701 research outputs found
Strong interference effects in the resonant Auger decay of atoms induced by intense X-Ray fields
The theory of resonant Auger decay of atoms in a high intensity coherent
X-ray pulse is presented. The theory includes the coupling between the ground
state and the resonance due to an intense X-ray pulse, taking into account the
decay of the resonance and the direct photoionization of the ground state, both
populating the final ionic states coherently. The theory also considers the
impact of the direct photoionization of the resonance state itself which
typically populates highly-excited ionic states. The combined action of the
resonant decay and of the direct ionization of the ground state in the field
induces a non-hermitian time-dependent coupling between the ground and the
'dressed' resonance stats. The impact of these competing processes on the total
electron yield and on the 2s2p3p P spectator and
2s2p S participator Auger decay spectra of the Ne 1s3p
resonance is investigated. The role of the direct photoionization of the ground
state and of the resonance increases dramatically with the field intensity.
This results in strong interference effects with distinct patterns in the
electron spectra, different for the participator and spectator final states.Comment: 31 pages, 6 figure
Entwicklung eines Referenzvorgehensmodells zur Auswahl und Einführung von Office Suiten
Resonant Auger decay of the core-excited CO molecule in intense X-ray laser fields
The dynamics of the resonant Auger (RA) process of the core-excited
CO(1s) molecule in an intense X-ray laser field is
studied theoretically. The theoretical approach includes the analogue of the
conical intersections of the complex potential energy surfaces of the ground
and `dressed' resonant states due to intense X-ray pulses, taking into account
the decay of the resonance and the direct photoionization of the ground state,
both populating the same final ionic states coherently, as well as the direct
photoionization of the resonance state itself. The light-induced non-adiabatic
effect of the analogue of the conical intersections of the resulting complex
potential energy surfaces gives rise to strong coupling between the electronic,
vibrational and rotational degrees of freedom of the diatomic CO molecule. The
interplay of the direct photoionization of the ground state and of the decay of
the resonance increases dramatically with the field intensity. The coherent
population of a final ionic state via both the direct photoionization and the
resonant Auger decay channels induces strong interference effects with distinct
patterns in the RA electron spectra. The individual impact of these physical
processes on the total electron yield and on the CO electron
spectrum are demonstrated.Comment: 13 figs, 1 tabe
Does a Hypertrophying Muscle Fibre Reprogramme its Metabolism Similar to a Cancer Cell?
In 1924, Otto Warburg asked “How does the metabolism of a growing tissue differ from that of a non-growing tissue?” Currently, we know that proliferating healthy and cancer cells reprogramme their metabolism. This typically includes increased glucose uptake, glycolytic flux and lactate synthesis. A key function of this reprogramming is to channel glycolytic intermediates and other metabolites into anabolic reactions such as nucleotide-RNA/DNA synthesis, amino acid-protein synthesis and the synthesis of, for example, acetyl and methyl groups for epigenetic modification. In this review, we discuss evidence that a hypertrophying muscle similarly takes up more glucose and reprogrammes its metabolism to channel energy metabolites into anabolic pathways. We specifically discuss the functions of the cancer-associated enzymes phosphoglycerate dehydrogenase and pyruvate kinase muscle 2 in skeletal muscle. In addition, we ask whether increased glucose uptake by a hypertrophying muscle explains why muscularity is often negatively associated with type 2 diabetes mellitus and obesity
Modified spin-wave theory with ordering vector optimization I: frustrated bosons on the spatially anisotropic triangular lattice
We investigate a system of frustrated hardcore bosons, modeled by an XY
antiferromagnet on the spatially anisotropic triangular lattice, using
Takahashi's modified spin-wave (MSW) theory. In particular we implement
ordering vector optimization on the ordered reference state of MSW theory,
which leads to significant improvement of the theory and accounts for quantum
corrections to the classically ordered state. The MSW results at zero
temperature compare favorably to exact diagonalization (ED) and projected
entangled-pair state (PEPS) calculations. The resulting zero-temperature phase
diagram includes a 1D quasi-ordered phase, a 2D Neel ordered phase, and a 2D
spiraling ordered phase. We have strong indications that the various ordered or
quasi-ordered phases are separated by spin-liquid phases with short-range
correlations, in analogy to what has been predicted for the Heisenberg model on
the same lattice. Within MSW theory we also explore the finite-temperature
phase diagram. We find that the zero-temperature long-range-ordered phases turn
into quasi-ordered phases (up to a Berezinskii-Kosterlitz-Thouless
temperature), while zero-temperature quasi-ordered phases become short-range
correlated at finite temperature. These results show that modified spin-wave
theory is very well suited for describing ordered and quasi-ordered phases of
frustrated XY spins (or, equivalently, of frustrated lattice bosons) both at
zero and finite temperatures. While MSW theory, just as other theoretical
methods, cannot describe spin-liquid phases, its breakdown provides a fast
