2,141 research outputs found
Dual enzyme-triggered controlled release on capped nanometric silica mesoporous supports
We thank the Spanish Government (project MAT2009-14564-C04 and CTQ2007-64735-AR07) the Generalitat Valencia (project PROMETEO/2009/016) for support. A.A. and L.M. thank the Generalitat Valenciana for their Santiago Grisolia Fellowship and VALI+D postdoctoral contract, respectively. We thank the confocal microscopy service from CIPF for technical support.Agostini, A.; Mondragón Martínez, L.; Coll Merino, MC.; Aznar Gimeno, E.; Marcos Martínez, MD.; Martínez Mañez, R.; Sancenón Galarza, F.... (2012). Dual enzyme-triggered controlled release on capped nanometric silica mesoporous supports. ChemistryOpen. 1:17-20. https://doi.org/10.1002/open.201200003S17201Saha, S., Leung, K. C.-F., Nguyen, T. D., Stoddart, J. F., & Zink, J. I. (2007). Nanovalves. Advanced Functional Materials, 17(5), 685-693. doi:10.1002/adfm.200600989Trewyn, B. G., Slowing, I. I., Giri, S., Chen, H.-T., & Lin, V. S.-Y. (2007). Synthesis and Functionalization of a Mesoporous Silica Nanoparticle Based on the Sol–Gel Process and Applications in Controlled Release. Accounts of Chemical Research, 40(9), 846-853. doi:10.1021/ar600032uAznar, E., Martínez-Máñez, R., & Sancenón, F. (2009). Controlled release using mesoporous materials containing gate-like scaffoldings. Expert Opinion on Drug Delivery, 6(6), 643-655. doi:10.1517/17425240902895980Beck, J. S., Vartuli, J. C., Roth, W. J., Leonowicz, M. E., Kresge, C. T., Schmitt, K. D., … Schlenker, J. L. (1992). A new family of mesoporous molecular sieves prepared with liquid crystal templates. Journal of the American Chemical Society, 114(27), 10834-10843. doi:10.1021/ja00053a020Wight, A. P., & Davis, M. E. (2002). Design and Preparation of Organic−Inorganic Hybrid Catalysts. Chemical Reviews, 102(10), 3589-3614. doi:10.1021/cr010334mKickelbick, G. (2004). Mesoporöse anorganisch-organische Hybridmaterialien. Angewandte Chemie, 116(24), 3164-3166. doi:10.1002/ange.200301751Kickelbick, G. (2004). Hybrid Inorganic–Organic Mesoporous Materials. Angewandte Chemie International Edition, 43(24), 3102-3104. doi:10.1002/anie.200301751Mal, N. K., Fujiwara, M., & Tanaka, Y. (2003). Photocontrolled reversible release of guest molecules from coumarin-modified mesoporous silica. Nature, 421(6921), 350-353. doi:10.1038/nature01362Mal, N. K., Fujiwara, M., Tanaka, Y., Taguchi, T., & Matsukata, M. (2003). Photo-Switched Storage and Release of Guest Molecules in the Pore Void of Coumarin-Modified MCM-41. Chemistry of Materials, 15(17), 3385-3394. doi:10.1021/cm0343296Zhu, Y., & Fujiwara, M. (2007). Installing Dynamic Molecular Photomechanics in Mesopores: A Multifunctional Controlled-Release Nanosystem. Angewandte Chemie, 119(13), 2291-2294. doi:10.1002/ange.200604850Zhu, Y., & Fujiwara, M. (2007). Installing Dynamic Molecular Photomechanics in Mesopores: A Multifunctional Controlled-Release Nanosystem. Angewandte Chemie International Edition, 46(13), 2241-2244. doi:10.1002/anie.200604850Liu, N., Chen, Z., Dunphy, D. R., Jiang, Y.-B., Assink, R. A., & Brinker, C. J. (2003). Angewandte Chemie, 115(15), 1773-1776. doi:10.1002/ange.200250189Liu, N., Chen, Z., Dunphy, D. R., Jiang, Y.-B., Assink, R. A., & Brinker, C. J. (2003). Photoresponsive Nanocomposite Formed by Self-Assembly of an Azobenzene-Modified Silane. Angewandte Chemie International Edition, 42(15), 1731-1734. doi:10.1002/anie.200250189Aznar, E., Casasús, R., García-Acosta, B., Marcos, M. D., Martínez-Máñez, R., Sancenón, F., … Amorós, P. (2007). Photochemical and Chemical Two-Channel Control of Functional Nanogated Hybrid Architectures. Advanced Materials, 19(17), 2228-2231. doi:10.1002/adma.200601958Park, C., Lee, K., & Kim, C. (2009). Photoresponsive Cyclodextrin-Covered Nanocontainers and Their Sol-Gel Transition Induced by Molecular Recognition. Angewandte Chemie International Edition, 48(7), 1275-1278. doi:10.1002/anie.200803880Ferris, D. P., Zhao, Y.