88 research outputs found
Aquatic-Terrestrial Linkages: Formation, Importance, and Disruption
We can no longer regard ecosystems as discrete entities in space. Similar to human societies, the natural environment is a product of a wide range of transport, propagation, and communication processes. Spatial coupling of ecosystems through cross-habitat fluxes of energy and matter may modify food web interactions, change ecosystem function, and alter community diversity. Lateral fluxes of matter and energy between discrete ecosystems have been shown to elicit variable responses in the recipient ones depending on trophic position, ecological process, biotic and abiotic conditions, and the ratio between the subsidy and local resources. In some cases, cross ecosystem nutrient fluxes can be as important as transfers within individual ecosystems. Some of the best documented ecosystem linkages occur in aquatic-terrestrial systems. For example, terrestrial animals feeding in freshwater and marine habitats transfer nutrients from these aquatic to adjacent terrestrial ecosystems leading to increases in primary production in the latter. Such increases in production are comparable in magnitude to positive effects of moderately elevated local herbivory observed in some systems or nitrogen fixation by alder. Nonetheless, recent human-induced ecosystem alterations result in disruption of the spatial continuity of ecosystem linkages. Here I evaluate the current knowledge on the formation and importance of aquatic-terrestrial linkages and provide examples of the consequences of discontinuity in these transport processes
Seasonal diets of mink and martens: Effects of spatial and temporal changes in resource abundance
Thesis (Ph.D.) University of Alaska Fairbanks, 1996Seasonal changes in food availability and feeding habits of mink (Mustela vison) and martens (Martes americana) on Chichagof Island, Southeast Alaska, were studied through the analysis of natural abundance of stable isotopes. Dependence of the two species on marine-derived nutrients, carried to the terrestrial system via the upstream migration of spawning Pacific salmon (Onchorhynchus sp.), was investigated. Twenty-four mink and 75 martens were live-trapped repeatedly in early summer (prior to salmon runs), early autumn (post salmon runs), late winter, and in spring (during the mating season). A blood sample was obtained from each individual. In addition, 25 mink and 165 marten carcasses were obtained from trappers during late autumn 1991-1994. Concurrently, prey availability was monitored, and tissues from prey were collected. The abundance of stable isotopes in prey tissues and blood samples were compared, indicating that riverine mink depended on salmon (carcasses and fry), with little seasonal or individual variation, whereas coastal mink relied on intertidal organisms in spring and summer, but fed on salmon carcasses when they became available in autumn. In addition, analysis of blood progesterone revealed that timing of reproduction in female mink appear to be shifted, so that lactation coincided with the availability of salmon carcasses. In contrast, martens showed individual variation in their diets, with some individuals feeding exclusively on terrestrial organisms, while the diets of others include salmon carcasses. Incorporation of salmon in the diet depended largely on availability of small rodents and location of the martens home range on the landscape. Although salmon carcasses are not a preferred food item for martens, they act as a suitable alternative to maintain body condition and allow successful reproduction even in years when preferred food is not readily available
Editorial: Radiation therapy using MRI-Linac - the right way to start: a guide for physicians and physicists
Associação Entre Estigma, dor e Qualidade de Vida em Mulheres com Cancro da Mama
Aim: We examined the association between cancer stigma and quality of life. We further explored the role of pain intensity in this association among women with breast cancer in the first months following diagnosis. Methods: 105 women with breast cancer within 8 months of diagnosis completed self-report measures assessing cancer stigma, pain intensity and quality of life. Results: Our findings show that stigma among breast cancer patients is associated with worse quality of life. Pain intensity partially mediated the relationship between cancer stigma and quality of life. We recruited a convenience sample of women with breast cancer, which may be subject to selection bias. The cross sectional design of the study precludes inferences regarding causality. Conclusions: Health professionals should recognize and mitigate the impact of stigma as an important factor that is associated