An age of opportunity: Education and employment in cyberspace

There are many trends in cyberspace that are directly affecting both universities\u27 education systems and the current job markets. This research provides an overview of some of these computer mediated trends. The purpose of this work is to look at the current job market, examine some of the computer related jobs for recent college graduates, look at distance education as an educational opportunity for many different people, and look at future opportunities that computer mediation will continue to provide. Students will have better insight of these trends, while professors will have a strong appreciation of the importance of teaching and understanding telecommunications

Tell Me That You Love Me (As You Never Loved Before)

https://digitalcommons.library.umaine.edu/mmb-vp/6331/thumbnail.jp

Fluorescent ligand for human progesterone receptor imaging in live cells.

We employed molecular modeling to design and then synthesize fluorescent ligands for the human progesterone receptor. Boron dipyrromethene (BODIPY) or tetramethylrhodamine were conjugated to the progesterone receptor antagonist RU486 (Mifepristone) through an extended hydrophilic linker. The fluorescent ligands demonstrated comparable bioactivity to the parent antagonist in live cells and triggered nuclear translocation of the receptor in a specific manner. The BODIPY labeled ligand was applied to investigate the dependency of progesterone receptor nuclear translocation on partner proteins and to show that functional heat shock protein 90 but not immunophilin FKBP52 activity is essential. A tissue distribution study indicated that the fluorescent ligand preferentially accumulates in tissues that express high levels of the receptor in vivo. The design and properties of the BODIPY-labeled RU486 make it a potential candidate for in vivo imaging of PR by positron emission tomography through incorporation of (18)F into the BODIPY core

Say it in Polish! : The Role of Heritage Language in preserving culture among families of Eastern European Origin

This project is part of a larger qualitative research study exploring the relationship between Eastern European American parenting styles and children\u27s academic achievement. Seven mothers who were either first- or second-generation Eastern European American participated in semi-structured individual interviews. This project focuses on heritage language preservation. It revealed motivations, strategies, and outcomes of parents\u27 desire to transmit their heritage language to the next generation. All participants had at least one child between ages five and eighteen. Based on our findings, four themes have emerged: 1) Motivations for heritage language preservation; 2) Resources and strategies to foster heritage language learning; 3) Family factors affecting heritage language transmission and fluency; and 4) Children\u27s evolving attitudes to heritage language.https://engagedscholarship.csuohio.edu/u_poster_2016/1001/thumbnail.jp

Development of the Parenting Style and Practice Scale (PSPS) in examining parenting practices and children\u27s academic performance

What roles do parents play in fostering children\u27s academic success in school? There is a general consensus that confirms the importance of parenting styles and practices on children\u27s academic performance (e.g., Pinquart, 2015). However, there is a lack of up-to-date systematic parenting scales with acceptable validity and reliability. For this reason, it limits our understanding of parenting related studies in the current context. Developing a questionnaire is critical to conduct cross diverse comparisons which would broaden the generalizability of the related research. Adopting the review of literature research approach, the purpose of this study was to develop a scale that contains essential elements of parenting styles and practices. Using this instrument tool, the goal would be to examine the relationship between parenting practices and children\u27s academic performance. Through a thorough literature review, the Parenting Styles and Practices Scale (PSPS) was developed. The PSPS includes four factors: (a) parental expectations, (b) autonomy, (c) discipline, and (d) parental involvement in education. Each factor includes 10 variables. The next step would be to examine the psychometric properties of the PSPS on a sample. The ultimate goal is to implement the PSPS to a wider population and make the scale available for adoption in the parenting research community.https://engagedscholarship.csuohio.edu/u_poster_2017/1003/thumbnail.jp

Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p1 in neurogenesis and s1p1–3 in angiogenesis

AbstractIn a comparison of embryonic brain expression patterns of lysophosphatidic acid and sphingosine 1-phosphate receptor genes (lpa1–3 and s1p1–5, respectively), transcripts detected by Northern blot were subsequently localized using in situ hybridization. We found striking s1p1 expression adjacent to several ventricles. Near the lateral ventricle, s1p1 expression was temporally and spatially coincident with neurogenesis and overlapped with lpa1 in the neocortical area. We also observed a widespread diffuse pattern for lpa2–3 and a scattered punctate pattern for s1p1–3. The punctate pattern colocalized with vascular endothelial markers. Together, these results suggest that s1p1 influences neurogenesis and s1p1–3 influence angiogenesis in the developing brain

Meet Me Tonight in Dreamland

[Verse 1] Dreaming of you that’s all I do Night and day for you I’m pining, And in your eyes, blue as the skies I can see the love-light softly shining; Because you love me there it seems, Pray meet me in the land of dreams. [Chorus] Meet me tonight in Dreamland Under the silv’ry moon Meet me tonight in Dreamland Where love’s sweet roses bloom; Come with the love-light gleaming In your dear eyes of blue, Meet me in Dreamland, sweet, dreamy Dreamland, There let my dreams come true [Verse 2] Sighing all day when you’re away Longing for you dear, you only; In blissful dreams, sweetheart it seems One is never sad and never lonely And if you’ll come with me to stay We’ll live in dream land night and day. [Chorus

Nerve-targeted probes for fluorescence-guided intraoperative imaging.