-L., Khashab, N. M., Khatib, H. A., Stoddart, J. F., & Zink, J. I. (2009). Light-Operated Mechanized Nanoparticles. Journal of the American Chemical Society, 131(5), 1686-1688. doi:10.1021/ja807798gLin, Q., Huang, Q., Li, C., Bao, C., Liu, Z., Li, F., & Zhu, L. (2010). Anticancer Drug Release from a Mesoporous Silica Based Nanophotocage Regulated by Either a One- or Two-Photon Process. Journal of the American Chemical Society, 132(31), 10645-10647. doi:10.1021/ja103415tKnežević, N. Ž., Trewyn, B. G., & Lin, V. S.-Y. (2011). Light- and pH-Responsive Release of Doxorubicin from a Mesoporous Silica-Based Nanocarrier. Chemistry - A European Journal, 17(12), 3338-3342. doi:10.1002/chem.201002960Knežević, N. Ž., Trewyn, B. G., & Lin, V. S.-Y. (2011). Functionalized mesoporous silica nanoparticle-based visible light responsive controlled release delivery system. Chemical Communications, 47(10), 2817. doi:10.1039/c0cc04424eTrewyn, B. G., Giri, S., Slowing, I. I., & Lin, V. S.-Y. (2007). Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems. Chemical Communications, (31), 3236. doi:10.1039/b701744hTorney, F., Trewyn, B. G., Lin, V. S.-Y., & Wang, K. (2007). Mesoporous silica nanoparticles deliver DNA and chemicals into plants. Nature Nanotechnology, 2(5), 295-300. doi:10.1038/nnano.2007.108Radu, D. R., Lai, C.-Y., Jeftinija, K., Rowe, E. W., Jeftinija, S., & Lin, V. S.-Y. (2004). A Polyamidoamine Dendrimer-Capped Mesoporous Silica Nanosphere-Based Gene Transfection Reagent. Journal of the American Chemical Society, 126(41), 13216-13217. doi:10.1021/ja046275mGiri, S., Trewyn, B. G., Stellmaker, M. P., & Lin, V. S.-Y. (2005). Stimuli-Responsive Controlled-Release Delivery System Based on Mesoporous Silica Nanorods Capped with Magnetic Nanoparticles. Angewandte Chemie, 117(32), 5166-5172. doi:10.1002/ange.200501819Giri, S., Trewyn, B. G., Stellmaker, M. P., & Lin, V. S.-Y. (2005). Stimuli-Responsive Controlled-Release Delivery System Based on Mesoporous Silica Nanorods Capped with Magnetic Nanoparticles. Angewandte Chemie International Edition, 44(32), 5038-5044. doi:10.1002/anie.200501819Fujiwara, M., Terashima, S., Endo, Y., Shiokawa, K., & Ohue, H. (2006). Switching catalytic reaction conducted in pore void of mesoporous material by redox gate control. Chemical Communications, (44), 4635. doi:10.1039/b610444dLiu, R., Zhao, X., Wu, T., & Feng, P. (2008). Tunable Redox-Responsive Hybrid Nanogated Ensembles. Journal of the American Chemical Society, 130(44), 14418-14419. doi:10.1021/ja8060886Nguyen, T. D., Liu, Y., Saha, S., Leung, K. C.-F., Stoddart, J. F., & Zink, J. I. (2007). Design and Optimization of Molecular Nanovalves Based on Redox-Switchable Bistable Rotaxanes. Journal of the American Chemical Society, 129(3), 626-634. doi:10.1021/ja065485rCasasús, R., Marcos, M. D., Martínez-Máñez, R., Ros-Lis, J. V., Soto, J., Villaescusa, L. A., … Latorre, J. (2004). Toward the Development of Ionically Controlled Nanoscopic Molecular Gates. Journal of the American Chemical Society, 126(28), 8612-8613. doi:10.1021/ja048095iCasasús, R., Climent, E., Marcos, M. D., Martínez-Máñez, R., Sancenón, F., Soto, J., … Ruiz, E. (2008). Dual Aperture Control on pH- and Anion-Driven Supramolecular Nanoscopic Hybrid Gate-like Ensembles. Journal of the American Chemical Society, 130(6), 1903-1917. doi:10.1021/ja0756772Aznar, E., Marcos, M. D., Martínez-Máñez, R., Sancenón, F., Soto, J., Amorós, P., & Guillem, C. (2009). pH- and Photo-Switched Release of Guest Molecules from Mesoporous Silica Supports. Journal of the American Chemical Society, 131(19), 6833-6843. doi:10.1021/ja810011pAngelos, S., Yang, Y.-W., Khashab, N. M., Stoddart, J. F., & Zink, J. I. (2009). Dual-Controlled Nanoparticles Exhibiting AND Logic. Journal of the American Chemical Society, 131(32), 11344-11346. doi:10.1021/ja9042752Angelos, S., Yang, Y.