O Grafite em Fortaleza

The article approaches the production of graffiti and the dynamics of its legitimation during the years of the municipal management known as Fortaleza Bela (2004-2012). In the light of recent urban transformations, we discuss how graffiti dialogues with cultural policies aimed at spectacularizing the city. The practice of graffiti is shaped by two different kind of actions: one advocate a greater adherence to popular demands; the other inserts this practice in the boundaries between the street and theartistic world.O artigo aborda a produção do grafite e as dinâmicas de sua legitimação durante a gestão municipal conhecida como Fortaleza Bela (2004-2012). Face às recentes transformações urbanas, discutimos de que modo o grafite dialoga com as políticas culturais voltadas para a espetacularização da cidade. A prática do grafite configura-se a partir de dois diferentes tipos de ação: uma defende maior adesão às demandas populares; a outra, insere essa prática nos limites entre a rua e o mundo artístico

THE EFFECT OF PLASMODIUM FLORIDENSE ON RELATIVE LEUKOCYTE COUNTS OF ANOLIS SAGREI AND A. CAROLINENSIS IN FLORIDA, USA

Native Green Anoles, Anolis carolinensis, and invasive Brown Anoles, Anolis sagrei, are commonly found in Florida and may be infected with the malarial parasite, Plasmodium floridense. Because no studies have directly addressed health effects of the parasite on Florida anoles, we collected blood smears of infected and uninfected anoles from Central and Southwest Florida and compared the overall leukocyte (WBC) counts, eosinophil counts, and heterophil/lymphocyte ratios. Eosinophils are generally elevated in response to protozoal infection and heterophil/lymphocyte ratios are often altered due to stress. A generalized linear model that tested contributions to erythrocyte/leukocyte ratios included infection status and locality as significant factors. We found significant differences in WBC counts between infected and uninfected lizards in Central Florida but not in Southwest Florida. Central Florida anoles also had higher mean WBC counts than Southwest Florida anoles. We did not detect significant differences in eosinophil counts or H/L ratios related to infection status. Our project is the first to examine leukocyte effects of Plasmodium infection in anoles and to provide leukocyte profiles of Anolis lizards. It appears that infected anoles sustain some negative immunological effects, at least in Central Florida. The differences in regions may be caused by the fact that Central Florida anoles still are under continuous interspecific competition whereas the Southwest Florida Brown Anoles are not because of low populations of Green Anoles. Additional studies that address leukocyte levels related to Plasmodium infection are needed to tease out the health and fitness effects on the lizards of Florida

Phase 1, first-in-human study of TYRP1-TCB (RO7293583), a novel TYRP1-targeting CD3 T-cell engager, in metastatic melanoma: active drug monitoring to assess the impact of immune response on drug exposure

Introduction: Although checkpoint inhibitors (CPIs) have improved outcomes for patients with metastatic melanoma, those progressing on CPIs have limited therapeutic options. To address this unmet need and overcome CPI resistance mechanisms, novel immunotherapies, such as T-cell engaging agents, are being developed. The use of these agents has sometimes been limited by the immune response mounted against them in the form of anti-drug antibodies (ADAs), which is challenging to predict preclinically and can lead to neutralization of the drug and loss of efficacy. Methods: TYRP1-TCB (RO7293583; RG6232) is a T-cell engaging bispecific (TCB) antibody that targets tyrosinase-related protein 1 (TYRP1), which is expressed in many melanomas, thereby directing T cells to kill TYRP1-expressing tumor cells. Preclinical studies show TYRP1-TCB to have potent anti-tumor activity. This first-in-human (FIH) phase 1 dose-escalation study characterized the safety, tolerability, maximum tolerated dose/optimal biological dose, and pharmacokinetics (PK) of TYRP1-TCB in patients with metastatic melanoma (NCT04551352). Results: Twenty participants with cutaneous, uveal, or mucosal TYRP1-positive melanoma received TYRP1-TCB in escalating doses (0.045 to 0.4 mg). All participants experienced ≥1 treatment-related adverse event (TRAE); two participants experienced grade 3 TRAEs. The most common toxicities were grade 1–2 cytokine release syndrome (CRS) and rash. Fractionated dosing mitigated CRS and was associated with lower levels of interleukin-6 and tumor necrosis factor-alpha. Measurement of active drug (dual TYPR1- and CD3-binding) PK rapidly identified loss of active drug exposure in all participants treated with 0.4 mg in a flat dosing schedule for ≥3 cycles. Loss of exposure was associated with development of ADAs towards both the TYRP1 and CD3 domains. A total drug PK assay, measuring free and ADA-bound forms, demonstrated that TYRP1-TCB-ADA immune complexes were present in participant samples, but showed no drug activity in vitro. Discussion: This study provides important insights into how the use of active drug PK assays, coupled with mechanistic follow-up, can inform and enable ongoing benefit/risk assessment for individuals participating in FIH dose-escalation trials. Translational studies that lead to a better understanding of the underlying biology of cognate T- and B-cell interactions, ultimately resulting in ADA development to novel biotherapeutics, are needed

