The influence of substrate and vegetation on extensive green roof hydrological performance

The objective of this research was to investigate the hydrological processes occurring in extensive green roof systems through data collected during a continuous monitoring programme of different green roof configurations. Nine green roof test beds (TB) which vary systematically in their substrate composition and vegetation options have been monitored since April 2010 at the University of Sheffield, UK. Three green roof substrates were tested: two commercial substrates manufactured by Alumasc – Heather with Lavender (HLS) and Sedum Carpet (SCS) Substrate were considered alongside a Lightweight Expanded Clay Aggregate (LECA)-based substrate. Three vegetation treatments have been tested: a drought tolerant specie (sedum), a meadow flower mixture and a no vegetation option. Per event retention performance varied depending on the initial water content within the substrate and the characteristics of the rainfall event. Consistent behaviour was observed among the tested green roof configurations with respect to per event retention. Greater retention was associated with HLS and SCS substrates when compared with LECA. Vegetated configurations showed consistently higher retention performance. Sedum vegetation resulted in higher retention performance than Meadow Flower. This was particularly evident on the LECA substrate

Predicting processing parameters in high temperature laser sintering (HT-LS) from powder properties

PublishedThis is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.There are two other ORE records for this publication: http://hdl.handle.net/10871/21707 and http://hdl.handle.net/10871/36733New materials for laser sintering (LS) are usually developed using a trial and-error approach that consists of a series of builds within LS systems. This strategy is time consuming, costly and focuses only on the optimisation of the processing parameters, ignoring the powder properties of the materials under examination. Being able to predict processing parameters on the basis of the powder material properties would enable a faster development of new materials and new applications, while acknowledging a more in-depth understanding of the mechanisms involved in LS. This paper provides new results into the prediction of processing conditions from the material properties. It is here shown that high temperature polymers such as poly ether ether ketone (PEEK) and poly aryl ether ketone (PEK) can be successfully used in LS despite the lack of a super-cooling window. The evaluation of the stable sintering region of PEEK 450PF and the application of the energy melt ratio parameter in relation to the mechanical performance of laser sintered PEEK samples are also provided. Lastly, a new method for estimating the powder bed temperature is proposed.The authors wish to acknowledge Victrex [23] and Invibio Biomaterials Solutions [44] for the supply of materials

Experiment K-6-03. Gravity and skeletal growth, part 1. Part 2: Morphology and histochemistry of bone cells and vasculature of the tibia; Part 3: Nuclear volume analysis of osteoblast histogenesis in periodontal ligament cells; Part 4: Intervertebral disc swelling pressure associated with microgravity

Bone area, bone electrophysiology, bone vascularity, osteoblast morphology, and osteoblast histogenesis were studied in rats associated with Cosmos 1887. The results suggest that the synchronous animals were the only group with a significantly larger bone area than the basal group, that the bone electrical potential was more negative in flight than in the synchronous rats, that the endosteal osteoblasts from flight rats had greater numbers of transitional Golgi vesicles but no difference in the large Golgi saccules or the alkaline phosphatase activity, that the perioteal vasculature in the shaft of flight rats often showed very dense intraluminal deposits with adjacent degenerating osteocytes as well as lipid accumulations within the lumen of the vessels and sometimes degeneration of the vascular wall (this change was not present in the metaphyseal region of flight animals), and that the progenitor cells decreased in flight rats while the preosteoblasts increased compared to controls. Many of the results suggest that the animals were beginning to recover from the effects of spaceflight during the two day interval between landing and euthanasia; flight effects, such as the vascular changes, did not appear to recover

A Primary Study into Graphene/Polyether Ether Ketone (PEEK) Nanocomposite for Laser Sintering

