Carcinomes nasopharynges localement avances

Les carcinomes nasopharyngés représentent une entité spécifique différente des cancers de la tête et du cou. L’incidence est plus élevée en Asie du Sud-Est et en Afrique du Nord. Le pronostic reste sombre pour les stades localement avancés (IIB—IVB), plus d’un tiers des cas présenteront une récidive locale et/ou métastatique, la survie globale à cinq ans tous stades confondus est estimée à 50—70 %. L’objectif de ce travail est de préciser les aspects cliniques, diagnostiques, thérapeutiques et pronostiques chez 100 malades porteur de carcinome nasopharyngé localement avancé traités à l’Institut Salah Azaiz (ISA) et de préciser l’impact de la chimiothérapie neoadjuvante (CNA) ainsi que les séquelles thérapeutiques à court et à long terme.Mots clés : carcinome nasopharyngé - chimiothérapie - radiothérapieNasopharyngeal carcinoma represents a specific entity different from cancers of head and neck. The incidence is highest in South- East Asia and North Africa. The prognosis remains poor for locally advanced stages (IIB -IVB), more than one third of cases presented locally recurrent and / or metastatic disease, the overall five-year survival for all stages is estimated at 50-70%. The objective of this study is to clarify the impact of neoadjuvant chemotherapy on long-term survival among 100 patients treated in Institut of Salah Azaiz by neo adjuvant chemotherapy followed by locoregional radiotherapy for locally advanced nasopharyngeal carcinoma, and identify prognostic factors and clinical long term effect.Key words: nasopharyngeal carcinoma – chemotherapy - radiotherap

Characterization of virgin olive oils obtained from minor Tunisian varieties for their valorization

Several compositional parameters (fatty acids, tocopherols, polar phenols and volatiles) in virgin olive oils from varieties located at the center of Tunisia, namely Baldi, Chemchali, Neb Jmel, Tounsi and Besbessi from Gafsa and Chemchali and Sehli cultivated in Sidi Bouzid, were studied. To the best of our knowledge, this is the first study focusing on the chemical composition of virgin olive oils (VOO) from Sidi Bouzid. Significant differences were found between varieties from Sidi Bouzid and Gafsa in monounsaturated saturated fatty acid levels, some volatile compounds and γ-tocopherol amounts. Notably, Tounsi and Baldi VOOs showed the highest six carbon atoms alcohol contents, whereas Neb Jmel VOO revealed the highest aldehyde six carbon atoms content. Fatty acid composition, as well as tocopherol content, showed differences among different VOO. Principal component analysis and hierarchical component analysis on polar phenols, fatty acids, tocopherols and volatiles data evidenced a good discrimination among oils from the different investigated varieties

Quantifying Acoustic and Pressure Sensing for In-Pipe Leak Detection

Experiments were carried out to study the effectiveness of using inside-pipe measurements for leak detection in plastic pipes. Acoustic and pressure signals due to simulated leaks, opened to air, are measured and studied for designing a detection system to be deployed inside water networks of 100 mm (4 inch) pipe size. Results showed that leaks as small as 2 l/min can be detected using both hydrophone and dynamic pressure transducer under low pipe flow rates. The ratio between pipe flow rate and leak flow rate seems to be more important than the absolute value of leak flow. Increasing this ratio resulted in diminishing and low frequency leak signals. Sensor location and directionality, with respect to the leak, are important in acquiring clean signal.King Fahd University of Petroleum and Mineral

A Thioredoxin Domain-Containing Protein Interacts with Pepino mosaic virus Triple Gene Block Protein 1

Pepino mosaic virus (PepMV) is a mechanically-transmitted tomato pathogen of importance worldwide. Interactions between the PepMV coat protein and triple gene block protein (TGBp1) with the host heat shock cognate protein 70 and catalase 1 (CAT1), respectively, have been previously reported by our lab. In this study, a novel tomato interactor (SlTXND9) was shown to bind the PepMV TGBp1 in yeast-two-hybrid screening, in vitro pull-down and bimolecular fluorescent complementation (BiFC) assays. SlTXND9 possesses part of the conserved thioredoxin (TRX) active site sequence (W__PC vs. WCXPC), and TXND9 orthologues cluster within the TRX phylogenetic superfamilyclosesttophosducin-likeprotein-3. InPepMV-infectedandhealthyNicotianabenthamiana plants,NbTXND9mRNAlevelswerecomparable,andexpressionlevelsremainedstableinbothlocal and systemic leaves for 10 days post inoculation (dpi), as was also the case for catalase 1 (CAT1). To localize the TXND9 in plant cells, a polyclonal antiserum was produced. Purified α-SlTXND9 immunoglobulin (IgG) consistently detected a set of three protein bands in the range of 27–35 kDa, in the 1000 and 30,000 g pellets, and the soluble fraction of extracts of healthy and PepMV-infected N. benthamiana leaves, but not in the cell wall. These bands likely consist of the homologous protein NbTXND9 and its post-translationally modified derivatives. On electron microscopy, immuno-gold labellingofultrathinsectionsofPepMV-infectedN.benthamianaleavesusingα-SlTXND9IgGrevealed particle accumulation close to plasmodesmata, suggesting a role in virus movement. Taken together, this study highlights a novel tomato-PepMV protein interaction and provides data on its localization in planta. Currently, studies focusing on the biological function of this interaction during PepMV infection are in progress

