275 research outputs found
Future evolution and uncertainty of river flow regime change in a deglaciating river basin
The flow regimes of glacier-fed rivers are sensitive to climate change due to
strong climate–cryosphere–hydrosphere interactions. Previous modelling
studies have projected changes in annual and seasonal flow magnitude but
neglect other changes in river flow regime that also have socio-economic and
environmental impacts. This study employs a signature-based analysis of
climate change impacts on the river flow regime for the deglaciating Virkisá
river basin in southern Iceland. Twenty-five metrics (signatures) are derived from 21st century projections of river flow time series to evaluate changes in
different characteristics (magnitude, timing and variability) of river flow
regime over sub-daily to decadal timescales. The projections are produced by
a model chain that links numerical models of climate and glacio-hydrology.
Five components of the model chain are perturbed to represent their
uncertainty including the emission scenario, numerical climate model,
downscaling procedure, snow/ice melt model and runoff-routing model. The
results show that the magnitude, timing and variability of glacier-fed river
flows over a range of timescales will change in response to climate change.
For most signatures there is high confidence in the direction of change, but
the magnitude is uncertain. A decomposition of the projection uncertainties
using analysis of variance (ANOVA) shows that all five perturbed model chain
components contribute to projection uncertainty, but their relative
contributions vary across the signatures of river flow. For example, the
numerical climate model is the dominant source of uncertainty for projections
of high-magnitude, quick-release flows, while the runoff-routing model is
most important for signatures related to low-magnitude, slow-release flows.
The emission scenario dominates mean monthly flow projection uncertainty, but
during the transition from the cold to melt season (April and May) the
snow/ice melt model contributes up to 23 % of projection uncertainty.
Signature-based decompositions of projection uncertainty can be used to
better design impact studies to provide more robust projections.</p
Trends in Antarctic Peninsula surface melting conditions from observations and regional climate modeling
Multidecadal meteorological station records and microwave backscatter time-series from the SeaWinds scatterometer onboard QuikSCAT (QSCAT) were used to calculate temporal and spatial trends in surface melting conditions on the Antarctic Peninsula (AP). Four of six long-term station records showed strongly positive and statistically significant trends in duration of melting conditions, including a 95% increase in the average annual positive degree day sum (PDD) at Faraday/Vernadsky, since 1948. A validated, threshold-based melt detection method was employed to derive detailed melt season onset, extent, and duration climatologies on the AP from enhanced resolution QSCAT data during 1999–2009. Austral summer melt on the AP was linked to regional- and synoptic-scale atmospheric variability by respectively correlating melt season onset and extent with November near-surface air temperatures and the October–January averaged index of the Southern Hemisphere Annular Mode (SAM). The spatial pattern, magnitude, and interannual variability of AP melt from observations was closely reproduced by simulations of the regional model RACMO2. Local discrepancies between observations and model simulations were likely a result of the QSCAT response to, and RACMO2 treatment of, ponded surface water, and the relatively crude representation of coastal climate in the 27 km RACMO2 grid
Dynamic response of Antarctic Peninsula Ice Sheet to potential collapse of Larsen C and George VI ice shelves
Ice shelf break-up and disintegration events over the past 5 decades have led to speed-up, thinning, and retreat of upstream tributary glaciers and increases to rates of global sea-level rise. The southward progression of these episodes indicates a climatic cause and in turn suggests that the larger Larsen C and George VI ice shelves may undergo a similar collapse in the future. However, the extent to which removal of the Larsen C and George VI ice shelves will affect upstream tributary glaciers and add to global sea levels is unknown. Here we apply numerical ice-sheet models of varying complexity to show that the centennial sea-level commitment of Larsen C embayment glaciers following immediate shelf collapse is low ( < 2.5 mm to 2100, < 4.2 mm to 2300). Despite its large size, Larsen C does not provide strong buttressing forces to upstream basins and its collapse does not result in large additional discharge from its tributary glaciers in any of our model scenarios. In contrast, the response of inland glaciers to a collapse of the George VI Ice Shelf may add up to 8mm to global sea levels by 2100 and 22mm by 2300 due in part to the mechanism of marine ice sheet instability. Our results demonstrate the varying and relative importance to sea level of the large Antarctic Peninsula ice shelves considered to present a risk of collapse
