11 research outputs found
State of the climate in 2018
- Author
- Ades M.
- Adler R.
- Aldeco Laura S.
- Alejandra G.
- Alfaro Eric J.
- Aliaga-Nestares Vannia
- Allan Richard P.
- Allan Rob
- Alves Lincoln M.
- Amador Jorge A.
- Andersen Andrea
- Andersen J. K.
- Anderson John
- Arndt Derek S.
- Arosio C.
- Arrigo Kevin
- Azorin-Molina César
- Bardin M. Yu
- Barichivich Jonathan
- Barreira Sandra
- Baxter Stephen
- Beck H. E.
- Becker Andreas
- Bell Gerald D.
- Bellouin Nicolas
- Belmont M.
- Benedetti Angela
- Benedict Imme
- Bernhard G. H.
- Berrisford Paul
- Berry David I.
- Bettio Lynette
- Bhatt U. S.
- Biskaborn B. K.
- Bissolli Peter
- Bjella Kevin L.
- Bjerke J. K.
- Blake Eric S.
- Blenkinsop Stephen
- Blunden Jessica
- Bock Olivier
- Bosilovich Michael G.
- Boucher Olivier
- Box J. E.
- Boyer Tim
- Braathen Geir
- Bringas Francis G.
- Bromwich David H.
- Brown Alrick
- Brown R.
- Brown Timothy J.
- Buehler S. A.
- Calderón Blanca
- Camargo Suzana J.
- Campbell Jayaka D.
- Campos Diaz Diego A.
- Cappelen J.
- Carrea Laura
- Carrier Seth B.
- Carter Brendan R.
- Castro Anabel Y.
- Cetinic Ivona
- Chambers Don P.
- Chen Lin
- Cheng Lijing
- Cheng Vincent Y.S.
- Christiansen Hanne H.
- Christy John R.
- Chung E. S.
- Claus Federico
- Clem Kyle R.
- Coelho Caio A.S.
- Coldewey-Egbers Melanie
- Colwell Steve
- Cooper Owen R.
- Cosca Cathy
- Covey Curt
- Coy Lawrence
- Cáceres Luis
- Davis Sean M.
- de Eyto Elvira
- de Jeu Richard A.M.
- De Laat Jos
- Decharme B.
- Degasperi Curtis L.
- Degenstein Doug
- Demircan Mesut
- Derksen C.
- Dhurmea K. R.
- Di Girolamo Larry
- Diamond Howard J.
- Diaz Eliecer
- Diniz Fransisco A.
- Dlugokencky Ed J.
- Dohan Kathleen
- Dokulil Martin T.
- Dolman A. Johannes
- Domingues Catia M.
- Domingues Ricardo
- Donat Markus G.
- Dorigo Wouter A.
- Drozdov D. S.
- Druckenmiller Matthew L.
- Dunn Robert J.H.
- Durre Imke
- Dutton Geoff S.
- Dávila Cristina P.
- Elkharrim M.
- Elkins James W.
- Epstein H. E.
- Espinoza Jhan C.
- Famiglietti James S.
- Farrell Sinead L.
- Fausto R. S.
- Feely Richard A.
- Feng Z.
- Fenimore Chris
- Fettweis X.
- Fioletov Vitali E.
- Flemming Johannes
- Fogt Ryan L.
- Forbes B. C.
- Foster Michael J.
- Francis S. D.
- Franz Bryan A.
- Frey Richard A.
- Frith Stacey M.
- Froidevaux Lucien
- Ganter Catherine
- Garforth J.
- Gerland Sebastian
- Gilson John
- Gleason Karin
- Gobron Nadine
- Goetz S.
- Goldenberg Stanley B.
- Goni Gustavo
- Gray Alison
- Griffin Jessicca
- Grooß Jens Uwe
- Gruber Alexander
- Gu Guojun
- Guard Charles Chip P.
- Gupta S. K.
- Gutiérrez Dimitri
- Haas Christian
- Hagos S.
- Hahn Sebastian
- Haimberger Leo
- Hall Brad D.
- Halpert Michael S.
- Hamlington Benjamin D.
- Hammer Gregory
- Hanna E.
- Hanssen-Bauer I.
- Harris Ian
- Hazeleger Wilco
- He Q.
- Heidinger Andrew K.
- Heim Richard R.
- Hemming D. L.
- Hendricks Stefan
- Hernández Rafael
- Hersbach H. E.
- Hidalgo Hugo G.
- Ho Shu Peng Ben
- Holmes R. M.
- Hu Chuanmin
- Huang Boyin
- Hubbard Katherine
- Hubert Daan
- Hurst Dale F.
- Ialongo Iolanda
- Ijampy J. A.
- Inness Antje
- Isaac Victor
- Isaksen K.
- Ishii Masayoshi
- Jeffries Martin O.
- Jevrejeva Svetlana
- Jia G.
- Jiménez C.
- Jin Xiangze
- John Viju
- Johnsen Bjørn
- Johnson Bryan
- Johnson Gregory C.
- Johnson Kenneth S.
- Jones Philip D.
- Jumaux Guillaume
- Kabidi Khadija
- Kaiser J. W.
- Karaköylü Erdem M.
- Karlsen S. R.
- Karnauskas Mandy
- Kato Seiji
- Kazemi A. Fazl
- Kelble Christopher
- Keller Linda M.
- Kennedy John
- Kholodov A. L.
- Khoshkam Mahbobeh
- Kidd R.
- Killick Rachel
- Kim Hyungjun
- Kim S. J.
- King A. D.
- King Brian A.
- Kipling Z.
- Klotzbach Philip J.
- Knaff John A.
- Korhonen Johanna
- Korshunova Natalia N.
- Kramarova Natalya A.
- Kratz D. P.
- Kruger Andries
- Kruk Michael C.
- Krumpen Thomas
- Labbé L.
- Ladd C.
- Lakatos Mónika
- Lakkala Kaisa
- Lander Mark A.
- Landschützer Peter
- Landsea Chris W.
- Lareau Neil P.
- Lavado-Casimiro Waldo
- Lazzara Matthew A.
- Lee T. C.
- Leuliette Eric
- Li Bailing
- Li Tim
- Lieser Jan L.
- Lim J. Y.
- Lin I. I.
- Liu Hongxing
- Locarnini Ricardo
- Loeb Norman G.
- Long Craig S.
- Lorrey Andrew M.
- Love-Brotak S. Elizabeth
- Loyola Diego
- Lumpkin Rick
- Luo Jing Jia
- Luojus K.
- Lyman John M.
- López Luis A.
- L’heureux Michelle
- Malkova G. V.
- Manney Gloria L.
- Marchenko S. S.
- Marengo José A.
- Marin Dora
- Marquardt Collow Allison B.
- Marra John J.
- Marszelewski Wlodzimierz
- Martens B.
- Martínez-Güingla Rodney
- Massom Robert A.
- May Linda
- Mayer Michael
- Mazloff Matthew
- McBride Charlotte
- McCabe M.
- McClelland J. W.
- McEvoy Daniel J.
- McGree Simon
- McVicar Tim R.
- Mears Carl A.
- Meier Walt
- Meijers Andrew
- Mekonnen Ademe
- Mengistu Tsidu G.
- Menzel W. Paul
- Merchant Christopher J.
- Meredith Michael P.
- Merrifield Mark A.
- Miller Ben
- Miralles Diego G.
- Misch Deborah J.
- Misevicius Noelia
- Mitchum Gary T.
- Mochizuki Y.
- Monselesan Didier
- Montzka Stephen A.
- Mora Natali
- Morice Colin
- Mosquera-Vásquez Kobi
- Mostafa Awatif E.
- Mote T.
- Mudryk L.
- Mullan A. Brett
- Myneni R.
- Mühle Jens
- Müller Rolf
- Nash Eric R.
- Nauslar Nicholas J.
- Nerem R. Steven
- Newman Paul A.
- Nicolas Julien P.
- Nieto Juan José
- Noetzli Jeannette
- Osborn Tim J.
- Osborne Emily
- Overland J.
- Oyunjargal Lamjav
- Park T.
- Pasch Richard J.
- Pascual Ramírez Reynaldo
- Pastor Saavedra Maria Asuncion
- Paterson Andrew M.
- Pearce Petra R.
- Pelto Mauri S.
- Perovich Don
- Petropavlovskikh Irina
- Pezza Alexandre B.
- Phillips C.
- Phillips David
- Phoenix G.
- Pinty Bernard
- Pitts Michael
- Po-Chedley S.
- Polashenski Chris
- Preimesberger W.
- Purkey Sarah G.
- Quispe Nelson
- Rajeevan Madhavan
- Rakotoarimalala C. L.
- Ramos Andrea M.
- Ramos Isabel
- Randel W.
- Raynolds M. K.
- Reagan James
- Reid Phillip
- Reimer Christoph
- Revadekar Jayashree V.
- Richardson A. D.
- Richter-Menge Jacqueline
- Ricker Robert
- Riddle Deborah B.
- Ripaldi A.
- Robinson David A.
- Rodell Matthew
- Rodriguez Camino Ernesto
- Romanovsky Vladimir E.
- Ronchail Josyane
- Rosenlof Karen H.
