Intrinsic Lipschitz graphs in Heisenberg groups and continuous solutions of a balance equation

In this paper we provide a characterization of intrinsic Lipschitz graphs in the sub-Riemannian Heisenberg groups in terms of their distributional gradients. Moreover, we prove the equivalence of different notions of continuous weak solutions to the equation \phi_y+ [\phi^{2}/2]_t=w, where w is a bounded function depending on \phi

Intoxicações provocadas pelo herbicida paraquat: estudo de 219 casos

Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina. Departamento de Saúde Pública

Some remarks about parametrizations of intrinsic regular surfaces in the Heisenberg group

We prove that, in general, H-regular surfaces in the Heisenberg group H1 are not bi-Lipschitz equivalent to the plane R2 en- dowed with the "parabolic" distance, which instead is the model space for C1 surfaces without characteristic points. In Heisenberg groups Hn, H-regular surfaces can be seen as intrinsic graphs: we show that such parametrizations do not belong to Sobolev classes of metric-space valued maps

Hybrid subjects in Spanish and Catalan: Halfway between agents and patients

We analyze an intransitive construction involving verbs like Spanish matarse ‘kill’ whose subjects appear to have both internal and external argument properties. Examples include Juan se mató en un accidente de coche ‘Juan got himself killed in a car accident’, in which the subject’s referent shows hybrid behavior between agent and patient as it needs to be engaged in an action leading to its accidental death. We propose that the subject’s internal and external argument properties can be accounted for if subjects can bear two semantic roles by virtue of being associated with more than one distinct head in the syntax (Pineda & Berro 2020). We argue that such intransitive uses involve a distinct argument structure from transitive reflexives despite sharing the same surface form, cf., El sospechoso del homicidio se mató al estar rodeado por la policía ‘The suspect killed himself when he was surrounded by the police’. The present account provides evidence that agents and external arguments do not always correlate since some verb classes can have identical surface form, despite involving underlyingly distinct argument alignment.Ausensi was supported by the project PID2022-136610NB-I00 (MCIN/AEI/10.13039/501100011033/FEDER, UE). Bigolin was supported by the grant FPI PRE2018-085396 (AEI/European Social Fund), and projects PID2021-123617NB-C41 (Ministerio de Ciencia e Innovación) and 2021SGR00787 (AGAUR-Generalitat de Catalunya)

Resultatives and low depictives in English

We argue against a purely semantic account of the Unique Path Constraint (Goldberg, Adele. 1991. It can’t go down the chimney up: Paths and the English resultative. In Proceedings of the seventeenth annual meeting of the Berkeley Linguistics Society, 368–378.), i.e., the constraint that there can only be one result state in a single clause, and in favor of a syntactic restriction regarding event structure. We propose, following Mateu, Jaume & Víctor Acedo-Matellán. 2012. The manner/result complementarity revisited: A syntactic approach. In M. Cristina Cuervo & Yves Roberge (eds.), The end of argument structure? Syntax and semantics, 209–228. New York: Academic Press, that structurally there can only be one result predicate per clause since the little v head selects for one result predicate as its complement. In order to make our claim, we provide novel data that violate the Unique Path Constraint defined as a semantic constraint. Further, we analyze examples that at first blush pose a problem for the present account as they appear to involve two result phrases, e.g., shot him dead off the horse. We argue, however, that the second result phrase is not syntactically a result, but rather constitutes a case of what Acedo-Matellán, Víctor, Josep Ausensi, Josep Maria Fontana & Cristina Real-Puigdollers. forthcoming. Old Spanish resultatives as low depictives. In Chad L. Howe, Timothy Gupton, Margaret Renwick & Pilar Chamorro (eds.), Open romance linguistics 1. Selected papers from the 49th linguistic symposium on romance languages. Berlin: Language Science Press have called low depictives, which join the syntactic derivation through a low applicative head.The first author acknowledges financial support from the project Connecting Conceptual and Referential Models of Meaning 2 (CONNECT 2) (PI: Louise McNally) from the Ministerio de Economía y Competitividad (FFI2016-76045-P;AEI/MINEICO/FEDER, UE) and from an ICREA Academia award to Louise McNally. The second author acknowledges financial support from a Formación de Personal Investigador (FPI) grant from the Spanish Agencia Estatal de Investigación (Ministerio de Ciencia, Innovación y Universidades) and the European Social Fund, within the project Redes de variación microparametricas en las lenguas románicas (PIs: Ángel Gallego and Jaume Mateu) from the Spanish Ministerio de Economía, Industria y Competitividad (FFI2017-87140-C4-1-P)