method for singling out Hamiltonians which may feature these intriguing quantum
phases. We thus suggest a tool for guiding our search for interesting systems
whose properties are necessarily studied with a physical quantum simulator.Comment: 40 pages, 16 figure
Semidefinite Characterization and Computation of Real Radical Ideals
For an ideal given by a set of generators, a new
semidefinite characterization of its real radical is
presented, provided it is zero-dimensional (even if is not). Moreover we
propose an algorithm using numerical linear algebra and semidefinite
optimization techniques, to compute all (finitely many) points of the real
variety as well as a set of generators of the real radical
ideal. The latter is obtained in the form of a border or Gr\"obner basis. The
algorithm is based on moment relaxations and, in contrast to other existing
methods, it exploits the real algebraic nature of the problem right from the
beginning and avoids the computation of complex components.Comment: 41 page
Quasimolecular electronic structure of the spin-liquid candidate Ba3InIr2O9
The mixed-valent iridate Ba3InIr2O9 has been discussed as a promising candidate for quantum spin-liquid behavior. The compound exhibits Ir4.5+ ions in face-sharing IrO6 octahedra forming Ir2O9 dimers with three t2g holes per dimer. Our results establish Ba3InIr2O9 as a cluster Mott insulator. Strong intradimer hopping delocalizes the three t2g holes in quasimolecular dimer states while interdimer charge fluctuations are suppressed by Coulomb repulsion. The magnetism of Ba3InIr2O9 emerges from spin-orbit entangled quasimolecular moments with yet unexplored interactions, opening up a new route to unconventional magnetic properties of 5d compounds. Using single-crystal x-ray diffraction we find the monoclinic space group C2/c already at room temperature. Dielectric spectroscopy shows insulating behavior. Resonant inelastic x-ray scattering reveals a rich excitation spectrum below 1.5 eV with a sinusoidal dynamical structure factor that unambiguously demonstrates the quasimolecular character of the electronic states. Below 0.3 eV, we observe a series of excitations. According to exact diagonalization calculations, such low-energy excitations reflect the proximity of Ba3InIr2O9 to a hopping-induced phase transition based on the condensation of a quasimolecular spin-orbit exciton. The dimer ground state roughly hosts two holes in a bonding j=12 orbital and the third hole in a bonding j=32 orbital
ISOGAL: A deep survey of the obscured inner Milky Way with ISO at 7 and 15 micron and with DENIS in the near-infrared
The ISOGAL project is an infrared survey of specific regions sampling the
Galactic Plane selected to provide information on Galactic structure,stellar
populations,stellar mass-loss and the recent star formation history of the
inner disk and Bulge of the Galaxy. ISOGAL combines 7 and 15 micron ISOCAM
observations - with a resolution of 6'' at worst - with DENIS IJKs data to
determine the nature of the sources and theinterstellar extinction. We have
observed about 16 square degrees with a sensitivity approaching 10-20mJy,
detecting ~10^5 sources,mostly AGB stars,red giants and young stars. The main
features of the ISOGAL survey and the observations are summarized in this
paper,together with a brief discussion of data processing and quality. The
primary ISOGAL products are described briefly (a full description is given in
Schuller et al. 2003, astro-ph/0304309): viz. the images and theISOGAL-DENIS
five-wavelength point source catalogue. The main scientific results already
derived or in progress are summarized. These include astrometrically calibrated
7 and 15um images,determining structures of resolved sources; identification
and properties of interstellar dark clouds; quantification of the infrared
extinction law and source dereddening; analysis of red giant and (especially)
AGB stellar populations in the central Bulge,determining luminosity,presence of
circumstellar dust and mass--loss rate,and source classification,supplemented
in some cases by ISO/CVF spectroscopy; detection of young stellar objects of
diverse types,especially in the inner Bulge with information about the present
and recent star formation rate; identification of foreground sources with
mid-IR excess. These results are the subject of about 25 refereed papers
published or in preparation.Comment: A&A in press. 19 pages,10 Ps figures; problems with figures fixe
Mucus detachment by host metalloprotease meprin \beta requires shedding of its inactive pro-form, which is abrogated by the pathogenic protease RgpB
The host metalloprotease meprin β is required for mucin 2 (MUC2) cleavage, which drives intestinal mucus detachment and prevents bacterial overgrowth. To gain access to the cleavage site in MUC2, meprin β must be proteolytically shed from epithelial cells. Hence, regulation of meprin β shedding and activation is important for physiological and pathophysiological conditions. Here, we demonstrate that meprin β activation and shedding are mutually exclusive events. Employing ex vivo small intestinal organoid and cell culture experiments, we found that ADAM-mediated shedding is restricted to the inactive pro-form of meprin β and is completely inhibited upon its conversion to the active form at the cell surface. This strict regulation of meprin β activity can be overridden by pathogens, as demonstrated for the bacterial protease Arg-gingipain (RgpB). This secreted cysteine protease potently converts membrane-bound meprin β into its active form, impairing meprin β shedding and its function as a mucus-detaching protease
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