Nodal involvement evaluation in advanced cervical cancer: a single institutional experience

Purpose: To assess the usefulness of different imaging techniques in the detection of nodal involvement in patients with advanced cervical carcinoma. Moreover, to analyze the correlation between the presurgical (FIGO) and postsurgical (pTNM) staging classifications. Materials and Methods: All patients diagnosed with advanced cervical cancer (FIGO Stages IIB-IV) from 2005 to 2012 were selected. The medical charts of 51 patients that underwent presurgical assessment with posterior surgical staging by means of paraaortic lymphadenectomy, were reviewed. Nodal status assessment by computed tomography scan (CT scan), magnetic resonance imaging (MRI), positron emission tomography (PET), and sonography was compared, as well as the size given in imaging techniques compared to the final pathologic report information. Results: Presurgical analysis by CT scan, MRI, PET, and sonography showed pelvic nodal involvement in 51.3% of patients, and para-aortic involvement in 30.8% of cases. CT scan showed positive pelvic nodes in 35% of cases, but pathologic confirmation was observed in just 17.6% of cases. However, MRI resulted in higher rates of up to 48.8% of cases. Concerning para-aortic nodal involvement, CT scan showed positive nodes in 25% of cases, MRI in 3.2% of cases, and the pathologic report in 15.6% of cases. The authors found significant differences between staging groups among both classifications (FIGO vs. pTNM; p < 0.001). Eight cases (15.7%) were understaged by FIGO classification. Conclusions: Despite all imaging techniques available, none has demonstrated to be efficient enough to avoid the systematic study of para-aortic nodal status by means of surgical evaluatio

Non-parametric mass reconstruction of A1689 from strong lensing data with SLAP

We present the mass distribution in the central area of the cluster A1689 by fitting over 100 multiply lensed images with the non-parametric Strong Lensing Analysis Package (SLAP, Diego et al. 2004). The surface mass distribution is obtained in a robust way finding a total mass of 0.25E15 M_sun/h within a 70'' circle radius from the central peak. Our reconstructed density profile fits well an NFW profile with small perturbations due to substructure and is compatible with the more model dependent analysis of Broadhurst et al. (2004a) based on the same data. Our estimated mass does not rely on any prior information about the distribution of dark matter in the cluster. The peak of the mass distribution falls very close to the central cD and there is substructure near the center suggesting that the cluster is not fully relaxed. We also examine the effect on the recovered mass when we include the uncertainties in the redshift of the sources and in the original shape of the sources. Using simulations designed to mimic the data, we identify some biases in our reconstructed mass distribution. We find that the recovered mass is biased toward lower masses beyond 1 arcmin (150 kpc) from the central cD and that in the very center we may be affected by degeneracy problems. On the other hand, we confirm that the reconstructed mass between 25'' and 70'' is a robust, unbiased estimate of the true mass distribution and is compatible with an NFW profile.Comment: 11 pages, 12 figures. MNRAS submitted. A full resolution of the paper can be found in http://darwin.physics.upenn.edu/SLAP

Probing the Protosolar Disk Using Dust Filtering at Gaps in the Early Solar System

Jupiter and Saturn formed early, before the gas disk dispersed. The presence of gap-opening planets affects the dynamics of the gas and embedded solids and halts the inward drift of grains above a certain size. A drift barrier can explain the absence of calcium aluminium rich inclusions (CAIs) in chondrites originating from parent bodies that accreted in the inner solar system. Employing an interdisciplinary approach, we use a $\mu$-X-Ray-fluorescence scanner to search for large CAIs and a scanning electron microscope to search for small CAIs in the ordinary chondrite NWA 5697. We carry out long-term, two-dimensional simulations including gas, dust, and planets to characterize the transport of grains within the viscous $\alpha$-disk framework exploring the scenarios of a stand-alone Jupiter, Jupiter and Saturn \textit{in situ}, or Jupiter and Saturn in a 3:2 resonance. In each case, we find a critical grain size above which drift is halted as a function of the physical conditions in the disk. From the laboratory search we find four CAIs with a largest size of $\approx$200$\,\mu$m. \Combining models and data, we provide an estimate for the upper limit of the $\alpha$-viscosity and the surface density at the location of Jupiter, using reasonable assumptions about the stellar accretion rate during inward transport of CAIs, and assuming angular momentum transport to happen exclusively through viscous effects. Moreover, we find that the compound gap structure in the presence of Saturn in a 3:2 resonance favors inward transport of grains larger than CAIs currently detected in ordinary chondrites.Comment: 16 pages, 10 figures, updated to match published version in Astrophysical Journa

