199 research outputs found
Liquorice for pain?
- Publication venue
- Publication date
- 01/07/2021
- Field of study
Liquorice has a long history of use in traditional Chinese, Ayurvedic and herbal medicine. The liquorice plant contains numerous bioactive compounds, including triterpenes, flavonoids and secondary metabolites, with glycyrrhizin being the main active compound. Liquorice constituents have been found to have anti-inflammatory, antioxidant, antiviral, anticancer, hepatoprotective and neuroprotective properties. In addition, they appear to have antidepressant actions and effects on morphine tolerance. Glycyrrhizin, its metabolite glycyrrhetic (glycyrrhetinic) acid and other liquorice-derived compounds such as isoflavonoids and trans-chalcones, exert potent anti-inflammatory effects via a wide range of mechanisms including high mobility group box 1 protein (HMGB1) inhibition, gap junction blockade and alpha(2A)-adrenoceptor antagonism. These properties, together with an increasing body of preclinical studies and a long history of use in herbal medicine, suggest that liquorice constituents may be useful for pain management. Glycyrrhizin is used widely in the confectionary, food and tobacco industries, but has documented adverse effects that may limit clinical use. Whether liquorice plant-derived compounds represent a novel class of analgesics is yet to be established. Having a host of bioactive compounds with a broad range of mechanisms of effect, liquorice is a plant that, in the future, may give rise to new therapies for pain.Peer reviewe
Topical review Food, pain, and drugs: Does it matter what pain patients eat?
- Publication venue
- Publication date
- 24/04/2020
- Field of study
Effect of early interdisciplinary rehabilitation for trauma patients: a systematic review
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Objective
To perform a systematic review to assess the current scientific evidence concerning the effect of EIR for trauma patients with or without an associated traumatic brain injury.
Data Source
We performed a systematic search of several electronic (Ovid MEDLINE, Embase, Cochrane Library Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health, and SveMed+) and 2 clinical trial registers (clinicaltrials.gov and International Clinical Trials Registry Platform). In addition, we handsearched reference lists from relevant studies.
Data Extraction
Two review authors independently identified studies that were eligible for inclusion. The primary outcome measures were functional-related outcomes and return to work. The secondary outcome measures were length of stay in hospital, number of days on respirator, complication rate, physical and mental health measures, quality of life, and socioeconomic costs.
Data Synthesis
Four studies with a total number of 409 subjects, all with traumatic brain–associated injuries, were included in this review. The included trials varied considerably in study design, inclusion and exclusion criteria, and had small numbers of participants. All studies were judged to have at least 1 high risk of bias. We found the quality of evidence, for both our primary and secondary outcomes, low.
Conclusions
No studies that matched our inclusion criteria for EIR for trauma patients without traumatic brain injuries could be found. For traumatic brain injuries, there are a limited number of studies demonstrating that EIR has a positive effect on functional outcomes and socioeconomic costs. This review highlights the need for further research in trauma care regarding early phase interdisciplinary rehabilitation.publishedVersio
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
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- Bao Yangyi
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- Barberi Theresa
- Barker Christopher A
- Barnea Eytan
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- Bartkowiak Todd
- Bartlett David
- Bartlett David
- Bartlett David
- Bartlett David
- Barton Sunjay M
- Barve Minal
- Bauer Todd
- Bauer Todd W
- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
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- Beckers Johannes
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- Bedognetti Davide
- Bedognetti Davide
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- Bell Charles J M
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- Berzofsky Jay A
- Bhardwaj Nina
- Bian Zhen
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- Biediger Ronald J
- Bifulco Carlo
- Bigley Alison
- Bingham Patrick
- Biniszkiewicz Detlev M
- Bischoff Helge
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- Blake Zoe
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- Blazar Bruce R
- Blogowski Wojciech
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- Boehm Jesse
- Bokovanov Vladimir
- Bommareddy Praveen K
- Bommareddy Praveen K
- Bommareddy Praveen K
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- Brockstedt Dirk G
- Brockstedt Dirk G
- Brody Joshua
- Bronson Roderick
- Brooks Alan
- Brooks Alan D
- Broucek Joseph
- Brown Alice
- Brown Brian
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- Brown Gail L
- Brown Sheila
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- Gajewski Thomas F
- Gajewski Thomas F
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- Gajewski Thomas F
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- Gamble Alicia
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- Gameiro Sofia
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- Gauthier Kelsey S
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- Hale Diane F
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- Herranz Mireia U
- Hess Kenneth R
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- Ho Po
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- Hong Henoch S
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- Lazorchak Adam S
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- Leong Justin L
- Leong Meredith L
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- Lu Yan
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- VanVlasselaer Peter
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- Xu Guifen
- Xu Xiaomei
- Xu Xin
- Xu Ya-Ming
- Xu Yitong
- Yadav Mahesh
- Yagiz Kader
- Yamashiro Darrell J
- Yan Jian
- Yang Chou
- Yang Ning
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- Yin Catherine
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- Ylösmäki Erkko
