FGF/heparin differentially regulates Schwann cell and olfactory ensheathing cell interactions with astrocytes: a role in astrocytosis

After injury, the CNS undergoes an astrocyte stress response characterized by reactive astrocytosis/proliferation, boundary formation, and increased glial fibrillary acidic protein (GFAP) and chondroitin sulfate proteoglycan (CSPG) expression. Previously, we showed that in vitro astrocytes exhibit this stress response when in contact with Schwann cells but not olfactory ensheathing cells (OECs). In this study, we confirm this finding in vivo by demonstrating that astrocytes mingle with OECs but not Schwann cells after injection into normal spinal cord. We show that Schwann cell-conditioned media (SCM) induces proliferation in monocultures of astrocytes and increases CSPG expression in a fibroblast growth factor receptor 1 (FGFR1)-independent manner. However, SCM added to OEC/astrocyte cocultures induces reactive astrocytosis and boundary formation, which, although sensitive to FGFR1 inhibition, was not induced by FGF2 alone. Addition of heparin to OEC/astrocyte cultures induces boundary formation, whereas heparinase or chlorate treatment of Schwann cell/astrocyte cultures reduces it, suggesting that heparan sulfate proteoglycans (HSPGs) are modulating this activity. In vivo, FGF2 and FGFR1 immunoreactivity was increased over grafted OECs and Schwann cells compared with the surrounding tissue, and HSPG immunoreactivity is increased over reactive astrocytes bordering the Schwann cell graft. These data suggest that components of the astrocyte stress response, including boundary formation, astrocyte hypertrophy, and GFAP expression, are mediated by an FGF family member, whereas proliferation and CSPG expression are not. Furthermore, after cell transplantation, HSPGs may be important for mediating the stress response in astrocytes via FGF2. Identification of factors secreted by Schwann cells that induce this negative response in astrocytes would further our ability to manipulate the inhibitory environment induced after injury to promote regeneration

Electrical and ultraviolet characterization of 4H-SiC Schottky photodiodes

Fabrication and electrical and optical characterization of 4H-SiC Schottky UV photodetectors with nickel silicide interdigitated contacts is reported. Dark capacitance and current measurements as a function of applied voltage over the temperature range 20 °C – 120 °C are presented. The results show consistent performance among devices. Their leakage current density, at the highest investigated temperature (120 °C), is in the range of nA/cm2 at high internal electric field. Properties such as barrier height and ideality factor are also computed as a function of temperature. The responsivities of the diodes as functions of applied voltage were measured using a UV spectrophotometer in the wavelength range 200 nm - 380 nm and compared with theoretically calculated values. The devices had a mean peak responsivity of 0.093 A/W at 270 nm and −15 V reverse bias

Lateral Segregation of Photosystem I in Cyanobacterial Thylakoids

Photosystem I (PSI) is the dominant photosystem in cyanobacteria and it plays a pivotal role in cyanobacterial metabolism. Despite its biological importance, the native organisation of PSI in cyanobacterial thylakoid membranes is poorly understood. Here, we use atomic force microscopy (AFM) to show that ordered, extensive macromolecular arrays of PSI complexes are present in thylakoids from Thermosynechococcus (T.) elongatus, Synechococcus sp. PCC 7002 and Synechocystis sp PCC 6803. Hyperspectral confocal fluorescence microscopy (HCFM) and three-dimensional structured illumination microscopy (3D-SIM) of Synechocystis sp PCC 6803 cells visualise PSI domains within the context of the complete thylakoid system. Crystallographic and AFM data were used to build a structural model of a membrane landscape comprising 96 PSI trimers and 27,648 chlorophyll a molecules. Rather than facilitating inter-trimer energy transfer the close associations between PSI primarily maximise packing efficiency; short-range interactions with Complex I and cytochrome b6f are excluded from these regions of the membrane, so PSI turnover is sustained by long-distance diffusion of the electron donors at the membrane surface. Elsewhere, PSI-photosystem II (PSII) contact zones provide sites for docking phycobilisomes and the formation of megacomplexes. PSI-enriched domains in cyanobacteria might foreshadow the partitioning of PSI into stromal lamellae in plants, similarly sustained by long-distance diffusion of electron carriers