- Roth Chris
- Rozanov A.
- Rusak James A.
- Rustemeier Elke
- Rutishäuser T.
- Rémy Samuel
- Rösner Benajamin
- Sallée Jean Baptiste
- Santee Michelle L.
- Sawaengphokhai P.
- Sayouri Amal
- Scambos Ted A.
- Scanlon T.
- Scardilli Alvaro S.
- Schenzinger Verena
- Schladow S. Geoffey
- Schmid Claudia
- Schmid Martin
- Schoeneich P.
- Schreck Carl J.
- Selkirk H. B.
- Sensoy Serhat
- Shi Lei
- Shiklomanov A. I.
- Shiklomanov Nikolai I.
- Shimpo A.
- Shuman Christopher A.
- Siegel David A.
- Sima Fatou
- Simmons Adrian J.
- Smeets C. J.P.P.
- Smith Adam
- Smith Sharon L.
- Soden B.
- Sofieva Viktoria
- Sparks T. H.
- Spence Jacqueline
- Spencer R. G.M.
- Spillane Sandra
- Srivastava A. K.
- Stabeno P. J.
- Stackhouse Paul W.
- Stammerjohn Sharon
- Stanitski Diane M.
- Steinbrecht Wolfgang
- Stella José L.
- Stengel M.
- Stephenson Tannecia S.
- Strahan Susan E.
- Streeter Casey
- Streletskiy Dimitri A.
- Sun-Mack Sunny
- Suslova A.
- Sutton Adrienne J.
- Swart Sebastiann
- Sweet William
- Sánchez-Lugo Ahira
- Takahashi Kenneth S.
- Tank S. E.
- Taylor Michael A.
- Tedesco M.
- Thackeray S. J.
- Thompson Philip R.
- Timbal Bertrand
- Timmermans M. L.
- Tobin Skie
- Tourpali Kleareti
- Trachte Katja
- Tretiakov M.
- Trewin Blair C.
- Triñanes Joaquin A.
- Trotman Adrian R.
- Tschudi Mark
- Tye Mari R.
- Tømmervik H.
- van As D.
- van de Wal R. S.W.
- van der A Ronald J.
- van der Schalie Robin
- van der Schrier Gerard
- van der Werf Guido R.
- van Heerwaarden Chiel
- Van Meerbeeck Cedric J.
- Veasey Sara W.
- Verburg Piet
- Vieira G.
- Vincent Lucie A.
- Vose Russell S.
- Vömel Holger
- Walker D. A.
- Walsh J. E.
- Wang Bin
- Wang Hui
- Wang Lei
- Wang M.
- Wang Mengqiu
- Wang Ray
- Wang Sheng Hung
- Wanninkhof Rik
- Watanabe Shohei
- Weber Mark
- Webster Melinda
- Weerts Albrecht
- Weller Robert A.
- Westberry Toby K.
- Weyhenmeyer Gesa A.
- Widlansky Matthew J.
- Wijffels Susan E.
- Wilber Anne C.
- Wild Jeanette D.
- Willett Kate M.
- Wong Takmeng
- Wood E. F.
- Woolway R. Iestyn
- Xue Yan
- Yin Xungang
- Yu Lisan
- Zambrano Eduardo
- Zeyaeyan Sadegh
- Zhang Huai Min
- Zhang Peiqun
- Zhao Guanguo
- Zhao Lin
- Zhou Xinjia
- Zhu Zhiwei
- Ziemke Jerry R.
- Ziese Markus
- Publication venue
- Publication date
- 01/01/2018
- Field of study
In 2018, the dominant greenhouse gases released into Earth’s atmosphere—carbon dioxide, methane, and nitrous oxide—continued their increase. The annual global average carbon dioxide concentration at Earth’s surface was 407.4 ± 0.1 ppm, the highest in the modern instrumental record and in ice core records dating back 800 000 years. Combined, greenhouse gases and several halogenated gases contribute just over 3 W m−2 to radiative forcing and represent a nearly 43% increase since 1990. Carbon dioxide is responsible for about 65% of this radiative forcing. With a weak La Niña in early 2018 transitioning to a weak El Niño by the year’s end, the global surface (land and ocean) temperature was the fourth highest on record, with only 2015 through 2017 being warmer. Several European countries reported record high annual temperatures. There were also more high, and fewer low, temperature extremes than in nearly all of the 68-year extremes record. Madagascar recorded a record daily temperature of 40.5°C in Morondava in March, while South Korea set its record high of 41.0°C in August in Hongcheon. Nawabshah, Pakistan, recorded its highest temperature of 50.2°C, which may be a new daily world record for April. Globally, the annual lower troposphere temperature was third to seventh highest, depending on the dataset analyzed. The lower stratospheric temperature was approximately fifth lowest. The 2018 Arctic land surface temperature was 1.2°C above the 1981–2010 average, tying for third highest in the 118-year record, following 2016 and 2017. June’s Arctic snow cover extent was almost half of what it was 35 years ago. Across Greenland, however, regional summer temperatures were generally below or near average. Additionally, a satellite survey of 47 glaciers in Greenland indicated a net increase in area for the first time since records began in 1999. Increasing permafrost temperatures were reported at most observation sites in the Arctic, with the overall increase of 0.1°–0.2°C between 2017 and 2018 being comparable to the highest rate of warming ever observed in the region. On 17 March, Arctic sea ice extent marked the second smallest annual maximum in the 38-year record, larger than only 2017. The minimum extent in 2018 was reached on 19 September and again on 23 September, tying 2008 and 2010 for the sixth lowest extent on record. The 23 September date tied 1997 as the latest sea ice minimum date on record. First-year ice now dominates the ice cover, comprising 77% of the March 2018 ice pack compared to 55% during the 1980s. Because thinner, younger ice is more vulnerable to melting out in summer, this shift in sea ice age has contributed to the decreasing trend in minimum ice extent. Regionally, Bering Sea ice extent was at record lows for almost the entire 2017/18 ice season. For the Antarctic continent as a whole, 2018 was warmer than average. On the highest points of the Antarctic Plateau, the automatic weather station Relay (74°S) broke or tied six monthly temperature records throughout the year, with August breaking its record by nearly 8°C. However, cool conditions in the western Bellingshausen Sea and Amundsen Sea sector contributed to a low melt season overall for 2017/18. High SSTs contributed to low summer sea ice extent in the Ross and Weddell Seas in 2018, underpinning the second lowest Antarctic summer minimum sea ice extent on record. Despite conducive conditions for its formation, the ozone hole at its maximum extent in September was near the 2000–18 mean, likely due to an ongoing slow decline in stratospheric chlorine monoxide concentration. Across the oceans, globally averaged SST decreased slightly since the record El Niño year of 2016 but was still far above the climatological mean. On average, SST is increasing at a rate of 0.10° ± 0.01°C decade−1 since 1950. The warming appeared largest in the tropical Indian Ocean and smallest in the North Pacific. The deeper ocean continues to warm year after year. For the seventh consecutive year, global annual mean sea level became the highest in the 26-year record, rising to 81 mm above the 1993 average. As anticipated in a warming climate, the hydrological cycle over the ocean is accelerating: dry regions are becoming drier and wet regions rainier. Closer to the equator, 95 named tropical storms were observed during 2018, well above the 1981–2010 average of 82. Eleven tropical cyclones reached Saffir–Simpson scale Category 5 intensity. North Atlantic Major Hurricane Michael’s landfall intensity of 140 kt was the fourth strongest for any continental U.S. hurricane landfall in the 168-year record. Michael caused more than 30 fatalities and 25billion(U.S.dollars)indamages.InthewesternNorthPacific,SuperTyphoonMangkhutledto160fatalitiesand6 billion (U.S. dollars) in damages across the Philippines, Hong Kong, Macau, mainland China, Guam, and the Northern Mariana Islands. Tropical Storm Son-Tinh was responsible for 170 fatalities in Vietnam and Laos. Nearly all the islands of Micronesia experienced at least moderate impacts from various tropical cyclones. Across land, many areas around the globe received copious precipitation, notable at different time scales. Rodrigues and Réunion Island near southern Africa each reported their third wettest year on record. In Hawaii, 1262 mm precipitation at Waipā Gardens (Kauai) on 14–15 April set a new U.S. record for 24-h precipitation. In Brazil, the city of Belo Horizonte received nearly 75 mm of rain in just 20 minutes, nearly half its monthly average. Globally, fire activity during 2018 was the lowest since the start of the record in 1997, with a combined burned area of about 500 million hectares. This reinforced the long-term downward trend in fire emissions driven by changes in land use in frequently burning savannas. However, wildfires burned 3.5 million hectares across the United States, well above the 2000–10 average of 2.7 million hectares. Combined, U.S. wildfire damages for the 2017 and 2018 wildfire seasons exceeded $40 billion (U.S. dollars)
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission
- Author
- Aanensen David M.
- Abell Chris
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Aggarwal Dinesh
- Ahmad Shazaad S. Y.
- Ahmadi-Assalemi Gabriela
- Aigrain Louise
- Alam Mohammad T.
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angelis Daniela De
- Angelis Daniela De
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina V.