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- Zeh Herbert
- Zelenetz Andrew D
- Zeng Weiping
- Zeng Xue
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- Zhang Jing
- Zhang Ping
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- Zhang Shannon S
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- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Evidence and methodology in clinical pain trials with special focus on ketamine
- Author
- Publication venue
- The University of Bergen
- Publication date
- 01/01/2006
- Field of study
Aims: To establish the evidence base for the use of the NMDA receptor antagonist ketamine in the treatment of acute postoperative pain and cancer pain, and in doing so, to assess the methodology used in acute pain and cancer pain trials. Methods: In paper I a clinical model was developed and tested. Paper II is a quantitative and qualitative Cochrane systematic review on perioperative ketamine for acute postoperative pain. Paper III is a qualitative Cochrane systematic review on ketamine as adjuvant to opioid for cancer pain. Paper IV is a qualitative systematic review of the methodology used in clinical trials of oral opioids for cancer pain. Results: The model developed in Paper I was tested and found to be sensitive. Thirty-seven randomised, controlled trials (RCTs) were included in paper II. The meta-analysis found that perioperative ketamine reduced 24 hr PCA morphine consumption and reduced PONV. In paper III, four RCT’s concerning ketamine as adjuvant to opioid for cancer pain were identified. Two were excluded due to flawed methodology. Both trials found that ketamine improved morphine analgesia. Meta-analysis was not appropriate. Thirty- four RCT’s were included in paper IV. Significant limitations in the trial methodology were identified. Conclusions: There is level 1 (strong) evidence that perioperative ketamine reduces 24 hr PCA morphine consumption, and post-operative nausea and vomiting. Adverse effects were mild or absent.There is currently insufficient evidence to permit conclusions regarding the benefits and harms of ketamine as adjuvant to opioid for cancer pain. Randomised, controlled trials are needed. Clinical pain trials require rigorous methodology if they are to produce reliable results. Recommendations for future analgesic trials in acute and cancer pain are made
Effect of early interdisciplinary rehabilitation for trauma patients: a systematic review
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Objective
To perform a systematic review to assess the current scientific evidence concerning the effect of EIR for trauma patients with or without an associated traumatic brain injury.
Data Source
We performed a systematic search of several electronic (Ovid MEDLINE, Embase, Cochrane Library Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health, and SveMed+) and 2 clinical trial registers (clinicaltrials.gov and International Clinical Trials Registry Platform). In addition, we handsearched reference lists from relevant studies.
Data Extraction
Two review authors independently identified studies that were eligible for inclusion. The primary outcome measures were functional-related outcomes and return to work. The secondary outcome measures were length of stay in hospital, number of days on respirator, complication rate, physical and mental health measures, quality of life, and socioeconomic costs.
Data Synthesis
Four studies with a total number of 409 subjects, all with traumatic brain–associated injuries, were included in this review. The included trials varied considerably in study design, inclusion and exclusion criteria, and had small numbers of participants. All studies were judged to have at least 1 high risk of bias. We found the quality of evidence, for both our primary and secondary outcomes, low.
Conclusions
No studies that matched our inclusion criteria for EIR for trauma patients without traumatic brain injuries could be found. For traumatic brain injuries, there are a limited number of studies demonstrating that EIR has a positive effect on functional outcomes and socioeconomic costs. This review highlights the need for further research in trauma care regarding early phase interdisciplinary rehabilitation
Recommended from our members
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016
- Author
- Abassi Yama
- Abelin Jennifer G.
- Abolhalaj Milad
- Abraham Tara S.
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F.
- Adamus Tomasz
- Addepalli Murali
- Adjei Alex A.
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G.
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T.
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C.
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T.
- Alley Evan W.
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H. I.
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S.
- Antonia Scott J.
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F.
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M.
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B.
- Atkinson Victoria
- Au Katrina
- Autio Karen A.
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A.
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Barton Sunjay M.
- Barve Minal
- Bauer Todd
- Bauer Todd W.
- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
- Beceren-Braun Figen
- Beck Kristen
- Becker Annette
- Beckers Johannes
- Beckett Michael A.
- Bedognetti Davide
- Bell Bryan
- Bell Charles J. M.
- Bell Peter
- Beltran Pedro
- Bender Lewis H.
- Bender Steven
- Bennett Mark K.
- Benz Steven
- Bera Tapan
- Berglund Peter
- Berkey Sara
- Bernatchez Chantale
- Berry John S.
- Berzofsky Jay A.
- Bhardwaj Nina
- Bian Zhen
- Bianco Alberto
- Biediger Ronald J.
- Bifulco Carlo
- Bigley Alison
- Bingham Patrick
- Biniszkiewicz Detlev M.
- Bischoff Helge
- Blake Zoe
- Blakely Collin
- Blazar Bruce R.
- Blogowski Wojciech
- Bloom Anja C.
- Boehm Jesse
- Bokovanov Vladimir
- Bommareddy Praveen K.
- Booth Jamie
- Bornschlegl Svetlana
- Bose Nandita
- Bossenmaier Birgit
- Boughorbel Sabri
- Boyer Jean
- Bramante Simona
- Branstetter Daniel
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- Siebenaler Kristen
- Silk Ann
- Silk Ann W.
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- Slomovitz Brian M.
- Smith Ernest
- Smith Jill
- Smith Kelly
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- Timmerman John
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- Tognon Christina E.