-W., Patel, K., Stoddart, J. F., & Zink, J. I. (2008). pH-Responsive Supramolecular Nanovalves Based on Cucurbit[6]uril Pseudorotaxanes. Angewandte Chemie, 120(12), 2254-2258. doi:10.1002/ange.200705211Angelos, S., Yang, Y.-W., Patel, K., Stoddart, J. F., & Zink, J. I. (2008). pH-Responsive Supramolecular Nanovalves Based on Cucurbit[6]uril Pseudorotaxanes. Angewandte Chemie International Edition, 47(12), 2222-2226. doi:10.1002/anie.200705211Angelos, S., Khashab, N. M., Yang, Y.-W., Trabolsi, A., Khatib, H. A., Stoddart, J. F., & Zink, J. I. (2009). pH Clock-Operated Mechanized Nanoparticles. Journal of the American Chemical Society, 131(36), 12912-12914. doi:10.1021/ja9010157Du, L., Liao, S., Khatib, H. A., Stoddart, J. F., & Zink, J. I. (2009). Controlled-Access Hollow Mechanized Silica Nanocontainers. Journal of the American Chemical Society, 131(42), 15136-15142. doi:10.1021/ja904982jYang, Q., Wang, S., Fan, P., Wang, L., Di, Y., Lin, K., & Xiao, F.-S. (2005). pH-Responsive Carrier System Based on Carboxylic Acid Modified Mesoporous Silica and Polyelectrolyte for Drug Delivery. Chemistry of Materials, 17(24), 5999-6003. doi:10.1021/cm051198vPark, C., Oh, K., Lee, S. C., & Kim, C. (2007). Controlled Release of Guest Molecules from Mesoporous Silica Particles Based on a pH-Responsive Polypseudorotaxane Motif. Angewandte Chemie, 119(9), 1477-1479. doi:10.1002/ange.200603404Park, C., Oh, K., Lee, S. C., & Kim, C. (2007). Controlled Release of Guest Molecules from Mesoporous Silica Particles Based on a pH-Responsive Polypseudorotaxane Motif. Angewandte Chemie International Edition, 46(9), 1455-1457. doi:10.1002/anie.200603404Chen, L., Di, J., Cao, C., Zhao, Y., Ma, Y., Luo, J., … Jiang, L. (2011). A pH-driven DNA nanoswitch for responsive controlled release. Chemical Communications, 47(10), 2850. doi:10.1039/c0cc04765aCliment, E., Bernardos, A., Martínez-Máñez, R., Maquieira, A., Marcos, M. D., Pastor-Navarro, N., … Amorós, P. (2009). Controlled Delivery Systems Using Antibody-Capped Mesoporous Nanocontainers. Journal of the American Chemical Society, 131(39), 14075-14080. doi:10.1021/ja904456dCliment, E., Martínez-Máñez, R., Sancenón, F., Marcos, M. D., Soto, J., Maquieira, A., & Amorós, P. (2010). Controlled Delivery Using Oligonucleotide-Capped Mesoporous Silica Nanoparticles. Angewandte Chemie, 122(40), 7439-7441. doi:10.1002/ange.201001847Climent, E., Martínez-Máñez, R., Sancenón, F., Marcos, M. D., Soto, J., Maquieira, A., & Amorós, P. (2010). Controlled Delivery Using Oligonucleotide-Capped Mesoporous Silica Nanoparticles. Angewandte Chemie International Edition, 49(40), 7281-7283. doi:10.1002/anie.201001847Patel, K., Angelos, S., Dichtel, W. R., Coskun, A., Yang, Y.-W., Zink, J. I., & Stoddart, J. F. (2008). Enzyme-Responsive Snap-Top Covered Silica Nanocontainers. Journal of the American Chemical Society, 130(8), 2382-2383. doi:10.1021/ja0772086Schlossbauer, A., Kecht, J., & Bein, T. (2009). Biotin-Avidin as a Protease-Responsive Cap System for Controlled Guest Release from Colloidal Mesoporous Silica. Angewandte Chemie, 121(17), 3138-3141. doi:10.1002/ange.200805818Schlossbauer, A., Kecht, J., & Bein, T. (2009). Biotin-Avidin as a Protease-Responsive Cap System for Controlled Guest Release from Colloidal Mesoporous Silica. Angewandte Chemie International Edition, 48(17), 3092-3095. doi:10.1002/anie.200805818Bernardos, A., Aznar, E., Marcos, M. D., Martínez-Máñez, R., Sancenón, F., Soto, J., … Amorós, P. (2009). Enzyme-Responsive Controlled Release Using Mesoporous Silica Supports Capped with Lactose. Angewandte Chemie, 121(32), 5998-6001. doi:10.1002/ange.200900880Bernardos, A., Aznar, E., Marcos, M. D., Martínez-Máñez, R., Sancenón, F., Soto, J., … Amorós, P. (2009). Enzyme-Responsive Controlled