A fundamental goal of many surgeries is nerve preservation, as inadvertent injury can lead to patient morbidity including numbness, pain, localized paralysis and incontinence. Nerve identification during surgery relies on multiple parameters including anatomy, texture, color and relationship to surrounding structures using white light illumination. We propose that fluorescent labeling of nerves can enhance the contrast between nerves and adjacent tissue during surgery which may lead to improved outcomes. Methods: Nerve binding peptide sequences including HNP401 were identified by phage display using selective binding to dissected nerve tissue. Peptide dye conjugates including FAM-HNP401 and structural variants were synthesized and screened for nerve binding after topical application on fresh rodent and human tissue and in-vivo after systemic IV administration into both mice and rats. Nerve to muscle contrast was quantified by measuring fluorescent intensity after topical or systemic administration of peptide dye conjugate. Results: Peptide dye conjugate FAM-HNP401 showed selective binding to human sural nerve with 10.9x fluorescence signal intensity (1374.44 ± 425.96) compared to a previously identified peptide FAM-NP41 (126.17 ± 61.03). FAM-HNP401 showed nerve-to-muscle contrast of 3.03 ± 0.57. FAM-HNP401 binds and highlight multiple human peripheral nerves including lower leg sural, upper arm medial antebrachial as well as autonomic nerves isolated from human prostate. Conclusion: Phage display has identified a novel peptide that selectively binds to ex-vivo human nerves and in-vivo using rodent models. FAM-HNP401 or an optimized variant could be translated for use in a clinical setting for intraoperative identification of human nerves to improve visualization and potentially decrease the incidence of intra-surgical nerve injury

The Neutrino Response of Low-Density Neutron Matter from the Virial Expansion

We generalize our virial approach to study spin-polarized neutron matter and the consistent neutrino response at low densities. In the long-wavelength limit, the virial expansion makes model-independent predictions for the density and spin response, based only on nucleon-nucleon scattering data. Our results for the neutrino response provide constraints for random-phase approximation or other model calculations, and we compare the virial vector and axial response to response functions used in supernova simulations. The virial expansion is suitable to describe matter near the supernova neutrinosphere, and this work extends the virial equation of state to predict neutrino interactions in neutron matter.Comment: 8 pages, 5 figures, minor additions, to appear in Phys. Lett.

Risk Model Development and Validation for Prediction of Coronary Artery Aneurysms in Kawasaki Disease in a North American Population.

Background Accurate prediction of coronary artery aneurysms ( CAAs ) in patients with Kawasaki disease remains challenging in North American cohorts. We sought to develop and validate a risk model for CAA prediction. Methods and Results A binary outcome of CAA was defined as left anterior descending or right coronary artery Z score ≥2.5 at 2 to 8 weeks after fever onset in a development cohort (n=903) and a validation cohort (n=185) of patients with Kawasaki disease. Associations of baseline clinical, laboratory, and echocardiographic variables with later CAA were assessed in the development cohort using logistic regression. Discrimination (c statistic) and calibration (Hosmer-Lemeshow) of the final model were evaluated. A practical risk score assigning points to each variable in the final model was created based on model coefficients from the development cohort. Predictors of CAAs at 2 to 8 weeks were baseline Z score of left anterior descending or right coronary artery ≥2.0, age <6 months, Asian race, and C-reactive protein ≥13 mg/ dL (c=0.82 in the development cohort, c=0.93 in the validation cohort). The CAA risk score assigned 2 points for baseline Z score of left anterior descending or right coronary artery ≥2.0 and 1 point for each of the other variables, with creation of low- (0-1), moderate- (2), and high- (3-5) risk groups. The odds of CAA s were 16-fold greater in the high- versus the low-risk groups in the development cohort (odds ratio, 16.4; 95% CI , 9.71-27.7 [ P<0.001]), and >40-fold greater in the validation cohort (odds ratio, 44.0; 95% CI, 10.8-180 [ P<0.001]). Conclusions Our risk model for CAA in Kawasaki disease consisting of baseline demographic, laboratory, and echocardiographic variables had excellent predictive utility and should undergo prospective testing