Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome associated with COVID-19: An Emulated Target Trial Analysis.

RATIONALE: Whether COVID patients may benefit from extracorporeal membrane oxygenation (ECMO) compared with conventional invasive mechanical ventilation (IMV) remains unknown. OBJECTIVES: To estimate the effect of ECMO on 90-Day mortality vs IMV only Methods: Among 4,244 critically ill adult patients with COVID-19 included in a multicenter cohort study, we emulated a target trial comparing the treatment strategies of initiating ECMO vs. no ECMO within 7 days of IMV in patients with severe acute respiratory distress syndrome (PaO2/FiO2 <80 or PaCO2 ≥60 mmHg). We controlled for confounding using a multivariable Cox model based on predefined variables. MAIN RESULTS: 1,235 patients met the full eligibility criteria for the emulated trial, among whom 164 patients initiated ECMO. The ECMO strategy had a higher survival probability at Day-7 from the onset of eligibility criteria (87% vs 83%, risk difference: 4%, 95% CI 0;9%) which decreased during follow-up (survival at Day-90: 63% vs 65%, risk difference: -2%, 95% CI -10;5%). However, ECMO was associated with higher survival when performed in high-volume ECMO centers or in regions where a specific ECMO network organization was set up to handle high demand, and when initiated within the first 4 days of MV and in profoundly hypoxemic patients. CONCLUSIONS: In an emulated trial based on a nationwide COVID-19 cohort, we found differential survival over time of an ECMO compared with a no-ECMO strategy. However, ECMO was consistently associated with better outcomes when performed in high-volume centers and in regions with ECMO capacities specifically organized to handle high demand. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Exploring continual learning strategies in artificial neural networks through graph-based analysis of connectivity: insights from a brain-inspired perspective

Artificial Neural Networks (ANNs) aim at mimicking information processing in biological networks. In cognitive neuroscience, graph modeling is a powerful framework widely used to study brain structural and functional connectivity. Yet, the extension of graph modeling to ANNs has been poorly explored especially in term of functional connectivity (i.e. the contextual change of the activity's units in networks). From the perspective of designing more robust and interpretable ANNs, we study how a brain-inspired graph-based approach can be extended and used to investigate their properties and behaviors. We focus our study on different continual learning strategies inspired by the human brain and modeled with ANNs. We show that graph modeling offers a simple and elegant framework to deeply investigate ANNs, compare their performances and explore deleterious behaviors such as catastrophic forgetting

Exploring continual learning strategies in artificial neural networks through graph-based analysis of connectivity: insights from a brain-inspired perspective

Artificial Neural Networks (ANNs) aim at mimicking information processing in biological networks. In cognitive neuroscience, graph modeling is a powerful framework widely used to study brain structural and functional connectivity. Yet, the extension of graph modeling to ANNs has been poorly explored especially in term of functional connectivity (i.e. the contextual change of the activity's units in networks). From the perspective of designing more robust and interpretable ANNs, we study how a brain-inspired graph-based approach can be extended and used to investigate their properties and behaviors. We focus our study on different continual learning strategies inspired by the human brain and modeled with ANNs. We show that graph modeling offers a simple and elegant framework to deeply investigate ANNs, compare their performances and explore deleterious behaviors such as catastrophic forgetting

Exploring continual learning strategies in artificial neural networks through graph-based analysis of connectivity: insights from a brain-inspired perspective

Artificial Neural Networks (ANNs) aim at mimicking information processing in biological networks. In cognitive neuroscience, graph modeling is a powerful framework widely used to study brain structural and functional connectivity. Yet, the extension of graph modeling to ANNs has been poorly explored especially in term of functional connectivity (i.e. the contextual change of the activity's units in networks). From the perspective of designing more robust and interpretable ANNs, we study how a brain-inspired graph-based approach can be extended and used to investigate their properties and behaviors. We focus our study on different continual learning strategies inspired by the human brain and modeled with ANNs. We show that graph modeling offers a simple and elegant framework to deeply investigate ANNs, compare their performances and explore deleterious behaviors such as catastrophic forgetting

Exploring continual learning strategies in artificial neural networks through graph-based analysis of connectivity: insights from a brain-inspired perspective

Artificial Neural Networks (ANNs) aim at mimicking information processing in biological networks. In cognitive neuroscience, graph modeling is a powerful framework widely used to study brain structural and functional connectivity. Yet, the extension of graph modeling to ANNs has been poorly explored especially in term of functional connectivity (i.e. the contextual change of the activity's units in networks). From the perspective of designing more robust and interpretable ANNs, we study how a brain-inspired graph-based approach can be extended and used to investigate their properties and behaviors. We focus our study on different continual learning strategies inspired by the human brain and modeled with ANNs. We show that graph modeling offers a simple and elegant framework to deeply investigate ANNs, compare their performances and explore deleterious behaviors such as catastrophic forgetting

Exploring continual learning strategies in artificial neural networks through graph-based analysis of connectivity: insights from a brain-inspired perspective

Artificial Neural Networks (ANNs) aim at mimicking information processing in biological networks. In cognitive neuroscience, graph modeling is a powerful framework widely used to study brain structural and functional connectivity. Yet, the extension of graph modeling to ANNs has been poorly explored especially in term of functional connectivity (i.e. the contextual change of the activity's units in networks). From the perspective of designing more robust and interpretable ANNs, we study how a brain-inspired graph-based approach can be extended and used to investigate their properties and behaviors. We focus our study on different continual learning strategies inspired by the human brain and modeled with ANNs. We show that graph modeling offers a simple and elegant framework to deeply investigate ANNs, compare their performances and explore deleterious behaviors such as catastrophic forgetting

Enhancing the learning of evolutionary anthropology skills by combining student‐active teaching with actual and virtual immersion of Master's students in fieldwork, laboratory practice, and dissemination

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