Maximally Realistic Causal Quantum Mechanics

We recently constructed a causal quantum mechanics in 2 dim. phase space which is more realistic than the de Broglie-Bohm mechanics as it reproduces not just the position but also the momentum probability density of ordinary quantum theory. Here we present an even more ambitious construction in 2n dim. phase space. We conjecture that the causal Hamiltonian quantum mechanics presented here is `maximally realistic'. The positive definite phase space density reproduces as marginals the correct quantum probability densities of $n+1$ different complete commuting sets of observables (e.g. $\vec q$, $\vec p$ and $n-1$ other sets). In general the particle velocities do not coincide with the de Broglie-Bohm velocities.Comment: Published versio

Association between family history and mismatch repair in colorectal cancer

BACKGROUND AND AIMS: Germline mutations in mismatch repair (MMR) genes cause a greatly increased risk of cancer of the gastrointestinal and female reproductive tracts (hereditary non-polyposis colorectal cancer (HNPCC)). Loss of MMR expression is common in colorectal cancer (CRC) overall. Such loss is assumed to be acquired predominantly, although a population of CRC cases will include individuals with unrecognised MMR mutations. This study examines the association between MMR gene expression and family history of cancer among the CRC population. METHODS: Individuals with CRC were identified from two well characterised populations: (1) consecutive hospital patients (n = 644) and (2) a population based cases series (n = 249). CRC was examined for expression of hMLH1 and hMSH2 using immunohistochemistry, and expression was related to family history using logistic regression. RESULTS: hMLH1 and hMSH2 expression was assessed in 732 CRCs with 8% showing loss of expression. No association was seen overall for hMLH1 or hMSH2 expression and family history of CRC. Loss of hMSH2 was predicted by family history of extracolonic cancer (odds ratio (OR) 5.78 (95% confidence interval (CI) 0.95–35.18)) and family history suggestive of HNPCC (OR 27.84 (95% CI 4.37–177.56)). Loss of hMLH1 was not predicted by family history of extracolonic cancer or a family history suggestive of HNPCC but was for a family history of at least two affected relatives (OR 4.88 (95% CI 1.25–19.03)). CONCLUSIONS: Individuals with hMSH2 deficient CRC in the general population exhibit a family history and other characteristics suggestive of HNPCC, and may carry germline MMR mutations. Loss of hMLH1 is only associated with a strong family history of extracolonic cancer at older ages, suggesting a novel mechanism of susceptibility

Soil carbon sequestration following agricultural land abandonment in the EU

Agricultural land abandonment (ALA) is a prominent land use change throughout the European Union (EU) with several notable implications for soil and ecosystem restoration. In particular, the cessation of certain agricultural practices (e.g., tillage and biomass removal) often induces an increase in soil organic carbon (SOC) and can potentially support land-based climate change mitigation efforts. However, large uncertainties on the variability of post-abandonment soil carbon sequestration (SCS) rates and the absolute storage potentials across the EU hinders the development of dedicated policies leveraging the restoration benefits of both intentional (i.e., managed restoration and direct conversions) and unintentional ALA. We collected and synthesized SOC stock changes following ALA derived from field sites in EU member states using published chronosequence/paired plot data. In doing so, we determined how rates of soil carbon accumulation during ecological succession differ in space and time. We found a slow, but significant, rate of SOC stock increase across the EU-27 member states of 1.14% yr–1 (p < 0.0001), with an average relative change of +34% and an average time since abandonment/conversion of 33 years in the dataset (n=706). These results provide some clarity to previous regional debates on the positive/negative/neutral SCS potential of post-agricultural soils, which have likely been confounded by other key factors. SOC responses were negatively correlated with initial SOC stock, indicating a soil carbon saturation effect, and negatively correlated with soil depth. Climatic conditions have both positive and negative effects on SOC response, with an ideal temperature and precipitation window for SCS of around 13 to <17 C and 450 to <1000 mm yr–1 Biogeographical regions with climatic conditions typically outside these ranges exhibited lower relative rates of SOC stock accumulation and even losses (e.g., alpine, continental). Both past land use (cropland vs. pasture) and post-abandonment/conversion land management strategy employed (natural vs. assisted) produced divergent responses in SOC change, implying that croplands managed through natural succession would show the greatest SOC accrual while pastures that are actively converted (e.g., afforestation) would result in the lowest increases in SOC, or even losses. This variability in postabandonment/conversion SOC dynamics must be considered in sustainable land use planning that strives to incorporate the positive ecological and climate change mitigation implications of ALA, taking into account site-specific conditions and past and present land management. Our results help inform EU ecosystem restoration policies and land management strategies on the potential soil carbon benefits, costs, and challenges of ALA

