Synthesis and evaluation of platinum complexes with potential antitumor activity

A novel series of platinum (II) complexes was synthesized and the complexes were evaluated for their in vitro cytotoxicity against four human cancer cells lines. Five platinum complexes showed activity against at least one tumor cell line. Complexes 3 and 6 were promising, being active, at micromolar concentrations, against all the assayed tumor cell lines. Compound 3 was selected for further studies in mice with Ehrlich solid tumors and it was able to reduce the rate of tumor growth significantly during the first seven days. However, at the end of the experiments, there was no significant difference between the group of animals treated with 3 and the control group. The low solubility of the compound in the assay conditions can explain, at least in part, these results

Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload

Iron accumulation in the brain has been recognized as a common feature of both normal aging and neurodegenerative diseases. Cognitive dysfunction has been associated to iron excess in brain regions in humans. We have previously described that iron overload leads to severe memory deficits, including spatial, recognition, and emotional memory impairments in adult rats. In the present study we investigated the effects of neonatal iron overload on proteins involved in apoptotic pathways, such as Caspase 8, Caspase 9, Caspase 3, Cytochrome c, APAF1, and PARP in the hippocampus of adult rats, in an attempt to establish a causative role of iron excess on cell death in the nervous system, leading to memory dysfunction. Cannabidiol (CBD), the main non-psychotropic component of Cannabis sativa, was examined as a potential drug to reverse iron-induced effects on the parameters analyzed. Male rats received vehicle or iron carbonyl (30 mg/kg) from the 12th to the 14th postnatal days and were treated with vehicle or CBD (10 mg/kg) for 14 days in adulthood. Iron increased Caspase 9, Cytochrome c, APAF1, Caspase 3 and cleaved PARP, without affecting cleaved Caspase 8 levels. CBD reversed iron-induced effects, recovering apoptotic proteins Caspase 9, APAF1, Caspase 3 and cleaved PARP to the levels found in controls. These results suggest that iron can trigger cell death pathways by inducing intrinsic apoptotic proteins. The reversal of iron-induced effects by CBD indicates that it has neuroprotective potential through its anti-apoptotic action

O Memorial de Imigração Polonesa em Curitiba: dinâmicas culturais e interesses políticos no âmbito memoralista

Neste artigo, analisa-se o conceito de memorial, considerando as atuais definições de Museu propostas pelo Conselho Internacional de Museus e pelo Instituto Brasileiro de Museus, tendo como objeto de investigação o Memorial de Imigração Polonesa de Curitiba. Evidenciam-se a importância e a complexidade no trato com o patrimônio e as dificuldades de pensá-lo a partir dos sujeitos e das referências culturais de determinado grupo em contraponto aos interesses políticos e econômicos; no caso em questão, voltadas às necessidades da política de city marketing como estratégia de construção da imagem da cidade. Para tanto, foram considerados os perfis de atuação dos memoriais em diferentes partes do mundo, na tentativa de delimitação conceitual, exemplificando-se a pluralidade de temas e formatos dessas instituições no âmbito nacional e global. As discussões levantadas permitem pensar que os Museus Memoriais desempenham as atividades de um memorial no âmbito museológico, confirmando a ambivalência dessas duas instituições e sua interface privilegiada com o poder político.This article analyzes the memorial concept, considering the Museum definition presented by the International Council of Museums and the Brazilian Institute of Museums. The aim of this study was the Curitiba Polish Immigration Memorial. It highlights the importance and complexity in dealing with the heritage and the difficulties of thinking it from the individuals and the cultural references of certain groups as opposed to political and economic interests; in this case the needs of the city marketing policy as city image building strategy. Therefore, the memorials performance profiles in different parts of the world in an attempt to conceptual definition, exemplifying the diversity of themes and formats of these institutions at the national and global levels. The discussions show that it is possible to consider that the Memorials Museums perform the same activities of a memorial within the museological context, confirming the ambivalence of these two institutions and prime interface with political power

Direitos humanos enquanto política pública no Brasil : retratando a experiência do estado do Rio de Janeiro