- Tomai Mark A.
- Toms Anne
- Torno Sebold
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- Tsang Kwong Y.
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- Tsouko Efrosini
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- VanVlasselaer Peter
- Varhegyi Nikole
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- Vaske Charles
- Vassilev Lotta
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- Velculescu Victor
- Verma Amita
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- Vogel Katharina
- Volkmuth Wayne
- Volz Barbara
- vonEbyen Rie
- Vreeland Timothy J.
- Vu Tuyen
- Wada Hiroshi
- Wagtmann Nicolai
- Waldman Michelle
- Waldman Scott A.
- Waller John
- Wallraven Gladice
- Walsh Richard
- Walters Ian B.
- Wang Ena
- Wang Hongjie
- Wang Ping
- Wang Shangzi
- Wang Weiyi
- Wang Ximi K.
- Wang Yi
- Wang Ziming
- Ward Stephen T.
- Waugh Katherine
- Weber Amy
- Wehler Thomas
- Wei Spencer
- Weichselbaum Ralph R.
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- Weiner Louis M.
- Weinstein Gregory
- Weiss Christian
- Welden Scott
- Wellstein Anton
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- Wennerberg Erik
- Wenthe Jessica
- Werner Lauryn R.
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- West James
- Wheatley Courtney
- Whetstone Ryan
- White James
- White-Stern Ashley
- Whiteside Melinda
- Whiting Chan C.
- Wicha Max S.
- Wieckowski Eva
- Wijeratne Kithsiri
- Wilhite Tyler
- Wilkinson Robert W.
- Williams Matthew
- Williamson Kevin
- Willingham Stephen
- Wilson James M.
- Wilson Nicholas
- Winters Kevin
- Withers Sita
- Wittig Burghardt
- Wolchok Jedd D.
- Wolfreys Alison
- Won Haejung
- Wong Chihunt
- Wong Deborah J.
- Wong Gabriel
- Wong Kenneth R.
- Wong Michael KK
- Wood Laura
- Woodside Darren G.
- Workman Creg
- Wu Bill X.
- Wu Dongyun
- Wu Jennifer
- Wu Yeting
- Wyant Timothy
- Wythes Martin
- Xi Biao
- Xia Leiming
- Xia Yang
- Xiang Bo
- Xiao Christine
- Xiao Hong
- Xiao Zhilan
- Xu Chun-wei
- Xu Chunxiao
- Xu Guifen
- Xu Xiaomei
- Xu Xin
- Xu Ya-Ming
- Xu Yitong
- Yadav Mahesh
- Yagiz Kader
- Yamashiro Darrell J.
- Yan Jian
- Yang Chou
- Yang Ning
- Yang Zane
- Yano Hiroshi
- Yao Shiyin
- Ye Yun-bin
- Yin Catherine
- Ylösmäki Erkko
- Young Gregory
- Young Kristina
- Young Rob
- Young Steve W.
- Youssoufian Hagop
- Yu Huakui
- Yu Ling
- Yu Naichen
- Zafar Sadia
- Zalevsky Jonathan
- Zappasodi Roberta
- Zauderer Maurice
- Zeh Herbert
- Zelenetz Andrew D.
- Zeng Weiping
- Zeng Xue
- Zha Yuanyuan
- Zhang Danhui
- Zhang Jing
- Zhang Ping
- Zhang Qifang
- Zhang Shannon S.
- Zhang Theresa
- Zhang Winter
- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 03/01/2017
- Field of study
Jet fragmentation transverse momentum distributions in pp and p-Pb collisions at s, sNN = 5.02 TeV
- Author
- Acharya Shreyasi
- Adamova Dagmar
- Adler Alexander
- Adolfsson Jonatan
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agrawal Neelima
- Ahammed Zubayer
- Ahmad Shakeel
- Ahn Sang Un
- Akbar Zaenal
- Akindinov Alexander
- Al-turany Mohammad
- Alarcon Do Passo Suaide Alexandre
- Aleksandrov Dmitry
- Alessandro Bruno
- Alfanda Haidar Mas'ud
- Alfaro Molina Jose Ruben
- Ali Bushra
- Ali Yasir
- ALICE Collaboration
- Alici Andrea
- Alizadehvandchali Negin
- Alkin Anton
- Alme Johan
- Alt Torsten
- Altenkamper Lucas
- Altsybeev Igor
- Alvarado Garcia Jesus Ricardo
- Anaam Mustafa
- Andrei Cristian
- Andreou Dimitra
- Andronic Anton
- Anguelov Venelin
- Anticic Tome
- Antinori Federico
- Antonioli Pietro
- Apadula Nicole
- Aphecetche Laurent Bernard
- Appelshaeuser Harald
- Arcelli Silvia
- Arnaldi Roberta
- Arratia Munoz Miguel Ignacio
- Arsene Ionut Cristian
- Arslandok Mesut
- Arteche Diaz Raul
- Augustinus Andre
- Averbeck Ralf Peter
- Aziz Sizar
- Azmi Mohd Danish
- Badala Angela
- Baek Yongwook
- Bai Xiaozhi
- Bailhache Raphaelle Marie
- Bala Renu
- Balbino Alessandro
- Baldisseri Alberto
- Ball Markus
- Banerjee Debjani
- Barbera Roberto
- Barioglio Luca
- Barlou Maria
- Barnafoldi Gergely Gabor
- Barnby Lee Stuart
- Bartels Clara
- Barth Klaus
- Bartsch Esther
- Baruffaldi Filippo
- Bashir Butt Jamila
- Bastid Nicole
- Basu Sumit
- Batigne Guillaume
- Batyunya Boris
- Bauri Dibakar
- Bautista Guzman Irais
- Bazo Alba Jose Luis
- Bearden Ian Gardner
- Beattie Caitlin
- Belikov Iouri
- Bell Hechavarria A. D. C.