Composição e abundância de macrófitas num troço do rio Ovelha

As macrófitas fluviais são um grupo relevante para a avaliação ecológica dos rios. Numa amostragem realizada num troço de 100 m do rio Ovelha, localizado a 217 m de altitude, na freguesia de Fornos, Marco de Canaveses, estudou-se a abundância, composição e distribuição das macrófitas. Verificou-se que o troço estudado é pobre em macrófitas, apresentando uma riqueza específica baixa, o que poderá estar relacionado, sobretudo, com o substrato rochoso. Considerando os resultados obtidos é fundamental que, futuramente, sejam estudadas as macrófitas conjuntamente com outros elementos biológicos, no sentido de se proceder a uma correta monitorização do estado ecológico do rio Ovelha.info:eu-repo/semantics/publishedVersio

REEDUCAÇÃO MUSCULAR EM PACIENTES COM ACOMETIMENTO DO NERVO FACIAL: UMA ABORDAGEM MULTIFACETADA

The facial nerve, or cranial nerve VII, is crucial for the control of facial muscles and sensory and autonomic functions, such as gustation and the regulation of the lacrimal and salivary glands. Lesions to this nerve can result in Bell's Palsy, characterized by sudden weakness or paralysis of the facial muscles, usually unilateral, significantly impacting quality of life. In view of the physical and psychological impacts of Bell's Palsy, this study aims to assess the importance of muscle re-education for early rehabilitation and minimization of sequelae in patients affected by the paralysis. In order to carry out this study, original articles and bibliographic reviews published in the last 28 years in English and Portuguese were collected from the main theoretical databases, such as SciELO and PubMed. The articles collected showed that the therapeutic approach in Bell's Palsy should be multimodal, encompassing pharmacological and behavioral therapies and physiotherapeutic support for the recovery of facial mimicry. In this scenario, muscle re-education is an essential therapeutic approach, combining facial exercises, biofeedback techniques and electrotherapy to restore muscle function and minimize sequelae. Early and personalized intervention, accompanied by a multidisciplinary team, is vital for optimal recovery, reducing physical and emotional complications such as social isolation and depression. Thus, early rehabilitation provides faster recovery of facial mobility, and muscle re-education plays an indispensable role in restoring muscle function and minimizing the sequelae resulting from the disease, which minimizes damage and restores quality of life to patientsO nervo facial, ou nervo craniano VII, é crucial para o controle dos músculos faciais e funções sensoriais e autonômicas, como a gustação e a regulação das glândulas lacrimais e salivares. Lesões nesse nervo podem resultar em Paralisia de Bell, caracterizada por fraqueza ou paralisia súbita dos músculos faciais, geralmente de forma unilateral, impactando significativamente a qualidade de vida. Diante disso, tendo em vista os impactos físicos e psicológicos gerados pela Paralisia de Bell, justifica-se o presente estudo, que objetiva avaliar a importância da reeducação muscular para a reabilitação precoce e minimização de sequelas em pacientes acometidos pela paralisia. Para a confecção do presente estudo, foram coletados artigos originais e de revisão bibliográfica, publicados nos últimos 28 anos, em inglês e português, nas principais bases de dados teóricos, como SciELO e PubMed. Percebeu-se, com os artigos coletados, que a abordagem terapêutica na Paralisia de Bell deve ser multimodal, abrangendo terapias farmacológicas, comportamentais e apoio fisioterapêutico para a recuperação da mímica facial. Nesse cenário, a reeducação muscular é uma abordagem terapêutica essencial, combinando exercícios faciais, técnicas de biofeedback e eletroterapia para restaurar a função muscular e minimizar sequelas. A intervenção precoce e personalizada, acompanhada por uma equipe multidisciplinar, é vital para a recuperação otimizada, reduzindo complicações físicas e emocionais, como o isolamento social e depressão. Assim, a reabilitação precoce propicia uma recuperação mais rápida à mobilidade facial, e a reeducação muscular tem papel indispensável para restaurar a função muscular e minimizar as sequelas decorrentes da doença, o que minimiza os danos e restabelece a qualidade de vida aos pacientes.&nbsp

