15 research outputs found
Numerical simulation of the filling and curing stages in reaction injection moulding, using CFX
Mestrado em Engenharia MecânicaOs métodos habitualmente utilizados para a simulação de injecção em
moldes envolvem um número considerável de simplificações, originando
reduções significativas do esforço computacional mas, nalguns casos
também limitações. Neste trabalho são efectuadas simulações de Reaction
Injection Moulding (RIM) com o mĂnimo de simplificações, atravĂ©s da
utilização do software de CFD multi-objectivos CFX, concebido para a
simulação numérica de escoamentos e transferência de calor e massa.
Verifica-se que o modelo homogéneo para escoamentos multifásicos do
CFX, geralmente considerado o apropriado para a modelação de
escoamentos de superfĂcie livre em que as fases estĂŁo completamente
estratificadas, Ă© incapaz de modelar correctamente o processo de
enchimento. Este problema é ultrapassado através da implementação do
modelo não homogéneo juntamente com a condição de fronteira de
escorregamento livre para o ar.
A reacção de cura é implementada no código como uma equação de
transporte para uma variável escalar adicional, com um termo fonte. São
testados vários esquemas transitórios e advectivos, com vista ao
reconhecimentos de quais os que produzem os resultados mais precisos.
Finalmente, as equações de conservação de massa, quantidade de
movimento, cura e energia sĂŁo implementadas conjuntamente para simular
os processos simultâneos de enchimento e cura presentes no processo
RIM. Os resultados numéricos obtidos reproduzem com boa fidelidade
outros resultados numĂ©ricos e experimentais disponĂveis, sendo
necessários no entanto tempos de computação consideravelmente longos
para efectuar as simulações.
ABSTRACT: Commonly used methods for injection moulding simulation involve
considerable number of simplifications, leading to a significant reduction of
the computational effort but, in some cases also to limitations. In this work,
Reaction Injection Moulding (RIM) simulations are performed with
minimum of simplifications, by using the general purpose CFD software
package CFX, designed for numerical simulation of fluid flow and heat and
mass transfer.
The CFX’s homogeneous multiphase flow model, which is generally
considered to be the appropriate choice for modelling free surface flows
where the phases are completely stratified and the interface is well defined,
is shown to be unable to model the filling process correctly. This problem is
overcome through the implementation of the inhomogeneous model in
combination with the free-slip boundary condition for the air phase.
The cure reaction is implemented in the code as a transport equation for an
additional scalar variable, with a source term. Various transient and
advection schemes are tested to determine which ones produce the most
accurate results.
Finally, the mass conservation, momentum, cure and energy equations are
implemented all together to simulate the simultaneous filling and curing
processes present in the RIM process. The obtained numerical results
show a good global accuracy when compared with other available
numerical and experimental results, though considerably long computation
times are required to perform the simulations
European Multicenter Study on Coronary Artery Bypass Grafting (E-CABG registry): Study Protocol for a Prospective Clinical Registry and Proposal of Classification of Postoperative Complications
Insights into sucrose pathway of chicory stems by integrative transcriptomic and metabolic analyses
The worldwide-cultivated chicory (Cichorium intybus L.) produces food and beneficial compounds, and young pre-flowering inflorescence stems are newly marketed vegetables. These sink-organs undergo growth by metabolizing sugars of leaf origin; the carbohydrate content and sweetness are crucial aspects for consumers' nutrition and acceptance. NMR profiling of 31 hydrosoluble phytochemicals showed that stem contents varied as influenced by genotype, environment and interaction, and that higher sucrose levels were associated with the sweeter of two landraces. Integrative analyses of metabolic and transcriptomic profile variations allowed the dissection of sucrose pathway. Overall, 427 and 23 unigenes respectively fell into the categories of sucrose metabolism and sugar carriers. Among 10 differentially expressed genes, the 11474/sucrose synthase, 53458/fructokinase, 9306 and 17035/hexokinases, and 20171/SWEET-type genes significantly associated to sugar content variation, and deduced proteins were characterised in silico. Correlation analyses encompassing sugar level variation, expressions of the former genes and of computationally assigned transcription factors (10938/NAC, 14712/bHLH, 40133/TALE and 17846/MIKC) revealed a gene network. The latter was minimally affected by the environment and accomplished with markers, representing a resource for biological studies and breeding
Corrigendum to “Insights into sucrose pathway of chicory stems by integrative transcriptomic and metabolic analyses” [Phytochemistry Vol. 167 (November 2019) 112086
Superior Myocardial Protection Using "Polarizing" Adenosine, Lidocaine, and Mg2+ Cardioplegia in Humans
[abstract not available
Transcriptome driven characterization of curly- and smooth-leafed endives reveals molecular differences in the sesquiterpenoid pathway
