New complexes of manganese (II) and copper (II) derived from the two new furopyran-3, 4-dione ligands: synthesis, spectral characterization, ESR, DFT studies and evaluation of antimicrobial activity

A total of four new metal complex derivatives of two new ligands 2-(hydroxy(phenyl)-6-methyl-2H-furo [3,2-c]pyran-3,4-dione (L1) and 2-(hydroxyl (2-hydroxyphenyl) -6-methyl-2H-furo [3,2-c]pyran-3,4-dione (L2) with the metal ions Mn(II) and Cu(II) have been successfully prepared in alcoholic medium. The complexes obtained are investigated by spectral studies with the use of FT-IR and UV–vis techniques, ESR and magnetic measurements. The IR spectra suggest that the oxygen atoms of the two ligands are engaged in the bond with the central metal. The electronic spectra of the complexes and their magnetic moments provide information about geometries. The molar conductance measurements showed that the complexes are non-electrolytes. Theoretical calculations invoking geometry optimization and molecular orbital description HOMO and LUMO are done using DFT density functional theory. The experimental results and the calculated structural parameters, bond distances and angles, revealed a distorted octahedral geometries around the manganese and copper center through the oxygen of the furan ring for the synthesized complexes ([M(L)2(H2O)2]nH2O; M: metal; L: ligand). The antimicrobial activity of the ligands and their complexes was evaluated in vitro against different bacteria and fungi using agar diffusion method. The ligands and their complexes of manganese (II) and copper (II) exhibited a strong antifungal activity. Copper and manganese complexes have different antibacterial properties against bacteria. The ligand L1 and there complexes were found to be more active against Gram-positive than Gram-negative bacteria.publishe

Synthesis, characterisation, estimation of ground-and excited-state dipole moments using solvatochromic shift and theoretical studies of new iminocoumarin derivatives

The study on the fluorescence and UV–Vis absorption of some iminocoumarins at ambient temperature in several solvents showed a bathochromic shift with the increase of the solvent polarity. The use of the solvathochromic method allowed us to determine the dipole moment in both ground and excited states. The studied molecules exhibit much higher dipole moments in the excited state than in the ground state, which can be due to the redistribution of π-electron densities in the excited state making molecules more polar with higher dipole moments. Furthermore, HOMO–LUMO gap were also estimated theoretically using B3LYP/6–311 + G (d,p) level of theory; the low energy gap indicated the eventual charge transfer interaction occurring in the molecules, and responsible for their light emitting properties.publishe

A One-Pot Diastereoselective Synthesis of 2-[Aryl(hydroxy)methyl]-6-methyl-2H-furo[3,2-c]pyran-3,4-diones: Crystallographic Evidence for the Furanone Ring Closure

Novel furopyran-3,4-dione-fused heterocycles have been obtained by a one-pot reaction of -brominated dehydroacetic acid and benzaldehydes under organobase conditions. The prepared 2-[aryl(hydroxy)methyl]-6-methyl-2H-furo[3,2-c]pyran-3,4-diones were fully characterized by 2D NMR spectroscopy and supported by single-crystal X-ray analysis to unequivocally prove the furan-3-one five-membered ring-closure mechanism instead of the dihydroflavanon-3-ol six-membered cyclization which has recently been proposed in the literature

Removal of phenol from aqueous solution using polymer inclusion membrane based on mixture of CTA and CA