Bell Inequalities in Phase Space and their Violation in Quantum Mechanics

We derive ``Bell inequalities'' in four dimensional phase space and prove the following ``three marginal theorem'' for phase space densities $\rho(\overrightarrow{q},\overrightarrow{p})$, thus settling a long standing conjecture : ``there exist quantum states for which more than three of the quantum probability distributions for $(q_1,q_2)$, $(p_1,p_2)$, $(q_1,p_2)$ and $(p_1,q_2)$ cannot be reproduced as marginals of a positive $\rho(\overrightarrow{q},\overrightarrow{p})$''. We also construct the most general positive $\rho(\overrightarrow{q},\overrightarrow{p})$ which reproduces any three of the above quantum probability densities for arbitrary quantum states. This is crucial for the construction of a maximally realistic quantum theory.Comment: 11 pages, latex, no figure

Uncertainty characteristics of generalized quantum measurements

The effects of any quantum measurement can be described by a collection of measurement operators {M_m} acting on the quantum state of the measured system. However, the Hilbert space formalism tends to obscure the relationship between the measurement results and the physical properties of the measured system. In this paper, a characterization of measurement operators in terms of measurement resolution and disturbance is developed. It is then possible to formulate uncertainty relations for the measurement process that are valid for arbitrary input states. The motivation of these concepts is explained from a quantum communication viewpoint. It is shown that the intuitive interpretation of uncertainty as a relation between measurement resolution and disturbance provides a valid description of measurement back action. Possible applications to quantum cryptography, quantum cloning, and teleportation are discussed.Comment: 8 pages, small additions on cloning and on definitions of delta A_mf, et

Real-time PCR based on SYBR-Green I fluorescence: An alternative to the TaqMan assay for a relative quantification of gene rearrangements, gene amplifications and micro gene deletions

BACKGROUND: Real-time PCR is increasingly being adopted for RNA quantification and genetic analysis. At present the most popular real-time PCR assay is based on the hybridisation of a dual-labelled probe to the PCR product, and the development of a signal by loss of fluorescence quenching as PCR degrades the probe. Though this so-called 'TaqMan' approach has proved easy to optimise in practice, the dual-labelled probes are relatively expensive. RESULTS: We have designed a new assay based on SYBR-Green I binding that is quick, reliable, easily optimised and compares well with the published assay. Here we demonstrate its general applicability by measuring copy number in three different genetic contexts; the quantification of a gene rearrangement (T-cell receptor excision circles (TREC) in peripheral blood mononuclear cells); the detection and quantification of GLI, MYC-C and MYC-N gene amplification in cell lines and cancer biopsies; and detection of deletions in the OPA1 gene in dominant optic atrophy. CONCLUSION: Our assay has important clinical applications, providing accurate diagnostic results in less time, from less biopsy material and at less cost than assays currently employed such as FISH or Southern blotting

Qubits from Number States and Bell Inequalities for Number Measurements

Bell inequalities for number measurements are derived via the observation that the bits of the number indexing a number state are proper qubits. Violations of these inequalities are obtained from the output state of the nondegenerate optical parametric amplifier.Comment: revtex4, 7 pages, v2: results identical but extended presentation, v3: published versio

Constructing and Characterising Solar Structure Models for Computational Helioseismology