Proglacial groundwater storage dynamics under climate change and glacier retreat
Proglacial aquifers are an important water store in glacierised mountain catchments that supplement meltwater‐fed river flows and support freshwater ecosystems. Climate change and glacier retreat will perturb water storage in these aquifers, yet the climate‐glacier‐groundwater response cascade has rarely been studied and remains poorly understood. This study implements an integrated modelling approach that combines distributed glacio‐hydrological and groundwater models with climate change projections to evaluate the evolution of groundwater storage dynamics and surface‐groundwater exchanges in a temperate, glacierised catchment in Iceland. Focused infiltration along the meltwater‐fed Virkisá River channel is found to be an important source of groundwater recharge and is projected to provide 14%–20% of total groundwater recharge by the 2080s. The simulations highlight a mechanism by which glacier retreat could inhibit river recharge in the future due to the loss of diurnal melt cycling in the runoff hydrograph. However, the evolution of proglacial groundwater level dynamics show considerable resilience to changes in river recharge and, instead, are driven by changes in the magnitude and seasonal timing of diffuse recharge from year‐round rainfall. The majority of scenarios simulate an overall reduction in groundwater levels with a maximum 30‐day average groundwater level reduction of 1 m. The simulations replicate observational studies of baseflow to the river, where up to 15% of the 30‐day average river flow comes from groundwater outside of the melt season. This is forecast to reduce to 3%–8% by the 2080s due to increased contributions from rainfall and meltwater runoff. During the melt season, groundwater will continue to contribute 1%–3% of river flow despite significant reductions in meltwater runoff inputs. Therefore it is concluded that, in the proglacial region, groundwater will continue to provide only limited buffering of river flows as the glacier retreats
Программа автоматизированного расчёта параметров прокатки, в комплексе «приводная – неприводная клети»
Разработан алгоритм программы автоматизированного расчёта параметров
процесса прокатки в комплексе ПК–НК и программа на языке С++, обеспечиваю-
щая расчёт энергосиловых и технологических параметров прокатки в комплексе
ПК–НК с учётом ограничивающих процесс факторов
GEANT4 : a simulation toolkit
Abstract Geant4 is a toolkit for simulating the passage of particles through matter. It includes a complete range of functionality including tracking, geometry, physics models and hits. The physics processes offered cover a comprehensive range, including electromagnetic, hadronic and optical processes, a large set of long-lived particles, materials and elements, over a wide energy range starting, in some cases, from 250 eV and extending in others to the TeV energy range. It has been designed and constructed to expose the physics models utilised, to handle complex geometries, and to enable its easy adaptation for optimal use in different sets of applications. The toolkit is the result of a worldwide collaboration of physicists and software engineers. It has been created exploiting software engineering and object-oriented technology and implemented in the C++ programming language. It has been used in applications in particle physics, nuclear physics, accelerator design, space engineering and medical physics. PACS: 07.05.Tp; 13; 2
The acridonecarboxamide GF120918 potently reverses P-glycoprotein-mediated resistance in human sarcoma MES-Dx5 cells