- Bellini Francesca
- Bellwied Rene
- Belokurova Svetlana
- Belyaev Vladimir
- Bencedi Gyula
- Beole Stefania
- Bercuci Alexandru
- Berdnikov Yaroslav
- Berdnikova Anastasia
- Berenyi Daniel
- Bergmann Luisa
- Besoiu Mihaela Gabriela
- Betev Latchezar
- Bhaduri Partha Pratim
- Bhasin Anju
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- Bhat Mohammad Asif
- Bhattacharjee Buddhadeb
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- Bianchi Livio
- Bianchi Nicola
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- Bielcikova Jana
- Bilandzic Ante
- Biro Gabor
- Biswas Saikat
- Blair Justin Thomas
- Blau Dmitry
- Blidaru Mihail Bogdan
- Blume Christoph
- Boca Gianluigi
- Bock Friederike
- Bogdanov Alexey
- Boi Stefano
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- Boldizsar Laszlo
- Bolozdynya Alexander
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- Witt William Edward
- Wright Josephina Rae
- Wu Yitao
- Xu Ran
- Yalcin Kuzu Serpil
- Yamaguchi Yorito
- Yamakawa Kosei
- Yang Shiming
- Yano Satoshi
- Yin Zhongbao
- Yokoyama Hiroki
- Yoo In Kwon
- Yoon Jin Hee
- Yu Zhi
- Yuan Shiming
- Yuncu Alperen
- Yurchenko Volodymyr
- Zaccolo Valentina
- Zaman Ali
- Zampolli Chiara
- Zardoshti Nima
- Zarochentsev Andrey
- Zavada Petr
- Zavyalov Nikolay
- Zbroszczyk Hanna Paulina
- Zhalov Mikhail
- Zhang Song
- Zhang Xiaoming
- Zhang Yifei
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- Zhou Daicui
- Zhou You
- Zhu Jianhui
- Zhu Ya
- Zichichi Antonino
- Zinovjev Gennady
- Zurlo Nicola
- Publication venue
- SISSA
- Publication date
- 10/11/2020
- Field of study
Jet fragmentation transverse momentum (jT) distributions are measured in proton-proton (pp) and proton-lead (p-Pb) collisions at sNN = 5.02 TeV with the ALICE experiment at the LHC. Jets are reconstructed with the ALICE tracking detectors and electromagnetic calorimeter using the anti-kT algorithm with resolution parameter R = 0.4 in the pseudorapidity range |η| < 0.25. The jT values are calculated for charged particles inside a fixed cone with a radius R = 0.4 around the reconstructed jet axis. The measured jT distributions are compared with a variety of parton-shower models. Herwig and Pythia 8 based models describe the data well for the higher jT region, while they underestimate the lower jT region. The jT distributions are further characterised by fitting them with a function composed of an inverse gamma function for higher jT values (called the “wide component”), related to the perturbative component of the fragmentation process, and with a Gaussian for lower jT values (called the “narrow component”), predominantly connected to the hadronisation process. The width of the Gaussian has only a weak dependence on jet transverse momentum, while that of the inverse gamma function increases with increasing jet transverse momentum. For the narrow component, the measured trends are successfully described by all models except for Herwig. For the wide component, Herwig and PYTHIA 8 based models slightly underestimate the data for the higher jet transverse momentum region. These measurements set constraints on models of jet fragmentation and hadronisation
Measurements of the groomed and ungroomed jet angularities in pp collisions at s = 5.02 TeV
- Author
- Acharya Shreyasi
- Adamova Dagmar
- Adler Alexander
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agrawal Neelima
- Ahammed Zubayer
- Ahmad Shakeel
- Ahn Sang Un
- Ahuja Ishaan
- Akbar Zaenal
- Akindinov Alexander
- Al-turany Mohammad
- Alam Sk Noor
- Alarcon Do Passo Suaide Alexandre
- Aleksandrov Dmitry
- Alessandro Bruno
- Alfanda Haidar Mas'ud
- Alfaro Molina Jose Ruben
- Ali Bushra
- Ali Yasir
- ALICE Collaboration
- Alici Andrea
- Alizadehvandchali Negin
- Alkin Anton
- Alme Johan
- Alt Torsten
- Altenkamper Lucas
- Altsybeev Igor
- Alvarado Garcia Jesus Ricardo
- Anaam Mustafa
- Andrei Cristian
- Andreou Dimitra
- Andronic Anton
- Angeletti Massimo
- Anguelov Venelin
- Antinori Federico
- Antonioli Pietro
- Apadula Nicole
- Aphecetche Laurent Bernard
- Appelshaeuser Harald
- Arcelli Silvia
- Arnaldi Roberta
- Arsene Ionut Cristian
- Arslandok Mesut
- Arteche Diaz Raul
- Augustinus Andre
- Averbeck Ralf Peter
- Aziz Sizar
- Azmi Mohd Danish
- Badala Angela
- Baek Yongwook
- Bai Xiaozhi
- Bailhache Raphaelle Marie
- Bailung Yoshini
- Bala Renu
- Balbino Alessandro
- Baldisseri Alberto
- Balis Bartosz
- Ball Markus
- Banerjee Debjani
- Barbera Roberto
- Barioglio Luca
- Barlou Maria
- Barnafoldi Gergely Gabor
- Barnby Lee Stuart
- Bartels Clara
- Barth Klaus
- Bartsch Esther
- Baruffaldi Filippo
- Bashir Butt Jamila
- Bastid Nicole
- Basu Sumit
- Batigne Guillaume
- Batyunya Boris
- Bauri Dibakar
- Bazo Alba Jose Luis
- Bearden Ian Gardner
- Beattie Caitlin
- Belikov Iouri
- Bell Hechavarria A. D. C.
