On the Mechanism of Protein Synthesis

Our knowledge about the mechanism of protein synthesis, one of the most important biochemical problems, is still extremely limited. It is evident from the very nature of proteins, their complexity and specificity, that the problem of protein synthesis presents numerous aspects. Theories of a template method of protein synthesis in the sense of Langmuir-Schaefer or Pauling are designed to explain the specificity of proteins. This paper will deal with only one aspect of protein synthesis, the mode of formation of the amide (peptide) linkage, which is the most typical linkage of every protein. In view of the close connection between protein synthesis and growth, any advance in understanding the former can he expected to shed some light not only on normal growth hut also on abnormal growth as typified by cancer formation. It is therefore essential that ideas on the problem of protein synthesis be communicated whereby impetus will be given for research efforts along new avenues of attack. On the more different fronts this problem will be tackled, the greater is the chance of ultimately solving it

HLA-G: expression in human keratinocytes in vitro and in human skin in vivo

Classical, polymorphic major histocompatibility complex class I molecules are expressed on most nucleated cells.They present peptides at the cell surface and, thus, enable the immune system to scan peptides for their antigenicity. The function of the other, nonclassical class I molecules in man is controversial. HLA-G which has been shown by transfection experiments to be expressed at the cell surface, is only transcribed in placental tissue and in the fetal eye.Therefore, a role of HLA-G in the control of rejection of the allogeneic fetus has been discussed. We found that HLA-G expression is induced in keratinocytes by culture in vitro. Three different alternative splicing products of HLA-G can be detected: a full length transcript, an mRNA lacking exon 3 and a transcript devoid of exon 3 and 4. Reverse transcription followed by polymerase chain reaction also revealed the presence of HLA-G mRNA in vivo in biopsies of either diseased or healthy skin

Scaffolding Discourse in Asynchronous Learning Networks

Discourse, a form of collaborative learning, is fundamentally a communications process. This in-progress study adapts Clark and Brennan’s grounding in communications principles to investigate how to “scaffold” asynchronous discourse. Scaffolding is defined as providing support for the learner at his or her level until the support is no longer needed. This paper presents early results from an experimental study measuring learning effectiveness. In the experiment, content and process scaffolding are manipulated based on pedagogic principles. A major contribution of the study is building and testing a technologymediated, discourse-centered, teaching and learning model called the Asynchronous Learning Networks Cognitive Discourse Model (ALNCDM). As discourse is one of the most widely used online methods of teaching and learning, the results of the study are expected to add to the body of knowledge on how to structure asynchronous online discourse assignments for more effective student learning

The Effect of Coherent Structures on Stochastic Acceleration in MHD Turbulence

We investigate the influence of coherent structures on particle acceleration in the strongly turbulent solar corona. By randomizing the Fourier phases of a pseudo-spectral simulation of isotropic MHD turbulence (Re $\sim 300$), and tracing collisionless test protons in both the exact-MHD and phase-randomized fields, it is found that the phase correlations enhance the acceleration efficiency during the first adiabatic stage of the acceleration process. The underlying physical mechanism is identified as the dynamical MHD alignment of the magnetic field with the electric current, which favours parallel (resistive) electric fields responsible for initial injection. Conversely, the alignment of the magnetic field with the bulk velocity weakens the acceleration by convective electric fields - \bfu \times \bfb at a non-adiabatic stage of the acceleration process. We point out that non-physical parallel electric fields in random-phase turbulence proxies lead to artificial acceleration, and that the dynamical MHD alignment can be taken into account on the level of the joint two-point function of the magnetic and electric fields, and is therefore amenable to Fokker-Planck descriptions of stochastic acceleration.Comment: accepted for publication in Ap

Mathematics, statistics and archaeometry: the past 50 years or so

This review of developments in the use of mathematics and statistics in archaeometry over the past 50 years is partial, personal and 'broad-brush'. The view is expressed that it is in the past 30 years or so that the major developments have taken place. The view is also expressed that, with the exception of methods for analysing radiocarbon dates and increased computational power, mathematical and statistical methods that are currently used, and found to be useful in widespread areas of application such as provenance studies, don't differ fundamentally from what was being done 30 years ago

Forbush decreases and solar events seen in the 10 - 20GeV energy range by the Karlsruhe Muon Telescope

