Imipramine as an alternative to formamide to detubulate rat ventricular cardiomyocytes

International audienceT-tubules are membrane invaginations essential for the excitation-contraction coupling (ECC). Imipramine like other cationic amphiphilic drugs, interfere with the PI(4,5)P2 interactions with proteins maintaining the tubular system connected to cell surface. Our main purpose was to validate imipramine as a new detubulating agent in cardiomyocytes. Staining adult rat ventricular myocytes (ARVMs) with di-4-ANEPPS, we showed that unlike formamide, imipramine induces a complete detubulation with no impact on cell viability. Using the patch-clamp technique, we observed a ~40% decrease in cell capacitance after imipramine pretreatment and a reduction of ICa,L Disclaimer: This is a confidential document

Computational Indistinguishability Logic ∗

Computational Indistinguishability Logic (CIL) is a logic for reasoning about cryptographic primitives in computational models. It captures reasoning patterns that are common in provable security, such as simulations and reductions. CIL is sound for the standard model, but also supports reasoning in the random oracle and other idealized models. We illustrate the benefits of CIL by formally proving the security of the probabilistic signature scheme (PSS). 1

Adaptive Remeshing for Real-Time Mesh Deformation

Dunyach M, Vanderhaeghe D, Barthe L, Botsch M. Adaptive Remeshing for Real-Time Mesh Deformation. In: Eurographics Short Papers. 2013: 29-32

Adaptive Remeshing for Real-Time Mesh Deformation

International audienceWe present an adaptive isotropic remeshing technique that is fast enough to be used in interactive applications, such as mesh deformation or mesh sculpting. Previous real-time remeshing techniques are either not adaptive, hence requiring too many triangles, or make compromises in terms of triangle quality. High quality adaptive remeshing techniques are too slow for interactive applications. In this short paper we present a simple extension of a uniform remeshing approach that results in an efficient, yet high quality, curvature-adaptive remeshing

Mechanism of formation of Co-Ru nanoalloys: the key role of Ru on the reduction pathway of Co

The chemical synthesis of alloy nanoparticles requires adequate conditions to obtain coreduction instead of separate reduction of the two metal cations. The mechanism of formation of bimetallic cobalt-ruthenium nanoalloys by reducing the metal salts in an alcohol medium was explored to draw general rules to extrapolate to other systems. The relative kinetics of reduction of both metal cations were studied by UV-visible and in situ Quick-X-ray absorption spectroscopies as well as H2 evolution. The addition of Co(II) ions does not influence the reduction kinetics of Ru(III) but adding Ru(III) to a Co(II) solution promotes the reduction of cobalt cations. Indeed, while CoO is formed when reaching the boiling temperature of the solvent for the monometallic system, a direct reduction of Co is observed at this temperature without formation of the oxide for the bimetallic one. The co-reduction of the metal cations results in the formation of bimetallic nanoplatelets, the size of which can be tuned by changing the Ru content