Spacelab Data Processing Facility (SLDPF) quality assurance expert systems development

The Spacelab Data Processing Facility (SLDPF) is an integral part of the Space Shuttle data network for missions that involve attached scientific payloads. Expert system prototypes were developed to aid in the performance of the quality assurance function of the Spacelab and/or Attached Shuttle Payloads processed telemetry data. The Spacelab Input Processing System (SIPS) and the Spacelab Output Processing System (SOPS), two expert systems, were developed to determine their feasibility and potential in the quality assurance of processed telemetry data. The capabilities and performance of these systems are discussed

Spacelab Data Processing Facility (SLDPF) quality assurance expert systems development

Spacelab Data Processing Facility (SLDPF) expert system prototypes were developed to assist in the quality assurance of Spacelab and/or Attached Shuttle Payload (ASP) processed telemetry data. The SLDPF functions include the capturing, quality monitoring, processing, accounting, and forwarding of mission data to various user facilities. Prototypes for the two SLDPF functional elements, the Spacelab Output Processing System and the Spacelab Input Processing Element, are described. The prototypes have produced beneficial results including an increase in analyst productivity, a decrease in the burden of tedious analyses, the consistent evaluation of data, and the providing of concise historical records

Profili evolutivi della governance assicurativa nell'applicazione di Solvency II.

La tesi sviluppa il sistema di corporate governance nelle imprese assicurative alla luce del nuovo regime di vigilanza prudenziale contenuto nella direttiva europea Solvency II, entrata in vigore il 1° gennaio 2016. Le disposizioni prevedono che le imprese di assicurazione si dotino di un sistema efficace di governance, che consenta una gestione sana e prudente dell’attività, conferendo un ruolo decisivo alla regolamentazione della governance ed alla disciplina dell’assetto organizzativo interno dell’impresa. Partendo dalla descrizione della nascita del nuovo regime di vigilanza prudenziale, viene approfondito il secondo pilastro della struttura di Solvency II. Nello specifico si evidenziano le motivazioni della sua introduzione, la corporate governance e gli orientamenti EIOPA in materia. Infine viene esaminata l’applicazione della direttiva europea in Italia, con particolare riferimento alla compagnia assicurativa Unipolsai Assicurazioni Spa

Prospectus, October 26, 1977

STAERKEL TELLS BOARD, \u27WILL START OUTDOOR FACILITIES THIS SPRING\u27; Pumpkin contest ends today, votes still taken; WIU announces visitation dates; Insuramce courses are offered at Parkland; Wheelchair Day today; Indoor courts now taking reservations; New regulations are announced; ACT test tomorrow; Historic Preservation classes give sneak preview Tuesday; Parkland Events; Hey! In trouble? Look for the jeep!; Mysterious!; Journ Club elects officers; METRO takes over on family calls; Curious Girl is curious film; Ghosts and goblins: ancient beginnings; Picnic: Play -- a chance to create; Radio meeting is tomorrow; Home for retarded pigeons: should it be considered?; Classifieds; Golfers 3rd of 4t in CIAC tourney; The top...: Wells chooses area\u27s best...; ...and the bottom: Hartman hits nation\u27s worst; Women spikers go two-for-four; X-country falls to state\u27s top teams; Michigan loss stumps all but five in Freddy; It\u27s IM sign-up time; Hartman qualifies for state tourney at 15-over-par 87https://spark.parkland.edu/prospectus_1977/1007/thumbnail.jp

Supporting the Formation of Communities of Practice: Urban Planning in the MR-Tent

We have developed a prototype of an integrated framework of tools, an MR application supporting a range of devices for collaborative multimodal interaction and individual expression. These tools allow groups of stakeholders in an urban project create and manipulate visual and auditory scenes, and mesh these scenes with the real environment of an urban planning site as an integral part of expressing and experiencing an evolving project. The technical infrastructure is housed in a specifically designed MR Tent (Figure 1), which allows bringing technologies that are normally available only in laboratory settings to the site of an urban project. On top of designing these tools in a user-centered design process, we have also developed an approach to supporting multiple interactions among the various agents (professionals, as well as lay people, referring to different temporal and spatial scales, representing various cultures) in real complex urban environments. We contend that when introducing participatory technologies, methods are needed that facilitate the constitution of multidisciplinary teams founded on public-private and local actors-global operators partnerships [Bourdin et al. 2006]