Heat transfer and pressure drop characteristics of a plate heat exchanger using water based Al2O3 nanofluid for 30° and 60° chevron angles

Nanofluid is a new class of engineering fluid that has good heat transfer characteristics which is essential to increase the heat transfer performance in various engineering applications such as heat exchangers and cooling of electronics. In this study, experiments were conducted to compare the heat transfer performance and pressure drop characteristics in a plate heat exchanger (PHE) for 30° and 60° chevron angles using water based Al2O3 nanofluid at the concentrations from 0 to 0.5 vol.% for different Reynolds numbers. The thermo-physical properties has been determined and presented in this paper. At 0.5 vol% concentration, the maximum heat transfer coefficient, the overall heat transfer coefficient and the heat transfer rate for 60° chevron angle have attained a higher percentage of 15.14%, 7.8% and 15.4%, respectively in comparison with the base fluid. Consequently, when the volume concentration or Reynolds number increases, the heat transfer coefficient and the overall heat transfer coefficient as well as the heat transfer rate of the PHE (Plate Heat Exchangers) increases respectively. Similarly, the pressure drop increases with the volume concentration. 60° chevron angle showed better performance in comparison with 30° chevron angle

Computing with and without arbitrary large numbers

In the study of random access machines (RAMs) it has been shown that the availability of an extra input integer, having no special properties other than being sufficiently large, is enough to reduce the computational complexity of some problems. However, this has only been shown so far for specific problems. We provide a characterization of the power of such extra inputs for general problems. To do so, we first correct a classical result by Simon and Szegedy (1992) as well as one by Simon (1981). In the former we show mistakes in the proof and correct these by an entirely new construction, with no great change to the results. In the latter, the original proof direction stands with only minor modifications, but the new results are far stronger than those of Simon (1981). In both cases, the new constructions provide the theoretical tools required to characterize the power of arbitrary large numbers.Comment: 12 pages (main text) + 30 pages (appendices), 1 figure. Extended abstract. The full paper was presented at TAMC 2013. (Reference given is for the paper version, as it appears in the proceedings.

The expected number of olympic medals: a case study of team Portugal at Tokyo 2020

The 2020 Summer Olympic Games reached to an end in Tokyo, Japan. Even though all the hiccups, constraints, and challenges imposed by the COVID-19 pandemic, the Games were successfully held in August 2021. For the first time in history, Team Portugal won four medals (one gold, one silver, and two bronzes). In 2018 the Portuguese Olympic Committee signed a contract with the Portuguese Institute of Sport and Youth (i.e., Portuguese government) listing the deliverables of the mission Tokyo 2020 against a funding scheme of 18.5 million euros (Contrato n.º 33-A/2018; Contrato -Programa de Desenvolvimento Desportivo n.º CP/1/DDF/2018). The document sets, among other goals and deliverables, that no less than two medals would be won at Tokyo 2020 (section IV.1. of the contract). On the road to Tokyo, Portugal got more than two medallists at World Championships in several Olympic sports. Indeed, there were six to eight potential medallists at the 2020 Olympic Games (O Jogo, 2021). There is evidence that just one-third to one-fourth of the Olympic athletes are able to excel and outperform at the Olympic Games. In the sport of competitive swimming, just 29.82% of all male Olympians and 53.84% of the finalists at Rio 2016 improved their entry times (Barbosa, 2016a). On average, only 30% of the swimmers were able to improve their entry time at the 2012 and 2016 Olympic Games (Barbosa, 2016b). At Rio 2016, Team Portugal was expected to win two medals out of nine potential medallists, i.e., almost 25% of effectiveness (Garcia, 2016). Thus, one can wonder if the Portuguese Olympic Committee was sensible, assuming that two athletes would reach the podium spot out of six to eight potential medallists. Also, it begs the question if the four medals won were an outstanding achievement, deemed as a substantial improvement of the Portuguese sports system or, if alternatively, the Portuguese Olympic Committee underestimated the number of medals that the country could win.info:eu-repo/semantics/publishedVersio

Analyzing Recent Coronary Heart Disease Mortality Trends in Tunisia between 1997 and 2009.

