House price Keynesianism and the contradictions of the modern investor subject

This article conceptualises the marked downturn in UK house prices in the 2007-2009 period in relation to longer-term processes of national economic restructuring centred on a new model of homeownership. The structure of UK house prices has been impacted markedly by the Labour Government‟s efforts to ingrain a particular notion of financial literacy amid the move towards an increasingly asset-based system of welfare. New model welfare recipients and new model homeowners have thereby been co-constituted in a manner consistent with a new UK growth regime of „house price Keynesianism‟. However, the investor subjects who drive such growth are necessarily rendered uncertain as compared with the idealised image of Government policy because of their reliance on the credit-creating decisions of private financial institutions. The recent steep decline in UK house prices is explained here as an epiphenomenon of the disruptive effect on the idealised image caused by the dependence of investor subjects on pricing dynamics not of their making

Compensated right ventricular function of the onset of pulmonary hypertension in a rat model depends on chamber remodeling and contractile augmentation.

Right-ventricular function is a good indicator of pulmonary arterial hypertension (PAH) prognosis; however, how the right ventricle (RV) adapts to the pressure overload is not well understood. Here, we aimed at characterizing the time course of RV early remodeling and discriminate the contribution of ventricular geometric remodeling and intrinsic changes in myocardial mechanical properties in a monocrotaline (MCT) animal model. In a longitudinal study of PAH, ventricular morphology and function were assessed weekly during the first four weeks after MCT exposure. Using invasive measurements of RV pressure and volume, heart performance was evaluated at end of systole and diastole to quantify contractility (end-systolic elastance) and chamber stiffness (end-diastolic elastance). To distinguish between morphological and intrinsic mechanisms, a computational model of the RV was developed and used to determine the level of prediction when accounting for wall masses and unloaded volume measurements changes. By four weeks, mean pulmonary arterial pressure and elastance rose significantly. RV pressures rose significantly after the second week accompanied by significant RV hypertrophy, but RV stroke volume and cardiac output were maintained. The model analysis suggested that, after two weeks, this compensation was only possible due to a significant increase in the intrinsic inotropy of RV myocardium. We conclude that this MCT-PAH rat is a model of RV compensation during the first month after treatment, where geometric remodeling on EDPVR and increased myocardial contractility on ESPVR are the major mechanisms by which stroke volume is preserved in the setting of elevated pulmonary arterial pressure. The mediators of this compensation might themselves promote longer-term adverse remodeling and decompensation in this animal model

Financialization and the monetary circuit : a macro-accounting approach

This paper aims to cross-breed the standard monetary circuit accounting model with elements from the Post-Keynesian literature. The goals are: (i) to analyse the implications of credit-based household consumption fed by capital asset inflation for the soundness of a pure credit-money economy of production; and (ii) to provide a more sophisticated description of the working of modern financial systems than the one grounded in the usual 'bank-based vs. market based' distinction

The Political Economy of Failure: The Euro as an International Currency

How do international currencies get established and consolidated? What domestic and international political foundations support an international currency? And what kinds of macro-economic flows enable an international currency? In this essay we consider these perennial questions of modern IPE scholarship in reverse order to ask whether the euro could ever have become, or seek to become, a true international currency rivalling the US dollar, used not only for passive foreign exchange reserves but also as a major commercial currency outside the EU. We argue that the EU lacks the will, the ideas and the capacity to promote the euro into the status of an international currency. In this article, we concentrate on this final issue of capacity, as the will and ideas issues have already been well explored. Capacity is an issue coeval with, if not prior to, the first two issues. The EU's current institutional arrangements and its economic geography create macro-economic consequences that diminish the euro's capacity to operate as a top currency. These conflicts go beyond the well-recognized issue that the euro-zone is not an optimum currency area. Examining the euro's debilities sheds light not only on the euro's (in)capacity to rival the dollar as an international currency, but also on the future of both the euro and the dollar in the aftermath of the euro-zone crisis