Diving into the genetics of endives Genetic analyses show molecular differences that could explain why curly endives taste bitterer than smooth ones. Donato Giannino of the Institute of Agricultural Biology and Biotechnology and colleagues in Italy analyzed the genetic differences between curly and smooth endives, a leafy vegetable used in salads. They found more than 3000 single sequence variations in genes distinguishing the two types from each other. Twenty six genes were involved in the biosynthesis of sesquiterpenoids, metabolites important for plant survival that also contribute to the bitter taste of endives and have antimalarial, sedative and analgesic effects when isolated for humans. Their levels were higher in curly than in smooth endives, potentially contributing to their more bitter taste. The information expands the genetic data available on endives for breeding programs
Superior Myocardial Protection Using “Polarizing” Adenosine, Lidocaine, and Mg 2+ Cardioplegia in Humans
Venoarterial extracorporeal membrane oxygenation after coronary artery bypass grafting : Results of a multicenter study
Background: The evidence of the benefits of using venoarterial extracorporeal membrane oxygenation (VA-ECMO) after coronary artery bypass grafting (CABG) is scarce. Methods: We analyzed the outcomes of patients who received VA-ECMO therapy due to cardiac or respiratory failure after isolated CABG in 12 centers between 2005 and 2016. Patients treated preoperatively with ECMO were excluded from this study. Results: VA-ECMO was employed in 148 patients after CABG for median of 5.0 days (mean, 6.4, SD 5.6 days). Inhospital mortality was 64.2%. Pooled in-hospital mortality was 65.9% without significant heterogeneity between the centers (I-2 8.6%). The proportion of VA-ECMO in each center did not affect in-hospital mortality (p = 0.861). No patients underwent heart transplantation and six patients received a left ventricular assist device. Logistic regression showed that creatinine clearance (p = 0.004, OR 0.98, 95% CI 0.97-0.99), pulmonary disease (p = 0.018, OR 4.42, 95% CI 1.29-15.15) and pre-VA-ECMO blood lactate (p = 0.015, OR 1.10, 95% CI 1.02-1.18) were independent baseline predictors of in-hospital mortality. One-, 2-, and 3-year survival was 31.0%, 27.9%, and 26.1%, respectively. Conclusions: One third of patients with need for VA-ECMO after CABG survive to discharge. In view of the burden of resources associated with VA-ECMO treatment and the limited number of patients surviving to discharge, further studies are needed to identify patients who may benefit the most from this treatment. (C) 2017 Elsevier B.V. All rights reserved.Peer reviewe
Venoarterial extracorporeal membrane oxygenation after coronary artery bypass grafting: Results of a multicenter study.
BACKGROUND:
The evidence of the benefits of using venoarterial extracorporeal membrane oxygenation (VA-ECMO) after coronary artery bypass grafting (CABG) is scarce.
METHODS:
We analyzed the outcomes of patients who received VA-ECMO therapy due to cardiac or respiratory failure after isolated CABG in 12 centers between 2005 and 2016. Patients treated preoperatively with ECMO were excluded from this study.
RESULTS:
VA-ECMO was employed in 148 patients after CABG for median of 5.0days (mean, 6.4, SD 5.6days). In-hospital mortality was 64.2%. Pooled in-hospital mortality was 65.9% without significant heterogeneity between the centers (I2 8.6%). The proportion of VA-ECMO in each center did not affect in-hospital mortality (p=0.861). No patients underwent heart transplantation and six patients received a left ventricular assist device. Logistic regression showed that creatinine clearance (p=0.004, OR 0.98, 95% CI 0.97-0.99), pulmonary disease (p=0.018, OR 4.42, 95% CI 1.29-15.15) and pre-VA-ECMO blood lactate (p=0.015, OR 1.10, 95% CI 1.02-1.18) were independent baseline predictors of in-hospital mortality. One-, 2-, and 3-year survival was 31.0%, 27.9%, and 26.1%, respectively.
CONCLUSIONS:
One third of patients with need for VA-ECMO after CABG survive to discharge. In view of the burden of resources associated with VA-ECMO treatment and the limited number of patients surviving to discharge, further studies are needed to identify patients who may benefit the most from this treatment
Bleeding, transfusion and the risk of stroke after coronary surgery: A prospective cohort study of 2357 patients
Introduction This study was planned to investigate the impact of severe bleeding and blood transfusion on the development of stroke after coronary surgery. Methods This cohort study includes 2357 patients undergoing isolated CABG from the prospective European Coronary Artery Bypass Grafting (E-CABG) registry. Severity of bleeding was categorized according to the Universal Definition of Perioperative Bleeding (UDPB), E-CABG and PLATO definitions. Results Thirty patients (1.3%) suffered postoperative stroke. The amount of transfused red blood cell (RBC) (OR 1.10, 95%CI 1.03\u20131.18), preoperative use of unfractioned heparin (OR 4.49, 95%CI 1.91\u201310.60), emergency operation (OR 3.97, 95%CI 1.47\u201310.74), diseased ascending aorta (OR 4.62, 95%CI 1.37\u201315.65) and use of cardiopulmonary bypass (p = 0.043, OR 4.85, 95%CI 1.05\u201322.36) were independent predictors of postoperative stroke. Adjusted analysis showed that UDPB classes 3\u20134 (crude rate: 3.6% vs. 1.0%; adjusted OR 2.66, 95%CI 1.05\u20136.73), E-CABG bleeding grades 2\u20133 (crudes rate: 6.3% vs. 0.9%; adjusted OR 5.91, 95%CI 2.43\u201314.36), and PLATO life-threatening bleeding (crude rate: 2.5% vs. 0.6%, adjusted OR 3.70, 95%CI 1.59\u20138.64) were associated with an increased risk of stroke compared with no or moderate bleeding. Conclusions Bleeding and blood transfusion are associated with an increased risk of stroke after CABG, which is highest in patients with severe bleeding