- Bellini Francesca
- Bellwied Rene
- Belokurova Svetlana
- Belyaev Vladimir
- Bencedi Gyula
- Beole Stefania
- Bercuci Alexandru
- Berdnikov Yaroslav
- Berdnikova Anastasia
- Bergmann Luisa
- Besoiu Mihaela Gabriela
- Betev Latchezar
- Bhaduri Partha Pratim
- Bhasin Anju
- Bhat Inayat Rasool
- Bhat Mohammad Asif
- Bhattacharjee Buddhadeb
- Bhattacharya Purba
- Bianchi Livio
- Bianchi Nicola
- Bielcik Jaroslav
- Bielcikova Jana
- Biernat Jacek
- Bilandzic Ante
- Biro Gabor
- Biswas Saikat
- Blair Justin Thomas
- Blau Dmitry
- Blidaru Mihail Bogdan
- Blume Christoph
- Boca Gianluigi
- Bock Friederike
- Bogdanov Alexey
- Boi Stefano
- Bok Jeongsu
- Boldizsar Laszlo
- Bolozdynya Alexander
- Bombara Marek
- Bond Peter Matthew
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- Borissov Alexander
- Bossi Hannah
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- Buthelezi Edith Zinhle
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- Cai Mengke
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- Camerini Paolo
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- Caron Robin Albert Andre
- Castillo Castellanos Javier Ernesto
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- Chibante Barroso Vasco Miguel
- Cho Soyeon
- Chochula Peter
- Christakoglou Panagiotis
- Christensen Christian Holm
- Christiansen Peter
- Chujo Tatsuya
- Cicalo Corrado
- Cifarelli Luisa
- Cindolo Federico
- Ciupek Michael Rudolf
- Clai Giulia
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- Vermunt Lucas Anne
- Vertesi Robert
- Verweij Marta
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- Vilakazi Zabulon
- Villalobos Baillie Orlando
- Vino Gioacchino
- Vinogradov Alexander
- Virgili Tiziano
- Vislavicius Vytautas
- Vodopyanov Alexander
- Voelkel Benedikt
- Volkl Martin Andreas
- Voloshin Kirill
- Voloshin Sergey
- Volpe Giacomo
- Von Haller Barthelemy
- Vorobyev Ivan
- Voscek Dominik
- Vozniuk Nikita
- Vrlakova Janka
- Wagner Boris
- Wang Chunzheng
- Wang Dongfang
- Weber Michael
- Wegrzynek Adam Tadeusz
- Wenzel Sandro Christian
- Wessels Johannes Peter
- Wiechula Jens
- Wikne Jon
- Wilk Grzegorz Andrzej
- Wilkinson Jeremy John
- Willems Guido Alexander
- Windelband Bernd Stefan
- Winn Michael Andreas
- Witt William Edward
- Wright Josephina Rae
- Wu Wenya
- Wu Yitao
- Xu Ran
- Yadav Arun Kumar
- Yalcin Kuzu Serpil
- Yamaguchi Yorito
- Yamakawa Kosei
- Yang Shiming
- Yano Satoshi
- Yin Zhongbao
- Yokoyama Hiroki
- Yoo In Kwon
- Yoon Jin Hee
- Yu Zhi
- Yuan Shiming
- Yuncu Alperen
- Zaccolo Valentina
- Zaman Ali
- Zampolli Chiara
- Zardoshti Nima
- Zarochentsev Andrey
- Zavada Petr
- Zavyalov Nikolay
- Zhalov Mikhail
- Zhang Biao
- Zhang Song
- Zhang Xiaoming
- Zhang Yifei
- Zherebchevskii Vladimir
- Zhigareva Natalia
- Zhou Daicui
- Zhou You
- Zhu Jianhui
- Zhu Ya
- Zichichi Antonino
- Zinovjev Gennady
- Zurlo Nicola
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 16/07/2021
- Field of study
International audienceThe jet angularities are a class of jet substructure observables which characterize the angular and momentum distribution of particles within jets. These observables are sensitive to momentum scales ranging from perturbative hard scatterings to nonperturbative fragmentation into final-state hadrons. We report measurements of several groomed and ungroomed jet angularities in pp collisions at s = 5.02 TeV with the ALICE detector. Jets are reconstructed using charged particle tracks at midrapidity (|η| < 0.9). The anti-kT algorithm is used with jet resolution parameters R = 0.2 and R = 0.4 for several transverse momentum {p}_{\mathrm{T}}^{\mathrm{ch}} ^{jet} intervals