Motivating Organizational Search

This paper investigates the value of high-powered incentives for motivating search for novelty in business organizations. While organizational search critically depends on the individual efforts of employees, motivating search effort is challenged by problems of unobservable behavior and the misalignment of individual and organizational interests. Prior work on organizational design thus suggests that stronger incentives can overcome these problems and make organizations more innovative. To address this conjecture, we develop a computational model of organizational search that rests on two opposing effects of high-powered incentives: On the one hand, they promote higher effort by increasing the potential rewards from search; on the other hand, they increase the competition among ideas, as the ability of an organization to implement and remunerate good ideas is limited by its resource base. Our results indicate that low-powered incentives are effective in generating a sufficient stream of incremental innovations, but that they also result in a shortage of more radical innovations. Stronger incentives, in contrast, do not systematically foster radical innovations either, but instead create a costly oversupply of good ideas. Nonetheless, higher-powered incentives can still be effective in small firms and if strong persistence is required to develop a new idea. Based on the analysis of our model, we develop a set of propositions that appear to be consistent with extant evidence and point to new avenues for empirical research.Organizational search, incentives, innovation, agent-based simulation

A Look Through a Broken Window: The Relationship Between Disorder and Toxicity on Social Networking Sites

Toxicity has increased on social networking sites (SNSs), sparking a debate on its underlying causes. While research readily explored eligible social factors, disorder induced by the very nature of SNSs has been neglected so far. The relationship between disorder and deviant behaviors could be revealed within the offline sphere. Incorporating the theoretical lens of the Broken Windows Theory, we propose that a similar mechanism is prevalent in the online context. To test the hypothesis that perceived disorder increases toxicity on SNSs, the study compares two subcommunities on Reddit dedicated to the same topic that differ in their perceived disorder. Sampling the toxicity scores via data collection and natural language processing yields the first evidence for our hypothesis. We further outline subsequent studies that aim to investigate further the phenomenon of how disorder-related factors contribute to toxic online environments

Observation of hybrid Tamm-plasmon exciton-polaritons with GaAs quantum wells and a MoSe2 monolayer

This work has been supported by the State of Bavaria. C.S. acknowledges financial support by the European Research Council (unLiMIt-2D project). AK acknowledged the support from the HORIZON 2020 RISE project CoExAn (Grant No. 644076). S.H and A.K acknowledge funding by the EPSRC.Strong light matter coupling between excitons and microcavity photons, as described in the framework of cavity quantum electrodynamics, leads to the hybridization of light and matter excitations. The regime of collective strong coupling arises, when various excitations from different host media are strongly coupled to the same optical resonance. This leads to a well-controllable admixture of various matter components in three hybrid polariton modes. Here, we study a cavity device with four embedded GaAs quantum wells hosting excitons that are spectrally matched to the A-valley exciton resonance of a MoSe2 monolayer. The formation of hybrid polariton modes is evidenced in momentum resolved photoluminescence and reflectivity studies. We describe the energy and k-vector distribution of exciton-polaritons along the hybrid modes by a thermodynamic model, which yields a very good agreement with the experiment.Publisher PDFPeer reviewe

Artificial intelligence in human genomics and biomedicine - Dynamics, potentials and challenges

The increasing availability of extensive and complex data has made human genomics and its applications in (bio)medicine an at­ tractive domain for artificial intelligence (AI) in the form of advanced machine learning (ML) methods. These methods are linked not only to the hope of improving diagnosis and drug development. Rather, they may also advance key issues in biomedicine, e. g. understanding how individual differences in the human genome may cause specific traits or diseases. We analyze the increasing convergence of AI and genom­ics, the emergence of a corresponding innovation system, and how these associative AI methods relate to the need for causal knowledge in biomedical research and development (R&D) and in medical prac­tice. Finally, we look at the opportunities and challenges for clinical practice and the implications for governance issues arising from this convergence.Die zunehmende Verfügbarkeit umfangreicher und komplexer Daten hat die Humangenomik und ihre Anwendungsbereiche in der (Bio-)Medizin zu einem attraktiven Bereich für künstliche Intelligenz (KI) vor allem in Form von fortgeschrittenen Methoden des maschinellen Lernens (ML) gemacht. Diese Methoden sind nicht nur mit der Hoffnung verbunden, Diagnosen und die Medikamentenentwicklung zu verbessern. Sie könnten auch darum, Kernthemen in der Biomedizin voranzubringen, z. B. zu verstehen, wie individuelle Unterschiede im menschlichen Genom bestimmte Merkmale oder Krankheiten verursachen können. Wir analysieren die zunehmende Konvergenz von KI und Genomik, das Entstehen eines entsprechenden Innovationssystems und wie diese assoziativen KI‑Methoden mit dem Bedarf an kausalem Wissen in der biomedizinischen Forschung und Entwicklung und in der medizinischen Praxis zusammenhängen. Schließlich betrachten wir die Potenziale und Herausforderungen für die klinische Praxis und die sich aus dieser Konvergenz ergebenden Implikationen für Governance-Fragen