Release Using Mesoporous Silica Supports Capped with Lactose. Angewandte Chemie International Edition, 48(32), 5884-5887. doi:10.1002/anie.200900880Bernardos, A., Mondragón, L., Aznar, E., Marcos, M. D., Martínez-Máñez, R., Sancenón, F., … Amorós, P. (2010). Enzyme-Responsive Intracellular Controlled Release Using Nanometric Silica Mesoporous Supports Capped with «Saccharides». ACS Nano, 4(11), 6353-6368. doi:10.1021/nn101499dPark, C., Kim, H., Kim, S., & Kim, C. (2009). Enzyme Responsive Nanocontainers with Cyclodextrin Gatekeepers and Synergistic Effects in Release of Guests. Journal of the American Chemical Society, 131(46), 16614-16615. doi:10.1021/ja9061085Thornton, P. D., & Heise, A. (2010). Highly Specific Dual Enzyme-Mediated Payload Release from Peptide-Coated Silica Particles. Journal of the American Chemical Society, 132(6), 2024-2028. doi:10.1021/ja9094439Coll, C., Mondragón, L., Martínez-Máñez, R., Sancenón, F., Marcos, M. 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A deterministic algorithm to compute approximate roots of polynomial systems in polynomial average time
We describe a deterministic algorithm that computes an approximate root of n
complex polynomial equations in n unknowns in average polynomial time with
respect to the size of the input, in the Blum-Shub-Smale model with square
root. It rests upon a derandomization of an algorithm of Beltr\'an and Pardo
and gives a deterministic affirmative answer to Smale's 17th problem. The main
idea is to make use of the randomness contained in the input itself
Pattern recognition. v- samp - a computer program for estimating surface area from contour maps
Fortran computer program for computing linear approximation of surface area for any given portion of digitized contour ma
Quinolones in goats' milk: Effect on the cheese-making process, chemical and microbial characteristics of acid-coagulated cheeses
[EN] The effect of the presence in goats' milk of enrofloxacin and ciprofloxacin on cheese-making and the characteristics of acid-coagulated cheeses was evaluated. Raw goats' milk was spiked with quinolones at maximum residue limit concentration (100 ¿g kg¿1). For each antibiotic, three batches of cheese were made by acid coagulation (pH 4.6) using a commercial starter culture. Cheese-making process, gross composition and microbial counts in the cheeses were unaffected by the presence of quinolones in milk. However, relatively high amounts of these substances were retained in the cheeses, with residual concentrations of 146.5 ± 4.9 ¿g kg¿1 and 150.7 ± 25.7 ¿g kg¿1 for enrofloxacin and ciprofloxacin, respectively, after 20 days of maturation. Results suggest that the use of goats' milk containing legally admissible amounts of enrofloxacin and/or ciprofloxacin would have no impact on cheese manufacturing, composition and microflora of acid-coagulated cheese. However, the transfer of these substances to the final products could compromise consumer safety.The authors are grateful for the financial support by the Ministerio de Ciencia e Innovacion (Madrid, Spain) project AGL-2013-45147-R.Beltrán Martínez, MC.; Sanna, A.; Molina Pons, MP.; Quintanilla, P.; Montes-Estellés, RM. (2023). Quinolones in goats' milk: Effect on the cheese-making process, chemical and microbial characteristics of acid-coagulated cheeses. International Dairy Journal. 138. https://doi.org/10.1016/j.idairyj.2022.10553813
Comedia famosa. Las siete estrellas de Francia, San Bruno / de Don Luis de Belmonte
Vega García Luengos, Germán, Fernández Lera, Rosa, Rey Sayagués, Andrés del. Ediciones de teatro español en la Biblioteca de Menéndez Pelayo, 3991Precede al tít.: "N. 26"Datos de imp. obtenidos del colofónSign.: A-D
Deformation Theory of Holomorphic Vector Bundles, Extended Conformal Symmetry and Extensions of 2D Gravity
Developing on the ideas of R. Stora and coworkers, a formulation of two