- Asad Hibo
- Asamaphan Patawee
- Ash Amy
- Ashcroft Fiona
- Atkinson Laura
- Attwood Stephen W.
- Auckland Cressida
- Awan Ali R.
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barrett Jeff
- Barton Edward
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Baxter Laura
- Bayzid Nadua
- Beale Mathew A.
- Beaver Charlotte
- Beckett Angela H.
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L.
- Berry Lisa
- Berry Louise
- Berry Sarah
- Best Angus
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M.
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- BoYes John
- Bradley Amanda
- Bradley Declan T.
- Bradshaw Daniel
- Braithwaite Vickie
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E.
- Brierley Craig
- Bronner Iraad F.
- Brooks Ellena
- Broos Alice
- Brown Christopher
- Brown Christopher A.
- Brown Julianne R.
- Brown Nicholas M.
- Brown Paul E.
- Brown Rebecca
- Bucca Giselda
- Buck David
- Bull Matthew
- Burton-Fanning Shirelle
- Campbell Sharon
- Carabelli Alessandro M.
- Carden Holli
- Carlile Matthew
- Carmichael Stephen N.
- Casey Anna
- Caspersz Michelle
- Ceaser Matt
- Cerda Alberto C.
- Chalker Vicki
- Chand Meera
- Chapman Michael H. S.
- Chapman Michael R.
- Chappell Joseph G.
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Afzal
- Chaudhry Yasmin
- Chauhan Anoop J.
- Cheng Jeffrey K. J.
- Churcher Carol M.
- Clark Gemma
- Clark Roger
- Clarke Rebecca
- Cogger Benjamin J.
- Coll Francesc
- Collins Jennifer
- Connor David
- Connor Thomas R.
- Constantinidou Chrystala
- Cook Kate
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nick
- Cotic Marius
- Cottrell Simon
- Coupland Lindsay
- Cowell Angela
- Cox Alison
- Craine Noel
- Crawford Liam
- Cronin Michelle
- Crook Derrick
- Crowcroft Jon
- Cumley Nicola
- Curran Martin D.
- Curran Tanya
- da Silva Filipe Ana
- Dabrera Gavin
- Dadrah Ashok
- Dahal Aastha
- Danaei Darius
- Danesh John
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davies Richard
- Davies Robert
- Davis Thomas
- de Cesare Mariateresa
- de Oliveira Martins Leonardo
- de Silva Thushan I.
- Debebe Johnny
- Dent Hannah
- Dervisevic Samir
- Dewar Rebecca
- Dhada Maharshi
- Dias Joana
- Dorman Matthew J.
- Dougan Gordon
- Douthwaite Julie
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- du Plessis Louis
- Duckworth Nichola
- Durham Jillian
- Dyer Rory
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Emanuela P.
- Enright Jessica
- Ensell Leah
- Essex Sarah
- Evans Cariad
- Evans Johnathan M.
- Eyre David
- Fairley Derek J.
- Fallon Karlie
- Farbos Audrey
- Farr Ben W.
- Fatseas Tania
- Faulkner Kathryn
- Fearn Christopher
- Feather Tom
- Feltwell Theresa
- Fenton Melisa L.
- Ferris Mark
- Fieldman Thomas
- Fina Laia
- Fisher Chloe L.
- Flaviani Flavia
- Fleming Vicki M.
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeling Anthony
- Freeman Timothy M.
- Frost Lucy R.
- Fuller Stewart
- Fuller William
- Galai Katerina
- Gallagher Eileen
- Gallagher Michael D.
- Gallis Marta
- Gaskin Amy
- Gatica-Wilcox Bree
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P.
- Georgiou Christine
- Gibbs Karen
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K.
- Girgis Sophia T.
- Glaysher Sharon
- Glew Rob
- Glover Michael
- Golubchik Tanya
- Goncalves Sonia
- Goodall Robin
- Goodfellow Ian
- Goodfellow Ian G.
- Goodwin Scott
- Goudarzi Salman
- Gourtovaia Marina
- Graham Clive
- Graham Lee
- Grammatopoulos Dimitris
- Gransden Lucie
- Greatorex Jane
- Green Angie
- Green Luke R.
- Greenaway Jane
- Gregory Richard
- Groves Danielle C.
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gunson Rory N.
- Gupta Ravi K.
- Gutierrez Bernardo
- Hadjirin Nazreen F.
- Haldenby Sam T.
- Hale Antony D.
- Hall Grant
- Halstead Fenella
- Hamilton William L.
- Hamilton William L.
- Hamilton William L.
- Hancock Dawn
- Hannan Sophie
- Haque Tanzina
- Harper Katherine L.
- Harris Kathryn A.
- Harrison Ewan M.
- Harrison Ian
- Harrison James W.
- Hart Jennifer
- Hartley John A.
- Hartman Hassan
- Hassan-Ibrahim Mohammed O.
- Heaney Judith
- Helmer Thomas
- Henderson Robert
- Hesketh Andrew R.
- Heyburn David
- Higginson Ellen E.
- Hilborne Sarah
- Hill Verity
- Hilvers Ember
- Hiscox Julian A.
- Hoensch Steve
- Hogsden Wendy
- Holden Matthew T. G.
- Holgate Jon
- Hollamby Victoria
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hopes Richard
- Hosaja Aleksandra
- Hosmillo Myra
- Hosmillo Myra
- Howe Robin
- Howes Rob
- Howson-Wells Hannah C.
- Hubb Jonathan
- Hughes Gareth J.
- Hughes Joseph
- Hughes Margaret
- Hughes Robert
- Hunt Martin
- Hutchings Stephanie
- Illingworth Chris
- Illingworth Chris J.
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Izuagbe Rhys
- Jackson Chris
- Jackson David K.
- Jackson Kathryn A.
- Jahun Aminu
- Jahun Aminu S.
- James Keith
- James Laura
- Jamrozy Dorota
- Jannoo Riaz
- Jeffries Aaron R.
- Jeremiah Sarah
- Jesudason Natasha G.
- John Michaela
- Johnson Dean
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnston Ian
- Jones Carl
- Jones Christopher R.
- Jones Daniel R.
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jordan Sinead
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kahkeshi Mahin Bagheri
- Kane Leanne
- Karamani Angeliki
- Kay Gemma L.
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J.
- Keen Martin
- Kenyon Anita
- Kermack Leanne M.
- Khakh Manjinder
- Kidd Stephen
- Kitchen Christine
- Knapton James
- Knight Bridget A.
- Koshy Cherian
- Kraemer Moritz U. G.
- Kristiansen Mark
- Kuenzi Fred
- Kumziene-SummerhaYes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Lacy Elen De
- Lambson Oliver
- Langford Cordelia F.
- Lawniczak Mara
- Le-Viet Thanh
- Ledesma Juan
- Lee David
- Lee Jack C. D.
- Leek Danielle
- Lehner Paul
- Lensing Stefanie V.
- Leonard Steven
- Leong Clare
- Leslie Ian
- Letchford Laura
- Levene Nick
- Levett Lisa J.
- Lewis Kevin
- Li Kathy K.
- Liddell Kathleen
- Liddle Jennifier
- Liggett Steven
- Lindsey Benjamin B.
- Lister Michelle M.
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loman Nicholas J.
- Loose Matthew W.
- Louka Stavroula F.
- Loveson Katie F.
- Lowe Hannah
- Lowe Helen L.
- Lucaci Anita O.
- Ludden Catherine
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A.
- Macfarlane-Smith Louissa R.
- Machin Nicholas W.
- MacIntyre-Cockett George
- Maclean Alasdair
- Mactavous Lenette
- Madona Pinglawathee
- Maes Mailis
- Mahanama Adhyana I. K.
- Mahungu Tabitha W.
- Mair Daniel
- Maksimovic Joshua
- Makunin Alex
- Malone Cassandra S.
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Marchetti Filippo
- Margolis Ben
- Martincorena Inigo
- Masoli Jane A. H.
- Mason Jenifer
- Mather Alison E.
- Matheson Nicholas
- Matheson Nicholas J.
- Mathieson Nick
- Matthews Steve
- Maxwell Patrick
- Maxwell Patrick H.
- Mayhew Megan
- Mbisa Tamyo
- McCann Clare
- McCarthy Shane
- McCluggage Kathryn
- McClure Patrick C.
- McFarlane Duncan
- McGuigan Samantha
- McHugh Martin P.
- McKenna James P.
- McKerr Caoimhe
- McManus Georgina M.
- McMurray Claire
- McNally Alan
- McNulty Claire
- Meader Emma J.
- Meadows Lizzie
- Megram Oliver
- Menegazzo Mirko
- Merrick Ian
- Merrill Tammy V.
- Metaxaki Marina
- Miah Shahjahan
- Michell Stephen L.
- Michelsen Michelle L.
- Mills John
- Mirza Jeremy
- Moles-Garcia Emma
- Moll Robin J.
- Mollett Guy
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Christopher
- Moore Jonathan
- Moore Nathan
- Morgan Mari
- Morgan Sally
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Mozdzen Barbara
- Muir Peter
- Mungovan Diane
- Munn Robert
- Murphy Edna
- Myers Richard
- Nascimento Fabricia F.