in the 20–100 GeV/c range. Using the jet grooming algorithm Soft Drop, the sensitivity to softer, wide-angle processes, as well as the underlying event, can be reduced in a way which is well-controlled in theoretical calculations. We report the ungroomed jet angularities, λα, and groomed jet angularities, λα,g, to investigate the interplay between perturbative and nonperturbative effects at low jet momenta. Various angular exponent parameters α = 1, 1.5, 2, and 3 are used to systematically vary the sensitivity of the observable to collinear and soft radiation. Results are compared to analytical predictions at next-to-leading-logarithmic accuracy, which provide a generally good description of the data in the perturbative regime but exhibit discrepancies in the nonperturbative regime. Moreover, these measurements serve as a baseline for future ones in heavy-ion collisions by providing new insight into the interplay between perturbative and nonperturbative effects in the angular and momentum substructure of jets. They supply crucial guidance on the selection of jet resolution parameter, jet transverse momentum, and angular scaling variable for jet quenching studies.[graphic not available: see fulltext
Inclusive quarkonium production in pp collisions at s=5.02 TeV
- Author
- Acharya Shreyasi
- Adamova Dagmar
- Adler Alexander
- Adolfsson Jonatan
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agrawal Neelima
- Ahammed Zubayer
- Ahmad Shakeel
- Ahn Sang Un
- Ahuja Ishaan
- Akbar Zaenal
- Akindinov Alexander
- Al-turany Mohammad
- Alam Sk Noor
- Alarcon Do Passo Suaide Alexandre
- Aleksandrov Dmitry
- Alessandro Bruno
- Alfanda Haidar Mas'ud
- Alfaro Molina Jose Ruben
- Ali Bushra
- Ali Yasir
- ALICE Collaboration
- Alici Andrea
- Alizadehvandchali Negin
- Alkin Anton
- Alme Johan
- Alt Torsten
- Altsybeev Igor
- Alvarado Garcia Jesus Ricardo
- Anaam Mustafa
- Andrei Cristian
- Andreou Dimitra
- Andronic Anton
- Angeletti Massimo
- Anguelov Venelin
- Antinori Federico
- Antonioli Pietro
- Apadula Nicole
- Aphecetche Laurent Bernard
- Appelshaeuser Harald
- Arcelli Silvia
- Arnaldi Roberta
- Arsene Ionut Cristian
- Arslandok Mesut
- Arteche Diaz Raul
- Augustinus Andre
- Averbeck Ralf Peter
- Aziz Sizar
- Azmi Mohd Danish
- Badala Angela
- Baek Yongwook
- Bai Xiaozhi
- Bailhache Raphaelle Marie
- Bailung Yoshini
- Bala Renu
- Balbino Alessandro
- Baldisseri Alberto
- Balis Bartosz
- Banerjee Debjani
- Barbera Roberto
- Barioglio Luca
- Barlou Maria
- Barnafoldi Gergely Gabor
- Barnby Lee Stuart
- Bartels Clara
- Barth Klaus
- Bartsch Esther
- Baruffaldi Filippo
- Bashir Butt Jamila
- Bastid Nicole
- Basu Sumit
- Batigne Guillaume
- Batyunya Boris
- Bauri Dibakar
- Bazo Alba Jose Luis
- Bearden Ian Gardner
- Beattie Caitlin
- Becht Pascal
- Belikov Iouri
- Bellini Francesca
- Bellwied Rene
- Belokurova Svetlana
- Belyaev Vladimir
- Bencedi Gyula
- Beole Stefania Maria
- Bercuci Alexandru
- Berdnikov Yaroslav
- Berdnikova Anastasia
- Bergmann Luisa
- Besoiu Mihaela Gabriela
- Betev Latchezar
- Bhaduri Partha Pratim
- Bhasin Anju
- Bhat Inayat Rasool
- Bhat Mohammad Asif
- Bhattacharjee Buddhadeb
- Bhattacharya Purba
- Bianchi Livio
- Bianchi Nicola
- Bielcik Jaroslav
- Bielcikova Jana
- Biernat Jacek Bogumil
- Bilandzic Ante
- Biro Gabor
- Biswas Saikat
- Blair Justin Thomas
- Blau Dmitry
- Blidaru Mihail Bogdan
- Blume Christoph
- Boca Gianluigi
- Bock Friederike
- Bogdanov Alexey
- Boi Stefano
- Bok Jeongsu
- Boldizsar Laszlo
- Bolozdynya Alexander
- Bombara Marek
- Bond Peter Matthew
- Bonomi Germano
- Borel Herve
- Borissov Alexander
- Bossi Hannah
