1,030 research outputs found
Quantum computation in optical lattices via global laser addressing
A scheme for globally addressing a quantum computer is presented along with
its realisation in an optical lattice setup of one, two or three dimensions.
The required resources are mainly those necessary for performing quantum
simulations of spin systems with optical lattices, circumventing the necessity
for single qubit addressing. We present the control procedures, in terms of
laser manipulations, required to realise universal quantum computation. Error
avoidance with the help of the quantum Zeno effect is presented and a scheme
for globally addressed error correction is given. The latter does not require
measurements during the computation, facilitating its experimental
implementation. As an illustrative example, the pulse sequence for the
factorisation of the number fifteen is given.Comment: 11 pages, 10 figures, REVTEX. Initialisation and measurement
procedures are adde
Quantification of nitrotyrosine in nitrated proteins
For kinetic studies of protein nitration reactions, we have developed a method for the quantification of nitrotyrosine residues in protein molecules by liquid chromatography coupled to a diode array detector of ultraviolet-visible absorption. Nitrated bovine serum albumin (BSA) and nitrated ovalbumin (OVA) were synthesized and used as standards for the determination of the protein nitration degree (ND), which is defined as the average number of nitrotyrosine residues divided by the total number of tyrosine residues in a protein molecule. The obtained calibration curves of the ratio of chromatographic peak areas of absorbance at 357 and at 280Â nm vs. nitration degree are nearly the same for BSA and OVA (relative deviations <5%). They are near-linear at low ND (< 0.1) and can be described by a second-order polynomial fit up to \documentclass[12pt]{minimal}
\usepackage{amsmath}
\usepackage{wasysym}
\usepackage{amsfonts}
\usepackage{amssymb}
\usepackage{amsbsy}
\usepackage{mathrsfs}
\usepackage{upgreek}
\setlength{\oddsidemargin}{-69pt}
\begin{document}\end{document}. A change of chromatographic column led to changes in absolute peak areas but not in the peak area ratios and related calibration functions, which confirms the robustness of the analytical method. First results of laboratory experiments confirm that the method is applicable for the investigation of the reaction kinetics of protein nitration. The main advantage over alternative methods is that nitration degrees can be efficiently determined without hydrolysis or digestion of the investigated protein molecules
Hsp70 in mitochondrial biogenesis
The family of hsp70 (70 kilodalton heat shock protein) molecular chaperones plays an essential and diverse role in cellular physiology, Hsp70 proteins appear to elicit their effects by interacting with polypeptides that present domains which exhibit non-native conformations at distinct stages during their life in the cell. In this paper we review work pertaining to the functions of hsp70 proteins in chaperoning mitochondrial protein biogenesis. Hsp70 proteins function in protein synthesis, protein translocation across mitochondrial membranes, protein folding and finally the delivery of misfolded proteins to proteolytic enzymes in the mitochondrial matrix
Inter-relationship of plasma markers of oxidative stress and thyroid hormones in schizophrenics
<p>Abstract</p> <p>Background</p> <p>The relationship of oxidative stress to thyroid hormones has not been studied in the schizophrenics. The present study determined the status and interrelationship of plasma markers of oxidative stress, nitric oxide and thyroid hormones in thirty (17 males and 13 females) newly diagnosed patients with acute schizophrenia before initiation of chemotherapy. Twenty five (13 males and 12 females) mentally healthy individuals served as controls. Patients and controls with history of hard drugs (including alcohol and cigarette), pre-diagnosis medications (e.g. antiparkinsonian/antipsychotic drugs), chronic infections, liver disease and diabetes mellitus were excluded from the study. Plasma levels of total antioxidant potential (TAP), total plasma peroxides (TPP), nitric oxide (NO), malondialdehyde (MDA), thyroxine (T4), tri-iodothyronine (T3) and thyroid stimulating hormone (TSH) were determined in all participants using spectrophotometric and enzyme linked immunosorbent assay (ELISA) methods respectively. Oxidative stress index (OSI) was calculated as the percent ratio of total plasma peroxides and total antioxidant potential.</p> <p>Findings</p> <p>Significantly higher plasma levels of MDA (p < 0.01), TPP (p < 0.01), OSI (p < 0.01), T3 (p < 0.01) and T4 (p < 0.05) were observed in schizophrenics when compared with the controls. The mean levels of TAP, NO and TSH were significantly lower in schizophrenics (p < 0.01) when compared with the controls. The result shows that T3 values correlate significantly with MDA (p < 0.05) and TPP (p < 0.01) in schizophrenics.</p> <p>Conclusions</p> <p>Higher level of TPP may enhance thyroid hormogenesis in schizophrenics. Adjuvant antioxidant therapy may be a novel approach in the treatment of schizophrenic patients.</p
Oxidative stress and vascular remodelling
Oxidative stress plays an important role in the pathophysiology of vascular diseases. Reactive
oxygen species, especially superoxide anion and hydrogen peroxide, are important signalling
molecules in cardiovascular cells. Enhanced superoxide production increases nitric oxide
inactivation and leads to an accumulation of peroxynitrites and hydrogen peroxide. Reactive
oxygen species participate in growth, apoptosis and migration of vascular smooth muscle cells,
in the modulation of endothelial function, including endothelium-dependent relaxation and
expression of proinflammatory phenotype, and in the modification of the extracellular matrix.
All these events play important roles in vascular diseases such as hypertension, suggesting that
the sources of reactive oxygen species and the signalling pathways that theymodifymay represent
important therapeutic targets. Potential sources of vascular superoxide production include
NADPH-dependent oxidases, xanthine oxidases, lipoxygenases, mitochondrial oxidases and
nitricoxide synthases. Studies performedduring the last decadehave shownthatNADPHoxidase
is the most important source of superoxide anion in phagocytic and vascular cells. Evidence from
experimental animal and human studies suggests a significant role ofNADPHoxidase activation
in the vascular remodelling and endothelial dysfunction found in cardiovascular diseases
In-Plane Deformation Mechanics for Highly Stretchable Electronics
Scissoring in thick bars suppresses buckling behavior in serpentine traces that have thicknesses greater than their widths, as detailed in a systematic set of analytical and experimental studies. Scissoring in thick copper traces enables elastic stretchability as large as approximate to 350%, corresponding to a sixfold improvement over previously reported values for thin geometries (approximate to 60%).</p
Hidden transcripts of the gig economy:Labour agency and the new art of resistance among African gig workers
MATISSE, perspective of imaging in the mid-infrared at the VLTI
International audienceMATISSE is foreseen as a mid-infrared spectro-interferometer combining the beams of up to four UTs/ATs of the Very Large Telescope Interferometer (VLTI) of the European Southern Observatory. The related science case study demonstrates the enormous capability of a new generation mid-infrared beam combiner. MATISSE will constitute an evolution of the two-beam interferometric instrument MIDI. MIDI is a very successful instrument which offers a perfect combination of spectral and angular resolution. New characteristics present in MATISSE will give access to the mapping and the distribution of the material (typically dust) in the circumstellar environments by using a wide mid-infrared band coverage extended to L, M and N spectral bands. The four beam combination of MATISSE provides an efficient UV-coverage : 6 visibility points are measured in one set and 4 closure phase relations which can provide aperture synthesis images in the mid-infrared spectral regime
- âŠ