Mexico in the United Nations

The purpose of this investigation is to look at the international organization from the point of view of a small, non-military nation to discover if and how it may be useful to such a nation in carrying out its foreign policy objectives in a bi-polar, nuclear world

Increasing Food Production in Drylands Using Agrivoltaics

In the desert, native plants respond to the hottest part of the day by either closing their stomata, which would stop photosynthesis, or by simply reducing their photosynthesis rates due to heat stress. Soil water resources are also impacted due to significant evaporation. If plants have more shade during the day, will they photosynthesize more in the afternoon than plants without shade? Will these plants with shade transpire less, and thus need to be watered less? This study takes a look at plants which have grown under a photovoltaics array (a new agriculture practice called agrivoltaics) as well as plants which have grown in the open (modeling traditional agriculture practices). It was hypothesized the agrivoltaics practice will benefit plants by providing them shade and retaining soil moisture during the day as well as benefiting the photovoltaics by keeping them cooler to increase their efficiency. This study was designed to determine whether growing under the photovoltaic panels is beneficial, by collecting and analyzing data on photosynthesis (carbon uptake) and transpiration (water loss) rates of 8+ different species. These measurements will help answer which plants are best suited for being planted in an agrivoltaics installation

The Impact of Coastal Phytoplankton Blooms on Ocean-Atmosphere Thermal Energy Exchange: Evidence From a Two-Way Coupled Numerical Modeling System

A set of sensitivity experiments are performed with a two-way coupled and nested ocean-atmosphere forecasting system in order to deconvolve how dense phytoplankton stocks in a coastal embayment may impact thermal energy exchange processes. Monterey Bay simulations parameterizing solar shortwave transparency in the surface ocean as an invariant oligotrophic oceanic water type estimate consistently colder sea surface temperature (SST) than simulations utilizing more realistic, spatially varying shortwave attenuation terms based on satellite estimates of surface algal pigment concentration. These SST differences lead to an similar to 88% increase in the cumulative turbulent thermal energy transfer from the ocean to the atmosphere over the three month simulation period. The result is a warmer simulated atmospheric boundary layer with respective local air temperature differences approaching similar to 2 degrees C. This study suggests that the retention of shortwave solar flux by ocean flora may directly impact even short-term forecasts of coastal meteorological variables. Citation: Jolliff, J. K., T. A. Smith, C. N. Barron, S. deRada, S. C. Anderson, R. W. Gould, and R. A. Arnone (2012), The impact of coastal phytoplankton blooms on ocean-atmosphere thermal energy exchange: Evidence from a two-way coupled numerical modeling system, Geophys. Res. Lett., 39, L24607, doi:10.1029/2012GL053634

Datos del subsuelo y su conocimiento para las Ciudades del Mañana: lecciones aprendidas de Glasgow y su aplicabilidad en otros lugares

El conocimiento del subsuelo es de vital importancia en la planificación y ejecución exitosa de proyectos de construcción y regeneración urbanas. Para abordar en el área de Glasgow éste y otros temas del subsuelo urbano (por ejemplo, la planificación, las inundaciones, la contaminación), el proyecto Clyde-Urban Super-Project (CUSP) del Servicio Geológico Británico (BGS, por sus siglas en inglés) ha desarrollado modelos 3D y 4D del subsuelo. Asimismo, se han producido otros conjuntos de datos de geociencias (geoquímica, agua subterránea, geología de ingeniería). Los modelos basados en información obtenida de decenas de miles de perforaciones y otras fuentes, proporcionan nuevos conocimientos sobre: la geología compleja de Glasgow, los impactos de su legado industrial, y las oportunidades para aprovechar el calor de las explotaciones mineras abandonadas. Para que los modelos y datos del proyecto CUSP fueran más accesibles, el BGS y el Ayuntamiento de Glasgow, socio clave, han establecido una red para acceder al conocimiento del subsuelo (ASK, por sus siglas en inglés). Esta red permite el intercambio de datos y conocimientos, implicando a socios de los sectores público y privado. ASK promueve el libre flujo digital de datos del subsuelo y el conocimiento entre sus socios. Las lecciones aprendidas en Glasgow se comparten a través de la Acción Europea COST (Sub-Urban), centrada en el uso sostenible del subsuelo urbano, y en la transformación de las relaciones entre los que desarrollan el conocimiento del subsuelo urbano y los que pueden beneficiarse más de él, los planificadores y promotores de las ciudades del futuro

Outreach:Impact on Skills and Future Careers of Postgraduate Practitioners Working with the Bristol ChemLabS Centre for Excellence in Teaching and Learning

Postgraduate engagement in delivering outreach activities is more commonplace than it once was. However, the impact on postgraduate students (typically studying for a Ph.D. degree) of participating in the delivery of these outreach activities has rarely, if ever, been recorded. The Bristol ChemLabS Outreach program has been running for ca. 17 years, and in that time, many postgraduate students have been involved (approximately 500), with around 250 typically for up to 3 years. We sought to investigate the impact of outreach engagement on postgraduate alumni who were involved in the program for over 3 years (32) and how the experiences and training of the outreach program had impacted on their careers postgraduation. Thirty of the 32 postgraduates engaged and ∼70% reported that their outreach experience had influenced their decision making on future careers. Many respondents reported that the skills and experiences gained through outreach participation had contributed to success in applying for and interviewing at their future employers. All respondents reported that outreach had helped them to develop key skills that were valued in the workplace, specifically, communication, teamwork, organizational skills, time planning, event planning, and event management. Rather than a pleasant distraction or an opportunity to supplement income, all participants noted that they felt there were many additional benefits and that this was time well spent. Outreach should not be viewed as a distraction to science research but rather an important enhancement to it provided that the program is well constructed and seeks to develop those delivering the outreach activities