A historical account on characterizations of C1-manifolds in Euclidean spaces by tangent cones

Abstract A historical account on characterizations of C 1 -manifolds in Euclidean spaces by tangent cones is provided. Old characterizations of smooth manifold (by tangent cones), due to Valiron (1926, 1927) and Severi (1929, 1934) are recovered; modern characterizations, due to Gluck (1966, 1968) and Tierno (1997) are restated. All these results are consequences of the Four-cones coincidence theorem due to [1]

Indicators to assess the quality of organizational attention: first steps towards a measurement instrument

Organizations increasingly have access to varied and sophisticated information about their internal and external environments. While there is the general belief that accessing high quality and sophisticated information leads to more effective decisions, this is not necessarily true. In a number of disciplinary fields, from economics to psychology and technology, scholars are emphasizing that information overload produces confusion and reduces consistent decision-making. This paper focuses organizational attention and presents a tool to assess the quality of organizational attention mediated by technology. This instrument was tested and will soon be applied in a pilot study to further refine it.This work has been supported by CAPES Foundation, Ministry of Education of Brazil and by FCT –Foundation for Science and Technology within the Project Scope UID/CEC/00319/2013

Investigação do mecanismo de morte celular induzido por compostos em células de linhagens de neoplasias hematológicas

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2016.As neoplasias hematológicas, que incluem as leucemias agudas e o mieloma múltiplo compreendem um grupo heterogêneo de doenças originadas a partir da proliferação anormal e descontrolada de uma célula clonal neoplásica de origem hematopoiética. Não é incomum a observação de células neoplásicas que desenvolvem resistência aos fármacos utilizados e pacientes que apresentam morbidade associada ao uso de quimioterápicos. Dessa forma, há necessidade de se investigar novas estruturas para o desenvolvimento de fármacos que tenham maior eficiência em induzir morte apenas nas células tumorais, que sejam de fácil administração, que não causem resistência e com poucos ou insignificantes efeitos adversos. Duas classes de compostos, as sulfonamidas e as quinonas, são bastante relatadas na literatura com atividade citotóxica. Nessa perspectiva, este estudo objetivou investigar o efeito citotóxico de um grupo de sulfonamidas e de uma quinona (GE2, primina) sobre linhagens celulares de neoplasias hematológicas. Entre as 26 sulfonamidas avaliadas, pelo método do MTT, o composto DFS16 (N-(3,3-difenilpropil)-2,4-dinitrobenzenosulfonamida) foi o selecionado para os ensaios posteriores, por apresentar maior atividade citotóxica sobre as três linhagens celulares utilizadas nesse trabalho (K562, Jurkat e MM.1S). Os resultados desse estudo permitem sugerir que a sulfonamida DFS16 possui atividade citotóxica sobre células K562 e Jurkat pela indução de apoptose (observada na microscopia com brometo de etídio e laranjada de acridina, fragmentação de DNA e marcação com Anexina V) por meio da ativação das vias intrínseca e extrínseca, além do envolvimento de alterações do potencial de membrana mitocondrial. A ativação da via intrínseca nessas células parece estar relacionada com a diminuição da expressão da proteína Bcl-2 e aumento da expressão da proteína Bax. Além disso, a diminuição da expressão da proteína de proliferação celular Ki-67 e o aumento da expressão do fator indutor de apoptose, observados por citometria de fluxo, demonstram possível relação com o mecanismo de morte induzido pelo tratamento com DFS16 nas células Jurkat. A apoptose induzida pela sulfonamida DFS16 nas células MM.1S sugere que a ativação ocorre por uma via diferente daquelas investigadas nesse trabalho, sem relação com a sinalização de caspases e