Dexketoprofen/tramadol 25 mg/75 mg: randomised double-blind trial in moderate-to-severe acute pain after abdominal hysterectomy

Statistical Analysis of TOTPAR over 2, 4, 6 and 8 h (ANCOVA) (ITT Population) (single-dose phase). (DOCX 16 kb

Dynamic optimization of a gas-liquid reactor

The final publication is available at Springer via http://dx.doi.org/10.1007/s10910-011-9941-1A dynamic gas-liquid transfer model without chemical reaction based on unsteady film theory is considered. In this case, the mathematical model presented for gas-liquid mass-transfer processes is based on mass balances of the transferred substance in both phases. The identificability property of this model is studied in order to confirm the possible identifiable parameters of the model from a given set of experimental data. For that, a different modeled of the system is given. A procedure for the identification is proposed. On the other hand, the aim of this work is to solve the quadratic optimal control problem, using an explicit representation of the model. The problem includes some results on controllability, observability and stability criteria and the relation between these properties and the parameters of the model. Using the optimal control problem we study the stability of the system and show how the choice of the weighting matrices can improve the behavior of the system but with an increase of the energy control cost. © 2011 Springer Science+Business Media, LLC.This work has been partially supported by PAID-05-10-003-295 and by MTM2010-18228.Cantó Colomina, B.; Cardona Navarrete, SC.; Coll, C.; Navarro-Laboulais, J.; Sánchez, E. (2012). Dynamic optimization of a gas-liquid reactor. Journal of Mathematical Chemistry. 50(2):381-393. https://doi.org/10.1007/s10910-011-9941-1S381393502Bayón L., Grau J.M., Ruiz M.M., Suárez P.M.: Initial guess of the solution of dynamic optimization of chemical processes. J. Math. Chem. Model. 48, 28–37 (2010)Ben-Zvi A., McLellan P.J., McAuley K.B.: Ind. Eng. Chem. Res. 42, 6607–6618 (2003)Cantó B., Coll C., Sánchez E.: Structural identifiability of a model of dialysis. Math. Comp. Model. 50, 733–737 (2009)Cantó B., Coll C., Sánchez E.: Identifiability of a class of discretized linear partial differential algebraic equations. Math. Probl. Eng. 2011, 1–12 (2011)Craciun G., Pantea C.: Identifiability of chemical reaction networks. J. Math. Chem. 44, 244–259 (2008)Dai L.: Descriptor Control Systems. Springer, New York (1989)Deckwer W.D.: Bubble Column Reactors. Wiley, Chichester (1992)Kantarci N., Borak F., Ulgen K.O.: Bubble column reactors. Proc. Biochem. 40(7), 2263–2283 (2005)Kawakernaak H., Sivan R.: Linear Optimal Control Systems. Wiley-Interscience, New York (1972)Kuo B.C.: Automatic Control Systems, 6th edn. Prentice-Hall, Englewood Cliffs (1991)Navarro-Laboulais J., Cardona S.C., Torregrosa J.I., Abad A., López F.: Practical identifiability analysis in dynamic gas-liquid reactors. Optimal experimental design for mass-transfer parameters determination. Comp. Chem. Eng. 32, 2382–2394 (2008)Navarro-Laboulais J., López F., Torregrosa J.I., Cardona S.C., Abad A.: Transient response, model structure and systematic errors in hybrid respirometers: structural identifiabilit analysis based on OUR and DO measurements. J. Math. Chem. 44(4), 969–990 (2007)Patel R., Munro N.: Multivariable Systen. Theory and Design. Pergamon Press, New York (1982)Sondergeld K.: A generalization of the Routh–Hurwitz stability criteria and a application to a problem in robust controller design. IEEE Trans. Automat. Contr. AC-28(10), 965–970 (1983

Circulating concentrations of GDF11 are positively associated with TSH levels in humans

Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor (TGF)-beta superfamily which declines with age and has been proposed as an anti-aging factor with regenerative effects in skeletal muscle in mice. However, recent data in humans and mice are conflicting, casting doubts about its true functional actions. The aim of the present study was to analyze the potential involvement of GFD11 in energy homeostasis in particular in relation with thyroid hormones. Serum concentrations of GDF11 were measured by enzyme-linked immunosorbent assay (ELISA) in 287 subjects. A highly significant positive correlation was found between GDF11 and thyroid-stimulating hormone (TSH) concentrations (r = 0.40, p 0.05 for both) with GDF11 levels. In a multiple linear regression analysis, the model that best predicted logGDF11 included logTSH, leptin, body mass index (BMI), age, and C-reactive protein (logCRP). This model explained 37% of the total variability of logGDF11 concentrations (p < 0.001), with only logTSH being a significant predictor of logGDF11. After segregating subjects by TSH levels, those within the low TSH group exhibited significantly decreased (p < 0.05) GDF11 concentrations as compared to the normal TSH group or the high TSH group. A significant correlation of GDF11 levels with logCRP (r = 0.19, p = 0.025) was found. GDF11 levels were not related to the presence of hypertension or cardiopathy. In conclusion, our results show that circulating concentrations of GDF11 are closely associated with TSH concentrations and reduced in subjects with low TSH levels. However, GDF11 is not related to the regulation of energy expenditure. Our data also suggest that GDF11 may be involved in the regulation of inflammation, without relation to cardiac function. Further research is needed to elucidate the role of GDF11 in metabolism and its potential involvement in thyroid pathophysiology

Lipopolysaccharides of brucella abortus and brucella melitensis induce nitric oxide synthesis in rat peritoneal macrophages

Producción CientíficaSmooth lipopolysaccharide (S-LPS) and lipid A of Brucella abortus and Brucella melitensis induced the production of nitric oxide (NO) by rat adherent peritoneal cells, but they induced lower levels of production of NO than Escherichia coli LPS. The participation of the inducible isoform of NO synthase (iNOS) was confirmed by the finding of an increased expression of both iNOS mRNA and iNOS protein. These observations might help to explain (i) the acute outcome of Brucella infection in rodents, (ii) the low frequency of septic shock in human brucellosis, and (iii) the prolonged intracellular survival of Brucella in humans.This work was supported by (grants FIS 96/1017, SAF96-0144, and SAF98-0176

Revista de Vertebrados de la Estación Biológica de Doñana

Clave preliminar de las escamas de los peces de agua dulce de España, a nivel de familiaExito reproductor del Buitre leonado (Gyps fulvus) en NavarraAlimentación del Gavilán (Accipiter nisus) en la Isla de TenerifeEl Verdecillo (Serinus serinus): Tendencias en la estación de nidificación, en el tamaño del huevo y en la supervivencia.las batidas como método de censo en especiesde caza mayor: aplicación al caso del Jabalí (Sus scrofa L.) en la provincia de Burgos (Norte de España)La adquisición de madurez sexual en el camaleón común (Chamaeleo chamaeleon)Nuevas citas de Hemidactylus turcicus en la provincia de CáceresLa focha común (Fulica atra) en la isla de Gran Canaria: nueva especie nidificante en el archipiélago CanarioTraslado de huevos en incubación por la urraca (Pica pica)Predación de Falco peregrinus sobre Oryctolagus cuniculusCuatro nuevas especies de aves para Bolivia.Sobre la utilización de nidos de golondrina común abandonados.Parasitismo múltiple del críalo (Clamator glandarius)Predación del topo de rio (Galemys pyrenaicus, Geoffroy 1811) por parte de la lechuza común (Tyto alba, Scopoli 1769)Predación del zorro (Vulpes vulpes) sobre un pollo de buitre leonado (Gyps fulvus).Vulpes vulpes L. criando en una colonia de marmota (Marmota marmota L.) en el pirineo de LéridaObservaciones sobre la incidencia de Rattus (Fischer, 1803) en los cultivos ibéricos de caña de azúcaSituación actual de la jutiita de la tierra Capromys sanfelipensis (Rodentia, Mammalia)Notas sobre la intraducción y expansión de la ardilla común en Sierra Nevada, sureste de EspañaPeer reviewe

The spatial structure of lithic landscapes : the late holocene record of east-central Argentina as a case study

Fil: Barrientos, Gustavo. División Antropología. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Catella, Luciana. División Arqueología. Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Oliva, Fernando. Centro Estudios Arqueológicos Regionales. Facultad de Humanidades y Artes. Universidad Nacional de Rosario; Argentin