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.This paper proposes two methods of preparation of graphene/PEEK powders for Laser Sintering (LS) and investigates their behaviour in relation to their microstructure, the powder bed process and their properties. Thin composite films were fabricated in an attempt to replicate the thin layer formation of the powder bed process. Both methods of composite powder preparation (wet and dry) led to enhanced mechanical performance of the composite films at 0.1 and 0.5% graphene nano-platelets (GNP) concentrations. The TEM images show that the GNP act as a nucleation point in crystallisation of PEEK, being at the centre of the spherulites. The hot stage microscopy revealed a 20 second delay in the onset of GNP/PEEK nanocomposite coalescence in comparison with plain PEEK. This is a very important observation for laser sintering, as it will influence the build strategy and specific parameters (e.g. time between layers deposition, multiple exposures). The excellent electrical conductivity properties of graphene were noticeable in the nanocomposite films at concentrations above 1 wt% GNP.The authors would like to thank the UK Engineering and Physical Science Research Council for its funding (EPSRC grant no EP/L017318/1-Particle Shape and Flow behaviour in Laser Sintering: from modelling to experimental validation), 2D-Tech for providing the graphene and John Benson for his help with the Raman evaluation

Multimodal approach of advanced gastric cancer: Based therapeutic algorithm

Gastric cancer (GC) is the third leading cause of cancer death in both sexes worldwide, with the highest estimated mortality rates in Eastern Asia and the lowest in Northern America. However, the availability of modern treatment has improved the survival and the prognosis is often poor due to biological characteristics of the disease. In oncology, we are living in the "Era" of target treatment and, to know biological aspects, prognostic factors and predictive response informations to therapy in GC is mandatory to apply the best strategy of treatment. The purpose of this review, according to the recently published English literature, is to summarize existing data on prognostic aspects and predictive factors to response to therapy in GC and to analyze also others therapeutic approaches (surgery and radiotherapy) in locally, locally advanced and advanced GC. Moreover, the multidisciplinary approach (chemotherapy, surgery and radiotherapy) can improve the prognosis of GC

Pharmacology and toxicology of xylazine: quid novum?

The current opioid overdose crisis is characterized by the presence of unknown psychoactive adulterants. Xylazine is an alpha-2 receptor agonist that is not approved for human use but is commonly used in veterinary medicine due to its sedative and muscle-relaxant properties. Cases of human intoxication due to accidental or voluntary use have been reported since the 1980s. However, reports of adulteration of illicit opioids (heroin and illicit fentanyl) with xylazine have been increasing all over Western countries. In humans, xylazine causes respiratory depression, bradycardia, and hypotension-posing individuals, using xylazine-adulterated opioids. We present a narrative review of the latest intoxication cases related to xylazine, to bring awareness to readers and also to help pathologists to detect and deal with xylazine cases

High Temperature Laser Sintering: An investigation into mechanical properties and shrinkage characteristics of Poly (Ether Ketone) structures

Copyright © 2014 Elsevier. NOTICE: this is the author’s version of a work that was accepted for publication in Materials and Design. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Materials and Design, Vol. 61 (2014). DOI: 10.1016/j.matdes.2014.04.035This paper presents an investigation into the properties of Poly Ether Ketone (PEK) components using the commercial high temperature laser sintering system, EOSINT P800. The shrinkage and the mechanical performance of components across the entire build chamber have been tested and a non-linear shrinkage profile has been obtained. The middle of the build chamber recorded the highest degree of shrinkage and the shrinkage in Z direction had the largest variation. The laser sintered components built in X and Y directions recorded a 10% lower tensile strength than the injection moulded samples of the same material where those built in the Z direction showed an approximately 50% decrease in strength in comparison with the injection moulded test specimens. The crystallinity between the skin and the core of the sintered samples was different; varied with the position within the build chamber and coincided with noticeable sample colour changes

Identification of a 5-Protein Biomarker Molecular Signature for Predicting Alzheimer's Disease