- Nebbia Gaia
- Neely Andy
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nichols Jenna
- Nickbakhsh Seema
- Niebel Marc O.
- Nikitina Katya
- Nomikou Kyriaki
- Nsonwu Olisaeloka
- Nunez Rocio T. Martinez
- Oliver Karen
- Orton Alexandra
- Orton Richard J.
- Osman Husam
- Ott Sascha
- O’Brien Sarah
- O’Grady Justin
- O’Toole Elaine
- O’Toole Áine
- Pacchiarini Nicole
- Packer Simon
- Padgett Debra
- Page Andrew J.
- Palmer Sophie
- Palmer Steve
- Pandey Sarojini
- Park Naomi R.
- Parker Matthew D.
- Parlikad Ajith
- Parmar Surendra
- Parsons Paul J.
- Partridge David G.
- Patel Amita
- Patel Minal
- Patel Vineet
- Paterson Steve
- Paul Hannah
- Payne Brendan AI.
- Peacock Sharon J.
- Peacock Sharon J.
- Pearson Clare
- Percival Benita
- Perry Malorie
- Peto Timothy
- Pinckert Malte
- Pinckert Malte L.
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Poppitt Steve
- Prestwood Liam
- Price Anna
- Price James
- Prieto Jacqui A.
- Puethe Christoph
- Pusok Monika
- Pybus Oliver G.
- Pymont Hannah M.
- Quail Michael A.
- Quick Joshua
- Quinnell Natalie
- Radecki Asako
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajan Diana
- Rajatileka Shavanthi
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A.
- Rankin Jennifer
- Ratcliffe Liz
- Raub Gabor
- Raviprakash Veena
- Raza Mohammad
- Redshaw Nicholas M.
- Rees Steve
- Rey Sara
- Reynolds Nicola
- Richter Alex
- Ridgman Tom
- Robertson David L.
- Robinson Esther
- Robinson Trevor I.
- Robson Samuel C.
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Rushton Steven
- Russell Matthew
- Saeed Kordo
- Saluja Tranprit
- Samaraweera Buddhini
- Sambles Christine M.
- Samtani Vijay
- Samworth Richard
- Sang Fei
- Sato Aris
- Scarlett Garry P.
- Schaefer Ulf
- Scott Carol
- Scott Garren
- Searle Paul
- Shaaban Sharif
- Shah Divya
- Shah Rajiv N.
- Shankar Giri
- Shaw Ashley
- Sheldrake Zara
- Shepherd James G.
- Sheridan Linda
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W.
- Sillitoe John
- Silveira Siona
- Simpson David A.
- Sing Robert
- Singer Joshua B.
- Sivaprakasam Venkat
- Siveroni Igor
- Sloan Tim J.
- Sluga Graciela
- Smith Colin P.
- Smith Darren
- Smith Kim S.
- Smith Louise
- Smith Nikki
- Smith Wendy
- Smollett Katherine L.
- Snell Luke B.
- Southgate Joel
- Spellman Karla
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D.
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David J.
- Swindells Emma
- Symmonds Amanda
- Taha Yusri
- Tang Julian
- Taylor Ben E. W.
- Taylor Graham P.
- Taylor Peter
- Taylor Sarah
- Taylor-Joyce Grace
- Temperton Ben
- Templeton Kate E.
- The Cambridge Covid-19 testing Centre
- The COVID-19 Genomics UK (COG-UK) Consortium
- Thompson Thomas
- Thomson Emma C.
- Thornton Alicia
- Thurston Scott A. J.
- Todd John A.
- Tolhurst Jonathan
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Tovar-Corona Jaime M.
- Trebes Amy
- Trotter Alexander J.
- Tsoleridis Theocharis
- Tucker Rachel M.
- Turtle Lance
- Twohig Katherine A.
- Tynan Jo
- Underwood Anthony P.
- University of Cambridge Asymptomatic COVID-19 Screening Programm
- Unnikrishnan Meera
- Valletta Sally
- Vamos Edith E.
- Vasylyeva Tetyana I.
- Vattipally Sreenu
- Vernet Gabrielle
- Vignoles Anna
- Vinnell Martin
- Vipond Ian B.
- Volz Erik M.
- Waddell Ian
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Emmeline
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Weale Gillian
- Webster Hermione J.
- Weekes Michael P.
- Weldon Danni
- Westhorpe Adam P.
- White Phil
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Williams Charlotte A.
- Williams Chris
- Williams David
- Williams Lesley-Anne
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Williman Jack
- Willingham Iona
- Wills Mark
- Wilson Harry D.
- Wilson Karl
- Wilson Rebekah E.
- Wilson-Davies Eleri
- Winster Jennifer
- Wise Emma
- Witele Eric
- Workman Chris
- Workman Trudy
- Wright Elizabeth
- Wright Elizabeth
- Wright Giles
- Wright Jo
- Wright Victoria
- Wyatt Tim
- Wyles Matthew
- Wyllie Sarah
- Xu-McCrae Li
- Yeats Corin A.
- Yew Wen Chyin
- Young Greg
- Young Jamie
- Zamudio Marina Escalera
- Zarebski Alex E.
- Zhang Peijun
- Publication venue
- Nature Communications
- Publication date
- 08/02/2022
- Field of study
AbstractUnderstanding SARS-CoV-2 transmission in higher education settings is important to limit spread between students, and into at-risk populations. In this study, we sequenced 482 SARS-CoV-2 isolates from the University of Cambridge from 5 October to 6 December 2020. We perform a detailed phylogenetic comparison with 972 isolates from the surrounding community, complemented with epidemiological and contact tracing data, to determine transmission dynamics. We observe limited viral introductions into the university; the majority of student cases were linked to a single genetic cluster, likely following social gatherings at a venue outside the university. We identify considerable onward transmission associated with student accommodation and courses; this was effectively contained using local infection control measures and following a national lockdown. Transmission clusters were largely segregated within the university or the community. Our study highlights key determinants of SARS-CoV-2 transmission and effective interventions in a higher education setting that will inform public health policy during pandemics.</jats:p
Separation and fragmentation study of isocoproporphyrin derivatives by UHPLC-ESI-exact mass MS/MS and identification of a new isocoproporphyrin sulfonic acid metabolite
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2014
- Field of study
Effectiveness of herpes zoster vaccination in an older United Kingdom population
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
e-Agricultural innovation using a human-centred systems lens, proposed conceptual framework
- Author
- A Borgmann
- AL Kroeber
- E Rogers
- EL Lesser
- F Davis
- G Baxter
- G Feder
- G Feder
- J Schumpeter
- JS Brown
- K Gill
- K Weick
- K Wilber
- L Stapleton
- L Stapleton
- L Stapleton
- L Stapleton
- Larry Stapleton
- LB Rasmussen
- LS Prokopy
- M Cooley
- M Warren
- M Warschauer
- P Carew
- P Checkland
- P Eckert
- P Selznick
- R Nelson
- S Barile
- S Corea
- S Samolienko
- Sinead Somers
- W Orlikowski
- WR Scott
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Splicing profile by capture RNA-seq identifies pathogenic germline variants in tumor suppressor genes
- Author
- Arulmoli Aarani
- Baxter Ruth
- Bunnell Ann
- Burdette Julia
- Cass Ashley A
- Chao Elizabeth
- Charpentier Sinead
- Conner Blair R
- Crandall Joy Rae-Radecki
- Dalton Emily
- Depas Morgan M
- Domchek Susan
- Elliott Aaron
- Farmer Meagan
- Fennessy Michele
- Fox Susanne
- Ganzak Amanda C
- Gaonkar Shraddha
- Geurts Jennifer L
- Haynes Ginger
- Heinlen Christopher
- Hoang Lily
- Hoodfar Elizabeth
- Karam Rachid
- Koptiuch Cathryn
- Krukenberg Rebekah
- LaDuca Holly
- Landrith Tyler
- Lee John
- Li Bing
- Lu Hsiao-Mei
- Maxwell Kara N
- McKenna Danielle B
- Milliron Kara
- Molparia Bhuvan
- Morman Nichole A
- Nathan Deepika
- Parra Melissa
- Patel Gayle
- Pesaran Tina
- Pilarski Robert
- Pirzadeh-Miller Sara
- Profato Jessica
- Pyrtel Khateriaa
- Rivera Ragene
- Seidel Meredith
- Smith Brandon
- Tippin-Davis Brigette
- Vagher Jennie
- Vuong Huy
- Wham Deborah
- Wu Sitao
- Xu Dong
- Publication venue
- Advocate Aurora Health Institutional Repository
- Publication date
- 24/02/2020
- Field of study
Germline variants in tumor suppressor genes (TSGs) can result in RNA mis-splicing and predisposition to cancer. However, identification of variants that impact splicing remains a challenge, contributing to a substantial proportion of patients with suspected hereditary cancer syndromes remaining without a molecular diagnosis. To address this, we used capture RNA-sequencing (RNA-seq) to generate a splicing profile of 18 TSGs (APC, ATM, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, MLH1, MSH2, MSH6, MUTYH, NF1, PALB2, PMS2, PTEN, RAD51C, RAD51D, and TP53) in 345 whole-blood samples from healthy donors. We subsequently demonstrated that this approach can detect mis-splicing by comparing splicing profiles from the control dataset to profiles generated from whole blood of individuals previously identified with pathogenic germline splicing variants in these genes. To assess the utility of our TSG splicing profile to prospectively identify pathogenic splicing variants, we performed concurrent capture DNA and RNA-seq in a cohort of 1000 patients with suspected hereditary cancer syndromes. This approach improved the diagnostic yield in this cohort, resulting in a 9.1% relative increase in the detection of pathogenic variants, demonstrating the utility of performing simultaneous DNA and RNA genetic testing in a clinical context
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- Abreu Maria
- Aguilar Salinas Carlos A.