Prospectus, October 19, 1977

WPCD GOES ON AIR JANUARY \u2778: KELLY; Security stymies petrol pilferers; Propeck resigns as Stu-Go secretary; Thompson vetoes House community college bill; Canteen hit again; Parkland Events; \u27Who\u27s Who… candidates due; Letters to the editor: Some thoughts on a lost friend..., Head Start Follow Up Program needs tutors, ...\u27why headlined?\u27, On student directories - \u27not hired to correct\u27; Thompson seeks candidates for national awards; ACT Test Oct. 27; Phone line available for disabled; Blood drive is \u27successful\u27; Student Directory problem brought before Stu-Go; Have any suggestions?; CCWAR begins training; Danville DJ not quite ready for funny farm; Art group meets tonight; U.S. goes hosteling; Fear of dentists extracted by psych project; CHI, Women\u27s Program sponsor workshop Oct. 27; Don\u27t buy the book: How to save money through the mail; Tours this fall for U. of I.\u27s IMPE; Classifieds; Trout not pleased with women\u27s 8-5 record; K-Action continues winning ways in IM; Halloween activities on October 27; Art students are working for spring show; A review: Moliere adaptation Scapino was \u27zany\u27; Graphic Art competitions at U. of I.; Upsets cause trouble 10-for-12 Freddy; Indoor tracksters are balanced team; Fast Freddy Football Forecast; Danville drives for CIAC title, Parkland second?; Three run best ever at DuPage; Golfers 14th of 20 at Lincoln Landhttps://spark.parkland.edu/prospectus_1977/1008/thumbnail.jp

Multiplicity Studies and Effective Energy in ALICE at the LHC

In this work we explore the possibility to perform ``effective energy'' studies in very high energy collisions at the CERN Large Hadron Collider (LHC). In particular, we focus on the possibility to measure in $pp$ collisions the average charged multiplicity as a function of the effective energy with the ALICE experiment, using its capability to measure the energy of the leading baryons with the Zero Degree Calorimeters. Analyses of this kind have been done at lower centre--of--mass energies and have shown that, once the appropriate kinematic variables are chosen, particle production is characterized by universal properties: no matter the nature of the interacting particles, the final states have identical features. Assuming that this universality picture can be extended to {\it ion--ion} collisions, as suggested by recent results from RHIC experiments, a novel approach based on the scaling hypothesis for limiting fragmentation has been used to derive the expected charged event multiplicity in $AA$ interactions at LHC. This leads to scenarios where the multiplicity is significantly lower compared to most of the predictions from the models currently used to describe high energy $AA$ collisions. A mean charged multiplicity of about 1000-2000 per rapidity unit (at $\eta \sim 0$) is expected for the most central $Pb-Pb$ collisions at $\sqrt{s_{NN}} = 5.5 TeV$.Comment: 12 pages, 19 figures. In memory of A. Smirnitski

Specific Uncoupling of GRB2 from the Met Receptor DIFFERENTIAL EFFECTS ON TRANSFORMATION AND MOTILITY

The biological effects of hepatocyte growth factor/scatter factor are mediated by autophosphorylation of its receptor, the Met tyrosine kinase, on two carboxyl-terminal tyrosines. These phosphotyrosines (Y1349VHVNATY1356VNV) are multifunctional docking sites for several effectors. Grb2, the adaptor for the Ras guanyl-nucleotide exchanger SOS, binds to Tyr1356 in the YVNV motif. By site-directed mutagenesis we either abrogated or duplicated the Grb2 consensus, without interfering with the other effectors. Loss of the link with Grb2 severely impaired transformation. The same mutation, however, had no effect on the "scattering" response, indicating that the level of signal which can be reached by Grb2-independent routes is permissive for motility. Duplication of the Grb2 binding site enhanced transformation and left motility unchanged. Thus, two Met-mediated biological responses, motility and growth, can be dissociated on the basis of their differential requirement for a direct link with Ras

Knowledge-driven binning approach for rare variant association analysis: application to neuroimaging biomarkers in Alzheimer’s disease