Perfil epidemiológico dos acidentes por animais peçonhentos em Alagoas de 2020 a 2023

Introdução:Os incidentes resultantes da interação com animais venenosos representam um desafio significativo para a saúde pública, contribuindo para um considerável número de problemas de saúde em todo o mundo. A pesquisa sobre esse assunto é limitada em Alagoas, destacando a urgência de investigar esses incidentes, pois são essenciais para orientar as estratégias de vigilância tanto epidemiológica quanto ambiental. Objetivo: Descrever  o  perfil epidemiológico  dos  acidentes  com  animais  peçonhentos  no Estado  de  Alagoas, entre 2020 a 2023. Metodologia: Este estudo adotou uma abordagem ecológica e descritiva, com foco quantitativo. Os dados foram obtidos do Sistema de Informação de Agravos de Notificação, vinculado ao Departamento de Informática do Sistema Único de Saúde, referentes aos casos notificados de acidentes com animais peçonhentos entre os anos de 2020 e 2023 em Alagoas. Resultados:Houve um total de 51.656 notificações de acidentes causados por animais peçonhentos em Alagoas.Os principais responsáveis por incidentes foram os Escorpiões, com uma incidência de 84,08%, ainda 45,06% eram mulheres. Conclusão:A importância dos incidentes envolvendo animais venenosos destaca a necessidade de um planejamento abrangente, envolvendo medidas coordenadas de vigilância epidemiológica em conjunto com agências ambientais, visando a redução do número de fatalidades

Manejo clínico de grande queimado em Unidade de Terapia Intensiva: uma revisão sistemática com metanálise

Atualmente trabalha-se com a estimativa de que ocorrem no mundo todo 265mil mortes por ano em decorrência de acidentes envolvendo eletricidade, calor e produtos químicos, resultando em queimaduras que podem ser graves. No que se refere ao Brasil, ocorrem em média 1 milhão de acidentes por queimadura todos os anos, sendo que deste total apenas 100mil buscam atendimento hospitalar e 2.500 vítimas vem a óbito. O grande queimado caracteriza a vítima que segundo a Regra dos nove ou de Wallace, possui mais de 55 anos e apresenta 10% de sua superfície corporal queimada ou então pessoas de 10 a 55 anos que apresentam 20% ou mais da superficie corporal lesionada. Um cenário desafiador no qual o profissional de enfermagem possui papel fundamental para o tratamento, sendo responsável por intervir e se manter atento a todas as possíveis complicações decorrentes das queimaduras. O tema do manejo de grande queimado em UTI será explorado a partir de uma revisão sistemática com meta análise com o emprego das palavras chave “unidade de terapia intensiva”, “grande queimado” e “assistência de enfermagem” nos bancos de dados PubMed, BVS, Lilacs, Medline e Scielo objetivando acessar artigos publicados entre 2015 e 2022. É de fundamental importância o atendimento primário a vítima de grande queimadura, ao contribuir para uma melhor evolução do quadro do paciente e sua sobrevida. O quadro precisa ser tratado como se fosse um trauma, sendo importante avaliar os agravos para as vias aéreas, sistema circulatório, promover uma avaliação neurológica e extensão da queimadura, levando em consideração que a abordagem ideal depende do agente causador e tempo de exposição