with impaired quality of life among patients with breast cancer. Continued attention should be paid to pain intensity and the complex relationship between stigma and pain in predicting quality of life.Objetivo: O presente estudo procurou analisar a associação entre o estigma e a qualidade de vida em pessoas com cancro. Foi ainda explorado o papel da intensidade da dor nesta associação, em mulheres com cancro de mama, nos primeiros meses após o diagnóstico. Método: 105 mulheres com cancro da mama (até 8 meses após o diagnóstico) completaram medidas de autorrelato avaliando o estigma relacionado com o cancro, a intensidade da dor e a qualidade de vida. Resultados: Os nossos resultados mostram que o estigma entre pacientes com cancro de mama está associado a uma pior qualidade de vida. A intensidade da dor mediou parcialmente a relação entre o estigma relativo ao cancro e a qualidade de vida. Duas limitações são o facto de a amostra de mulheres com cancro da mama ser de conveniência, podendo ter estado sujeita a algum viés de seleção, e o facto de ser um estudo correlacional, que não permite inferências sobre causalidade. Conclusões: Os profissionais de saúde devem reconhecer e mitigar o impacto do estigma como um fator importante associado à diminuição da qualidade de vida de pacientes com cancro da mama. Deverá prestar-se atenção contínua à intensidade da dor e à complexa relação entre estigma e dor na previsão da qualidade de vida
High altitude diving in river otters: coping with combined hypoxic stresses
River otters (Lontra canadensis) are highly active, semi-aquatic mammals indigenous to a range of elevations and represent an appropriate model for assessing the physiological responses to diving at altitude. In this study, we performed blood gas analyses and compared blood chemistry of river otters from a high-elevation (2357 m) population at Yellowstone Lake with a sea-level population along the Pacific coast. Comparisons of oxygen dissociation curves (ODC) revealed no significant difference in hemoglobin-oxygen (Hb-O2) binding affinity between the two populations - potentially because of demands for tissue oxygenation. Instead, high-elevation otters had greater Hb concentrations (18.7 g dl-1) than sea-level otters (15.6 g dl-1). Yellowstone otters displayed higher levels of the vasodilator nitric oxide (NO), and half the concentration of the serum protein albumin, possibly to compensate for increased blood viscosity. Despite compensation in several hematological and serological parameters, theoretical aerobic dive limits (ADL) were similar between high-elevation and sea-level otters because of the lower availability of O2 at altitude. Our results suggest that recent disruptions to the Yellowstone Lake food web could be detrimental to otters because at this high elevation, constraints on diving may limit their ability to switch to prey in a deep-water environment
The Acute Physiological Response of Polar Bears to Helicopter Capture
Many wildlife species are live captured, sampled, and released; for polar bears (Ursus maritimus) capture often requires chemical immobilization via helicopter darting. Polar bears reduce their activity for approximately 4 days after capture, likely reflecting stress recovery. To better understand this stress, we quantified polar bear activity (via collar‐mounted accelerometers) and body temperature (via loggers in the body core [Tabd] and periphery [Tper]) during 2–6 months of natural behavior, and during helicopter recapture and immobilization. Recapture induced bouts of peak activity higher than those that occurred during natural behavior for 2 of 5 bears, greater peak Tper for 3 of 6 bears, and greater peak Tabd for 1 of 6 bears. High body temperature (\u3e39.0°C) occurred in Tper for 3 of 6 individuals during recapture and 6 of 6 individuals during natural behavior, and in Tabd for 2 of 6 individuals during recapture and 3 of 6 individuals during natural behavior. Measurements of Tabd and Tper correlated with rectal temperatures measured after immobilization, supporting the use of rectal temperatures for monitoring bear response to capture. Using a larger dataset (n = 66 captures), modeling of blood biochemistry revealed that maximum ambient temperature during recapture was associated with a stress leukogram (7–26% decline in percent lymphocytes, 12–21% increase in percent neutrophils) and maximum duration of helicopter operations had a similar but smaller effect. We conclude that polar bear activity and body temperature during helicopter capture are similar to that which occurs during the most intense events of natural behavior; high body temperature, especially in warm capture conditions, is a key concern; additional study of stress leukograms in polar bears is needed; and additional data collection regarding capture operations would be useful