Development and validation of the Spanish hazard perception test

Objective: The aim of the current study is to develop and obtain validity evidence for a Hazard Perception test suitable for the Spanish driving population. To obtain validity evidence to support the use of the test, the effect of hazardous and quasi-hazardous situations on the participants’ Hazard Prediction is analysed and the pattern of results of drivers of different driving experience: learner, novice and expert drivers and re-offender vs. non-offender drivers, is compared. Potentially hazardous situations are those that develop without involving any real hazard (i.e., the driver didn’t actually have to decelerate or make any evasive manoeuvre to avoid a potential collision). The current study analysed multiple offender drivers attending compulsory re-education programmes as a result of reaching the maximum number of penalty points on their driving licence, due to repeated violations of traffic laws. Method: A new video-based hazard perception test was developed, using a total of 20 hazardous situation videos plus 8 quasi-hazardous situation videos. They were selected from 167 recordings of natural hazards in real Spanish driving settings

A species-level trait dataset of bats in Europe and beyond

Knowledge of species’ functional traits is essential for understanding biodiversity patterns, predicting the impacts of global environmental changes, and assessing the efficiency of conservation measures. Bats are major components of mammalian diversity and occupy a variety of ecological niches and geographic distributions. However, an extensive compilation of their functional traits and ecological attributes is still missing. Here we present EuroBaTrait 1.0, the most comprehensive and up-to-date trait dataset covering 47 European bat species. The dataset includes data on 118 traits including genetic composition, physiology, morphology, acoustic signature, climatic associations, foraging habitat, roost type, diet, spatial behaviour, life history, pathogens, phenology, and distribution. We compiled the bat trait data obtained from three main sources: (i) a systematic literature and dataset search, (ii) unpublished data from European bat experts, and (iii) observations from largescale monitoring programs. EuroBaTrait is designed to provide an important data source for comparative and trait-based analyses at the species or community level. The dataset also exposes knowledge gaps in species, geographic and trait coverage, highlighting priorities for future data collection.EU Framework Horizon 2020COST Action CA18107 ‘Climate change and bats: from science to conservation – ClimBats’ (https://climbats.eu/)The Région Bretagne (SAD grant number 19041)Leverhulme Trust (grant number: ECF-2020-571)Bulgarian National Science Fund (CP-06-COST/15 from 16.12.2020)Natural Environment Research Council Independent Research Fellowship (NE/M018660/1

Physical Properties of Four SZE-Selected Galaxy Clusters in the Southern Cosmology Survey

We present the optical and X-ray properties of four clusters recently discovered by the South Pole Telescope (SPT) using the Sunyaev-Zel'dovich effect (SZE). The four clusters are located in one of the common survey areas of the southern sky that is also being targeted by the Atacama Cosmology Telescope (ACT) and imaged by the CTIO Blanco 4-m telescope. Based on publicly available griz optical images and XMM-Newton and ROSAT X-ray observations we analyse the physical properties of these clusters and obtain photometric redshifts, luminosities, richness and mass estimates. Each cluster contains a central elliptical whose luminosity is consistent with SDSS cluster studies. Our mass estimates are well above the nominal detection limit of SPT and ACT; the new SZE clusters are very likely massive systems with M>~5x10^14 M_sun.Comment: 5 pages, 2 figures. ApJL accepte

