683 research outputs found
Effect of the Structure of Amido-polynitrogen Molecules on the Complexation of Actinides
AbstractThe complexation and solvent extraction of Eu(III) and actinides in different oxidation states (Am(III), Pu(IV), Np(V)) by bitopic molecules with a dipyridyl-phenanthroline cycle as nitrogen unit and one or two amido functions are described. The complexation has been studied in methanol-water solution with hydrophilic molecules to enhance knowledge about this new family of ligands and to identify the most interesting structural effect. Some extraction tests have been performed with lipophilic molecules of the family to check the possible utility of the new class of ligands under representative fuel reprocessing conditions. These first studies have demonstrated that the presence of a preorganized N-donors unit like dipyridyl-phenanthroline improves the ligand's affinity for actinides and its An/Ln selectivity
Effet d'une expérimentation de brassage artificiel epilimnique par aération sur les poussées cyanobactériennes dans la retenue hypereutrophe de Grangent (France)
Dans la retenue hypereutrophe de Grangent, le phytoplancton estival est dominé par la cyanobactérie Microcystis aeruginosa. Dans le but de lutter contre la formation de ces blooms cyanobactériens, une expérimentation de brassage artificiel épilimnique par aération a été réalisée en 1997-1998. Ce dispositif avait pour but de créer des turbulences supprimant l'avantage adaptatif que constitue, chez M. aeruginosa, la faculté de réguler sa flottabilité. Il devait également permettre l'homogénéisation des teneurs en oxygène dissous, la réduction des pics de pH, de la turbidité des eaux superficielles et des teneurs en ammonium.Les résultats escomptés ont été vérifiés pour les paramètres physicochimiques. Les valeurs se sont révélées plus homogènes, mais seulement à proximité des lignes de brassage et uniquement jusqu'à 10 m de profondeur. En revanche, les blooms cyanobactériens n'ont pas été réduits. Il apparaît même au contraire que, sous l'influence du mélange, les cyanobactéries ont eu à leur disposition une plus grande quantité de nutriments qu'elles ont utilisés pour constituer des réserves glucidiques. Ainsi, en aval de la zone brassée, ces réserves ont permis une synthèse protéique plus importante.Sur la retenue de Grangent, le dispositif de brassage peut offrir une solution palliative du point de vue touristique en limitant l'accumulation de cyanobactéries en surface, mais il ne permet pas d'éliminer, ni même de diminuer, les proliférations de M. aeruginosa en période estivale.In the reservoir of Grangent, a highly eutrophic lake located on the upper part of the Loire River, about 10 miles south of Saint-Étienne (France), Microcystis aeruginosa usually dominates the phytoplankton community in late summer and early autumn for many years. Mass developments of this cyanobacterium led to serious difficulties in multi-purpose usage. In order to fight against blooms, an epilimnic artificial mixing was experimented. M. aeruginosa is adapted to stable stratification of the water column. Therefore, partial destratification or bubbling with air are employed to replace M. aeruginosa by better grazable, non- " blooming " and non-toxic species. This cyanobacterium is supposed to lose its advantage of buoyancy and to reduce his growth. This system was also employed to reduce peaks of pH, turbidity of surface waters and concentration of NH4 and to homogenize the dissolved oxygen concentration inside the water column. Three lines of mixing were tested in 1998: one located at "Châtelet", upstream of reservoir, measuring 700 m at 11 m depth; one near the beach of Saint-Victor, with the same length and immersed to 15 m depth and, finally, a line of 400 m, near the port, at 16 m depth (figure 1).Data were collected from representative sites, upstream, near and downstream the artificial mixing. They were sampled weekly since April to November 1998. At each site the vertical profiles of temperature and dissolved oxygen were measured (figure 2). For each sample, the parameters following were analyzed: pH, NO3, NH4, PO4, carbohydrates, proteins, chlorophyll a and phytoplankton enumeration.Concerning the physicochemical parameters, the assumptions were checked: the values appeared more homogeneous near the lines of mixing than at the other stations. For example, the average temperatures varied between 20,6°C (at 10 m depth) and 21,3°C (at 0,5 m depth) at Saint-Victor. This variation reached 1,3°C at the station Camaldules. On the other hand, this effect was perceived only up to 10 m of depth and at a limited distance of mixing.In the same way, the colonies of M. aeruginosa were mixed in the water column but only up 10 m depth and near mixing. Moreover, their growth has not decreased on the whole of reservoir. In period of bloom (August 25), G/P ratio was higher in the mixing zone than in the neighbourhoods, primarily because of an increase in carbohydrates (figure 3). In the mixed zone, M. aeruginosa seemed to benefit greater quantity of mineral elements it could use to constitute carbohydrates reserves (figure 4). In this way, when the conditions that became less favourable, like downstream, cyanobacteria were able to follow their development by synthesizing proteins starting from their reserves in carbohydrates.In the reservoir of Grangent, artificial mixing did not allow to fight effectively against blooms of cyanobacteria. Colonies of M. aeruginosa were simply diluted in the water column near mixing but did not reduce their growth