- Botta Elena
- Bratrud Lars
- Braun-munzinger Peter
- Bregant Marco
- Broz Michal
- Bruno Giuseppe Eugenio
- Buckland Matthew Daniel
- Budnikov Dmitry
- Buesching Henner
- Bufalino Stefania
- Bugnon Ophelie
- Buhler Paul Alois
- Buthelezi Edith Zinhle
- Bylinkin Aleksandr
- Bysiak Sebastian Adam
- Cai Mengke
- Caines Helen Louise
- Caliva Alberto
- Calvo Villar Ernesto
- Camerini Paolo
- Carnesecchi Francesca
- Caron Robin Albert Andre
- Castillo Castellanos Javier Ernesto
- Casula Ester Anna Rita
- Catalano Fabio
- Ceballos Sanchez Cesar
- Chakraborty Pritam
- Chandra Anuj
- Chandra Sinjini
- Chapeland Sylvain
- Chartier Marielle
- Chattopadhyay Subhasis
- Chattopadhyay Sukalyan
- Chauvin Alex Henri Jean
- Cheng Tiantian
- Cheshkov Cvetan Valeriev
- Cheynis Brigitte
- Chibante Barroso Vasco Miguel
- Cho Soyeon
- Chochula Peter
- Christakoglou Panagiotis
- Christensen Christian Holm
- Christiansen Peter
- Chujo Tatsuya
- Cicalo Corrado
- Cifarelli Luisa
- Cindolo Federico
- Ciupek Michael Rudolf
- Clai Giulia
- Cleymans Jean Willy Andre
- Colamaria Fabio Filippo
- Colburn Jonathan Samuel
- Colella Domenico
- Collu Alberto
- Colocci Manuel
- Concas Matteo
- Conesa Balbastre Gustavo
- Conesa Del Valle Zaida
- Contin Giacomo
- Contreras Nuno Jesus Guillermo
- Coquet Maurice Louis
- Cormier Thomas Michael
- Correia Zanoli Henrique Jose
- Cortese Pietro
- Cosentino Mauro Rogerio
- Costa Filippo
- Costanza Susanna
- Crochet Philippe
- Cruz Torres Reynier
- Cuautle Flores Eleazar
- Cui Pengyao
- Cunqueiro Mendez Leticia
- Czeslaw Miskowiec Dariusz
- Dainese Andrea
- Damas Florian Paul Andre
- Danisch Meike Charlotte
- Danu Andrea
- Das Indranil
- Das Prottay
- Das Prottoy
- Das Supriya
- Dash Sadhana
- De Caro Annalisa
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- De Cilladi Lorenzo
- De Cuveland Jan
- De Falco Alessandro
- De Gruttola Daniele
- De Leone Gay Maria Beatriz
- De Marco Nora
- De Martin Chiara
- De Moraes Canedo Fabio
- De Pasquale Salvatore
- Deb Suman
- Deja Kamil Rafal
- Dello Stritto Luigi
- Demmich Katharina
- Deng Wenjing
- Dhankher Preeti
- Di Bari Domenico
- Di Mauro Antonio
- Dietel Thomas
- Ding Yanchun
- Divia Roberto
- Dixit Dhruv Utpalkumar
- Djuvsland Oeystein
- Dmitrieva Uliana
- Do Jaehyeon
- Dobrigkeit Chinellato David
- Dobrin Alexandru Florin
- Dominguez Rosas Edgar
- Donigus Benjamin
- Duarte Galvan Carlos
- Dubey Anand Kumar
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- Dudi Sandeep
- Dupieux Pascal
- Dzalaiova Natalia
- Eder Tabea Maria
- Ehlers Raymond James, III
- Eikeland Viljar Nilsen
- Eisenhut Florian
- Elia Domenico
- Erazmus Barbara Ewa
- Ercolessi Francesca
- Erhardt Filip
- Erokhin Andrey
- Ersdal Magnus Rentsch
- Espagnon Bruno
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- Evans David
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- Fan Feng
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- Finogeev Dmitry
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- Flor Fernando Antonio
- Flores Amanda Nicole
- Foertsch Siegfried Valentin
- Fokin Sergey
- Fragiacomo Enrico
- Frajna Eszter
- Franz Degenhardt Hermann
- Fuchs Ulrich
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- Furget Christophe
- Furs Artur
- Gaardhoeje Jens Joergen
- Gagliardi Martino
- Gago Medina Alberto Martin
- Gal Arthur Willem Jean
- Gameiro Munhoz Marcelo
- Ganoti Paraskevi
- Garabatos Cuadrado Jose Maria
- Garcia Chavez Tonatiuh
- Garcia Guardiano Gabriel
- Garcia-solis Edmundo Javier
- Garg Kunal
- Gargiulo Corrado
- Garibli Aydan
- Garner K.
- Gasik Piotr Jan
- Gauger Erin Frances
- Gautam Amrit
- Gay Ducati M. B.