The theme of Human Rights, as public policy, is recent in Brazil. Only after 40 years, the Universal Declaration of Human Rights started inspiring local governments, and the country has effectively included the theme in its political agenda when motivated by the World Conference on Human Rights (Vienna, 1993). In 1996, the first National Program for Human Rights was launched, followed by the foundation of the National Secretariat for Human Rights, in 1997. This thesis is dedicated to the study of human rights and public policy in Brazil, by exposing the experience of the State of Rio de Janeiro.Within this purposes, this study examines issues concerning exclusion, inequality and human rights: it explain the concept and some categories of analysis, whereas the use of these expressions must be guide by the conceptions of human condition and violation of rights. In addition, this paper points out the contributions of philosophers and different conceptions about the notion and history of Human Rights. Moreover, it is presented a reflection about Human Rights in Brazil, by discussing the importance that the Brazilian Constitutions gave to the Human Rights. Besides focusing on the construction process of this policy within the federal government, this study focuses on the same process in the State of Rio de Janeiro the first State of the Federation to establish a Department of government (Secretariat) dedicated to this theme and presents the point of view of three managers,which at some point during the past 11 years, ran State Secretaries for Human RightsEnquanto política pública, o tema Direitos Humanos é recente no Brasil. Mais de 40 anos depois da Declaração Universal dos Direitos Humanos esta começou a inspirar os governos, e, estimulado pela Conferência Mundial dos Direitos Humanos (Viena, 1993), o país efetivamente pautou o tema na agenda governamental. Em 1996 foi lançado o Primeiro Programa Nacional de Direitos Humanos, seguido, em 1997, da criação da Secretaria Nacional de Direitos Humanos. Este trabalho se dedica ao estudo dos Direitos Humanos enquanto política pública no Brasil, e busca retratar a experiência do Estado do Rio de Janeiro. Tem como recorte e pano de fundo para aprofundamento no tema a reflexão sobre exclusão, desigualdades e Direitos Humanos: discorre sobre o conceito, algumas categorias de análise, considerando que o uso dessas expressões deve estar vinculada à condição humana e à violação de diretos. Pontua as contribuições dos filósofos, as diferentes correntes sobre concepção e história dos Direitos Humanos, e reflete sobre Direitos Humanos no Brasil, discorrendo sobre a importância das Constituições brasileiras para os Direitos Humanos. Além de enfocar o processo de construção dessa política no âmbito do governo federal, busca retratar o processo análogo no Estado do Rio de Janeiro primeiro Estado da Federação a instituir uma Secretaria de governo dedicada ao tema , e apresenta a visão de três gestores, que, em algum momento, durante os últimos 11 anos, ocuparam a função de Secretários de Estado de Direitos Humano

Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload

Iron accumulation in the brain has been recognized as a common feature of both normal aging and neurodegenerative diseases. Cognitive dysfunction has been associated to iron excess in brain regions in humans. We have previously described that iron overload leads to severe memory deficits, including spatial, recognition, and emotional memory impairments in adult rats. In the present study we investigated the effects of neonatal iron overload on proteins involved in apoptotic pathways, such as Caspase 8, Caspase 9, Caspase 3, Cytochrome c, APAF1, and PARP in the hippocampus of adult rats, in an attempt to establish a causative role of iron excess on cell death in the nervous system, leading to memory dysfunction. Cannabidiol (CBD), the main non-psychotropic component of Cannabis sativa, was examined as a potential drug to reverse iron-induced effects on the parameters analyzed. Male rats received vehicle or iron carbonyl (30 mg/kg) from the 12th to the 14th postnatal days and were treated with vehicle or CBD (10 mg/kg) for 14 days in adulthood. Iron increased Caspase 9, Cytochrome c, APAF1, Caspase 3 and cleaved PARP, without affecting cleaved Caspase 8 levels. CBD reversed iron-induced effects, recovering apoptotic proteins Caspase 9, APAF1, Caspase 3 and cleaved PARP to the levels found in controls. These results suggest that iron can trigger cell death pathways by inducing intrinsic apoptotic proteins. The reversal of iron-induced effects by CBD indicates that it has neuroprotective potential through its anti-apoptotic action

UM NOVO PERCURSO DE TRABALHO: PERCEPÇÃO DO ALUNADO DOS CURSOS DE GRADUAÇÃO EAD UNIMONTES SOBRE A APLICAÇÃO DE NOVA METODOLOGIA DE ENSINO COM AULAS AO VIVO

A Universidade Estadual de Montes Claros (Unimontes), sob a atuação de seu Centro de Educação a Distância (CEAD), promoveu uma alteração metodológica na condução dos cursos de graduação a distância oferecidos. O novo modelo proporciona aulas ao vivo e gravadas ministradas por professores especializados – os docentes formadores – de cada disciplina e distribuídas a todos os polos, mantendo usual o atendimento de docentes tutores presenciais e a distância, entre outras mudanças pontuais em termos de avaliação. Nesse sentido, o objetivo deste trabalho foi analisar a percepção do alunado dos cursos de graduação EaD Unimontes quanto à implantação desta nova metodologia de ensino com base em aulas ao vivo. Trata-se de um estudo quantitativo e de levantamento. O estudo contou com a participação do corpo discente dos 9 cursos de graduação a distância (Educação Física, Pedagogia, Ciências da Religião, Ciências Sociais, Letras Inglês, Letras Espanhol, Letras Português, Geografia e História) da Unimontes oferecidos pela Universidade Aberta do Brasil (UAB). A amostra compreendeu 828 discentes que responderam a um questionário alocado no Ambiente Virtual de Aprendizagem institucional, com o qual responderam a 20 questões acerca do modelo de ensino, sua viabilidade e experiência geral com o processo. Os resultados apontaram satisfação expressiva pelas modificações metodológicas promovidas, sinalizando um movimento de melhoramento continuado do processo de ensino-aprendizagem no que toca à percepção do aluno e a gestão educacional dos cursos à distância no âmbito da universidade