The contribution of archeometry in characterization of decorative materials from the site of Villa di Teodorico in Galeata (Italy)

Villa di Teodorico in Galeata (Forlì-Cesena, Emilia Romagna) is an important archeological site in the north of Italy occupied from sixth century BC to twelfth century AD. The most interesting results concern the Roman age, when a large villa was built, and the late antiquity, when the Ostrogothic king Theodoric decided to build in this area his palatium (early sixth century AD). The archeometric investigation was performed on Roman wall paintings fragments and on late antique glass sectilia fragments belonging to Palazzo di Teodorico by using a multi-technique approach that included micro-Raman spectroscopy, scanning electron microscopy with energy-dispersive spectroscopy, X-ray powder diffraction, UV–visible–NIR diffuse reflectance spectrophotometry with optic fibers and optical stereo-microscopy. This analytical approach allowed the identification of all components, collecting molecular, elemental, microscopic, morphological and chromatic data. The characterization of samples supplied essential archeological, historical and technological information. The production techniques and the rich materials employed suggest the importance of the site in different periods. The evolution of the manufacturing technologies and the possible trade routes mainly during late antique period are witnessed by the change in the raw materials. Graphical abstract: [Figure not available: see fulltext.]

Prefronto-cerebellar transcranial direct current stimulation increases amplituded and decreases latency of P3b component in patients with euthymic bipolar disorder

INTRODUCTION: Neurocognitive impairments have been observed in patients with bipolar disorder (BD) even during the euthymic phase of the disease, potentially representing trait-associated rather than state-associated characteristics of the disorder. In the present study, we used transcranial direct current stimulation (tDCS) applied to cerebellar and prefrontal cortices to improve the neurophysiological performances of patients with euthymic BD. METHODS: Twenty-five outpatients with BD underwent open-label prefrontocerebellar tDCS for 3 consecutive weeks. Neurophysiological performances were assessed through the examination of the P3b and P3a subcomponents of P300 event-related potential at baseline and after stimulation. RESULTS: Compared to baseline, P3b component after tDCS showed significantly higher amplitude and shorter latency (latency: Fz P=0.02, Cz P=0.03, and Pz P=0.04; amplitude: Fz P=0.24, Cz P=0.02, and Pz P=0.35). CONCLUSION: In our sample of patients with euthymic BD, concomitant prefrontoexcitatory and cerebellar-inhibitory modulations led to improved brain information processing stream. This improvement may at least partially result from neuroplastic modulation of prefrontocerebellar circuitry activity

Prefronto–cerebellar transcranial direct current stimulation improves visuospatial memory, executive functions, and neurological soft signs in patients with euthymic bipolar disorder

Objective: The aim of the study was to improve neuropsychological functioning of euthymic patients with bipolar disorder (BD) using transcranial direct current stimulation (tDCS) applied to cerebellar and prefrontal cortices. Methods: Twenty-five BD outpatients underwent prefrontal (anodal) and cerebellar (cathodal) tDCS for 3 consecutive weeks. All participants were assessed through the Rey Complex Figure Test delay and copy and the Neurological Examination Scale at baseline and after therapy with tDCS. Results: After tDCS treatment, patients showed significant improvements in visuospatial memory tasks. Patients with worse baseline cognitive performances also showed a significant improvement in executive functioning tasks. Neurological Examination Scale total score and motor coordination subscale significantly improved. Conclusion: Prefrontal-excitatory and cerebellar-inhibitory stimulations in euthymic BD patients may lead to better neurocognitive performances. This improvement could result from the modulation of prefronto-thalamic-cerebellar circuit activity pattern, which can be disrupted in BD

Inhibitory Effect of Helicteres gardneriana Ethanol Extract on Acute Inflammation

The anti-inflammatory effect of an ethanol extract of Helicteres gardneriana (Nees) Castiglioni was assayed in experimental models of pleurisy and microcirculation in situ. Treatment of animals with 500 mg/kg body weight reduced the exudate volume (35% reduction) induced by intrapleural injection of carrageenan and the migration of polymorphonuclear cells into the inflamed pleural cavity of rats (40%). Additionally, rolling and adhesion of leukocytes and the number of leukocytes that migrated toward the perivascular space in response to the carrageenan injection were decreased by the extract (500 mg/kg). These data demonstrate the anti-inflammatory effect of the ethanol extract of Helicteres gardneriana and imply that inhibition of leukocyte-endothelial interactions is important in the extract's mechanism of action

Effetti di tipologie di suolo e colture foraggere sulle perdite per ruscellamento di azoto, fosforo e potassio in differenti areali italiani