com o envolvimento do bloqueio na progressão do ciclo celular na fase G2/M. Os resultados encontrados para a quinona GE2 indicam que a apoptose possivelmente é ativada pelas vias intrínseca e extrínseca nas células K562, Jurkat e MM.1S, com diminuição do potencial mitocondrial, além de diminuição da expressão da proteína Ki-67. Assim como, a quinona GE2 apresentou excelente seletividade para as células neoplásicas quando comparado com o tratamento em células não neoplásicas. O conjunto de resultados sugere que os compostos DFS16 e GE2 são promissores protótipos para o estudo e desenvolvimento de novos fármacos para o tratamento de neoplasias hematológicas.Abstract : Hematological malignancies, including acute leukemias and multiple myeloma, comprise a heterogeneous group of diseases originated from an abnormal and uncontrolled proliferation of neoplastic clonal cells of hematopoietic origin. It is not uncommon to observe neoplastic cells that develop resistance to the used drugs, as well as patients with morbidity associated to chemotherapy. Thus, it is necessary to investigate new structures for the development of drugs that present higher efficiency and specificity in inducing tumor cells death, that are easy to administer, that do not cause resistance and that have little or negligible adverse effects. Two classes of compounds, sulfonamides and quinones, were reported in the literature with a wide range of pharmacological properties and among them, the antitumor activity. In this perspective, this study aimed to investigate the cytotoxic effect of a group of sulfonamides and a quinone (GE2, primina) on hematological malignancies cell lines. Among the 26 sulfonamides evaluated, by MTT method, the compound DFS16 (N-(3,3-diphenylpropyl)-2,4-dinitrobenzenesulfonamide) was selected for the further tests due to its higher cytotoxic activity against the three cell lines that were analyzed in this study (K562, Jurkat and MM.1S). The results suggest that sulfonamide DFS16 has cytotoxic activity against K562 and Jurkat cells by apoptosis induction (observed in ethidium bromide and acridine orange microscopy, DNA fragmentation and labeling with Annexin V) by the intrinsic and the extrinsic pathways, involving also the mithocondrial membrane potential. The activation of the intrinsic pathway in these cells appears to be related by decreased Bcl-2 expression and increased Bax expression. Furthermore, the decreased expression of the cellular proliferation protein Ki-67 and the increased expression of apoptosis-inducing factor, observed by flow cytometry, also appear to be related to the death mechanism induced by DFS16 in Jurkat cells. Apoptosis induced by sulfonamide DFS16 in MM.1S cells appear to be activated by a different pathway from those investigated in this work, i.e. no relation with caspase signaling and blocking the cell cycle progression at G2/M phase. The quinone GE2 appears to induce apoptosis by activation of the intrinsic and the extrinsic pathways in K562, Jurkat and MM.1S cell lines, and by decreasing the expression of Ki-67 protein. The results suggest that the compounds DFS16 and GE2 are promising molecules for the use in hematological malignancies therapy or as prototypes for the development of new chemotherapics

Regularity of minimal intrinsic graphs in 3 dimensional sub-Riemannian structures of step 2

This work provides a characterization of the regularity of noncharacteristic intrinsic minimal graphs for a class of vector fields that includes non nilpotent Lie algebras as the one given by Euclidean motions of the plane. The main result extends a previous one on the Heisenberg group, using similar techniques to deal with nonlinearities. This wider setting provides a better understanding of geometric constraints, together with an extension of the potentialities of specific tools as the lifting-freezing procedure and interpolation inequalities. As a consequence of the regularity, a foliation result for minimal graphs is obtained