Substrate engineering for high quality emission of free and localized excitons from atomic monolayers in hybrid architectures

We acknowledge financial support by the State of Bavaria and the European Research Council (Project Unlimit-2D).Atomic monolayers represent a novel class of materials to study localized and free excitons in two dimensions and to engineer optoelectronic devices based on their significant optical response. Here, we investigate the role of the substrate on the photoluminescense response of MoSe2 and WSe2 monolayers exfoliated either on SiO2 or epitaxially grown InGaP substrates. In the case of MoSe2, we observe a significant qualitative modification of the emission spectrum, which is widely dominated by the trion resonance on InGaP substrates. However, the effects of inhomogeneous broadening of the emission features are strongly reduced. Even more strikingly, in sheets of WSe2, we could routinely observe emission lines from localized excitons with linewidths down to the resolution limit of 70 μeV. This is in stark contrast to reference samples featuring WSe2 monolayers on SiO2 surfaces, where the emission spectra from localized defects are widely dominated by spectral diffusion and blinking behaviour. Our experiment outlines the enormous potential of III-V-monolayer hybrid architectures to obtain high quality emission signals from atomic monolayers, which are straight forward to integrate into nanophotonic and integrated optoelectronic devices.PostprintPeer reviewe

Cascaded emission of single photons from the biexciton in monolayered WSe2

This work has been supported by the State of Bavaria and the European Research Council (Project UnLiMIt-2D).Monolayers of transition metal dichalcogenide materials emerged as a new material class to study excitonic effects in solid state, as they benefit from enormous Coulomb correlations between electrons and holes. Especially in WSe2, sharp emission features have been observed at cryogenic temperatures, which act as single photon sources. Tight exciton localization has been assumed to induce an anharmonic excitation spectrum; however, the evidence of the hypothesis, namely the demonstration of a localized biexciton, is elusive. Here we unambiguously demonstrate the existence of a localized biexciton in a monolayer of WSe2, which triggers an emission cascade of single photons. The biexciton is identified by its time-resolved photoluminescence, superlinearity and distinct polarization in micro-photoluminescence experiments. We evidence the cascaded nature of the emission process in a cross-correlation experiment, which yields a strong bunching behaviour. Our work paves the way to a new generation of quantum optics experiments with two-dimensional semiconductors.PostprintPublisher PDFPeer reviewe

Fixed low-dose ultrasound-assisted catheter-directed thrombolysis for intermediate and high-risk pulmonary embolism

Aims No standardized local thrombolysis regimen exists for the treatment of pulmonary embolism (PE). We retrospectively investigated efficacy and safety of fixed low-dose ultrasound-assisted catheter-directed thrombolysis (USAT) for intermediate- and high-risk PE. Methods and results Fifty-two patients (65 ± 14 years) of whom 14 had high-risk PE (troponin positive in all) and 38 intermediate-risk PE (troponin positive in 91%) were treated with intravenous unfractionated heparin and USAT using 10 mg of recombinant tissue plasminogen activator per device over the course of 15 h. Bilateral USAT was performed in 83% of patients. During 3-month follow-up, two [3.8%; 95% confidence interval (CI) 0.5-13%] patients died (one from cardiogenic shock and one from recurrent PE). Major non-fatal bleeding occurred in two (3.8%; 95% CI, 0.5-13%) patients: one intrathoracic bleeding after cardiopulmonary resuscitation requiring transfusion, one intrapulmonary bleeding requiring lobectomy. Mean pulmonary artery pressure decreased from 37 ± 9 mmHg at baseline to 25 ± 8 mmHg at 15 h (P < 0.001) and cardiac index increased from 2.0 ± 0.7 to 2.7 ± 0.9 L/min/m2 (P < 0.001). Echocardiographic right-to-left ventricular end-diastolic dimension ratio decreased from 1.42 ± 0.21 at baseline to 1.06 ± 0.23 at 24 h (n = 21; P < 0.001). The greatest haemodynamic benefit from USAT was found in patients with high-risk PE and in those with symptom duration < 14 days. Conclusion A standardized catheter intervention approach using fixed low-dose USAT for the treatment of intermediate- and high-risk PE was associated with rapid improvement in haemodynamic parameters and low rates of bleeding complications and mortalit

