Evaluation of a ducted-fan power plant designed for high output and good cruise fuel economy

Theoretical analysis of performance of a ducted-fan power plant designed both for high-output, high-altitude operation at low supersonic Mach numbers and for good fuel economy at lower fight speeds is presented. Performance of ducted fan is compared with performance (with and without tail-pipe burner) of two hypothetical turbojet engines. At maximum power, the ducted fan has propulsive thrust per unit of frontal area between thrusts obtained by turbojet engines with and without tail-pipe burners. At cruise, the ducted fan obtains lowest thrust specific fuel consumption. For equal maximum thrusts, the ducted fan obtains cruising flight duration and range appreciably greater than turbojet engines

Differential Post-Exercise Blood Pressure Responses between Blacks and Caucasians

Post-exercise hypotension (PEH) is widely observed in Caucasians (CA) and is associated with histamine receptors 1- and 2- (H1R and H2R) mediated post-exercise vasodilation. However, it appears that blacks (BL) may not exhibit PEH following aerobic exercise. Hence, this study sought to determine the extent to which BL develop PEH, and the contri- bution of histamine receptors to PEH (or lack thereof) in this population. Forty-nine (22 BL, 27 CA) young and healthy subjects completed the study. Subjects were randomly assigned to take either a combined H1R and H2R antagonist (fexofenadine and ranitidine) or a con- trol placebo. Supine blood pressure (BP), cardiac output and peripheral vascular resistance measurements were obtained at baseline, as well as at 30 min, 60 min and 90 min after 45 min of treadmill exercise at 70% heart rate reserve. Exercise increased diastolic BP in young BL but not in CA. Post-exercise diastolic BP was also elevated in BL after exercise with histamine receptor blockade. Moreover, H1R and H2R blockade elicited differential responses in stroke volume between BL and CA at rest, and the difference remained follow- ing exercise. Our findings show differential BP responses following exercise in BL and CA, and a potential role of histamine receptors in mediating basal and post-exercise stroke vol- ume in BL. The heightened BP and vascular responses to exercise stimulus is consistent with the greater CVD risk in BL

Теорія та практика менеджменту безпеки

У збірнику подано тези доповідей та виступів учасників Міжнародної науково-практичної конференції, присвяченої питанням теорії менеджменту безпеки, безпеки особистості, прикладним аспектам забезпечення соціальної, екологічної, економічної безпеки підприємств, питанням механізму забезпечення соціоекологоекономічної безпеки регіону, проблемам забезпечення національної безпеки

TECHNOLOGICAL ASPECTS OF THE APPLICATION OF ADHESIVE POLYMER COMPOSITIONS FOR HYDRAULIC STRUCTURES

In the article the aspects of use of adhesion polymeric compositions for repair, renewal and waterproofing of concrete and ferro-concrete constructions are presented

NACA Research Memorandums

Theoretical analysis of performance of a ducted-fan power plant designed both for high-output, high-altitude operation at low supersonic Mach numbers and for good fuel economy at lower fight speeds is presented. Performance of ducted fan is compared with performance (with and without tail-pipe burner) of two hypothetical turbojet engines. At maximum power, the ducted fan has propulsive thrust per unit of frontal area between thrusts obtained by turbojet engines with and without tail-pipe burners. At cruise, the ducted fan obtains lowest thrust specific fuel consumption. For equal maximum thrusts, the ducted fan obtains cruising flight duration and range appreciably greater than turbojet engines

ТЕХНОЛОГІЧНІ АСПЕКТИ ЗАСТОСУВАННЯ АДГЕЗІЙНИХ ПОЛІМЕРНИХ КОМПОЗИЦІЙ ДЛЯ ГІДРОТЕХНІЧНИХ СПОРУД

In the article the aspects of use of adhesion polymeric compositions for repair, renewal and waterproofing ofconcrete and ferro-concrete constructions are presented.В статье представлены аспекты использования адгезионных полимерных композиций для ремонта, восстановления и гидроизоляции бетонных и железобетонных конструкций.У статті наведені аспекти використання адгезійних полімерних композицій для ремонту, відновлення і гідроізоляції бетонних і залізобетонних конструкцій

Divergent functions of the left and right central amygdala in visceral nociception

