MxCuBE: a synchrotron beamline control environment customized for macromolecular crystallography experiments

MxCuBE is a beamline control environment optimized for the needs of macromolecular crystallography. This paper describes the design of the software and the features that MxCuBE currently provides

Assessment of radiation damage behaviour in a large collection of empirically optimized datasets highlights the importance of unmeasured complicating effects

A retrospective analysis of radiation damage behaviour in a statistically significant number of real-life datasets is presented, in order to gauge the importance of the complications not yet measured or rigorously evaluated in current experiments, and the challenges that remain before radiation damage can be considered a problem solved in practice

Mammalian cell expression, purification, crystallization and microcrystal data collection of autotaxin/ENPP2, a secreted mammalian glycoprotein

Autotaxin, a four-domain ∼100 kDa mammalian glycoprotein, was expressed in stably transfected mammalian cells, purified from the medium and crystallized. Diffraction data from micrometre-thick crystal plates were collected on various European synchrotron beamlines and are presented and analysed

The ID23-2 structural biology microfocus beamline at the ESRF

Beamline ID23-2, the first dedicated and highly automated high-throughput monochromatic macromolecular crystallography microfocus beamline, is described

BLISS - Experiments Control for ESRF EBS Beamlines

International audienceBLISS is the new ESRF control system for running experiments, with full deployment aimed for the end of the EBS upgrade program in 2020. BLISS provides a global approach to run synchrotron experiments, thanks to hardware integration, Python sequences and an advanced scanning engine. As a Python package, BLISS can be easily embedded into any Python application and data management features enable online data analysis. In addition, BLISS ships with tools to enhance scientists user experience and can easily be integrated into TANGO based environments, with generic TANGO servers on top of BLISS controllers. BLISS configuration facility can be used as an alternative TANGO database. Delineating all aspects of the BLISS project from beamline device configuration up to the integrated user interface, this talk will present the technical choices that drove BLISS design and will describe the BLISS software architecture and technology stack in depth

BLISS - Experiments Control for ESRF Beamline

International audienceBLISS is the new ESRF control system for running experiments, with full deployment aimed for the end of the EBS upgrade program in 2020. BLISS provides a global approach to run synchrotron experiments, thanks to hardware integration, Python sequences and an advanced scanning engine. As a Python package, BLISS can be easily embedded into any Python application and data management features enable online data analysis. In addition, BLISS ships with tools to enhance scientists user experience and can easily be integrated into TANGO based environments, with generic TANGO servers on top of BLISS controllers. BLISS configuration facility can be used as an alternative TANGO database. Delineating all aspects of the BLISS project from beamline device configuration up to the integrated user interface, this poster will present the technical choices that drove BLISS design and will describe the BLISS software architecture and technology stack in depth

MXCuBE3 Bringing MX Experiments to the WEB

International audienceOriginally conceived at ESRF and first deployed in 2005 MXCuBE, Macromolecular Xtallography Customized Beamline Environment, has with its successor MXCuBE2, become a successful international collaboration. The aim of the collaboration is to develop a beamline control application for macromolecular crystallography (MX) that are independent of underlying instrument control software and thus deployable at the MX beamlines of any synchrotron source. The continued evolution of the functionality offered at MX beamlines is to a large extent facilitated by active software development. New demands and advances in technology have led to the development of a new version of MXCuBE, MXCuBE3, The design of which was inspired by the results of a technical pre-study and user survey. MXCuBE3 takes advantage of the recent development in web technologies such as React and Redux to create an intuitive and user friendly application. The access to the application from any web browser further simplifies the operation and natively facilitates the execution of remote experiments