBC palette into programmable humidity responsive aperture openings. This culminated in pilot performance testing of a humidity-responsive ventilation panel fabricated with aggregatedBacillusHBCs as a bench-top prototype and suggests potential for this novel biotechnology to be further developed

Weathering the storm: developments in the acoustic sensing of wind and rain

An Acoustic Rain Gauge (ARG) analyses the underwater sound levels across a wide frequency range, classifies the observed spectrum according to likely source and then determines the local wind speed or rain rate as appropriate. Thispaper covers a trial on the Scotian Shelf off Canada, comparing the geophysical information derived from the acoustic signals with those obtained from other sources

Child health in Syria: recognising the lasting effects of warfare on health

The war in Syria, now in its fourth year, is one of the bloodiest in recent times. The legacy of war includes damage to the health of children that can last for decades and affect future generations. In this article we discuss the effects of the war on Syria's children, highlighting the less documented longer-term effects. In addition to their present suffering, these children, and their own children, are likely to face further challenges as a result of the current conflict. This is essential to understand both for effective interventions and for ethical reasons

The impact of changing provider remuneration on clinical activity and quality of care: evaluation of a pilot NHS contract in Northern Ireland

Objectives A pilot NHS dental contract was introduced in Northern Ireland between 2015 and 2016, which involved changing the method for paying general dental practitioners working in the NHS from Fee-For-Service (FFS) to capitation-based payments, providing an opportunity for a robust evaluation. We investigated the impact of a change in payment methods on clinical activity and the quality of care provided. Design A difference-in-difference (DiD) evaluation was applied to clinical activity data from pilot NHS dental practices in Northern Ireland compared to matched control NHS practices, and applied to a questionnaire survey of patient-rated outcomes of health outcomes and care quality. We estimated the impact on access to care, treatment activity levels, practice finances and patient-rated outcomes of care of a change from FFS to a capitation-based system for one year, as well as the impact of a reversion back to FFS at the end of the pilot period. Results The monthly number of registered patients in the pilot practices increased more than the control practices during the capitation period, by 1.5 registrations per 1,000 registered patients. The monthly reductions in the volumes of all treatments in the pilot practices during the capitation period was much larger than the control practices, with 175 fewer treatment items. All measures rapidly returned to baseline levels following reversion from capitation back to FFS. NHS income per month increased in pilot practices, by £5,920 per month (calculated on FFS item cost basis) more than controls in the capitation period. The analysis of patient questionnaires suggest found that patients notices differences only in waiting times, skill-mix and number of radiographs, but not on other measures of healthcare process and quality. Conclusion General dental practitioners working in the NHS respond rapidly and consistently to changes in provider payment methods. A move from FFS to a capitation-based system had little impact on access to care, but did produce large reductions in clinical activity and patient charge income. Patients noticed little change in the service they received. This shows that changes in remuneration contracts have the potential to meet policy goals, such as meeting the expectations of patients within a predictable cost envelope. However, it is unlikely that all policy goals can be met simply by changing payment methods. Therefore, work is also needed to identify and evaluate interventions that can complement changes in remuneration to achieve desirable outcomes

A Characterization of Cold Pools in the West African Sahel

Cold pools are integral components of squall-line mesoscale convective systems and the West African Monsoon, but are poorly represented in operational global models. Observations of thirty-eight cold pools made at Niamey during the 2006 AMMA (African Monsoon Multidisciplinary Analysis) campaign (1 June to 30 September 2006), are used to generate a seasonal characterization of cold-pool properties by quantifying related changes in surface meteorological variables. Cold pools were associated with temperature decreases of 2 to 14 ͦC, pressure increases of 0 to 8 hPa and wind gusts of 3 to 22 m s-1. Comparison with published values of similar variables from the Great Plains of the USA showed comparable differences. The leading part of most cold pools had decreased water vapour mixing ratios compared to the environment, with moister air, likely related to precipitation, approximately 30 minutes behind the gust front. A novel diagnostic used to quantify how consistent observed cold pool temperatures are with saturated or unsaturated descent from mid-levels (Fractional Evaporational Energy Deficit, FEED) shows that early-season cold pools are consistent with less saturated descents. Early season cold pools were relatively colder, windier and wetter, consistent with drier mid-levels, although this was only statistically significant for the change in moisture. Late season cold pools tended to decrease equivalent potential temperature from the pre-cold-pool value, whereas earlier in the season changes were smaller, with more increases. The role of cold pools may therefore change through the season, with early season cold-pools more able to feed subsequent convection