- Germain Marie
- Ghosh Jhuma
- Ghosh Premomoy
- Ghosh Sanjay Kumar
- Giacalone Marco
- Gianotti Paola
- Giubellino Paolo
- Giubilato Piero
- Glaenzer Aude Marie Camille
- Glassel Peter
- Goh Daniel Jia Qin
- Gonzalez Hernandez Emma
- Gonzalez Trueba Laura Helena
- Gonzalez Victor
- Gorbunov Sergey
- Gorgon Marek Boguslaw
- Gorlich Lidia Maria
- Gotovac Sven
- Grabski Varlen
- Graczykowski Lukasz Kamil
- Greiner Leo Clifford
- Grelli Alessandro
- Grigoras Costin
- Grigoryan Smbat
- Grigoryev Vladislav
- Gromada Alena
- Grosa Fabrizio
- Grosse-oetringhaus Jan Fiete
- Grosso Raffaele
- Guernane Rachid
- Guilbaud Maxime Rene Joseph
- Gulbrandsen Kristjan Herlache
- Gunji Taku
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- Habib Michael Karim
- Hachiya Shimomura Maya
- Hadjidakis Cynthia Marie
- Hamagaki Hideki
- Hamid Mohammed
- Hannigan Ryan Patrick
- Haque Md Rihan
- Harlenderova A.
- Harris John William
- Harton Austin Vincent
- Hasenbichler Jan Anton
- Hassan Hadi
- Hatzifotiadou Despina
- Hauer Philip
- Havener Laura Brittany
- Hechavarria A. D. C. Bell
- Heckel Stefan Thomas
- Hellbar Ernst
- Helstrup Haavard
- Herman Tomas
- Herrera Corral Gerardo Antonio
- Herrmann Florian
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- Hou Yongzhen
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- Huang Chun-lu
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- Huhn Patrick
- Huhta Laura Maria
- Humanic Thomas
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- Husova L. A.
- Hutson Alek
- Iddon James Philip
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- Islam Md Samsul
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- Jalotra Ashish
- Janik Malgorzata Anna
- Janson Thomas
- Jercic Marko
- Jevons Oliver Thomas
- Jonas Florian
- Jones Peter Graham
- Jowett John
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- Jung Michael
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- Kalweit Alexander Philipp
- Kaplin Vladimir
- Karasu Uysal Ayben
- Karatovic David
- Karavichev Oleg
- Karavicheva Tatiana
- Karczmarczyk Przemyslaw
- Karpechev Evgeny
- Kashyap Varchaswi
- Kazantsev Andrey
- Kebschull Udo Wolfgang
- Keidel Ralf
- Keijdener D. L. D.
- Keil Markus
- Ketzer Bernhard Franz
- Khabanova Zhanna
- Khan Ahsan Mehmood
- Khan Mohammed Mohisin
- Khan Shaista
- Khanzadeev Alexei
- Kharlov Yury
- Khatun Anisa
- Khuntia Arvind
- Kileng Bjarte
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- Kollegger Thorsten Sven
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- Kroesen Martin
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- Willems Guido Alexander
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- Witt William Edward
- Wright Josephina Rae
- Wu Wenya
- Wu Yitao
- Xu Ran
- Yadav Arun Kumar
- Yalcin Kuzu Serpil
- Yamaguchi Yorito
- Yamakawa Kosei
- Yang Shiming
- Yano Satoshi
- Yin Zhongbao
- Yoo In Kwon
- Yoon Jin Hee
- Yu Zhi
- Yuan Shiming
- Yuncu Alperen
- Zaccolo Valentina
- Zampolli Chiara
- Zardoshti Nima
- Zarochentsev Andrey
- Zavada Petr
- Zavyalov Nikolay
- Zhalov Mikhail
- Zhang Biao
- Zhang Song
- Zhang Xiaoming
- Zhang Yifei
- Zherebchevskii Vladimir
- Zhigareva Natalia
- Zhou Daicui
- Zhou You
- Zhu Jianhui
- Zhu Ya
- Zinovjev Gennady
- Zurlo Nicola
- Publication venue
- HAL CCSD
- Publication date
- 22/09/2021
- Field of study
This article reports on the inclusive production cross section of several quarkonium states, J/ψ, ψ(2S), Υ(1S), Υ(2S), and Υ(3S), measured with the ALICE detector at the LHC, in \pp collisions at s=5.02 TeV. The analysis is performed in the dimuon decay channel at forward rapidity (2.5<y<4). The measured cross sections, assuming unpolarized quarkonia, are: σJ/ψ=5.88±0.03±0.34 μb, σψ(2S)=0.87±0.06±0.10 μb, σΥ(1S)=45.5±3.9±3.5 nb, σΥ(2S)=22.4±3.2±2.7 nb, and σΥ(3S)=4.9±2.2±1.0 nb, where the first (second) uncertainty is the statistical (systematic) one. The transverse-momentum (pT) and rapidity (y) differential cross sections for J/ψ, ψ(2S), Υ(1S), and the ψ(2S)-to-J/ψ cross section ratios are presented. For the first time, the cross sections of the three Υ states, as well as the ψ(2S) one as a function of pT and y, are measured at s=5.02 TeV at forward rapidity. These measurements also significantly extend the J/ψpT reach with respect to previously published results. A comparison with ALICE measurements in pp collisions at s=2.76, 7, 8, and 13 TeV is presented and the energy dependence of quarkonium production cross sections is discussed. Finally, the results are compared with the predictions from several production models
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