Abstract Nowadays, there are increasingly stringent regulations requiring more and more treatment of industrial effluents to generate product waters which could be easily reused or disposed of to the environment without any harmful effects. In the present work, the removal of phenol from aqueous solution across polymer inclusion membrane (PIM), based on mixture of cellulose triacetate and cellulose acetate as support (75/25%), calix[4]resorcinarene derivative as a carrier and 2-nitrophenyl octyl ether (2-NPOE) as plasticizer was investigated. The experimental part of this investigation involved the influence of carrier nature, plasticizer concentration, pH phases, and phenol initial concentration on the removal efficiency of phenol from synthetic wastewater. A PIM containing 0.1 g (of mixture polymer), (0.15 g/g mixture of polymer) of carrier and (0.03 ml/g mixture of polymer) of 2-NPOE provided the highest percentage of phenol removal efficiency over a 6-day transport; the removal was found to be about 95%, indeed the removal was found to be highly dependent of pH phases. The feed solution in these transport experiments was at pH 2, while the stripping solution contained 0.20 M NaOH. This study claims that the PIM with a mixture of cellulose derivatives can be used effectively to remove phenols from wastewaters

A Microwave-Assisted and Heteropolyacids-Catalysed Cyclocondensation Reaction for the Synthesis of 4(3H)-Quinazolinones

We have investigated a microwave–assisted synthesis of 4(3H)–quinazolinonesby condensation of anthranilic acid, orthoesters (or formic acid) and substituted anilines,using Keggin-type heteropolyacids (H3PW12O40·13H2O, H4SiW12O40·13H2O,H4SiMo12O40·13H2O or H3PMo12O40·13H2O) as catalysts. We found that the the use of H3PW12O40·13H2O acid coupled to microwave irradiation allows a solvent-free, rapid (~ 13min) and high-yielding reaction

Recyclable Keggin Heteropolyacids as an Environmentally Benign Catalyst for the Synthesis of New 2-Benzoylamino-N-phenyl-benzamide Derivatives under Microwave Irradiations at Solvent-Free Conditions and the Evaluation of Biological Activity

2-Benzoylamino-N-phenyl-benzamide derivatives (5a–h) were prepared from 2-phenyl-3,1-(4H)-benzoxazin-4-one 3 and substituted anilines 4a–h in the presence of a Keggin-type heteropolyacids series (H3PW12O40·13H2O; H4SiW12O40·13H2O; H4SiMo12O40·13H2O; and H3PMo12O40·13H2O) as catalysts without solvent and under microwave irradiation. We found that the use of H3PW12O40·13H2O acid coupled to microwave irradiation allowed obtaining a high-yielding reaction with a short time. The compound structures were established by 1H-NMR and 13C-NMR. The antibacterial and antifungal activities of the synthesized compounds exhibited an inhibition of the growth of bacteria and fungi

New complexes of manganese (II) and copper (II) derived from the two new furopyran-3, 4-dione ligands: Synthesis, spectral characterization, ESR, DFT studies and evaluation of antimicrobial activity

A total of four new metal complex derivatives of two new ligands 2-(hydroxy(phenyl)-6-methyl-2H-furo [3,2-c]pyran-3,4-dione (L1) and 2-(hydroxyl (2-hydroxyphenyl) -6-methyl-2H-furo [3,2-c]pyran-3,4-dione (L2) with the metal ions Mn(II) and Cu(II) have been successfully prepared in alcoholic medium. The complexes obtained are investigated by spectral studies with the use of FT-IR and UV–vis techniques, ESR and magnetic measurements. The IR spectra suggest that the oxygen atoms of the two ligands are engaged in the bond with the central metal. The electronic spectra of the complexes and their magnetic moments provide information about geometries. The molar conductance measurements showed that the complexes are non-electrolytes. Theoretical calculations invoking geometry optimization and molecular orbital description HOMO and LUMO are done using DFT density functional theory. The experimental results and the calculated structural parameters, bond distances and angles, revealed a distorted octahedral geometries around the manganese and copper center through the oxygen of the furan ring for the synthesized complexes ([M(L)2(H2O)2]nH2O; M: metal; L: ligand). The antimicrobial activity of the ligands and their complexes was evaluated in vitro against different bacteria and fungi using agar diffusion method. The ligands and their complexes of manganese (II) and copper (II) exhibited a strong antifungal activity. Copper and manganese complexes have different antibacterial properties against bacteria. The ligand L1 and there complexes were found to be more active against Gram-positive than Gram-negative bacteria.publishe