1,105 research outputs found
Pediatric Kawasaki Disease and Adult Human Immunodeficiency Virus Kawasaki-Like Syndrome Are Likely the Same Malady.
Background.âPediatric Kawasaki disease (KD) and human immunodeficiency virus (HIV)+ adult Kawasaki-like syndrome (KLS) are dramatic vasculitides with similar physical findings. Both syndromes include unusual arterial histopathology with immunoglobulin (Ig)A+ plasma cells, and both impressively respond to pooled Ig therapy. Their distinctive presentations, histopathology, and therapeutic response suggest a common etiology. Because blood is in immediate contact with inflamed arteries, we investigated whether KD and KLS share an inflammatory signature in serum.Methods.âA custom multiplex enzyme-linked immunosorbent assay (ELISA) defined the serum cytokine milieu in 2 adults with KLS during acute and convalescent phases, with asymptomatic HIV+ subjects not taking antiretroviral therapy serving as controls. We then prospectively collected serum and plasma samples from children hospitalized with KD, unrelated febrile illnesses, and noninfectious conditions, analyzing them with a custom multiplex ELISA based on the KLS data.Results.âPatients with KLS and KD subjects shared an inflammatory signature including acute-phase reactants reflecting tumor necrosis factor (TNF)-α biologic activity (soluble TNF receptor I/II) and endothelial/smooth muscle chemokines Ccl1 (Th2), Ccl2 (vascular inflammation), and Cxcl11 (plasma cell recruitment). Ccl1 was specifically elevated in KD versus febrile controls, suggesting a unique relationship between Ccl1 and KD/KLS pathogenesis.Conclusions.âThis study defines a KD/KLS inflammatory signature mirroring a dysfunctional response likely to a common etiologic agent. The KD/KLS inflammatory signature based on elevated acute-phase reactants and specific endothelial/smooth muscle chemokines was able to identify KD subjects versus febrile controls, and it may serve as a practicable diagnostic test for KD
Zooming into local active galactic nuclei: The power of combining SDSS-IV MaNGA with higher resolution integral field unit observations
Ionised gas outflows driven by active galactic nuclei (AGN) are ubiquitous in
high luminosity AGN with outflow speeds apparently correlated with the total
bolometric luminosity of the AGN. This empirical relation and theoretical work
suggest that in the range L_bol ~ 10^43-45 erg/s there must exist a threshold
luminosity above which the AGN becomes powerful enough to launch winds that
will be able to escape the galaxy potential. In this paper, we present pilot
observations of two AGN in this transitional range that were taken with the
Gemini North Multi-Object Spectrograph Integral Field Unit (IFU). Both sources
have also previously been observed within the Sloan Digital Sky Survey-IV
(SDSS) Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey.
While the MaNGA IFU maps probe the gas fields on galaxy-wide scales and show
that some regions are dominated by AGN ionization, the new Gemini IFU data zoom
into the centre with four times better spatial resolution. In the object with
the lower L_bol we find evidence of a young or stalled biconical AGN-driven
outflow where none was obvious at the MaNGA resolution. In the object with the
higher L_bol we trace the large-scale biconical outflow into the nuclear region
and connect the outflow from small to large scales. These observations suggest
that AGN luminosity and galaxy potential are crucial in shaping wind launching
and propagation in low-luminosity AGN. The transition from small and young
outflows to galaxy-wide feedback can only be understood by combining
large-scale IFU data that trace the galaxy velocity field with higher
resolution, small scale IFU maps.Comment: 14 pages, accepted for publication in MNRA
The Hamiltonian formulation of General Relativity: myths and reality
A conventional wisdom often perpetuated in the literature states that: (i) a
3+1 decomposition of space-time into space and time is synonymous with the
canonical treatment and this decomposition is essential for any Hamiltonian
formulation of General Relativity (GR); (ii) the canonical treatment
unavoidably breaks the symmetry between space and time in GR and the resulting
algebra of constraints is not the algebra of four-dimensional diffeomorphism;
(iii) according to some authors this algebra allows one to derive only spatial
diffeomorphism or, according to others, a specific field-dependent and
non-covariant four-dimensional diffeomorphism; (iv) the analyses of Dirac
[Proc. Roy. Soc. A 246 (1958) 333] and of ADM [Arnowitt, Deser and Misner, in
"Gravitation: An Introduction to Current Research" (1962) 227] of the canonical
structure of GR are equivalent. We provide some general reasons why these
statements should be questioned. Points (i-iii) have been shown to be incorrect
in [Kiriushcheva et al., Phys. Lett. A 372 (2008) 5101] and now we thoroughly
re-examine all steps of the Dirac Hamiltonian formulation of GR. We show that
points (i-iii) above cannot be attributed to the Dirac Hamiltonian formulation
of GR. We also demonstrate that ADM and Dirac formulations are related by a
transformation of phase-space variables from the metric to lapse
and shift functions and the three-metric , which is not canonical. This
proves that point (iv) is incorrect. Points (i-iii) are mere consequences of
using a non-canonical change of variables and are not an intrinsic property of
either the Hamilton-Dirac approach to constrained systems or Einstein's theory
itself.Comment: References are added and updated, Introduction is extended,
Subsection 3.5 is added, 83 pages; corresponds to the published versio
Human rights and community work. Complementary theories and practices