Experimental And Topological Determination of the Pressure-Temperature Phase Diagram of Racemic Etifoxine, a Pharmaceutical Ingredient with Anxyolitic Properties
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Wild blueberry extract intervention in healthy older adults: a multi-study, randomised, controlled investigation of acute cognitive and cardiovascular effects
Background: Circadian and homeostatic declines in cognitive performance are observed during the day, most commonly at 14:00. Additionally, postprandial reductions in cognitive ability have been widely demonstrated 1 h after lunch consumption, affecting domains of executive functioning (EF), episodic memory (EM), and attention. Existing evidence shows that anthocyanin-rich foods such as berries may improve or attenuate the decline in EF and EM in ageing adults. Further research is required to assess whether extracts such as wild blueberry extract (WBE) may be
beneficial for cognitive function across an acute timeframe, including known periods of reduced functioning. Objectives: (1) Study 1: ROAB: To investigate the efficacy of WBE in maintaining EF and EM throughout the day alongside measures of cardiovascular outcomes in healthy older adults. A range of WBE doses were utilised to identify the optimal dose at which cognitive and cardiovascular effects occur. (2) Study 2: BEAT: To replicate alleviation of cognitive decline during a predicted post-lunch dip whilst also improving cardiovascular outcomes following acute WBE 222 mg supplementation. Methods: Both studies employed a randomised, double-blind, cross-over, placebo-controlled design to explore the effects of WBE intervention versus placebo on several outcomes, including EM, EF, blood pressure, and heart rate in a healthy older adult population
(aged 68–75). In ROAB, 28 participants received a single dose of WBE 111 mg, 222 mg, 444 mg, or 888 mg or placebo over a 5-week period, each separated by a 1-week washout. Outcomes were measured at 0 h, 2 h, 4 h, and 6 h post intervention, with intervention occurring immediately after baseline (0 h). In BEAT, 45 participants received WBE 222 mg and placebo (1-week washout). Outcomes were measured at 0 h and 6 h (14:00) when a post-lunch dip was anticipated. This was further enhanced by consumption of lunch 1 h prior to cognitive testing. The WBE 222 mg intervention aligned with
known peaks in plasma blueberry polyphenol metabolites at 2 h post dosing, which would coincide with a predicted drop in post-lunch performance. Results: ROAB: A significant dip in executive function was apparent at the 4 h timepoint for placebo only, indicating attenuation for WBE doses.
Strikingly, WBE 222 mg produced acute reductions in both systolic and diastolic blood pressure compared with placebo. BEAT: EF reaction time was found to be significantly faster for WBE 222 compared to placebo at the predicted post-lunch dip (14:00), with no other notable benefits on a range
of cognitive and cardiovascular outcomes. Conclusion: These two studies indicate that WBE may have cardiovascular benefits and attenuate the natural cognitive decline observed over the course of the day, particularly when a decline is associated with a circadian rhythm-driven postprandial dip. However, it is important to acknowledge that effects were subtle, and benefits were only observed on
a small number of outcomes. Further research is required to explore the utility of WBE in populations already experiencing mild cognitive impairment
Hereditary prostate cancer in African American families: linkage analysis using markers that map to five candidate susceptibility loci
Intercalibration of the barrel electromagnetic calorimeter of the CMS experiment at start-up
Calibration of the relative response of the individual channels of the barrel electromagnetic calorimeter of the CMS detector was accomplished, before installation, with cosmic ray muons and test beams. One fourth of the calorimeter was exposed to a beam of high energy electrons and the relative calibration of the channels, the intercalibration, was found to be reproducible to a precision of about 0.3%. Additionally, data were collected with cosmic rays for the entire ECAL barrel during the commissioning phase. By comparing the intercalibration constants obtained with the electron beam data with those from the cosmic ray data, it is demonstrated that the latter provide an intercalibration precision of 1.5% over most of the barrel ECAL. The best intercalibration precision is expected to come from the analysis of events collected in situ during the LHC operation. Using data collected with both electrons and pion beams, several aspects of the intercalibration procedures based on electrons or neutral pions were investigated