Abstract Background Rapid advancement of next generation sequencing technologies such as whole genome sequencing (WGS) has facilitated the search for genetic factors that influence disease risk in the field of human genetics. To identify rare variants associated with human diseases or traits, an efficient genome-wide binning approach is needed. In this study we developed a novel biological knowledge-based binning approach for rare-variant association analysis and then applied the approach to structural neuroimaging endophenotypes related to late-onset Alzheimer’s disease (LOAD). Methods For rare-variant analysis, we used the knowledge-driven binning approach implemented in Bin-KAT, an automated tool, that provides 1) binning/collapsing methods for multi-level variant aggregation with a flexible, biologically informed binning strategy and 2) an option of performing unified collapsing and statistical rare variant analyses in one tool. A total of 750 non-Hispanic Caucasian participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort who had both WGS data and magnetic resonance imaging (MRI) scans were used in this study. Mean bilateral cortical thickness of the entorhinal cortex extracted from MRI scans was used as an AD-related neuroimaging endophenotype. SKAT was used for a genome-wide gene- and region-based association analysis of rare variants (MAF (minor allele frequency) < 0.05) and potential confounding factors (age, gender, years of education, intracranial volume (ICV) and MRI field strength) for entorhinal cortex thickness were used as covariates. Significant associations were determined using FDR adjustment for multiple comparisons. Results Our knowledge-driven binning approach identified 16 functional exonic rare variants in FANCC significantly associated with entorhinal cortex thickness (FDR-corrected p-value < 0.05). In addition, the approach identified 7 evolutionary conserved regions, which were mapped to FAF1, RFX7, LYPLAL1 and GOLGA3, significantly associated with entorhinal cortex thickness (FDR-corrected p-value < 0.05). In further analysis, the functional exonic rare variants in FANCC were also significantly associated with hippocampal volume and cerebrospinal fluid (CSF) Aβ1–42 (p-value < 0.05). Conclusions Our novel binning approach identified rare variants in FANCC as well as 7 evolutionary conserved regions significantly associated with a LOAD-related neuroimaging endophenotype. FANCC (fanconi anemia complementation group C) has been shown to modulate TLR and p38 MAPK-dependent expression of IL-1β in macrophages. Our results warrant further investigation in a larger independent cohort and demonstrate that the biological knowledge-driven binning approach is a powerful strategy to identify rare variants associated with AD and other complex disease.https://deepblue.lib.umich.edu/bitstream/2027.42/136776/1/12911_2017_Article_454.pd

Prospectus, September 14, 1977

TWO VIE FOR VEEP POST: STUDENT GOVERNMENT ELECTIONS TODAY; Elections scheduled today and tomorrow; District 505 entitled to minimum credit grants; Activities postponed; Unopposed; Shiloh\u27s and Sonshine Circle to perform; Survival of democratic society topic at forum; Vets must go by book; \u27Self Defense\u27 is under attack; Youngest brew master is nun; Warners, women battle over \u27Jump On It\u27; Male prostitute makes history; News From \u27Her Say\u27: Ten women earn wings; UAW asks Congress for maternity benefits \u27as soon as possible\u27; Career Awareness Course for women Wednesday eve.; Instructors earn high grades from PC students; Back orders on home insulation cause woes; Blowing of the shofar means Rosh Hashanah, start of 5,738 New Year; Springfield news: senior citizens, equal language; The gas man cometh...; Holograph exhibit at PC tomorrow; Letting out some Slack...: Answers for queries on PC; Chicago painter displays at KCPA; Prospectus Pigskin Preview: Cobra Grid Schedule, Parkland Roster, Fight on Cobras; Alaskan wilderness is summer home to Basler; Parkland Learning Laboratory: Early help available to students; Stu-Go explores check cashing for PC people; PC music groups have many openings; Jumers: German touch; \u27Elite\u27 women to get public house; Home care topic to be presented; Classifieds; X-country opens Saturday; Spikettes look good; Sports shorts; Bio instructor Cox wins Fast Freddy; Intramural sign up closing; The continuing battle for Number 1; Parkland to host nationalshttps://spark.parkland.edu/prospectus_1977/1013/thumbnail.jp