- Ahmad Tariq
- Albert Christine M.
- Alfoeldi Jessica
- Ardissino Diego
- Armean Irina M.
- Atkinson Elizabeth G.
- Atzmon Gil
- Banks Eric
- Barnard John
- Baxter Samantha M.
- Beaugerie Laurent
- Benjamin David
- Benjamin Emelia J.
- Bergelson Louis
- Boehnke Michael
- Bonnycastle Lori L.
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- Chao Katherine R.
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- Chasman Daniel I.
- Chen Siwei
- Chisholm Rex
- Cho Judy
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- Chung Mina K.
- Chung Wendy K.
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- Cohen Bruce
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- Danesh John
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- Publication venue
- NATURE PORTFOLIO
- Publication date
- 15/01/2024
- Field of study
A genomic mutational constraint map using variation in 76,156 human genomes
- Author
- Abreu Maria
- Aguilar Salinas Carlos A.
- Ahmad Tariq
- Albert Christine M.
- Alfoldi Jessica
- Alfoldi Jessica
- Ardissino Diego
- Armean Irina M.
- Atkinson Elizabeth G.
- Atzmon Gil
- Banks Eric
- Banks Eric
- Barnard John
- Baxter Samantha M.
- Beaugerie Laurent
- Benjamin David
- Benjamin Emelia J.
- Bergelson Louis
- Bergelson Louis
- Boehnke Michael
- Bonnycastle Lori L.
- Bottinger Erwin P.
- Bowden Donald W.
- Bown Matthew J.
- Brand Harrison
- Brant Steven
- Brookings Ted
- Bryant Sam
- Calvo Sarah E.
- Campos Hannia
- Chambers John C.
- Chan Juliana C.
- Chao Katherine R.
- Chapman Sinead
- Chasman Daniel I.
- Chen Siwei
- Chen Siwei
- Chisholm Rex
- Cho Judy
- Chowdhury Rajiv
- Chung Mina K.
- Chung Wendy K.
- Cibulskis Kristian
- Cohen Bruce
- Collins Ryan L.
- Collins Ryan L.
- Connolly Kristen M.
- Correa Adolfo
- Covarrubias Miguel
- Covarrubias Miguel
- Cummings Beryl B.
- Dabelea Dana
- Daly Mark J.
- Danesh John
- Darbar Dawood
- Darnowsky Phil
- Denny Joshua
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- Donnelly Stacey
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- Dupuis Josee
- Ellinor Patrick T.
- Elosua Roberto
- Emery James
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- Kenny Eimear E.
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- McCarthy Mark I.
- McCauley Jacob L.
- McGovern Dermot
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- Munshi Ruchi
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- Nazarian Saman
- Neale Benjamin M.
- Nilsson Peter M.
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- Roden Dan M.
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Prospective observational cohort study on grading the severity of postoperative complications in global surgery research
- Author
- Abayasinghe Chamika
- Abbas Muntadhar
- Abbott T. E. F.
- Abbott Tom
- Abdullah Noor Hairiza
- Abdur-Rahman Lukman
- Abeloos Jacques
- Abernethy Caroline
- Abidin Ucu Nurhadiat
- Abrunhosa Alexandra
- Absar Mohammed
- Adam Suwayba
- Adams George
- Adamson Michael
- Adekola Oyebola
- Adelaja Yemi
- Ademola Adeyinka
- Adenekan Anthony
- Adenike Odewabi
- Adeolu Augustine A
- Adetoye Adedapo
- Adewale Badru
- Adigun Tinuola
- Adolfsson Anne
- Aflori Laura
- Africander Cucu
- Afshari Arash
- Agarwal Vandana
- Agodirin Olayide
- Aguzzoli Crisitiano
- Ahmad Abdurrahman
- Ahmad Norfaizan
- Ahmad T.
- Ahmad Tahania
- Ahmad Yousra
- Ahmed Ahmed
- Ahmed Jamil
- Ahmed Tahania
- Ai Yanqiu
- Aignatoaie Mariana
- Aimoniotou-Georgiou Eleni
- Akanmu Olanrewaju
- Akerman Nik
- Akinwale Mukaila
- Al Amri Khalid
- Al Hussaini Sabah
- Al-Soudaine Yassr
- Aladin Hafiz
- Alagbe-Briggs Olubusola
- Albaj Safauldeensalem
- Alcock David
- Alcock Liam
- Aldecoa Cesar
- Aldecoa Cesar
- Aleixo Fábia Berganton
- Alexander Hazel
- Alexander Maini
- Alexander-Sefre Farhad
- Alherz Fadhel
- Ali Hani
- Ali Marlynn
- Ali Sarah
- Alias Abdul Hafiz
- Alias Anita
- Alias Raja Liza Raja
- Allen Samantha
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- Cherrett Veronica
- Chetty Rubendraj R
- Chew Michelle
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- Choi Hyun-min David
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- Daya Bhavika
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- De Baerdemaeker Luc
- De Bruyne Ann
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- De Kegel Dirk
- De Meyer Jenine N
- De Oliveira Mirella Cristine
- Deacon Matthew
- Deblaere Isabel
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- Deen Tariq
- Deepak Shantal
- Deighton Kerry
- Deja Maria
- Del Valle Santiago Garcia
- Delgado García David R
- Demartines Nicolas
- Dempsey Ged
- Dempster Angie
- Denham Samuel
- Dent Kathy
- Dermitzaki Despina
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- Dragoescu Nicoleta Alice
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- Du Fang
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- Duca Alejandro
- Dudgeon Lucy
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- Ekelund Kim
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- Elabib Ali
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- Fei Yue
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- Filipescu Daniela
- Filippopoulos Andreas
- Finch Amanda
- Fiorentza Klara
- Fischbach Norbert
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- Fleischer Andreas
- Fleisher Lee
- Fleisher Lee
- Fleisher Lee A.
- Flores Armando Adolfo Alvarez
- Flores Kathrina
- Flossos Andreas
- Foers William
- Foglia Julena
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- Fonck Kristine
- Foord Denise
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- Fulton Graham
- Funk Bonita
- Funk Duane
- Furrer Markus
- Futier E.
- Futier Emmanuel
- Futier Emmanuel
- Gaitanakis Stylianos
- Gall Lewis
- Gallacher Pete
- Gallard Sian
- Gallego Laura
- Gama N Sibusiso
- Gambhir Rajiv
- Ganter Donna Louise
- Ganter Michael T
- Gao Hong
- Garcia Carolina Soledad Romero
- Garcia Juliana
- Garcia-Saiz Irene
- García-Pérez Maria Luisa
- Gardikou Varvara Vanessa
- Gardiner Matthew
- Garg Atul
- Garg Sameer
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- Garrett Emily
- Gasperi Julia
- Gastaldi Christian
- Gatta Alessandro
- Gaudin Christophe
- Gavril Laura
- Gbolahan Olalere
- Ge Xiaodong
- Geddoa Burair
- Geddoa Emad
- Geddoa Emad
- Geisen Martin
- Geldenhuys Jacques
- Gemert Ankie Koopman-van
- Geng Wujun
- Georgakakis Georgios
- George Ronald
- George Ronald
- George Ronald
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- Georgopoulou Eleni
- Gercek Yuksel
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- Ghosh Alison
- Ghushe Neil
- Giancarlo Luigi
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- Gibson-Lapsley Hannah
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- Gill James
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- Gille Jochen
- Gillespie David
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- Gilmore Jemma
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- Gkini Konstantia-Paraskevi
- Gkiokas Georgios
- Gkioni Panagiota
- Gkonezou Elena
- Glasbey James
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- Glister Georgina
- Glover Lyn
- Goad Ehab Helmy Abdel
- Goebel Ulrich
- Goga Ismail E
- Goga Riaz
- Goldberg Olivia
- Golder Kim
- Gondo Prisca
- Gonzalez Alba Perez
- Gordon Paul
- Goss Harry
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- Govender Komalan
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- Granum Simon Nørgaard
- Graterol Juan
- Gratrix Karen
- Graves Lynne
- Gray Carol
- Gray Catherine
- Gray Sophie
- Greaves K. E.
- Greaves Rosanna
- Green Garyth M
- Green-Thompson Randolph
- Greene Michael
- Gregory Peter
- Grey Ben
- Griffiths Ewen
- Grigoras Ioana
- Grigoryev Evgeny
- Grintescu Ioana
- Grishkowez Elena
- Grocott Mike
- Grosu Ramona-Mihaela
- Grubmueller Karl Gernot
- Gudaca Mariethel
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- Guizeline Jaqueline
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- Guo Baolei
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- Guok Eng Ching
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- Guttenthaler Vera
- Guy Kramer
- Gätke Mona Ring
- Habicher Marit
- Hack Yvonne
- Haddow J.