Background: Alzheimer’s disease (AD) is a progressive brain disease with a huge cost to human lives. The impact of the disease is also a growing concern for the governments of developing countries, in particular due to the increasingly high number of elderly citizens at risk. Alzheimer’s is the most common form of dementia, a common term for memory loss and other cognitive impairments. There is no current cure for AD, but there are drug and non-drug based approaches for its treatment. In general the drug-treatments are directed at slowing the progression of symptoms. They have proved to be effective in a large group of patients but success is directly correlated with identifying the disease carriers at its early stages. This justifies the need for timely and accurate forms of diagnosis via molecular means. We report here a 5-protein biomarker molecular signature that achieves, on average, a 96% total accuracy in predicting clinical AD. The signature is composed of the abundances of IL-1α, IL-3, EGF, TNF-α and G-CSF. Methodology/Principal Findings: Our results are based on a recent molecular dataset that has attracted worldwide attention. Our paper illustrates that improved results can be obtained with the abundance of only five proteins. Our methodology consisted of the application of an integrative data analysis method. This four step process included: a) abundance quantization, b) feature selection, c) literature analysis, d) selection of a classifier algorithm which is independent of the feature selection process. These steps were performed without using any sample of the test datasets. For the first two steps, we used the application of Fayyad and Irani’s discretization algorithm for selection and quantization, which in turn creates an instance of the (alpha-beta)-k-Feature Set problem; a numerical solution of this problem led to the selection of only 10 proteins. Conclusions/Significance: the previous study has provided an extremely useful dataset for the identification of A biomarkers. However, our subsequent analysis also revealed several important facts worth reporting: 1. A 5-protein signature (which is a subset of the 18-protein signature of Ray et al.) has the same overall performance (when using the same classifier). 2. Using more than 20 different classifiers available in the widely-used Weka software package, our 5- protein signature has, on average, a smaller prediction error indicating the independence of the classifier and the robustness of this set of biomarkers (i.e. 96% accuracy when predicting AD against non-demented control). 3. Using very simple classifiers, like Simple Logistic or Logistic Model Trees, we have achieved the following results on 92 samples: 100 percent success to predict Alzheimer’s Disease and 92 percent to predict Non Demented Control on the AD dataset

Baccharis dracunculifolia, the main source of green propolis, exhibits potent antioxidant activity and prevents oxidative mitochondrial damage

Baccharis dracunculifolia DC (Asteraceae) is the main botanical source used by honeybees to produce Brazilian green propolis whose hepatoprotective properties have been already described. in this work we investigated the protective effects of the glycolic extract of B. dracunculifolia (GEBd) against oxidative stress in isolated rat liver mitochondria (RLM). the GEBd was prepared by fractionated percolation using propylene glycol as solvent. the total phenols and flavonoids, which are substances with recognized antioxidant action, were quantified in GEBd and the phytochemical analysis was carried out by HPLC. GEBd exhibited significant scavenger activity towards DPPH radicals and superoxide anions in a concentration-dependent manner, and also a Fe2+ chelating activity. GEBd decreased the basal H2O2 generation and the Fe2+- or t-BuOOH-induced ROS production in isolated mitochondria. Lipid oxidation of mitochondrial membranes, protein thiol groups and GSH oxidation were also prevented by GEBd. This shows that B. dracunculifolia exhibit potent antioxidant activity protecting liver mitochondria against oxidative damage and such action probably contribute to the antioxidant and hepatoprotective effects of green propolis. (C) 2011 Elsevier B.V. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Mogi das Cruzes UMC, Ctr Interdisciplinar Invest Bioquim CIIB, Mogi Das Cruzes, SP, BrazilUniv Estadual Paulista UNESP, Inst Quim, São Paulo, BrazilFac Ciencias Farmaceut Ribeirao Preto FCFRP USP, São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Dept Bioquim, São Paulo, BrazilUniv Fed ABC UFABC, Ctr Ciencias Nat & Humanas CCNH, Santo Andre, SP, BrazilUniversidade Federal de São Paulo UNIFESP, Dept Bioquim, São Paulo, BrazilFAPESP: 2008/01724-4FAPESP: 2008/07246-7CNPq: 301672/2009-1CNPq: 136255/2009-4Web of Scienc