\u3cem\u3eTrifolium vesiculosum\u3c/em\u3e: Exploring Its Potential in the Uruguay Lowlands Rice Region

Trifolium vesiculosum, commonly known as arrowleaf clover, is a winter-growing annual legume native to Europe (Duke, 1981), with high persistence and low risk of bloat. Several reports show a wide annual production range between 1.9 and 9.8 t DM/ha/year (Gomes and Reis 1999; Evans and Mills 2008). It shows a high nutritional value (Tekeli et al. 2005) that declines with increasing maturity. Grazing management should consider the need for seed production to ensure natural re-seeding in subsequent years. Recently, INIA Uruguay released the T. vesiculosum cultivar Sagit (Glencoe EC1), characterized by intermediate growth habit and flowering period. The objective of this paper is to report the adaptation and performance of cv. Sagit (Glencoe EC1) in the lowlands rice region of Uruguay, under different grazing intensities with weaned calves

Management Strategies to Increase Festulolium Productivity and Persistence

A biennial hybrid of Lolium multiflorum x Festuca pratensis (Festulolium INIA Merlin) was released by the National Institute of Agricultural Research of Uruguay (INIA) in 2008. INIA Merlin is a tetraploid cultivar with a long growing season, semi-prostrate habit and high herbage quality (García 2003). These characteristics make it potentially useful to include Festulolium in short and intensive pasture-crop rotation systems. Grazing management can be used to modify growth, sward structure and persistence, and is known to be critical during the second year of production for stability and sustainability of farming systems that include this type of species. The objective of this trial was to measure the effect of different grazing strategies on the productivity and persistence of this novel cultivar

Cover Crops Alternatives for Sustainable Agriculture Systems in Uruguay

In Uruguay, the increase of cropland area during the last decade was based on rotation systems intensification and soybean expansion, achieving 1.321.000 ha (Souto, 2014). Diaz (2007) demonstrated the value of the ley-farming systems where the integration of livestock and crop production achieved benefits on sustainability. Despite the advantages of crop-pasture rotation systems (García Prechac et al., 2004), grain market prices and food demand resulted in pasture phase losses in rotation with crops. Recently, Livestock Agriculture and Fisheries Ministry implemented a national soil conservation plan, that regulates cropping rotation systems based on soil erosion estimations and other key soil quality indicators. Although, no-till was full adopted, climatic and soil conditions determine that soil must be cover by residues or vegetation all year to reduce erosion and degradation (Thorup-Kristensen et al., 2003). Cover crops contribute to protect soils during fallow periods. The 17% of total soybean area cultivated is in Eastern Uruguay, being soils with erosion risk , fertility, structure and drainage limitations. This paper evaluates cover crops adaptation, subsequent effects on soybean productivity, and estimations of nitrogen supply and extraction from cover crops and soybean, respectively

Scouting Benefits and Developing Innovations in Temperate Grassland to Sustainable Agriculture Production

Agricultural intensification raises concern about land use and future effects to natural resources. The world demand for grain, meat and forest products is increasing constantly. Changes are occurring at large scale, being a compromise for policy makers to contribute to identify opportunities to readdress the productive scenario. There is available technology to reduce impacts, without restricting necessarily productivity. Grasslands provide a large series of economical and ecological benefits to the agricultural systems, being the literature exhaustive in examples. Ley-farming and cover crops technologies are good examples of environmentally sound soil management practices. The society is also worried about an improper use of the natural resources involved. The drastic increase in the grain crops area leaded by soybean in Uruguay, determined that the government implemented Sustainable Soil Use and Management Plans, based on erosion estimation using the USLE-RUSLE model adapted locally by research conducted over more than 50 years on a series of long term experimental platforms. There is an opportunity for this type of local innovative initiatives to be widely diffused, adopted or adapted. In essence, grasslands will continue playing a key role in maintaining a sustainable production

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Elaboración de documentación e implementación de salud y seguridad industrial para la empresa Everlife con base en la norma Coguanor NTG OHSAS 18001.

Un sistema de este tipo le permitirá a la empresa desarrollar una eficiente política de SST. Se establecieron objetivos y procesos para alcanzar los compromisos de la política, se tomaron las acciones necesarias para mejorar el desempeño del sistema con los requisitos de esta norma OHSA

Galectin-8 as an immunosuppressor in experimental autoimmune encephalomyelitis and a target of human early prognostic antibodies in multiple sclerosis.

Galectin-8 (Gal-8) is a member of a glycan-binding protein family that regulates the immune system, among other functions, and is a target of antibodies in autoimmune disorders. However, its role in multiple sclerosis (MS), an autoimmune inflammatory disease of the central nervous system (CNS), remains unknown. We study the consequences of Gal-8 silencing on lymphocyte subpopulations and the development of experimental autoimmune encephalitis (EAE), to then assess the presence and clinical meaning of anti-Gal-8 antibodies in MS patients. Lgals8/Lac-Z knock-in mice lacking Gal-8 expression have higher polarization toward Th17 cells accompanied with decreased CCR6+ and higher CXCR3+ regulatory T cells (Tregs) frequency. These conditions result in exacerbated MOG35-55 peptide-induced EAE. Gal-8 eliminates activated Th17 but not Th1 cells by apoptosis and ameliorates EAE in C57BL/6 wild-type mice. β-gal histochemistry reflecting the activity of the Gal-8 promoter revealed Gal-8 expression in a wide range of CNS regions, including high expression in the choroid-plexus. Accordingly, we detected Gal-8 in human cerebrospinal fluid, suggesting a role in the CNS immune-surveillance circuit. In addition, we show that MS patients generate function-blocking anti-Gal-8 antibodies with pathogenic potential. Such antibodies block cell adhesion and Gal-8-induced Th17 apoptosis. Furthermore, circulating anti-Gal-8 antibodies associate with relapsing-remitting MS (RRMS), and not with progressive MS phenotypes, predicting clinical disability at diagnosis within the first year of follow-up. Our results reveal that Gal-8 has an immunosuppressive protective role against autoimmune CNS inflammation, modulating the balance of Th17 and Th1 polarization and their respective Tregs. Such a role can be counteracted during RRMS by anti-Gal-8 antibodies, worsening disease prognosis. Even though anti-Gal-8 antibodies are not specific for MS, our results suggest that they could be a potential early severity biomarker in RRMS

Gal-8 deficit favors Th17 polarization during MOGp-induced EAE and <i>ex-vivo</i> re-stimulation.

<p>Th17 and Th1 subpopulations in splenocytes from <i>Lgals8</i>^-/- (KO) and <i>Lgals8</i>^+/+ (WT) mice obtained after 10 days of EAE induction were analyzed either immediately or after 72 h of <i>ex vivo</i> MOGp re-stimulation, in the absence or presence of Gal-8. Gal-8 KO mice show higher frequency of Th17 cells both at steady state and after MOGp re-stimulation. Incubation with Gal-8 reduced Th17 cells only in Gal-8 KO. Graph shows frequency +/-SD (*p<0.05; ANOVA; n = 4).</p