Personality traits modulate stress responses after enclosure change of captive capuchin monkeys (Sapajus libidinosus)

International audienceHusbandry procedures may cause behavioral and physiological changes to animals living in captivity. However, an individual's reaction is not uniform and may be related to different coping strategies. In this study, we analyzed whether and how 12 adult captive capuchin monkeys (Sapajus libidinosus) varying in four personality axes ('Feeding', 'Sociability', 'Exploration', and 'Activity') differed in their stress responses to an enclosure change. Behavioral data and fecal samples of the individuals were collected for two months before (97 h and 246 fecal samples) and 14 days after the enclosure change (52 h and 666 fecal samples). We used Akaike Information Criteria to select the best linear regression models having personality axes and the period after enclosure change as predictive factors and behaviors potentially indicative of stress (BPIS) and levels of fecal glucocorticoid metabolites (FGM) as the response variables. Best models indicate that specific personality axes acted as a buffer and improved individual stress coping, mainly at the physiological level. More sociable and more active individuals did not show the peak of FGM levels as that exhibited by their less sociable and less active counterparts on the first day of the enclosure change. The link between exploration and resilience to acute stress was less clear: more exploratory individuals showed an increase in FGM levels during the first week of enclosure change, while the less exploratory ones showed a later increase, during the second-week post-enclosure change, suggesting a lesser capacity to recover from stressful stimuli in these individuals. The results presented in this study build on growing literature showing that animals differ in their behavioral profiles and that these differences relate to resilience to environmental disturbances, which may impact individual survival and reproduction, resulting in less genetic diversity of captive colonies and increased issues related to research replicability. We argue that these interindividual differences must be considered in husbandry decisions and during research data collection for the sake of animal welfare and reliable science

ÉCRITURES ET/EN MIGRATION(S) Expériences, tensions, transformations

International audienceThis book, written after the completion of a local experiment (Stains, Seine Saint -Denis, France), includes theoretical aspects from experienced researchers but also, and this is what makes it so interesting, a situated approach rooted in practices, experiences and experiments. It examines both the social role of various institutions - school, university, art centre, community centre - and the place of individual players in the construction of representations of languages. It evokes idioms - based on their male and female speakers - that are often stigmatised and repressed in their relationship with 'the' norm, and sometimes liberated by creative practices or simply by their recognition.The result of a meeting between a small group of researchers, involved in various ways in the theme of writing and/or migration, and participants (students, teachers, children and parents of nursery school pupils, artists) in this project, which was then underway, it takes a number of different approaches, giving a polyphonic form to the issues of language and writing in migration.Cet ouvrage, rédigé après l’achèvement d’une expérimentation locale (Stains, Seine Saint -Denis), comporte des aspects théoriques de chercheur·e·s expérimenté·e·s mais également, et c’est tout son intérêt, une approche située et ancrée dans des pratiques, expériences et expérimentations. Il interroge à la fois le rôle social de diverses institutions - école, université, centre d’art, maison de quartier- mais aussi la place de chaque acteur·trice dans la construction de représentations sur les langues. Il évoque des idiomes -en s’appuyant sur leurs locuteurs et locutrices- stigmatisées volontiers réprimées dans leurs rapports à « la » norme et parfois libérées par des pratiques créatives ou simplement par leur reconnaissance.Fruit de la rencontre d’un petit groupe de chercheur·e·s, impliqué·e·s de diverses manières dans la thématique des écritures et/en migration(s) et de participant·e·s (étudiant·e·s, enseignant·e·s, enfants et parents d’élèves de la maternelle, artistes) de ce projet alors en cours, il chemine à travers différents éclairages, donnant ainsi une forme polyphonique aux questions de langues et d’écritures en migrations