When and how ruling out cystic fibrosis in adult patients with bronchiectasis

Background: Bronchiectasis is the final result of different processes and most of the guidelines advocate for a careful evaluation of those etiologies which might be treated or might change patients' management, including cystic fibrosis (CF). Main body: CFTR mutations have been reported with higher frequency in bronchiectasis population. Although ruling out CF is considered as a main step for etiological screening in bronchiectasis, CF testing lacks of a standardized approach both from a research and clinical point of view. In this review a list of most widely used tests in CF is provided. Conclusions: Exclusion of CF is imperative for patients with bronchiectasis and CFTR testing should be implemented in usual screening for investigating bronchiectasis etiology. Physicians taking care of bronchiectasis patients should be aware of CFTR testing and its limitations in the adult population. Further studies on CFTR expression in human lung and translational research might elucidate the possible role of CFTR in the pathogenesis of bronchiectasis

When and how ruling out cystic fibrosis in adult patients with bronchiectasis

Background: Bronchiectasis is the final result of different processes and most of the guidelines advocate for a careful evaluation of those etiologies which might be treated or might change patients' management, including cystic fibrosis (CF). Main body: CFTR mutations have been reported with higher frequency in bronchiectasis population. Although ruling out CF is considered as a main step for etiological screening in bronchiectasis, CF testing lacks of a standardized approach both from a research and clinical point of view. In this review a list of most widely used tests in CF is provided. Conclusions: Exclusion of CF is imperative for patients with bronchiectasis and CFTR testing should be implemented in usual screening for investigating bronchiectasis etiology. Physicians taking care of bronchiectasis patients should be aware of CFTR testing and its limitations in the adult population. Further studies on CFTR expression in human lung and translational research might elucidate the possible role of CFTR in the pathogenesis of bronchiectasis

Advances in rheumatology: new targeted therapeutics

Treatment of inflammatory arthritides - including rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis - has seen much progress in recent years, partially due to increased understanding of the pathogenesis of these diseases at the cellular and molecular levels. These conditions share some common mechanisms. Biologic therapies have provided a clear advance in the treatment of rheumatological conditions. Currently available TNF-targeting biologic agents that are licensed for at east one of the above-named diseases are etanercept, infliximab, adalimumab, golimumab, and certolizumab. Biologic agents with a different mechanism of action have also been approved in rheumatoid arthritis (rituximab, abatacept, and tocilizumab). Although these biologic agents are highly effective, there is a need for improved management strategies. There is also a need for education of family physicians and other healthcare professionals in the identification of early symptoms of inflammatory arthritides and the importance of early referral to rheumatologists for diagnosis and treatment. Also, researchers are developing molecules - for example, the Janus kinase inhibitor CP-690550 (tofacitinib) and the spleen tyrosine kinase inhibitor R788 (fostamatinib) - to target other aspects of the inflammatory cascade. Initial trial results with new agents are promising, and, in time, head-to-head trials will establish the best treatment options for patients. The key challenge is identifying how best to integrate these new, advanced therapies into daily practice