BACKGROUND: In Tunisia, Cardiovascular Diseases are the leading causes of death (30%), 70% of those are coronary heart disease (CHD) deaths and population studies have demonstrated that major risk factor levels are increasing. OBJECTIVE: To explain recent CHD trends in Tunisia between 1997 and 2009. METHODS: DATA SOURCES: Published and unpublished data were identified by extensive searches, complemented with specifically designed surveys. ANALYSIS: Data were integrated and analyzed using the previously validated IMPACT CHD policy model. Data items included: (i)number of CHD patients in specific groups (including acute coronary syndromes, congestive heart failure and chronic angina)(ii) uptake of specific medical and surgical treatments, and(iii) population trends in major cardiovascular risk factors (smoking, total cholesterol, systolic blood pressure (SBP), body mass index (BMI), diabetes and physical inactivity). RESULTS: CHD mortality rates increased by 11.8% for men and 23.8% for women, resulting in 680 additional CHD deaths in 2009 compared with the 1997 baseline, after adjusting for population change. Almost all (98%) of this rise was explained by risk factor increases, though men and women differed. A large rise in total cholesterol level in men (0.73 mmol/L) generated 440 additional deaths. In women, a fall (-0.43 mmol/L), apparently avoided about 95 deaths. For SBP a rise in men (4 mmHg) generated 270 additional deaths. In women, a 2 mmHg fall avoided 65 deaths. BMI and diabetes increased substantially resulting respectively in 105 and 75 additional deaths. Increased treatment uptake prevented about 450 deaths in 2009. The most important contributions came from secondary prevention following Acute Myocardial Infarction (AMI) (95 fewer deaths), initial AMI treatments (90), antihypertensive medications (80) and unstable angina (75). CONCLUSIONS: Recent trends in CHD mortality mainly reflected increases in major modifiable risk factors, notably SBP and cholesterol, BMI and diabetes. Current prevention strategies are mainly focused on treatments but should become more comprehensive

Customer acceptance of humanoid service robots in hotels: moderating effects of service voluntariness and culture

Purpose: The current study proposes a research model integrating TAM3 constructs and human aspects of humanoid service robots (HSRs), measured by the Godspeed questionnaire series (GQS), and tested across two hotel properties in Japan and the US. Design/methodology/approach: Potential participants were approached randomly by e-mail invitation. A final sample size of 395, across two hotels, one in Japan and the other in the US, was obtained and the data were analyzed using structural equation modelling. Findings: The results confirm that perceived usefulness (PU), driven by subjective norms and output quality, and perceived ease of use (PEOU), driven by perceived enjoyment and absence of anxiety, are the immediate direct determinants of users' re-patronage intentions for HSRs. Results also showed that users prefer anthropomorphism, perceived intelligence, and the safety of an HSR for re-using it. Implications: The findings have practical implications for the hospitality industry suggesting multiple attributes of an HSRs that managers need to consider before deploying them in their properties. Originality: The current study proposes an integrated model determining factors that affect the re-patronage of HSRs in hotels

Pomological and Olive Oil Quality Characteristics Evaluation under Short Time Irrigation of Olive Trees cv. Chemlali with Untreated Industrial Poultry Wastewater

The aim of this work was the investigation of the effect of wastewater generated from the poultry meat industry on the irrigation of olive trees, during a short time period, in order to evaluate its impact on pomological criteria and olive oil quality. Olive trees were subjected to irrigation with different water qualities: (i) poultry wastewater (PWW), (ii) poultry wastewater diluted with tap water 50:50 (v/v) (PWTWW), (iii) rain-fed cultivation system (control). The results showed that PWTWW contains the optimal mineral proportions, leading to improved pomological criteria. However, the highest significant pulp oil content was obtained using poultry wastewater irrigation (69.51%), while this was 66.71% using diluted poultry wastewater, and 58.03 % for the control. Poultry wastewater irrigation yielded the best results in oil standard quality indices. In addition, an enrichment in oil total polyphenols content was achieved. The oil fatty acid profile was not affected following irrigation with poultry wastewater. Nevertheless, there was a significant increase in the contents of oleic acid and alcohols, accompanied by a decrease in total sterols. However, heavy metals accumulation was observed in both fruits and olive oil. In conclusion, our results suggest that among the three water qualities, poultry wastewater is the best alternative to improve olive oil quality