- Haddow James
- Hadebe Bernard
- Hadfield Daniel
- Hadi Husni Zaeem Abd
- Hagau Natalia
- Haigh Kathryn
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- Hall Roger
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- Halliwell Richard
- Hambidge Oliver
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- Hamilton Caroline
- Hamzah Zulkarnain
- Han Kunyuan
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- Harden Catherine
- Hare Gregory
- Hariharan Vimal
- Harrichandparsad R
- Harries Rhiannon
- Harris Benjamin
- Harris Clair
- Harris James
- Harris Meredyth
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- Hedin Annika
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- Helliwell Laurence
- Hellstrom Johanna
- Helmy Naeder
- Hennings Charles
- Hering Jens Peter
- Hernandez Carlos B
- Hernandez Miguel
- Hert Stefan
- Hesketh Sue
- Hewson Russ
- Hewson Russell
- Heyse Bjorn
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- Hidayatullah Rahmat
- Hiesmayr Michael
- Higgie Kushlin
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- Hinther Ashley
- Hinther Ashley
- Hinxman Honor
- Hitchcock Rachael
- Hoare Siobhan
- Hobrok Maria
- Hodgkiss Tracey
- Hodgson Richard E
- Hodzovic Emil
- Hoedt Marielle
- Hoeft Andreas
- Hoeft Andreas
- Hofer Christoph
- Hofer Christoph
- Hoffer Franz
- Hoffmann João
- Holaubek Caroline
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- Hopkins Thomas
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- Hosdurga Gurunath
- Hou Benchao
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- Hubner Martin
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- Hugill Keith
- Hulme Jonathan
- Hulst Abraham
- Humphreys Sally
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- Hutchings Melanie
- Hutchins David
- Hutton Monica
- Huygens Christel
- Huynh Wilson Binh Quan
- Hwan Haifang
- Härtl Christine
- Hübner Martin
- Hüppe Michael
- Iasonidou Christina
- Idowu Olusola
- Ijuo Eke
- Iloabachie Ikechukwu
- Ilyina Yana
- Incertis Raul
- Indra Imai
- Ioannidis Orestis
- Ionescu Daniela
- Ionita Victor
- Iosep Gabriel Florin
- Ip Peter
- Irshad Mariam
- Ischaki Eleni
- Ishimaru Alexander
- Iurin Aleksandr
- Jacobs Tom
- Jaffray David
- Jain Megha
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- James Sarah
- Jammer Ib
- Jansen Tracy-Lee
- Janssen Bruno
- Januszewska Marta
- Januszewska Marta
- Jaquet Yves
- Jardim Jaquelline
- Jawad Monir
- Jee Chiun Chen
- Jeeraz Mohammud A
- Jeffery Holly
- Jeffs Carol
- Jehosua Brillyan
- Jelschen Florian
- Jemmett Kim
- Jemna Ramona
- Jenkins Nia
- Jenkins Nicole
- Jensen-Gadegaard Peter
- Jesus Joana Sofia Teixeira
- Jeyanthan Somasundaram
- Ji Binbin
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- Jia Danyun
- Jiang Linghui
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- Jin Lin
- Jin Shenhui
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- Johnson Robert
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- Jones Dawn
- Jones Eleanor
- Jones Philip
- Jones Stephanie
- Jones Timothy
- Joory Kavita
- Jordaan J
- Joseph James
- Jowitt Tom
- Juj Joanne
- Julian Howes
- Jumbe Sandra
- Junge Marina
- Júnior La Hore Correa Rodrigues
- Kabagenyi Fiona
- Kafkalaki Kalliopi
- Kahn David
- Kakembo Nasser
- Kalafatis Nicky
- Kalaitzopoulos Ioannis
- Kalashetty Gunasheela
- Kalles Vasileios
- Kalliafa Elli
- Kalogridaki Marina
- Kamali Nelson
- Kampagiannis Nikolaos
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- Kanathiban Kathirgamanathan
- Kantsedikas Ilya
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- Karelov Alexey
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- Karthikeyan Arvind
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- Katime Antonio
- Katralis Petros
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- Katsika Eleni
- Katsourakis Anastasios
- Kaunang Jonathan
- Kaur Satwant
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- Kaushik Shuchi
- Keen Abigail
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- Keevil Edward
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- Kessler Ulf
- Kesut Saiful Aizar
- Khader Ahamed
- Khalaf Abdel Razzaq
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- King Angela
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- King Helen
- Kinoo Suman Mewa
- Kiourtzieva Ellada
- Kirchgaessner Katharina
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- Weatherill J
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- Wijeysundera Duminda
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- Woolsey Adrianna
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- Worreth Marc
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- Wouters Patrick
- Wrench Ian
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- Wu Jie
- Wu Qiong
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- Xia Yanfei
- Xia Zhong-yuan
- Xiao Wangpin
- Xiao Wei
- Xie Guohao
- Xie Jue
- Xie Junjie
- Xie Keliang
- Xifara Archontoula
- Xiong Xiapei
- Xiong Yingfen
- Xouplidis Kyriakos
- Xu Guan-Jie
- Xu Lin
- Xu Liyuan
- Xu Qiong
- Xu Shixia
- Xue Rui
- Yagnik Anmol
- Yan Yixiu
- Yang Jian
- Yang Lu
- Yang Qiuhong
- Yang Shuangjia
- Yang Tianqin
- Yang Yang
- Yao Shanglong
- Yao Yurui
- Yap Huey Ling
- Yarwood Jamie
- Yassaee Arrash
- Ye Haiwang
- Ye Hui
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- Yeh Erlinda
- Yin Ning
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- Yong Johnny
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- Yuan Dajiang
- Yuan Fang
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- Yuan Jing
- Yuan Yazhuo
- Yuliana Annika
- Yun Bai
- Zaane Bas
- Zaimi Donika
- Zakynthinos Spyros
- Zamudio Diana
- Zangrillo Alberto
- Zapata Darcy Danitza Mari
- Zbitnew Geoff
- Zeggeren Laura
- Zeidan Lisa
- Zeng Qiuting
- Zettergren Jan
- Zhang Baoling
- Zhang Enman
- Zhang Huaigen
- Zhang Huan
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- Zhang Min
- Zhang Mingxiao
- Zhang Qin
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- Zhang Shihai
- Zhang Weiwei
- Zhang Xiaoguang
- Zhang Xiaolin
- Zhang Xiaoyan
- Zhang Yan
- Zhang Yapping
- Zhang Ye
- Zhang Yuan
- Zhao Bing
- Zhao Bo
- Zhao Chong
- Zhao Jiashi
- Zhao Jinning
- Zhao Lei
- Zhao Shuna
- Zhao Ting
- Zhao Weihong
- Zhao Weilu
- Zhao Xiaoying
- Zhen Jungang
- Zheng Kang
- Zheng Lina
- Zheng Tianzhao
- Zhong Yi
- Zhou Ce
- Zhou Dachun
- Zhou Haidong
- Zhou Haiyan
- Zhou Jiali
- Zhou Jialong
- Zhou Jing
- Zhou Xian-jin
- Zhu Xiaomao
- Zhu Yi
- Zhu Zhipeng
- Zhuang Xiuxiu
- Zilis Georgios
- Zin Nor Hafizah Mohd
- Zingerle Nicolette
- Zingg Urs
- Zoerner Frank
- Zonneveldt Harry
- Zou Xiaohua
- Zoulamoglou Menelaos
- Zsisku Lajos
- Zundert Tom
- Zyl Rebekka
- åkring Irene
- Ögren Katrin
- Publication venue
- 'Wiley'
- Publication date
- 22/10/2018
- Field of study
Background
The Clavien–Dindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the Clavien–Dindo system can be used internationally in studies across differing healthcare systems in high- (HICs) and low- and middle-income countries (LMICs).
Methods
This was a secondary analysis of the International Surgical Outcomes Study (ISOS), a prospective observational cohort study of elective surgery in adults. Data collection occurred over a 7-day period. Severity of complications was graded using Clavien–Dindo and the simpler ISOS grading (mild, moderate or severe, based on guided investigator judgement). Severity grading was compared using the intraclass correlation coefficient (ICC). Data are presented as frequencies and ICC values (with 95 per cent c.i.). The analysis was stratified by income status of the country, comparing HICs with LMICs.
Results
A total of 44 814 patients were recruited from 474 hospitals in 27 countries (19 HICs and 8 LMICs). Some 7508 patients (16·8 per cent) experienced at least one postoperative complication, equivalent to 11 664 complications in total. Using the ISOS classification, 5504 of 11 664 complications (47·2 per cent) were graded as mild, 4244 (36·4 per cent) as moderate and 1916 (16·4 per cent) as severe. Using Clavien–Dindo, 6781 of 11 664 complications (58·1 per cent) were graded as I or II, 1740 (14·9 per cent) as III, 2408 (20·6 per cent) as IV and 735 (6·3 per cent) as V. Agreement between classification systems was poor overall (ICC 0·41, 95 per cent c.i. 0·20 to 0·55), and in LMICs (ICC 0·23, 0·05 to 0·38) and HICs (ICC 0·46, 0·25 to 0·59).