Much effort has been placed on developing international understandings of human rights without the corresponding attention to responsibilities. The authors argue that a community development framework may be useful in re-conceiving human rights in a more holistic way, and that social workers and community development workers are well placed to be 'grass roots human rights workers
Black Holes in the Early Universe
The existence of massive black holes was postulated in the sixties, when the
first quasars were discovered. In the late nineties their reality was proven
beyond doubt, in the Milky way and a handful nearby galaxies. Since then,
enormous theoretical and observational efforts have been made to understand the
astrophysics of massive black holes. We have discovered that some of the most
massive black holes known, weighing billions of solar masses, powered luminous
quasars within the first billion years of the Universe. The first massive black
holes must therefore have formed around the time the first stars and galaxies
formed. Dynamical evidence also indicates that black holes with masses of
millions to billions of solar masses ordinarily dwell in the centers of today's
galaxies. Massive black holes populate galaxy centers today, and shone as
quasars in the past; the quiescent black holes that we detect now in nearby
bulges are the dormant remnants of this fiery past. In this review we report on
basic, but critical, questions regarding the cosmological significance of
massive black holes. What physical mechanisms lead to the formation of the
first massive black holes? How massive were the initial massive black hole
seeds? When and where did they form? How is the growth of black holes linked to
that of their host galaxy? Answers to most of these questions are work in
progress, in the spirit of these Reports on Progress in Physics.Comment: Reports on Progress in Physics, in pres
On the co-evolution of supermassive black holes and their host galaxies since z = 3
[Abridged] To investigate the evolution in the relation between galaxy
stellar and central black hole mass we construct a volume limited complete
sample of 85 AGN with host galaxy stellar masses M_{*} > 10^{10.5} M_{sol}, and
specific X-ray luminosities L_{X} > 2.35 x 10^{43} erg s^{-1} at 0.4 < z < 3.
We calculate the Eddington limiting masses of the supermassive black holes
residing at the centre of these galaxies, and observe an increase in the
average Eddington limiting black hole mass with redshift. By assuming that
there is no evolution in the Eddington ratio (\mu) and then that there is
maximum possible evolution to the Eddington limit, we quantify the maximum
possible evolution in the M_{*} / M_{BH} ratio as lying in the range 700 <
M_{*}/M_{BH} < 10000, compared with the local value of M_{*}/M_{BH} ~ 1000. We
furthermore find that the fraction of galaxies which are AGN (with L_{X} > 2.35
x 10^{43} erg s^{-1}) rises with redshift from 1.2 +/- 0.2 % at z = 0.7 to 7.4
+/- 2.0 % at z = 2.5. We use our results to calculate the maximum timescales
for which our sample of AGN can continue to accrete at their observed rates
before surpassing the local galaxy-black hole mass relation. We use these
timescales to calculate the total fraction of massive galaxies which will be
active (with L_{X} > 2.35 x 10^{43} erg s^{-1}) since z = 3, finding that at
least ~ 40% of all massive galaxies will be Seyfert luminosity AGN or brighter
during this epoch. Further, we calculate the energy density due to AGN activity
in the Universe as 1.0 (+/- 0.3) x 10^{57} erg Mpc^{-3} Gyr^{-1}, potentially
providing a significant source of energy for AGN feedback on star formation. We
also use this method to compute the evolution in the X-ray luminosity density
of AGN with redshift, finding that massive galaxy Seyfert luminosity AGN are
the dominant source of X-ray emission in the Universe at z < 3.Comment: 25 pages, 10 figures, accepted for publication in MNRA
Anticancer Gene Transfer for Cancer Gene Therapy
Gene therapy vectors are among the treatments currently used to treat malignant tumors. Gene therapy vectors use a specific therapeutic transgene that causes death in cancer cells. In early attempts at gene therapy, therapeutic transgenes were driven by non-specific vectors which induced toxicity to normal cells in addition to the cancer cells. Recently, novel cancer specific viral vectors have been developed that target cancer cells leaving normal cells unharmed. Here we review such cancer specific gene therapy systems currently used in the treatment of cancer and discuss the major challenges and future directions in this field
Spintronics: Fundamentals and applications
Spintronics, or spin electronics, involves the study of active control and
manipulation of spin degrees of freedom in solid-state systems. This article
reviews the current status of this subject, including both recent advances and
well-established results. The primary focus is on the basic physical principles
underlying the generation of carrier spin polarization, spin dynamics, and
spin-polarized transport in semiconductors and metals. Spin transport differs
from charge transport in that spin is a nonconserved quantity in solids due to
spin-orbit and hyperfine coupling. The authors discuss in detail spin
decoherence mechanisms in metals and semiconductors. Various theories of spin
injection and spin-polarized transport are applied to hybrid structures
relevant to spin-based devices and fundamental studies of materials properties.
Experimental work is reviewed with the emphasis on projected applications, in
which external electric and magnetic fields and illumination by light will be
used to control spin and charge dynamics to create new functionalities not
feasible or ineffective with conventional electronics.Comment: invited review, 36 figures, 900+ references; minor stylistic changes
from the published versio
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