Reduction of Machine Tool Times Through a Software/Hardware Integrated Solution

Toolmaking is an industry that creates metal moulds, generally of durable tool steels, for producing vacuum-formed and injection moulded plastic parts, which are used in thousands of everyday items such as mobile phones. At present toolmaking is labour intensive with each machining operation requiring manual supervision. The FASTOOL project was a European Union funded collaboration that was aimed at reducing the manpower content of mould toolmaking, and extending the working day. This paper focuses on one element which utilised specially created scheduling and control software that operated an automated overhead gantry system and could remotely start the workshop machines. The software was completely object oriented which allows future proofing by creating new objects for new machines. The results demonstrate that this manufacturing process can be automated, leading to better working conditions for employees and an increase in efficiency and profitability.Mechanical Engineerin

Symmetry violations at BABAR

Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Published under licence by IOP Publishing Ltd.2014 J. Phys.: Conf. Ser. 556 012042 (http://iopscience.iop.org/1742-6596/556/1/012042

Digital Doppler extraction demonstration with the advanced receiver

A digital Doppler extraction demonstration with the Advanced Receiver 2 (ARX 2) tracking Pioneer 10 and Voyager 2 is described. The measured results are compared with those of the Block 4 receiver that was operating in parallel with the ARX 2. It is shown that the ARX 2 outperforms the Block 4 receiver in terms of Allan variance of the Doppler residuals, the amount of which depends on the scenario of interest

Asymptotic motion of a single vortex in a rotating cylinder

We study numerically the behavior of a single quantized vortex in a rotating cylinder. We study in particular the spiraling motion of a vortex in a cylinder that is parallel to the rotation axis. We determine the asymptotic form of the vortex and its axial and azimuthal propagation velocities under a wide range of parameters. We also study the stability of the vortex line and the effect of tilting the cylinder from the rotation axis.Comment: 9 pages, 10 figures. Considerable changes, now close to the published versio

A decade of ejecta dust formation in the Type IIn SN 2005ip

In order to understand the contribution of core-collapse supernovae to the dust budget of the early universe, it is important to understand not only the mass of dust that can form in core-collapse supernovae but also the location and rate of dust formation. SN 2005ip is of particular interest since dust has been inferred to have formed in both the ejecta and the post-shock region behind the radiative reverse shock. We have collated eight optical archival spectra that span the lifetime of SN 2005ip and we additionally present a new X-shooter optical-near-IR spectrum of SN 2005ip at 4075d post-discovery. Using the Monte Carlo line transfer code DAMOCLES, we have modelled the blueshifted broad and intermediate width H$\alpha$, H$\beta$ and He I lines from 48d to 4075d post-discovery using an ejecta dust model. We find that dust in the ejecta can account for the asymmetries observed in the broad and intermediate width H$\alpha$, H$\beta$ and He I line profiles at all epochs and that it is not necessary to invoke post-shock dust formation to explain the blueshifting observed in the intermediate width post-shock lines. Using a Bayesian approach, we have determined the evolution of the ejecta dust mass in SN 2005ip over 10 years presuming an ejecta dust model, with an increasing dust mass from ~10$^{-8}$ M$_{\odot}$ at 48d to a current dust mass of $\sim$0.1 M$_{\odot}$.Comment: Accepted by MNRAS, 17 pages, 11 figures. Author accepted manuscript. Accepted on 04/03/19. Deposited on 07/03/1

Interactions In Space For Archaeological Models

In this article we examine a variety of quantitative models for describing archaeological networks, with particular emphasis on the maritime networks of the Aegean Middle Bronze Age. In particular, we discriminate between those gravitational networks that are most likely (maximum entropy) and most efficient (best cost/benefit outcomes).Comment: 21 pages, 6 figures, 2 tables. Contribution to special issue of Advances in Complex Systems from the conference `Cultural Evolution in Spatially Structured Populations', UCL, London, September 2010. To appear in Advances in Complex System