Conclusion
Caution is recommended when using a treatment approach to grade complications in global surgery studies, as this may introduce bias unintentionally
The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis
- Author
- Ab Majid Mohd Azuan
- Ab Rahman Ahmad Sufian
- Ab Rahman Rusnah
- Abayasinghe Chamika
- Abbas Muntadhar
- Abbott T. E. F.
- Abbott Tom
- Abd Ghafar Fara Nur Idayu
- Abd Hadi Husni Zaeem
- Abdel Goad Ehab Helmy
- Abdullah Noor Hairiza
- Abdur-Rahman Lukman
- Abeloos Jacques
- Abernethy Caroline
- Abidin Ucu Nurhadiat
- Abrunhosa Alexandra
- Absar Mohammed
- Adam Suwayba
- Adams David
- Adams George
- Adamson Michael
- Adekola Oyebola
- Adelaja Yemi
- Ademola Adeyinka
- Adenekan Anthony
- Adenike Odewabi
- Adeolu Augustine A.
- Adetoye Adedapo
- Adewale Badru
- Adigun Tinuola
- Adolfsson Anne
- Africander Cucu
- Afshari Arash
- Agarwal Vandana
- Agodirin Olayide
- Aguzzoli Crisitiano
- Ahamed khader null
- Ahmad Azam Ummi Azmira
- Ahmad Abdurrahman
- Ahmad Norfaizan
- Ahmad T.
- Ahmad Tahania
- Ahmad Yousra
- Ahmed Ahmed
- Ahmed Jamil
- Ahmed Tahania
- Ai Yanqiu
- Aignatoaie Mariana
- Aimoniotou-Georgiou Eleni
- Akanmu Olanrewaju
- Akerman Nik
- Akinwale Mukaila
- Al Anizi Mashel
- Al hussaini Sabah
- Al'Amri Khalid
- Al-Soudaine Yassr
- Aladin Hafiz
- Alagbe-Briggs Olubusola
- Albaj Safauldeensalem
- Alberto Lisi Zaheer Moolla
- AlbertoVolta Carlo
- Alcock David
- Alcock Liam
- Aldecoa Cesar
- Aleixo Fábia Berganton
- Alexander Hazel
- Alexander Maini
- Alexander-Sefre Farhad
- Alherz Fadhel
- Ali Hani
- Ali Marlynn
- Ali Sarah
- Alias Abdul Hafiz
- Alias Anita
- Alit Mahaalit Aribawa
- Allen Samantha
- Allen Sara Jane
- Allison Joanna
- Alloj Chiara
- Allorto Nikki Leigh
- Allsop Joanne
- Almeida William
- Alonso Eduardo
- Alonso José Ignacio
- Alphonsus Christella
- Alvares Danielle
- Alves Maria Joao
- Amador Juan Carlos Bravo
- Ameer Yusuf
- Amendola Cristina Prata
- Ami Noam
- Amstrup-Hansen Louise
- Anagnou Athina
- Andersen Cheme
- Anderson Charlotte
- Anderson Colette
- Anderson Frank
- Anderson Philip
- Andreadaki Evangelia
- Andreou Alexandros
- Andreou Prematie
- Andrew Alyson
- Andrews Emma
- Angermair Stefan
- Angus Kirsty
- Anillo Victor
- Antal Oana
- Antill Philip
- Antoniadou Eleni
- Antonina Webombesa
- Apagaki Eymorfia
- Apostolou Konstantinos
- Applewhaite Christopher
- Aquino Laura Patricia González
- Ar Praburaj
- Arawwawala Dilshan
- Ardern Diane
- Argue Ruth
- Arkalaki Eleni
- Arlo whitehouse null
- Armaganidis Apostolos
- Armstrong John
- Armstrong Richard
- Arnaoutoglou Christina
- Arnaoutoglou Elena
- Arnold Glenn
- Arrandale Lindsay
- Arrich James
- Arrigo Mario
- Arshad Homa
- Arshad Mohammed Asif
- Artiles Tania Socorro
- Arumugam Swarna
- Arustei Mirela
- Arvaniti Kostoula
- Arya Aryabiantara
- Arya Shobhit
- Asimakos Andreas
- Aslam F Noorbhai M.
- Asudo Felicia
- Athanasakis Elias
- Atiku Mamuda
- Attrill Elizabeth
- Attwood Clare
- Auer Patrick
- Avidan Michael
- Avila Erendira Jocelin Dominguez
- Avis Joanne
- Awad Hadi
- Axioti Elena
- Azambuja Pedro
- Azevedo Caroline
- Aziz Faizal Zuhri
- Baas Peter
- Baghirzada Leyla
- Bai Hui-Ping
- Bai Yun
- Baillie Shelley
- Baines Duncan
- Baio Thalissa Hermínia
- Bairaktari Aggeliki
- Baker Gerard
- Baker Katie-Anne
- Baker Paul
- Balain Birender
- Balaji Packianathaswamy
- Balajonda Naraida
- Balanescu Andreea
- Balasubramaniam Madhu
- Baldisserotto Sérgio
- Baldwin Jacqueline
- Baldwin Matthew
- Balfoussia Danai
- Bali Christina
- Bandeira Maria Expedito
- Banerjee Robin
- Bankewitz Carla
- Banner-Goodspeed Valerie
- Bao Qi
- Barcraft-Barnes Helena
- Barneto Lisa
- Barnett Andrew
- Baroselli Antonio
- Barraclough James
- Barras Jean-Pierre
- Barrett Stephen
- Barrett Wendy Joan
- Basanth Sujith
- Batchelor Nick
- Bateman Brian
- Bates Alexander
- Bates Sarah
- Batista Hugo Dias
- Bauchmuller Kris
- Bauer Marlene
- Baumgarten Georg
- Baxter Linden
- Beaton Ceri
- Beattie Scott
- Beavis Vanessa
- Beavis Vanessa
- Bechan Sudha
- Bejia Tarek
- Belciu Ioana
- Belda Margarita Tormo
- Bell Gillian
- Bell Rachel
- Bell Stephanie
- Bellandi Mattia
- Bello Jibril
- Beloeil Helene
- Belskiy Vladislav
- Beltran Anna Valle
- Ben-Menachem Erez
- Benavent Pau
- Benedikt Preckel Osne Kirzner
- Benevento Angelo
- Bengeri Sheshagiri
- Bennett Cambell
- Bennett Michael
- Bennett Rachael
- Bennett Victoria
- Bentley Conor
- Beretta Luigi
- Berg Andrew
- Bergin Colin
- Bernard Andre
- Bernat Maria Jose
- Berntsen Emer
- Bertram Wendy
- Bester Delia
- Bester Marlet
- Bettega Fernanda
- Bettinelli Alessandra
- Bhardwaj Neeraj
- Bhatia Kailash
- Bhula Chettan
- Bi Yanbing
- Biais Matthieu
- Biccard B. M.
- Biccard Bruce
- Biccard Bruce M.
- Bidd Heena
- Bidgoli Jawad
- Biffen Andrew
- Bignami Elena
- Bilolikar Anjali
- Bin Mustapha Mohd Tarmimi
- Birch Julie
- Bishop David Gray
- Biyase Thuli
- Bizios Christol
- Blackwell Clare
- Blackwood Douglas
- Blaj Mihaela
- Blakemore Stephen P.