In this paper, we construct background solar models that are stable against convection, by modifying the vertical pressure gradient of Model S (Christensen-Dalsgaard et al., 1996, Science, 272, 1286) relinquishing hydrostatic equilibrium. However, the stabilisation affects the eigenmodes that we wish to remain as close to Model S as possible. In a bid to recover the Model S eigenmodes, we choose to make additional corrections to the sound speed of Model S before stabilisation. No stabilised model can be perfectly solar-like, so we present three stabilised models with slightly different eigenmodes. The models are appropriate to study the f and p1 to p4 modes with spherical harmonic degrees in the range from 400 to 900. Background model CSM has a modified pressure gradient for stabilisation and has eigenfrequencies within 2% of Model S. Model CSM_A has an additional 10% increase in sound speed in the top 1 Mm resulting in eigenfrequencies within 2% of Model S and eigenfunctions that are, in comparison with CSM, closest to those of Model S. Model CSM_B has a 3% decrease in sound speed in the top 5 Mm resulting in eigenfrequencies within 1% of Model S and eigenfunctions that are only marginally adversely affected. These models are useful to study the interaction of solar waves with embedded three-dimensional heterogeneities, such as convective flows and model sunspots. We have also calculated the response of the stabilised models to excitation by random near-surface sources, using simulations of the propagation of linear waves. We find that the simulated power spectra of wave motion are in good agreement with an observed SOHO/MDI power spectrum. Overall, our convectively stabilised background models provide a good basis for quantitative numerical local helioseismology. The models are available for download from http://www.mps.mpg.de/projects/seismo/NA4/.Comment: 35 pages, 23 figures Changed title Updated Figure 1

Deficits in mitochondrial spare respiratory capacity contribute to the neuropsychological changes of alzheimer’s disease

Alzheimer’s disease (AD) is diagnosed using neuropsychological testing, supported by amyloid and tau biomarkers and neuroimaging abnormalities. The cause of neuropsychological changes is not clear since they do not correlate with biomarkers. This study investigated if changes in cellular metabolism in AD correlate with neuropsychological changes. Fibroblasts were taken from 10 AD patients and 10 controls. Metabolic assessment included measuring total cellular ATP, extracellular lactate, mitochondrial membrane potential (MMP), mitochondrial respiration and glycolytic function. All participants were assessed with neuropsychological testing and brain structural MRI. AD patients had significantly lower scores in delayed and immediate recall, semantic memory, phonemic fluency and Mini Mental State Examination (MMSE). AD patients also had significantly smaller left hippocampal, left parietal, right parietal and anterior medial prefrontal cortical grey matter volumes. Fibroblast MMP, mitochondrial spare respiratory capacity (MSRC), glycolytic reserve, and extracellular lactate were found to be lower in AD patients. MSRC/MMP correlated significantly with semantic memory, immediate and delayed episodic recall. Correlations between MSRC and delayed episodic recall remained significant after controlling for age, education and brain reserve. Grey matter volumes did not correlate with MRSC/MMP. AD fibroblast metabolic assessment may represent an emergent disease biomarker of AD

Altered frontal and insular functional connectivity as pivotal mechanisms for apathy in Alzheimer’s disease

Background: Apathy is a common and early symptom in Alzheimer’s disease (AD) and is linked to poorer prognosis. Theoretical interpretations of apathy implicate alterations of connections amongst fronto-striatal and limbic regions. Objective: To test the association between presence of apathy and patterns of brain functional connectivity in patients with clinically-established AD. Methods: Seventy AD patients were included. Thirty-five patients experienced apathy as defined by the screening question of the Neuropsychiatric Inventory, and thirty-five did not. All patients agreed to undergo an MRI protocol inclusive of resting-state acquisitions. The hemodynamic-dependent signal was extracted bilaterally from five regions of interest: ventromedial prefrontal cortices, anterior cingulate cortices, dorsolateral prefrontal cortices, insulae and amygdalae. t tests were run to compare connectivity maps of apathetic and non-apathetic patients. Age, education, Mini Mental State Examination score, gray matter volumes and gray matter fractions served as covariates. Results: At a pFWE < 0.05 threshold, apathetic patients had reduced connectivity between the left insula and right superior parietal cortex. Apathetic patients had also increased connectivity between the right dorsolateral prefrontal seed and the right superior parietal cortex. Patients with apathy were significantly more likely to experience other psychiatric symptoms. Conclusion: Our findings support a role of frontal and insular connections in coordinating value-based decisions in AD. Both down-regulation and maladaptive up-regulation mechanisms appear to be at play in these regions