dimensional field theory endowed with extended conformal symmetry is given,
which is based on deformation theory of holomorphic and Hermitian spaces. The
geometric background consists of a vector bundle over a closed surface
endowed with a holomorphic structure and a Hermitian structure
subordinated to it. The symmetry group is the semidirect product of the
automorphism group of and the extended Weyl group of and acts on the holomorphic and Hermitian structures. The
extended Weyl anomaly can be shifted into an automorphism chirally split
anomaly by adding to the action a local counterterm, as in ordinary conformal
field theory. The dependence on the scale of the metric on the fiber of is
encoded in the Donaldson action, a vector bundle generalization of the
Liouville action. The Weyl and automorphism anomaly split into two
contributions corresponding respectively to the determinant and
projectivization of . The determinant part induces an effective ordinary
Weyl or diffeomorphism anomaly and the induced central charge can be computed.Comment: 49 pages, plain TeX. A number of misprints have been correcte
English language learners’ spoken interaction: What a multimodal perspective reveals about pragmatic competence
Broadly speaking, pragmatic competence can be defined as the ability to communicate appropriately in a social context. Learning how to use pragmatic features adequately in a particular setting is paramount for language users in order to achieve communicative purposes effectively. However, since communication involves the interplay of various semiotic modes such as spoken language, gestures, facial expression, head movement or gaze, researchers examining face-to-face interaction should go a step further to explore pragmatic competence from a multimodal perspective, which leads them to focus on multimodal pragmatics. The aim of this paper is to show how a multimodal approach can shed some light in the study of interlanguage pragmatics. We conducted a microanalysis of the performance of learners of English as an additional language at two different proficiency levels, who produced complaint sequences. Results suggest that spoken language is just one of the resources that learners use during the interaction, which is not always prevalent in all the moves in which the complaint is structured, the different roles, and the proficiency levels under examination. This confirms that the centrality of the linguistic mode in the analysis of this speech act will lead to a biased understanding of the interlanguage pragmatic competence
The Polynomial Eigenvalue Problem is Well Conditioned for Random Inputs
We compute the exact expected value of the squared condition number for the polynomial eigenvalue problem, when the input matrices have entries coming from the standard complex Gaussian distribution, showing that in general this problem is quite well conditioned.The first author's work was partially supported by Agencia Nacional de Investigación
e Innovación (ANII), Uruguay, and by CSIC group 618, Universidad de La República, Uruguay. The
second author's work was partially supported by MTM2017-83816-P and MTM2017-90682-REDT
from Spanish Ministry of Science MICINN and by 21.SI01.64658 from Universidad de Cantabria and
Banco de Santander
Boston University Symphony Orchestra, March 2, 1984
This is the concert program of the Boston University Symphony Orchestra performance on Friday, March 2, 1984 at 8:00 p.m., at the Concert Hall, 855 Commonwealth Avenue. Works performed were Symphoyn Concertante by Ross Lee Finney, Piano Concerto in G major by Maurice Ravel, and Symphony No. 5 in B-flat major, Op. 100 by Sergei Prokofiev. Digitization for Boston University Concert Programs was supported by the Boston University Humanities Library Endowed Fund
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