Wheatear molt and assignment tests: ongoing lessons in using stable isotopes to infer origins
Pancreatic cancer outcome—local treatment with radiation using MRI-LINAC
IntroductionStereotactic MR-guided on-table adaptive radiotherapy (SMART) allows the precise delivery of high-dose radiation to tumors in great proximity to radiation-sensitive organs. The aim of this study is to evaluate the toxicity and clinical outcome in locally advanced or recurrent pancreatic tumors, with or without prior irradiation, treated with SMART.MethodsPatients were treated for pancreatic cancer (PC) using SMART technology to a prescribed dose of 50 Gy (BED10, 100 Gy) in five fractions, with daily on-table adaptation of treatment plan. Endpoints were acute and late toxicities, local control, local disease-free period, and overall survival.ResultsA total of 54 PC patients were treated between August 2019 and September 2022, with a median follow-up of 8.9 months from SMART. The median age was 70.4 (45.2–86.9) years. A total of 40 patients had upfront inoperable PC (55% were locally advanced and 45% metastatic), and 14 had local recurrence following prior pancreatectomy (six patients also had prior adjuvant RT). Of the patients, 87% received at least one chemotherapy regimen (Oxaliplatin based, 72.2%), and 25.9% received ≥2 regimens. Except from lower CA 19-9 serum level at the time of diagnosis and 6 weeks prior to SMART in previously operated patients, there were no significant differences in baseline parameters between prior pancreatectomy and the inoperable group. On-table adaptive replanning was performed for 100% of the fractions. No patient reported grade ≥2 acute GI toxicity. All previously irradiated patients reported only low-grade toxicities during RT. A total of 48 patients (88.9%) were available for evaluation. Complete local control was achieved in 21.7% (10 patients) for a median of 9 months (2.8–28.8); three had later local progression. Eight patients had regional or marginal recurrence. Six- and 12-month OS were 75.0% and 52.1%, respectively. Apart from mild diarrhea 1–3 months after SMART and general fatigue, there were no significant differences in toxicity and outcomes between post-pancreatectomy and inoperable groups.ConclusionSMART allows safe delivery of an ablative dose of radiotherapy, with minimal treatment-related toxicity, even in previously resected or irradiated patients. In this real-world cohort, local control with complete response was achieved by 20% of the patients. Further studies are needed to evaluate long-term outcome and late toxicity
25th annual computational neuroscience meeting: CNS-2016
The same neuron may play different functional roles in the neural circuits to which it belongs. For example, neurons in the Tritonia pedal ganglia may participate in variable phases of the swim motor rhythms [1]. While such neuronal functional variability is likely to play a major role the delivery of the functionality of neural systems, it is difficult to study it in most nervous systems. We work on the pyloric rhythm network of the crustacean stomatogastric ganglion (STG) [2]. Typically network models of the STG treat neurons of the same functional type as a single model neuron (e.g. PD neurons), assuming the same conductance parameters for these neurons and implying their synchronous firing [3, 4]. However, simultaneous recording of PD neurons shows differences between the timings of spikes of these neurons. This may indicate functional variability of these neurons. Here we modelled separately the two PD neurons of the STG in a multi-neuron model of the pyloric network. Our neuron models comply with known correlations between conductance parameters of ionic currents. Our results reproduce the experimental finding of increasing spike time distance between spikes originating from the two model PD neurons during their synchronised burst phase. The PD neuron with the larger calcium conductance generates its spikes before the other PD neuron. Larger potassium conductance values in the follower neuron imply longer delays between spikes, see Fig. 17.Neuromodulators change the conductance parameters of neurons and maintain the ratios of these parameters [5]. Our results show that such changes may shift the individual contribution of two PD neurons to the PD-phase of the pyloric rhythm altering their functionality within this rhythm. Our work paves the way towards an accessible experimental and computational framework for the analysis of the mechanisms and impact of functional variability of neurons within the neural circuits to which they belong
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