The doxorubicin-selected, P-glycoprotein (P-gp)-expressing human sarcoma cell line MES-Dx5 showed the following levels of resistance relative to the non-P-gp-expressing parental MES-SA cells in a 72 h exposure to cytotoxic drugs: etoposide twofold, doxorubicin ninefold, vinblastine tenfold, taxotere 19-fold and taxol 94-fold. GF120918 potently reversed resistance completely for all drugs. The EC50s of GF120918 to reverse resistance of MES-Dx5 cells were: etoposide 7 ± 2 nM, vinblastine 19 ± 3 nM, doxorubicin 21 ± 6 nM, taxotere 57 ± 14 nM and taxol 91 ± 23 nM. MES-Dx5 cells exhibited an accumulation deficit relative to the parental MES-SA cells of 35% for [3H]-vinblastine, 20% for [3H]-taxol and [14C]-doxorubicin. The EC50 of GF120918, to reverse the accumulation deficit in MES-Dx5 cells, ranged from 37 to 64 nM for all three radiolabelled cytotoxics. [3H]-vinblastine bound saturably to membranes from MES-Dx5 cells with a KD of 7.8 ± 1.4 nM and a Bmax of 5.2 ± 1.6 pmol mg–1 protein. Binding of [3H]-vinblastine to P-gp in MES-Dx5 membranes was inhibited by GF120918 (Ki = 5 ± 1 nM), verapamil (Ki = 660 ± 350 nM) and doxorubicin (Ki = 6940 ± 2100 nM). Taxol, an allosteric inhibitor of [3H]-vinblastine binding to P-gp, could only displace 40% of [3H]-vinblastine (Ki = 400 ± 140 nM). The novel acridonecarboxamide derivative GF120918 potently overcomes P-gp-mediated multidrug resistance in the human sarcoma cell line MES-Dx5. Detailed analysis revealed that five times higher GF120918 concentrations were needed to reverse drug resistance to taxol in the cytotoxicity assay compared to doxorubicin, vinblastine and etoposide. An explanation for this phenomenon had not been found. © 1999 Cancer Research Campaig
Bedmap2: improved ice bed, surface and thickness datasets for Antarctica
We present Bedmap2, a new suite of gridded products describing surface elevation, ice-thickness and the seafloor and subglacial bed elevation of the Antarctic south of 60° S. We derived these products using data from a variety of sources, including many substantial surveys completed since the original Bedmap compilation (Bedmap1) in 2001. In particular, the Bedmap2 ice thickness grid is made from 25 million measurements, over two orders of magnitude more than were used in Bedmap1. In most parts of Antarctica the subglacial landscape is visible in much greater detail than was previously available and the improved data-coverage has in many areas revealed the full scale of mountain ranges, valleys, basins and troughs, only fragments of which were previously indicated in local surveys. The derived statistics for Bedmap2 show that the volume of ice contained in the Antarctic ice sheet (27 million km3) and its potential contribution to sea-level rise (58 m) are similar to those of Bedmap1, but the mean thickness of the ice sheet is 4.6% greater, the mean depth of the bed beneath the grounded ice sheet is 72 m lower and the area of ice sheet grounded on bed below sea level is increased by 10%. The Bedmap2 compilation highlights several areas beneath the ice sheet where the bed elevation is substantially lower than the deepest bed indicated by Bedmap1. These products, along with grids of data coverage and uncertainty, provide new opportunities for detailed modelling of the past and future evolution of the Antarctic ice sheets
Bedmap2: improved ice bed, surface and thickness datasets for Antarctica
We present Bedmap2, a new suite of gridded
products describing surface elevation, ice-thickness and the seafloor and subglacial bed elevation of the Antarctic south of 60 S. We derived these products using data from a variety of sources, including many substantial surveys completed
since the original Bedmap compilation (Bedmap1) in 2001. In particular, the Bedmap2 ice thickness grid is made
from 25 million measurements, over two orders of magnitude more than were used in Bedmap1. In most parts of Antarctica
the subglacial landscape is visible in much greater detail than was previously available and the improved datacoverage has in many areas revealed the full scale of mountain
ranges, valleys, basins and troughs, only fragments of which were previously indicated in local surveys. The derived statistics for Bedmap2 show that the volume of ice
contained in the Antarctic ice sheet (27 million km3) and its potential contribution to sea-level rise (58 m) are similar
to those of Bedmap1, but the mean thickness of the ice sheet is 4.6% greater, the mean depth of the bed beneath the grounded ice sheet is 72m lower and the area of ice
sheet grounded on bed below sea level is increased by 10 %.
The Bedmap2 compilation highlights several areas beneath the ice sheet where the bed elevation is substantially lower
than the deepest bed indicated by Bedmap1. These products, along with grids of data coverage and uncertainty, provide new opportunities for detailed modelling of the past and future evolution of the Antarctic ice sheets
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