They are not all same: variations in Asian consumers' value perceptions of luxury brands
Asian markets are steadily becoming key growth regions for luxury brands. However, despite the growth, many luxury brand firms are unable to obtain the desired economic returns through their marketing strategies in Asia. Often these firms treat consumers across Asian markets as homogenous groups, which could lead to inaccurate luxury brand management strategy. Additionally, there is limited understanding of consumer value perceptions toward luxury brands across the Asian markets. Employing impression management theory and the horizontal/vertical collectivistic cultural distinctions, this study examines differences and similarities in constituent luxury value perceptions across three prominent Asian markets, namely China, India, and Indonesia. The results of a quantitative survey conducted with 626 real luxury consumers in these three countries identify variations in perceptions of symbolic, experiential, and functional value of luxury brands. The study contributes to knowledge on constituent luxury value perceptions, along with providing theoretical explanations for the differences between consumers across Asian markets. With the emerging novel insights on Asian consumers, luxury brand firms can align their marketing strategies to respective markets by leveraging the similarities and differences in consumer value perceptions. This approach, informed by empirical evidence, will enhance luxury brands’ competitiveness and profit opportunities in the high-growth Asian markets. The study identifies a number of future research directions
Decreased Autocrine EGFR Signaling in Metastatic Breast Cancer Cells Inhibits Tumor Growth in Bone and Mammary Fat Pad
Breast cancer metastasis to bone triggers a vicious cycle of tumor growth linked to osteolysis. Breast cancer cells and osteoblasts express the epidermal growth factor receptor (EGFR) and produce ErbB family ligands, suggesting participation of these growth factors in autocrine and paracrine signaling within the bone microenvironment. EGFR ligand expression was profiled in the bone metastatic MDA-MB-231 cells (MDA-231), and agonist-induced signaling was examined in both breast cancer and osteoblast-like cells. Both paracrine and autocrine EGFR signaling were inhibited with a neutralizing amphiregulin antibody, PAR34, whereas shRNA to the EGFR was used to specifically block autocrine signaling in MDA-231 cells. The impact of these was evaluated with proliferation, migration and gene expression assays. Breast cancer metastasis to bone was modeled in female athymic nude mice with intratibial inoculation of MDA-231 cells, and cancer cell-bone marrow co-cultures. EGFR knockdown, but not PAR34 treatment, decreased osteoclasts formed in vitro (p<0.01), reduced osteolytic lesion tumor volume (p<0.01), increased survivorship in vivo (p<0.001), and resulted in decreased MDA-231 growth in the fat pad (p<0.01). Fat pad shEGFR-MDA-231 tumors produced in nude mice had increased necrotic areas and decreased CD31-positive vasculature. shEGFR-MDA-231 cells also produced decreased levels of the proangiogenic molecules macrophage colony stimulating factor-1 (MCSF-1) and matrix metalloproteinase 9 (MMP9), both of which were decreased by EGFR inhibitors in a panel of EGFR-positive breast cancer cells. Thus, inhibiting autocrine EGFR signaling in breast cancer cells may provide a means for reducing paracrine factor production that facilitates microenvironment support in the bone and mammary gland
Elongation, rooting and acclimatization of micropropagated shoots from mature material of hybrid larch
Factors were defined for elongation, rooting and acclimatization of micropropagated shoots of Larix x eurolepis Henry initiated from short shoot buds of plagiotropic stecklings serially propagated for 9 years from an 8-year-old tree. Initiation and multiplication were on Schenk and Hildebrandt (SH) medium supplemented with 5 ÎĽM 6-benzyladenine (BA) and 1 ÎĽM indole-butyric acid (IBA). Stem elongation was obtained in 36% of the shoots on SH medium containing 0.5 ÎĽM BA and 63% of the remaining non-elongated shoots initiated stem elongation after transfer on SH medium devoid of growth regulators. Rooting involved 2 steps: root induction on Campbell and Durzan mineral salts and Murashige and Skoog organic elements, both half-strength (CD-MS/2), supplemented with 1 ÎĽM of both naphthaleneacetic acid (NAA) and IBA, and root elongation following transfer to CD-MS/2 medium devoid of growth regulators. Repeating this 2-step sequence yielded up to 67% rooted shoots. Acclimatization of plantlets ranged from 83% to 100%. Over 300 plants were transferred to the greenhouse; some showed plagiotropic growth
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