The left and right central amygdalae (CeA) are limbic regions involved in somatic and visceral pain processing. These 2 nuclei are asymmetrically involved in somatic pain modulation; pain-like responses on both sides of the body are preferentially driven by the right CeA, and in a reciprocal fashion, nociceptive somatic stimuli on both sides of the body predominantly alter molecular and physiological activities in the right CeA. Unknown, however, is whether this lateralization also exists in visceral pain processing and furthermore what function the left CeA has in modulating nociceptive information. Using urinary bladder distension (UBD) and excitatory optogenetics, a pronociceptive function of the right CeA was demonstrated in mice. Channelrhodopsin-2-mediated activation of the right CeA increased visceromotor responses (VMRs), while activation of the left CeA had no effect. Similarly, UBD-evoked VMRs increased after unilateral infusion of pituitary adenylate cyclase-Activating polypeptide in the right CeA. To determine intrinsic left CeA involvement in bladder pain modulation, this region was optogenetically silenced during noxious UBD. Halorhodopsin (NpHR)-mediated inhibition of the left CeA increased VMRs, suggesting an ongoing antinociceptive function for this region. Finally, divergent left and right CeA functions were evaluated during abdominal mechanosensory testing. In naive animals, channelrhodopsin-2-mediated activation of the right CeA induced mechanical allodynia, and after cyclophosphamide-induced bladder sensitization, activation of the left CeA reversed referred bladder pain-like behaviors. Overall, these data provide evidence for functional brain lateralization in the absence of peripheral anatomical asymmetries

Differential Post-Exercise Blood Pressure Responses between Blacks and Caucasians

Post-exercise hypotension (PEH) is widely observed in Caucasians (CA) and is associated with histamine receptors 1- and 2- (H1R and H2R) mediated post-exercise vasodilation. However, it appears that blacks (BL) may not exhibit PEH following aerobic exercise. Hence, this study sought to determine the extent to which BL develop PEH, and the contri- bution of histamine receptors to PEH (or lack thereof) in this population. Forty-nine (22 BL, 27 CA) young and healthy subjects completed the study. Subjects were randomly assigned to take either a combined H1R and H2R antagonist (fexofenadine and ranitidine) or a con- trol placebo. Supine blood pressure (BP), cardiac output and peripheral vascular resistance measurements were obtained at baseline, as well as at 30 min, 60 min and 90 min after 45 min of treadmill exercise at 70% heart rate reserve. Exercise increased diastolic BP in young BL but not in CA. Post-exercise diastolic BP was also elevated in BL after exercise with histamine receptor blockade. Moreover, H1R and H2R blockade elicited differential responses in stroke volume between BL and CA at rest, and the difference remained follow- ing exercise. Our findings show differential BP responses following exercise in BL and CA, and a potential role of histamine receptors in mediating basal and post-exercise stroke vol- ume in BL. The heightened BP and vascular responses to exercise stimulus is consistent with the greater CVD risk in BL

Peer-Led Diabetes Self-Management Program for Patients With Glycated Hemoglobin Values Greater Than 7%

INTRODUCTION: Type II diabetes mellitus is the 7th leading cause of death in Kalamazoo County. Glycated hemoglobin (HbA1c) is a biomarker used to evaluate blood glucose control spanning a 3-month period; a value \u3e7% indicates poorly controlled diabetes over the past 3 months. PURPOSE: To determine the effectiveness of a free diabetes self-management program when implemented in Kalamazoo County. METHODS: Nineteen individuals (5 males, 14 females, average age 58 years, range 39 to 82 years) with type II diabetes mellitus and a self-reported HbA1c \u3e7% enrolled in the study. These individuals began a 6-week diabetes self-management program, during which participants met in small groups for 2.5 hours each week. The focus of this program was for participants to build skills that enabled them to better manage their chronic disease by improving problem solving, nutrition, blood glucose monitoring, and working with healthcare providers. HbA1c values were obtained via medical records prior to program completion (baseline) and 3-months post-program. Surveys that evaluated subjective information were also obtained at baseline and 3-months post-program. RESULTS: Nearly 950 members of the Kalamazoo community with type II diabetes mellitus were contacted to participate in this free self-management program. Recruitment was a challenge as only 99 verbally agreed they would attend the program, of which 48 attended the first session and 19 of those enrolled in the study. Five participants were excluded due to medical-record-documented HbA1c values \u3c7%, 6 did not complete the program, and 1 was lost to follow-up. Of the 7 participants who completed their 3-month follow-up, most variables exhibited desirable trends from baseline to 3-months post-program, and those that remained unchanged were already within a desirable range at baseline. The variables closest to significance were an increase in median self-efficacy score (49 to 78 using a 0-80 scale, p = 0.062) and a decrease in median HbA1c (10.2% to 8.5%, p = 0.31). DISCUSSION: Despite limited statistical power due to small sample size, this program provided valuable education to many community members who may be considered underserved and have HbA1c values as high as 14%. Future work is needed to analyze the healthcare barriers these individuals endure and how they may be overcome. Facilitation of healthcare provider referral to the program may be an option that encourages both participant adherence and expansion of this low-cost diabetes education model throughout the community