- Bland Martin
- Blunt Mark
- Blyth Katharine
- Bocchino Speranza
- Bodansky Daniella
- Bodger Phoebe
- Boer Christa
- Boereboom Catherine
- Boggiano Victoria
- Bogner Gerhard
- Bokkel-Andela Janneke ten
- Bolaji Benjamin
- Bolton David
- Boone Myles
- Boschi Luca
- Boshier Piers
- Botes Marisa
- Botis Ioannis
- Bottini Corrado
- Bottrill Fiona
- Bouchez Stefaan
- Boulton Kerenza
- Bouris Vasilios
- Bourner Lynsey
- Boutsikos Georgios
- Bouwman Arthur
- Bowrey Sarah
- Boxall Leigh
- Boyd Christine
- Bradburn Mike
- Bradley Jacqueline
- Branagan Graham
- Branco Teresa
- Brand Bastiaan
- Brandsborg Birgitte
- Breitenstein Stefan
- Brennan Andrew
- Brennan Emma
- Brenner Laura
- Brincat Maximilian
- Briscoe Richard
- Bristogiannis Sotirios
- Brooke Jenny
- Brookes Jamie
- Brookes Morag
- Brooks Carolyn
- Broomby Rupert
- Brotto Ana Flavia
- Brown Andrew
- Brown Caroline Wrey
- Brown Gemma
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- Brown Janette
- Brown Lynne
- Brown Richard
- Brown Robyn
- Browning Julie
- Bruma Dana
- Brunete Tamara
- Brunswicker Annemarie
- Bryant Helen
- Bua Emmanuel
- Buccimazza Ines
- Buckley Sarah
- Buerkle Christian
- Buhre Wolfgang
- Builu Pierre Monji
- Buise Marc
- Bullock Clare
- Bunwarie Bimalshakth
- Burns Karen
- Burrows Lorna
- Burrows Tom
- Burston Ben
- Burtenshaw Andrew
- Burton Megan
- Busuioc Mihai
- Butryn Izabella
- Butt Georgina
- Byrne Kelly
- Bührer Thomas
- Cabezuelo Estefania
- Cabral Raquel
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- Cabrini Luca
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- Cai Fang
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- Cain Helen
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- Cancho David
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- Cang Jing
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- Cao Jianqiao
- Cao Ying
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- Cardy Jon
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- Carr Adrienne
- Carrera Ronald
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- Carroll Jo
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- Chandler Ben
- Chandra Susilo
- Chandrasekharan Shardha
- Chang Yuan Hsuan
- Chaniotaki Fotini
- Charitos Efthimios
- Charlalampidoy Alexandra
- Charles Rob
- Chatterjee Devnandan
- Chatterjee Jayanta
- Chatzimichali Chatzimichali Aikaterini
- Chau Simon
- Chazova Elena
- Cheah Clarissa
- Cheah Seleen
- Cheeseman Michelle
- Cheing Yushio
- Chen Chao
- Chen Chen
- Chen Feifei
- Chen Fumei
- Chen Hong
- Chen James
- Chen Junping
- Chen Lee-lynn
- Chen Linbi
- Chen Liyong
- Chen Pushan
- Chen Qiang
- Chen Rong
- Chen Shasha
- Chen Shiyu
- Chen Sijia
- Chen Yaqiu
- Chen Yijiao
- Chen Yijun
- Chen Yongjie
- Chen Zhang
- Cheng Baoli
- Cheng Ka Ho
- Cheng Zhonggui
- Cheong Edward
- Cherian Ritchie
- Cherrett Veronica
- Chetty Rubendraj R.
- Chew M. S.
- Chew Michelle
- Chhabra Ashok
- Chicken Dennis-Wayne
- Chilinciuc Ion
- Chin Im Im
- Chirkut Subash
- Chlorou Dimitra
- Choi Hyun-min David
- Choi Stephen
- Chow Lorraine
- Christian Rachel
- Christiansen Ida Cecilie
- Christmas Natasha
- Christodoulidis Gregory
- Christodoulopoulou Theodora
- Christofaki Maria
- Christoforidis Dimitri
- Chronis Christos
- Chu Hiu Man
- Chu Susanna
- Chua Pandora
- Chukkambotla Srikanth
- Chung Chun Kwong Eric
- Cifra Elna
- Ciobanu Cristina
- Ciobotaru Oana Roxana
- Cirstea Emanuel
- Clark Richard
- Clarkson Aisling
- Clarkson Rachel
- Clavien Pierre-Alain
- Claxton Andrew
- Clemmons Karen
- Cloro Luigi Maria
- Clyde Antony
- Cobzaru Isabelle
- Codita Anisoara
- Colangelo Antonio
- Colangelo Chiara
- Colling Kerry
- Collins Hannah
- Collins Michelle
- Collins Nwokoro
- Colvin Carolyn
- Commey Thelma
- Comptaer Nicolas
- Conde Carlos
- Conradie Alae
- Constantin Kathryn
- Cook Tim
- Cooper Lauren
- Cooper Lucy
- Cooper Mariese
- Cooper Richard
- Cooper Sarah
- Copaciu Elena
- Cope Jennifer
- Copetti Elisa
- Copley Edward
- Copotoiu Sanda Maria
- Coppens Marc
- Corneci Dan
- Cornell Jonathan
- Cornish Julie
- Correia da Silva Rui Freitas Mendonça
- Corti Daniele
- Costa Ana Cristina Miranda Martins
- Costanzo Eleonora
- Costelloe Hannah
- Cotter Rochelle
- Cotterell Sharon
- Cotterill Donna
- Coughlan Elaine
- Coulter Ian
- Coulter Suzanne
- Coutinho Francisco
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- Cox Hannah
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- Critchley Rebecca
- Cronje Larissa
- Cruickshank Ross
- Cruikshanks Andrew
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- Currow Helen
- Czepanski Carolyn
- Czeslick Elke
- D'Andrea Rocco
- Dafnios Nikolaos
- Dai Hanying
- Dai Qingqing
- Dai Qinxue
- Dai Si Yuan
- Daikou Panagoula
- Dalamagka Maria
- Dalampini Eleftheria
- Dali-Kemmery Lola
- Dalton Emma
- Damant Rose
- Daniel Conway
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- Daniel Harvey
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- Dankl Daniel
- Darko Julia
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- Daya Bhavika
- De Andrés Ibanez José Antonio
- De Baerdemaeker Luc
- de Beer Johan
- de Boer Hans Donald
- De Bruyne Ann
- de Fretes Jennifer
- de Gasperi Julia
- de Hert Stefan
- De Jongh Karen
- De Kegel Dirk
- De Meyer Jenine N.
- De Oliveira Mirella Cristine
- de Rudnicki Stéphane
- de Swardt Mathew
- de Vasconcellos Kim
- de Villiers Martin
- de Wet Jacques
- Deacon Matthew
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- Yagnik Anmol
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- Yang Yang
- Yao Shanglong
- Yao Yurui
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- Yarwood Jamie
- Yassaee Arrash
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- Yegnaram Shashikant
- Yeh Erlinda
- Yin Ning
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- Yong Johnny
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- Yuan Dajiang
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- Yuan Jing
- Yuan Yazhuo
- Yuliana Annika
- Zaimi Donika
- Zakynthinos Spyros
- Zamudio Diana
- Zangrillo Alberto
- Zapata Darcy Danitza Mari
- Zbitnew Geoff
- Zeidan Lisa
- Zeng Qiuting
- Zerman Luiza
- Zettergren Jan
- Zhang Baoling
- Zhang Enman
- Zhang Hongyan
- Zhang Huaigen
- Zhang Huan
- Zhang Jie
- Zhang Kai
- Zhang Lina
- Zhang Min
- Zhang Mingxiao
- Zhang Qin
- Zhang Ruilin
- Zhang Shihai
- Zhang Weiwei
- Zhang Xiaoguang
- Zhang Xiaolin
- Zhang Xiaoyan
- Zhang Xuekang
- Zhang Yan
- Zhang Yapping
- Zhang Ye
- Zhang Yuan
- Zhao Bing
- Zhao Bo
- Zhao Chong
- Zhao Jiashi
- Zhao Jinning
- Zhao Lei
- Zhao Lili
- Zhao Shuna
- Zhao Ting
- Zhao Weihong
- Zhao Weilu
- Zhao Xiaoying
- Zhen Jungang
- Zheng Kang
- Zheng Lina
- Zheng Tianzhao
- Zhong Yi
- Zhou Ce
- Zhou Dachun
- Zhou Haidong
- Zhou Haiyan
- Zhou Jiali
- Zhou Jialong
- Zhou Jing
- Zhou Xian-jin
- Zhu Xiaomao
- Zhu Xiaoping
- Zhu Yi
- Zhu Zhipeng
- Zhuang Xiuxiu
- Zilis Georgios
- Zingerle Nicolette
- Zingg Urs
- Zoerner Frank
- Zonneveldt Harry
- Zou Xiaohua
- Zoulamoglou Menelaos
- Zsisku Lajos
- Åkring Irene
- Ögren Katrin
- Publication venue
- Health Sciences Research Commons
- Publication date
- 30/10/2017
- Field of study
© 2017 British Journal of Anaesthesia Background: The surgical safety checklist is widely used to improve the quality of perioperative care. However, clinicians continue to debate the clinical effectiveness of this tool. Methods: Prospective analysis of data from the International Surgical Outcomes Study (ISOS), an international observational study of elective in-patient surgery, accompanied by a systematic review and meta-analysis of published literature. The exposure was surgical safety checklist use. The primary outcome was in-hospital mortality and the secondary outcome was postoperative complications. In the ISOS cohort, a multivariable multi-level generalized linear model was used to test associations. To further contextualise these findings, we included the results from the ISOS cohort in a meta-analysis. Results are reported as odds ratios (OR) with 95% confidence intervals. Results: We included 44 814 patients from 497 hospitals in 27 countries in the ISOS analysis. There were 40 245 (89.8%) patients exposed to the checklist, whilst 7508 (16.8%) sustained ≥1 postoperative complications and 207 (0.5%) died before hospital discharge. Checklist exposure was associated with reduced mortality [odds ratio (OR) 0.49 (0.32–0.77); P\u3c0.01], but no difference in complication rates [OR 1.02 (0.88–1.19); P=0.75]. In a systematic review, we screened 3732 records and identified 11 eligible studies of 453 292 patients including the ISOS cohort. Checklist exposure was associated with both reduced postoperative mortality [OR 0.75 (0.62–0.92); P\u3c0.01; I2=87%] and reduced complication rates [OR 0.73 (0.61–0.88); P\u3c0.01; I2=89%). Conclusions: Patients exposed to a surgical safety checklist experience better postoperative outcomes, but this could simply reflect wider quality of care in hospitals where checklist use is routine