Le colture foraggere svolgono un ruolo importante in molti areali italiani. Per una corretta pianificazione del territorio agricolo è necessario approfondire la conoscenza non solo delle caratteristiche produttive di queste colture, ma anche dei loro rapporti con l'ambiente. Questo lavoro prende in considerazione le perdite di azoto, fosforo e potassio dovute al ruscellamento in colture foraggere a diverso livello di intensificazione (dal pascolo alla coltura di erba medica, dal mais al doppio ciclo di mais e loiessa) in tre ambienti italiani: la Pianura Padana nord-occidentale, l'Appennino Toscano e la pianura sarda, con suoli varianti da franco-sabbioso a franco-argilloso. Il monitoraggio quanti-qualitativo del ruscellamento è stato fatto per periodi variabili da due a sei anni. La pendenza era dello 0,5% per gli appezzamenti in Piemonte e Sardegna e del 10% in Toscana. Per quanto riguarda l'azoto i rilasci sono risultati più bassi nei terreni più pianeggianti, anche per i ridotti volumi di ruscellamento registrati, non superando mai 15 kg di N ha -1 anno -1. Nei terreni in pendenza si sono invece registrati valori più elevati, con un massimo annuale di circa 30 kg ha -1 anno -1 di azoto, in relazione anche all'elevato ruscellamento ed erosione di un evento eccezionale. Per il fosforo solo in pochi casi si sono raggiunte perdite di 5 kg ha -1 anno -1, mentre nella maggior parte dei casi non sono stati superati 2 kg ha -1 anno -1. In Sardegna i rilasci di tale elemento sono da considerarsi pressoché trascurabili. Le perdite di potassio sono risultate minime in Sardegna e massime in Piemonte, dove si sono registrati valori dell' ordine di 10 kg ha -1 anno -1. Ove era possibile il confronto, si è verificato che le colture prative riducono il rilascio di elementi nutritivi rispetto alla coltura del mais e che la qualità delle acque di superficie appare legata piuttosto alle tecniche colturali che alla tipologia di suolo. Fodder crops play an important role in many Italian environments. The knowledge of the main productive characteristics of these crops is as important as their relationships with the environment, expecially for a proper territorial management. This paper compares nitrogen, phosphorous and potassium contents in runoff of some forage crops of different intensity (pasture, lucerne, silage maize, Italian ryegrass/maize double cropping) in different ltalian environments (north-western plain of Piemonte, Apennines hills of Tuscany and Mediterranean plain of Sardegna) on different typology of soils. Runoff data have been collected for periods ranging between two and six year, from plots of different extension and slope (0,5% in the plains, 10% in Apennine hills). Nitrogen losses, for the small amount of runoff, have been qui te low from ilat fields, being always less than 15 kg ha -1 year-1. Losses from slope fields have been higher, with a maximum of 30 kg ha -1 year-1, due to very high level of runoff and erosion in a conspicuous episode. Phosphorous losses only in a few cases were higher than 5 kg ha -I year -I, while mostly they have b>!en less than 2 kg ha -1 year-1. In the Mediterranean plain such losses have been quite insignificant. Minimum potassium 10sses were recorded in the Mediterranean plain, while in north-western plain they reached about 10 kg-1 year-1. Maize was, on average, the crop with highest nutrient losses, while quality of the runoff water was more related to agricultural practices than to soil types

Problematic Use of the Internet Mediates the Association between Reduced Mentalization and Suicidal Ideation: A Cross-Sectional Study in Young Adults

© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Suicide is a major public health problem, and it is urgent to investigate its underlying clinical and psychological concomitants. It has been suggested that low mentalization skills and problematic use of the internet (PUI) are factors that can play a role in suicidal behaviors. It is possible that poor mentalization skills contribute to leading to forms of PUI, which, in turn, can represent triggers for suicidal ideation (SI). We tested this hypothesis through a quantitative and cross-sectional study on a sample (n = 623) of young adults (age range: 18−34). Self-report measures investigating symptoms related to Social Media Addiction (SMA), Internet Gaming Disorder (IGD), mentalization capacity, and SI were used. A single mediation analysis with two mediators was carried out to evaluate the direct and indirect effects of mentalization on SI through the mediating role of SMA- and IGD-related symptoms, controlling for potential confounding factors (e.g., socio-demographic and addiction-related variables). The four explored variables were significantly associated with each other (all p 0.001) across all subjects; the mediational model showed that the total effect of mentalization on SI was significant (B = −0.821, SE = 0.092 (95% CI: −1.001; −0.641)) and that both SMA- (B = −0.073, SE = 0.034 (95% CI: −0.145; −0.008)) and IGD-related symptoms (B = 0.046, SE = 0.027 (95% CI: −0.107; −0.001)) were significant mediators of such association. Our findings support the possibility that PUI severity plays a relevant role in mediating the association between low mentalization skills and levels of SI.Peer reviewedFinal Published versio

A tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is one of the most devastating and painful cancers. It is often highly resistant to therapy owing to inherent chemoresistance and the desmoplastic response that creates a barrier of fibrous tissue preventing transport of chemotherapeutics into the tumor. The growth of the tumor in pancreatic cancer often leads to invasion of other organs and partial or complete biliary obstruction, inducing intense pain for patients and necessitating tumor resection or repeated stenting. Here, we have developed a delivery device to provide enhanced palliative therapy for pancreatic cancer patients by providing high concentrations of chemotherapeutic compounds locally at the tumor site. This treatment could reduce the need for repeated procedures in advanced PDAC patients to debulk the tumor mass or stent the obstructed bile duct. To facilitate clinical translation, we created the device out of currently approved materials and drugs. We engineered an implantable poly(lactic-co-glycolic)-based biodegradable device that is able to linearly release high doses of chemotherapeutic drugs for up to 60 days. We created five patient-derived PDAC cell lines and tested their sensitivity to approved chemotherapeutic compounds. These in vitro experiments showed that paclitaxel was the most effective single agent across all cell lines. We compared the efficacy of systemic and local paclitaxel therapy on the patient-derived cell lines in an orthotopic xenograft model in mice (PDX). In this model, we found up to a 12-fold increase in suppression of tumor growth by local therapy in comparison to systemic administration and reduce retention into off-target organs. Herein, we highlight the efficacy of a local therapeutic approach to overcome PDAC chemoresistance and reduce the need for repeated interventions and biliary obstruction by preventing local tumor growth. Our results underscore the urgent need for an implantable drug-eluting platform to deliver cytotoxic agents directly within the tumor mass as a novel therapeutic strategy for patients with pancreatic cancer. Keywords: Pancreatic cancer; Chemoresistance; Local delivery; Patient-derived xenograft; Paclitaxel; Poly(lactic-co-glycolic acid)National Institutes of Health (U.S.) (Grant P30-CA14051

Antiinflammatory activity of Cayaponia podantha crude extract and fractions

The effects of the crude extract and fractions of Cayaponia podantha (Cp) on experimental inflammation models were investigated. Paw edema induced by carrageenan (Cg) and peritonitis induced by Cg, LPS, and LTB4 were evaluated in rats treated orally with different doses of extract. Croton oil (CO) induced ear edema and the determination of MPO activity were evaluated in mice. Crude Cp extract and hexane (HF), ethyl-acetate (AF) and hidromethanol (MF) fractions were topically applied immediately after the application of the CO. Four hours after Cg injection, animals treated with crude extract (250 and 500 mg/kg) displayed significantly decreased paw edema. The Cp extract (250, 500, and 750 mg/kg) decreased vascular permeability and leukocyte migration in the peritonitis model in the 3rd h after induction of the inflammatory reaction. Furthermore, the 500 mg/kg dose of Cp extract also reduced LPS- and LTB4-induced migration. Crude extract and hexane and ethyl-acetate fractions (5.0 mg) significantly inhibited ear edema and MPO activity. Our results showed that Cp crude extract and fractions exhibited anti-inflammatory effects when they are administered orally or topically in animals.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Validation of techniques to mitigate copper surface contamination in CUORE

In this article we describe the background challenges for the CUORE experiment posed by surface contamination of inert detector materials such as copper, and present three techniques explored to mitigate these backgrounds. Using data from a dedicated test apparatus constructed to validate and compare these techniques we demonstrate that copper surface contamination levels better than 10E-07 - 10E-08 Bq/cm2 are achieved for 238U and 232Th. If these levels are reproduced in the final CUORE apparatus the projected 90% C.L. upper limit on the number of background counts in the region of interest is 0.02-0.03 counts/keV/kg/y depending on the adopted mitigation technique.Comment: 10 pages, 6 figures, 6 table

Results From the Cuore Experiment †

The Cryogenic Underground Observatory for Rare Events (CUORE) is the first bolometric experiment searching for neutrinoless double beta decay that has been able to reach the 1-ton scale. The detector consists of an array of 988 TeO2 crystals arranged in a cylindrical compact structure of 19 towers, each of them made of 52 crystals. The construction of the experiment was completed in August 2016 and the data taking started in spring 2017 after a period of commissioning and tests. In this work we present the neutrinoless double beta decay results of CUORE from examining a total TeO2 exposure of 86.3kg yr, characterized by an effective energy resolution of 7.7 keV FWHM and a background in the region of interest of 0.014 counts/ (keV kg yr). In this physics run, CUORE placed a lower limit on the decay half- life of neutrinoless double beta decay of 130Te \u3e 1.3.1025 yr (90% C. L.). Moreover, an analysis of the background of the experiment is presented as well as the measurement of the 130Te 2 &nuββ decay with a resulting half- life of T 2v 1/2 = [7.9 ±0.1 (stat.) ±0.2 (syst.)] x 1020 yr which is the most precise measurement of the half- life and compatible with previous results