High redshift AGNs from the 1Jy catalogue and the magnification bias

We have found a statistically significant (99.1 \%) excess of red ($O-E>2$) galaxies with photographic magnitudes $E<19.5$, $O< 21$ taken from the APM Sky Catalogue around $z \sim 1$ radiosources from the 1Jy catalogue. The amplitude, scale and dependence on galaxy colours of the observed overdensity are consistent with its being a result of the magnification bias caused by the weak gravitational lensing of large scale structures at redshift $z \approx 0.2-0.4$ and are hardly explained by other causes, as obscuration by dust.Comment: uuencoded file containing 3 ps files: the main text, a table and a figure. To appear in ApJ Letter

Low molecular weight ϵ-caprolactone-pcoumaric acid copolymers as potential biomaterials for skin regeneration applications

ϵ-caprolactone-p-coumaric acid copolymers at different mole ratios (ϵ-caprolactone:p-coumaric acid 1:0, 10:1, 8:1, 6:1, 4:1, and 2:1) were synthesized by melt-polycondensation and using 4-dodecylbenzene sulfonic acid as catalyst. Chemical analysis by NMR and GPC showed that copolyesters were formed with decreasing molecular weight as p-coumaric acid content was increased. Physical characteristics, such as thermal and mechanical properties, as well as water uptake and water permeability, depended on the mole fraction of pcoumaric acid. The p-coumarate repetitive units increased the antioxidant capacity of the copolymers, showing antibacterial activity against the common pathogen Escherichia coli. In addition, all the synthesized copolyesters, except the one with the highest concentration of the phenolic acid, were cytocompatible and hemocompatible, thus becoming potentially useful for skin regeneration applications

Metástasis musculares del adenocarcinoma renal

El carcinoma renal puede producir metástasis, siendo las más frecuentes en pulmón, hígado, esqueleto y encéfalo. Las metástasis aisladas en el músculo esquelético son muy raras, existiendo alrededor de veinte casos publicados en la literatura. Presentamos dos casos de metástasis de carcinoma renal, localizadas en el músculo esquelético. Es importante el diagnóstico diferencial de estas metástasis con los sarcomas de partes blandas, ya que su tratamiento y pronóstico son muy diferentes.The renal cell carcinoma can produce metastatic, the most common are in lung, liver, bones and encephalon. The isolated metastatic in muscle are unusual, there are only twenty cases published, most of them isolated cases. We present two cases of metastatic of renal cell carcinoma isolated in skeletal muscle. It is very important the differential diagnosis of this kind of lesions with soft tissue sarcomas because treatment and prognosis are very different

LensPerfect: Gravitational Lens Massmap Reconstructions Yielding Exact Reproduction of All Multiple Images

We present a new approach to gravitational lens massmap reconstruction. Our massmap solutions perfectly reproduce the positions, fluxes, and shears of all multiple images. And each massmap accurately recovers the underlying mass distribution to a resolution limited by the number of multiple images detected. We demonstrate our technique given a mock galaxy cluster similar to Abell 1689 which gravitationally lenses 19 mock background galaxies to produce 93 multiple images. We also explore cases in which far fewer multiple images are observed, such as four multiple images of a single galaxy. Massmap solutions are never unique, and our method makes it possible to explore an extremely flexible range of physical (and unphysical) solutions, all of which perfectly reproduce the data given. Each reconfiguration of the source galaxies produces a new massmap solution. An optimization routine is provided to find those source positions (and redshifts, within uncertainties) which produce the "most physical" massmap solution, according to a new figure of merit developed here. Our method imposes no assumptions about the slope of the radial profile nor mass following light. But unlike "non-parametric" grid-based methods, the number of free parameters we solve for is only as many as the number of observable constraints (or slightly greater if fluxes are constrained). For each set of source positions and redshifts, massmap solutions are obtained "instantly" via direct matrix inversion by smoothly interpolating the deflection field using a recently developed mathematical technique. Our LensPerfect software is straightforward and easy to use and is made publicly available via our website.Comment: 17 pages, 18 figures, accepted by ApJ. Software and full-color version of paper available at http://www.its.caltech.edu/~coe/LensPerfect