Since 1993, a muon telescope located at Forschungszentrum Karlsruhe (Karlsruhe Muon Telescope) has been recording the flux of single muons mostly originating from primary cosmic-ray protons with dominant energies in the 10 - 20 GeV range. The data are used to investigate the influence of solar effects on the flux of cosmic-rays measured at Earth. Non-periodic events like Forbush decreases and ground level enhancements are detected in the registered muon flux. A selection of recent events will be presented and compared to data from the Jungfraujoch neutron monitor. The data of the Karlsruhe Muon Telescope help to extend the knowledge about Forbush decreases and ground level enhancements to energies beyond the neutron monitor regime.Comment: 9 pages, 7 figures, in Press AS

On the Estimation of Solar Energetic Particle Injection Timing from Onset Times near Earth

We examine the accuracy of a common technique for estimating the start time of solar energetic particle injection based on a linear fit to the observed onset time versus 1/(particle velocity). This is based on a concept that the first arriving particles move directly along the magnetic field with no scattering. We check this by performing numerical simulations of the transport of solar protons between 2 and 2000 MeV from the Sun to the Earth, for several assumptions regarding interplanetary scattering and the duration of particle injection, and analyzing the results using the inverse velocity fit. We find that in most cases, the onset times align close to a straight line as a function of inverse velocity. Despite this, the estimated injection time can be in error by several minutes. Also, the estimated path length can deviate greatly from the actual path length along the interplanetary magnetic field. The major difference between the estimated and actual path lengths implies that the first arriving particles cannot be viewed as moving directly along the interplanetary magnetic field.Comment: 19 pages, 3 Postscript figures. Astrophys. J., in pres

?We all Black innit??: Analysing relations between African and African-Caribbean groups in Britain

‘We all Black innit?’ examines ‘intra ethnic’ relationships between second and third generation members of British African and British African Caribbean groups, located in two key urban settings (London and Birmingham). Through unstructured interviews, it explores ways in which positive informal/formal ‘race based coalitions’ (Rogers 2004), have been forged, partly as a result of supporting and celebrating each other’s contributions to professionality (e.g education and work), and popular culture (e.g music and sports). Moreover, it discusses how members of these generations have come to embrace difference and commonalities in terms of ‘histories language and culture’ (Hall 1988:5), and the role of ‘pan ethnicity’ in facilitating these positive relationships. There is, however, acknowledgement of ‘intra ethnic’ tensions existing between these groups, largely resulting from historical (and often negative) stereotypes of each other’s cultural attributes (Mwakigale 2009, Fanon 1952), and competition for scare socio-economic resources, intensified by allocation along colour or ethnic lines (Malik 2012). The findings suggest that although this appears to have been a greater issue for migrant generations who arrived in Britain, especially between the post war era and the 1980s, to an extent it has impacted on ‘intra ethnic’ relations between the second and third generations. In the main, however, it would seem that the mutual respect between younger generations of British African and British African Caribbean people, has grown with time

Possible Tomography of the Sun's Magnetic Field with Solar Neutrinos

The data from solar neutrino experiments together with standard solar model predictions are used in order to derive the possible profile of the magnetic field inside the Sun, assuming the existence of a sizeable neutrino magnetic moment and the resonant spin flavour mechanism. The procedure is based on the relationship between resonance location and the energy dependent neutrino suppression, so that a large neutrino suppression at a given energy is taken to be connected to a large magnetic field in a given region of the Sun. In this way it is found that the solar field must undergo a very sharp increase by a factor of at least 6 - 7 over a distance no longer than 7 - 10% of the solar radius, decreasing gradually towards the surface. The range in which this sharp increase occurs is likely to be the bottom of the convective zone. There are also indications in favour of the downward slope being stronger at the start and more moderate on approaching the solar surface. Typical ranges for the magnetic moment are from a few times 10^{-13}\mu_B to its laboratory upper bounds while the mass square difference between neutrino flavours is of order (0.6-1.9) x 10^{-8}eV^2.Comment: Several minor corrections performed, sunspot anticorrelation discussed, references added, 29 pages including 8 figures in PostScrip

Screened Coulomb interactions in metallic alloys: II Screening beyond the single-site and atomic sphere approximations

A quantitative description of the configurational part of the total energy of metallic alloys with substantial atomic size difference cannot be achieved in the atomic sphere approximation: It needs to be corrected at least for the multipole moment interactions in the Madelung part of the one-electron potential and energy. In the case of a random alloy such interactions can be accounted for only by lifting the atomic sphere and single-site approximations, in order to include the polarization due to local environment effects. Nevertheless a simple parameterization of the screened Coulomb interactions for the ordinary single-site methods, including the generalized perturbation method, is still possible. We obtained such a parameterization for bulk and surface NiPt alloys, which allows one to obtain quantitatively accurate effective interactions in this system.Comment: 24 pages, 2 figure