Extended Huckel theory for bandstructure, chemistry, and transport. II. Silicon

In this second paper, we develop transferable semi-empirical parameters for the technologically important material, silicon, using Extended Huckel Theory (EHT) to calculate its electronic structure. The EHT-parameters areoptimized to experimental target values of the band dispersion of bulk-silicon. We obtain a very good quantitative match to the bandstructure characteristics such as bandedges and effective masses, which are competitive with the values obtained within an $sp^3 d^5 s^*$ orthogonal-tight binding model for silicon. The transferability of the parameters is investigated applying them to different physical and chemical environments by calculating the bandstructure of two reconstructed surfaces with different orientations: Si(100) (2x1) and Si(111) (2x1). The reproduced $\pi$- and $\pi^*$-surface bands agree in part quantitatively with DFT-GW calculations and PES/IPES experiments demonstrating their robustness to environmental changes. We further apply the silicon parameters to describe the 1D band dispersion of a unrelaxed rectangular silicon nanowire (SiNW) and demonstrate the EHT-approach of surface passivation using hydrogen. Our EHT-parameters thus provide a quantitative model of bulk-silicon and silicon-based materials such as contacts and surfaces, which are essential ingredients towards a quantitative quantum transport simulation through silicon-based heterostructures.Comment: 9 pages, 9 figure

Allosteric Conversation in the Androgen Receptor Ligand-Binding Domain Surfaces

Androgen receptor (AR) is a major therapeutic target that plays pivotal roles in prostate cancer (PCa) and androgen insensitivity syndromes. Wepreviously proposed that compounds recruited to ligand-binding domain (LBD) surfaces could regulate AR activity in hormone-refractory PCa and discovered several surface modulators of AR function. Surprisingly, the most effective compounds bound preferentially to a surface of unknown function [binding function 3 (BF-3)] instead of the coactivator-binding site [activation function 2 (AF-2)]. Different BF-3 mutations have been identified in PCa or androgen insensitivity syndrome patients, and they can strongly affect AR activity. Further, comparison of AR x-ray structures with and without bound ligands at BF-3 and AF-2 showed structural coupling between both pockets. Here, we combine experimental evidence and molecular dynamic simulations to investigate whether BF-3 mutations affect AR LBD function and dynamics possibly via allosteric conversation between surface sites. Our data indicate that AF-2 conformation is indeed closely coupled to BF-3 and provide mechanistic proof of their structural interconnection. BF-3 mutations may function as allosteric elicitors, probably shifting the AR LBD conformational ensemble toward conformations that alter AF-2 propensity to reorganize into subpockets that accommodate N-terminal domain and coactivator peptides. The induced conformation may result in either increased or decreased AR activity. Activating BF-3 mutations also favor the formation of another pocket (BF-4) in the vicinity of AF-2 and BF-3, which we also previously identified as a hot spot for a small compound. We discuss the possibility that BF-3 may be a protein-docking site that binds to the N-terminal domain and corepressors. AR surface sites are attractive pharmacological targets to develop allosteric modulators that might be alternative lead compounds for drug design. © 2012 by The Endocrie Society

What drives biodiversity patterns? Using long-term multidisciplinary data to discern centennial-scale change

1. Biodiversity plays an important role in ecosystem functioning, habitat recovery following disturbance and resilience to global environmental change. Long‐term ecological records can be used to explore biodiversity patterns and trends over centennial to multi‐millennial time‐scales across broad regions. Fossil pollen grains preserved in sediment over millennia reflect palynological richness and diversity, which relates to changes in landscape diversity. Other long‐term environmental data, such as fossil insects, palaeoclimate and archaeologically inferred palaeodemographic (population) data, hold potential to address questions about the drivers and consequences of diversity change when combined with fossil pollen records. 2. This study tests a model of Holocene palynological diversity change through a synthesis of pollen and insect records from across the British Isles along with palaeodemographic trends and palaeoclimate records. We demonstrate relationships between human population change, insect faunal group turnover, palynological diversity and climate trends through the Holocene. 3. Notable increases in population at the start of the British Neolithic (~6,000 calendar years before present [bp]) and Bronze Age (~4,200 bp) coincided with the loss of forests, increased agricultural activity and changes in insect faunal groups to species associated with human land use. Pollen diversity and evenness increased, most notably since the Bronze Age, as landscapes became more open and heterogeneous. However, regionally distinctive patterns are also evident within the context of these broad‐scale trends. Palynological diversity is correlated with population while diversity and population are correlated with some climate datasets during certain time periods (e.g. Greenland temperature in the mid‐late Holocene). 4. Synthesis. This study has demonstrated that early human societies contributed to shaping palynological diversity patterns over millennia within the context of broader climatic influences upon vegetation. The connections between population and palynological diversity become increasingly significant in the later Holocene, implying intensifying impacts of human activity, which may override climatic effects. Patterns of palynological diversity trends are regionally variable and do not always follow expected trajectories. To fully understand the long‐term drivers of biodiversity change on regionally relevant ecological and management scales, future research needs to focus on amalgamating diverse data types, along with multi‐community efforts to harmonise data across broad regions