LA DETERMINACIÓN DEL “ELEMENTO HISTÓRICO Y MORAL” DEL VALOR DE LA FUERZA DE TRABAJO

El objetivo de este artículo es discutir la interpretación marxista dominante respecto del significado de lo que Marx llamó el “elemento histórico y moral” del valor de la fuerza de trabajo y ofrecer una lectura alternativa que sea consistente con los fundamentos de la crítica marxiana de la economía política. Para tal fin, en la primera parte del artículo, se realiza una crítica de dicha interpretación basada en el reconocimiento de su génesis histórica y su filiación con la base textual y fundamentos de la crítica marxiana de la economía política. En la segunda parte, se realiza una reconstrucción crítica del legado de Marx respecto a la determinación del valor de la fuerza de trabajo y se presenta una resignificación del elemento histórico y moral en cuestión. A DETERMINAÇÃO DO “ELEMENTO HISTÓRICO E MORAL” DO VALOR DA FORÇA DE TRABALHOO objetivo deste artigo é discutir a interpretação marxista dominante sobre o significado do que Marx chamou de “elemento histórico e moral” do valor da força de trabalho e oferecer uma leitura alternativa atrelada aos fundamentos da crítica marxiana da economia política. Para tanto, na primeira parte do artigo, realizamos uma crítica da interpretação acima citada, baseada no reconhecimento de sua gênese histórica e sua filiação com a base textual e com os fundamentos da crítica marxiana da economia política. Na segunda parte, realizamos uma reconstrução crítica do legado de Marx quanto à determinação do valor da força de trabalho e apresentamos uma ressignificação do elemento histórico e moral em questão.Palavras-chave: Elemento histórico e moral. Valor da força de trabalho. Debates marxistas. Teoria marxista do salário.THE DETERMINATION OF THE “HISTORIC AND MORAL ELEMENT” OF THE VALUE OF LABOUR POWERThe aim of this article is to challenge the prevailing Marxist interpretation of what Marx called the “historical and moral component” of the value of labour-power, and to offer an alternative reading which is consistent with the foundations of the critique of political economy. In order to do so, the first part of the article develops a critique of the aforementioned Marxist view, on the basis of a reconstruction of its historical genesis, its support on textual evidence from Marx’s works and its theoretical consistency with the foundations of the critique of political economy. Subsequently, the second part of the article undertakes a critical reconstruction of Marx’s legacy on the determination of the value of labour-power and proposes a reconsideration of the meaning of its socalled “historical and moral” component.Keywords: Historical and moral element. Value of labour-power. Marxist debates. Marx’s theory of wages.LA DÉTERMINATION DE L “ÉLÉMENT HISTORIQUE ET MORAL” DE LA VALEUR DE LA FORCE DE TRAVAILL’objectif de cet article est de discuter de l’interprétation marxiste dominante de ce que Marx appelait “l’élément historique et moral” de la valeur de la force de travail et d’offrir une lecture alternative liée aux fondements de la critique marxienne de l’économie politique. Pour ce faire, dans la première partie de l’article nous critiquons l’interprétation susmentionnée, fondée sur la reconnaissance de sa genèse historique et son affiliation à la base textuelle et aux fondements de la critique marxienne de l’économie politique. Dans la deuxième partie, nous effectuons une reconstruction critique de l’héritage de Marx concernant la détermination de la valeur de la force de travail et nous y présentons une nouvelle signification de l’élément historique et moral en question.Mots-clés: Elément historique et moral. Valeur de la force de travail. Débats marxistes. Théorie marxiste du salaire

COPD management as a model for all chronic respiratory conditions : report of the 4th Consensus Conference in Respiratory Medicine

Background: Non-communicable diseases (NCDs) kill 40 million people each year. The management of chronic respiratory NCDs such as chronic obstructive pulmonary disease (COPD) is particularly critical in Italy, where they are widespread and represent a heavy burden on healthcare resources. It is thus important to redefine the role and responsibility of respiratory specialists and their scientific societies, together with that of the whole healthcare system, in order to create a sustainable management of COPD, which could become a model for other chronic respiratory conditions. Methods: These issues were divided into four main topics (Training, Organization, Responsibilities, and Sustainability) and discussed at a Consensus Conference promoted by the Research Center of the Italian Respiratory Society held in Rome, Italy, 3-4 November 2016. Results and conclusions: Regarding training, important inadequacies emerged regarding specialist training - both the duration of practical training courses and teaching about chronic diseases like COPD. A better integration between university and teaching hospitals would improve the quality of specialization. A better organizational integration between hospital and specialists/general practitioners (GPs) in the local community is essential to improve the diagnostic and therapeutic pathways for chronic respiratory patients. Improving the care pathways is the joint responsibility of respiratory specialists, GPs, patients and their caregivers, and the healthcare system. The sustainability of the entire system depends on a better organization of the diagnostic-therapeutic pathways, in which also other stakeholders such as pharmacists and pharmaceutical companies can play an important role