Acetylcholine content and viability of cholinergic neurons are influenced by the activity of protein histidine phosphatase

Background: The first mammalian protein histidine phosphatase (PHP) was discovered in the late 90s of the last century. One of the known substrates of PHP is ATP-citrate lyase (ACL), which is responsible - amongst other functions - for providing acetyl-CoA for acetylcholine synthesis in neuronal tissues. It has been shown in previous studies that PHP downregulates the activity of ACL by dephosphorylation. According to this our present work focused on the influence of PHP activity on the acetylcholine level in cholinergic neurons. Results: The amount of PHP in SN56 cholinergic neuroblastoma cells was increased after overexpression of PHP by using pIRES2-AcGFP1-PHP as a vector. We demonstrated that PHP overexpression reduced the acetylcholine level and induced cell death. The acetylcholine content of SN56 cells was measured by fast liquid chromatographytandem mass spectrometry method. Overexpression of the inactive H53A-PHP mutant also induced cell damage, but in a significantly reduced manner. However, this overexpression of the inactive PHP mutant did not change the acetylcholine content of SN56 cells significantly. In contrast, PHP downregulation, performed by RNAitechnique, did not induce cell death, but significantly increased the acetylcholine content in SN56 cells. Conclusions: We could show for the first time that PHP downregulation increased the acetylcholine level in SN56 cells. This might be a potential therapeutic strategy for diseases involving cholinergic deficits like Alzheimer’s disease

Erarbeitung von Massnahmen und Kennzahlen zum Ziel 8 des Green Impact Book : die ZHAW steigert die ökologisch bewirtschafteten Grün- und Dachflächen

Diese Forschung wurde von einem Forschungsteam im Auftrag von ZHAW sustainable, dem strategischen Programm für nachhaltige Entwicklung der Zürcher Hochschule für Angewandte Wissenschaften (ZHAW), unabhängig durchgeführt und im Rahmen der Umsetzung der ZHAW-Nachhaltigkeitsstrategie finanziert. www.zhaw.ch/sustainableDie ZHAW hat im Ziel 8 des Green Impact Books das Ziel definiert, die Grün- und Dachflächen an ihren Standorten ökologisch zu bewirtschaften, um Mitarbeitern und Studierenden ein ökologisch wertvolles Umfeld zu bieten und die Biodiversität insgesamt zu verbessern. Die meisten Mietobjekte weisen erhebliche Mängel in Bezug auf die ökologische Qualität auf, da sie oft keine Grünflächen haben und somit kaum Lebensräume für Flora und Fauna bieten. Es besteht ein grosses Potenzial zur Aufwertung dieser Objekte durch Entsiegelung und klimaangepasste Vegetationssysteme. Die Liegenschaften im kantonalen Eigentum haben zwar einen hohen Grünflächenanteil, aber ihr ökologisches Potenzial ist noch nicht vollständig ausgeschöpft. Es sollten Strukturelemente wie Wildhecken und standortgerechte Pflanzen hinzugefügt und Asphaltflächen entsiegelt werden. Die Aufwertung trägt zur Biodiversitätsförderung und Hitzeminderung bei und hat positive Auswirkungen auf die Gesundheit und Arbeitszufriedenheit der Mitarbeiter und Studierenden. Der Schutz bestehender Grünflächen und Bäume ist von höchster Priorität, da Bäume eine der wirkungsvollsten Massnahmen zur Förderung von Biodiversität und Hitzeminderung sind