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Clinical Efficacy and Safety of Bevacizumab Monotherapy in Patients with Metastatic Melanoma: Predictive Importance of Induced Early Hypertension

Background: VEGF driven angiogenesis plays a key role in cancer progression. We determined the clinical efficacy of bevacizumab monotherapy in patients with metastatic melanoma. Methods and Findings: Thirty-five patients with metastatic melanoma in progression were enrolled in this phase II, single arm clinical trial. Each patient received bevacizumab monotherapy 10 mg/kg q14 d until intolerable toxicity or disease progression occurred. Clinical efficacy was evaluated as objective response, disease control (DC), and survival. We observed one complete (3%) and 5 partial (14%) responses. In addition, 5 patients experienced stable disease >6 months (14%) while 24 patients had progressive disease (PD, 69%), corresponding to a total DC at 6 months in 11 out of 35 patients (31%). Median progression free survival (PFS) was 2.14 months and median overall survival (OS) was 9 months (1.12–49). Seven of the 11 patients experiencing DC developed early hypertension (<2 months) compared to 3/24 of patients with PD (P = 0.001), and hypertension was associated with PFS (P = 0.005) and OS (P = 0.013). Conclusion: Bevacizumab monotherapy demonstrated promising clinical efficacy in patients with metastatic melanoma with disease control in 31% of the patients. Induced early hypertension was a marker for clinical efficacy of bevacizumab

Experimental Inoculation of Juvenile Rhesus Macaques with Primate Enteric Caliciviruses

Tissue culture-adapted Tulane virus (TV), a GI.1 rhesus enteric calicivirus (ReCV), and a mixture of GII.2 and GII.4 human norovirus (NoV)-containing stool sample were used to intrastomacheally inoculate juvenile rhesus macaques (Macaca mulatta) in order to evaluate infection caused by these viruses. METHODOLOGY & FINDINGS: Two of the three TV-inoculated macaques developed diarrhea, fever, virus-shedding in stools, inflammation of duodenum and 16-fold increase of TV-neutralizing (VN) serum antibodies but no vomiting or viremia. No VN-antibody responses could be detected against a GI.2 ReCV strain FT285, suggesting that TV and FT285 represent different ReCV serotypes. Both NoV-inoculated macaques remained asymptomatic but with demonstrable virus shedding in one animal. Examination of duodenum biopsies of the TV-inoculated macaques showed lymphocytic infiltration of the lamina propria and villous blunting. TV antigen-positive (TV+) cells were detected in the lamina propria. In most of the TV+ cells TV co-localized perinuclearly with calnexin--an endoplasmic reticulum protein. A few CD20+TV+ double-positive B cells were also identified in duodenum. To corroborate the authenticity of CD20+TV+ B cells, in vitro cultures of peripheral blood mononuclear cells (PBMCs) from healthy macaques were inoculated with TV. Multicolor flow cytometry confirmed the presence of TV antigen-containing B cells of predominantly CD20+HLA-DR+ phenotype. A 2-log increase of viral RNA by 6 days post inoculation (p<0.05) suggested active TV replication in cultured lymphocytes.Taken together, our results show that ReCVs represent an alternative cell culture and animal model to study enteric calicivirus replication, pathogenesis and immunity

International consensus conference recommendations on ultrasound education for undergraduate medical students

Objectives: The purpose of this study is to provide expert consensus recommendations to establish a global ultrasound curriculum for undergraduate medical students. Methods: 64 multi-disciplinary ultrasound experts from 16 countries, 50 multi-disciplinary ultrasound consultants, and 21 medical students and residents contributed to these recommendations. A modified Delphi consensus method was used that included a systematic literature search, evaluation of the quality of literature by the GRADE system, and the RAND appropriateness method for panel judgment and consensus decisions. The process included four in-person international discussion sessions and two rounds of online voting. Results: A total of 332 consensus conference statements in four curricular domains were considered: (1) curricular scope (4 statements), (2) curricular rationale (10 statements), (3) curricular characteristics (14 statements), and (4) curricular content (304 statements). Of these 332 statements, 145 were recommended, 126 were strongly recommended, and 61 were not recommended. Important aspects of an undergraduate ultrasound curriculum identified include curricular integration across the basic and clinical sciences and a competency and entrustable professional activity-based model. The curriculum should form the foundation of a life-long continuum of ultrasound education that prepares students for advanced training and patient care. In addition, the curriculum should complement and support the medical school curriculum as a whole with enhanced understanding of anatomy, physiology, pathophysiological processes and clinical practice without displacing other important undergraduate learning. The content of the curriculum should be appropriate for the medical student level of training, evidence and expert opinion based, and include ongoing collaborative research and development to ensure optimum educational value and patient care. Conclusions: The international consensus conference has provided the first comprehensive document of recommendations for a basic ultrasound curriculum. The document reflects the opinion of a diverse and representative group of international expert ultrasound practitioners, educators, and learners. These recommendations can standardize undergraduate medical student ultrasound education while serving as a basis for additional research in medical education and the application of ultrasound in clinical practice