European Lung Cancer Working Party Clinical Practice Guidelines Non-small Cell Lung Cancer: II. Unresectable Non-metastatic Stages

The present guidelines on the management of unresectable non-metastatic non-small cell lung cancer (NSCLC) were formulated by the ELCWP in October 2005. They are designed to answer the following eight questions: 1) Is chest irradiation curative for NSCLC? 2) What are the contra-indications (anatomical or functional) to chest irradiation? 3) Does the addition of chemotherapy add an advantage to radiotherapy? 4) Does the addition of radiotherapy add an advantage to chemotherapy? 5) Is irradiation as effective as surgery for marginally resectable stage III? 6) How to best combine chemotherapy with radiotherapy: sequentially, concomitantly, as consolidation, as induction, as radiosensitiser? 7) In case of too advanced locoregional disease, is there a role for consolidation (salvage) local treatment (surgery or radiotherapy) after induction chemotherapy? 8) In 2005, what are the technical characteristics of an adequate radiotherapy

European Lung Cancer Working Party Clinical Practice Guidelines. Non-small cell lung cancer: I. Early stages

The present guidelines on the management of resectable non-small cell lung cancer (NSCLC) were formulated by the (ELCWP) in April 2005. They aim in answering the following eleven questions: 1) Is surgery the best therapy for a potentially resectable cancer? 2) How is complete resection defined? 3) Is systematic lymph node dissection necessary during surgery? 4) What is the role of radiotherapy after complete resec tion? 5) Should adjuvant or neoadjuvant chemotherapy be administered in clinical stages I or II? 6) Should adjuvant chemotherapy be administered in pathological stages I or II? 7) Is adjuvant therapy advisable after complete resection for pathologi cal stage IIIA N2? If yes, of what type: chemotherapy, radiotherapy or chemotradio herapy? 8) What are the indications for surgery after induction treatment, in clinical stages IIIA or IIIB? 9) In clinical stages IIIA or IIIB, is preoperative therapy required and of what type? 10) What type of treatment is indicated after an incomplete surgical resection? 11) What is the best regimen for (neo)adjuvant chemotherapy