Mesoscopic scattering in the half-plane: squeezing conductance through a small hole

We model the 2-probe conductance of a quantum point contact (QPC), in linear response. If the QPC is highly non-adiabatic or near to scatterers in the open reservoir regions, then the usual distinction between leads and reservoirs breaks down and a technique based on scattering theory in the full two-dimensional half-plane is more appropriate. Therefore we relate conductance to the transmission cross section for incident plane waves. This is equivalent to the usual Landauer formula using a radial partial-wave basis. We derive the result that an arbitrarily small (tunneling) QPC can reach a p-wave channel conductance of 2e^2/h when coupled to a suitable reflector. If two or more resonances coincide the total conductance can even exceed this. This relates to recent mesoscopic experiments in open geometries. We also discuss reciprocity of conductance, and the possibility of its breakdown in a proposed QPC for atom waves.Comment: 8 pages, 3 figures, REVTeX. Revised version (shortened), accepted for publication in PR

Contact Interactions Involving Right-handed Neutrinos and SN1987A

We consider lepton-quark contact interactions in models with right-handed neutrinos, and find that observational data from SN1987A restricts the scale of such interactions to be at least $\Lambda>90$ TeV.Comment: 7 pages, latex, no figures. Minor corrections to match final version to appear in Phys. Rev.

Chaos in a double driven dissipative nonlinear oscillator

We propose an anharmonic oscillator driven by two periodic forces of different frequencies as a new time-dependent model for investigating quantum dissipative chaos. Our analysis is done in the frame of statistical ensemble of quantum trajectories in quantum state diffusion approach. Quantum dynamical manifestation of chaotic behavior, including the emergence of chaos, properties of strange attractors, and quantum entanglement are studied by numerical simulation of ensemble averaged Wigner function and von Neumann entropy.Comment: 9 pages, 18 figure

Quantifying Entanglement Production of Quantum Operations

The problem of entanglement produced by an arbitrary operator is formulated and a related measure of entanglement production is introduced. This measure of entanglement production satisfies all properties natural for such a characteristic. A particular case is the entanglement produced by a density operator or a density matrix. The suggested measure is valid for operations over pure states as well as over mixed states, for equilibrium as well as nonequilibrium processes. Systems of arbitrary nature can be treated, described either by field operators, spin operators, or any other kind of operators, which is realized by constructing generalized density matrices. The interplay between entanglement production and phase transitions in statistical systems is analysed by the examples of Bose-Einstein condensation, superconducting transition, and magnetic transitions. The relation between the measure of entanglement production and order indices is analysed.Comment: 20 pages, Revte

Pentagonal nanowires: a first-principles study of atomic and electronic structure

We performed an extensive first-principles study of nanowires in various pentagonal structures by using pseudopotential plane wave method within the density functional theory. Our results show that nanowires of different types of elements, such as alkali, simple, transition and noble metals and inert gas atoms, have a stable structure made from staggered pentagons with a linear chain perpendicular to the planes of the pentagons and passing through their centers. This structure exhibits bond angles close to those in the icosahedral structure. However, silicon is found to be energetically more favorable in the eclipsed pentagonal structure. These quasi one dimensional pentagonal nanowires have higher cohesive energies than many other one dimensional structures and hence may be realized experimentally. The effect of magnetic state are examined by spin-polarized calculations. The origin of the stability are discussed by examining optimized structural parameters, charge density and electronic band structure, and by using analysis based on the empirical Lennard-Jones type interaction. Electronic band structure of pentagonal wires of different elements are discussed and their effects on quantum ballistic conductance are mentioned. It is found that the pentagonal wire of silicon exhibits metallic band structure.Comment: 4 figures, accepted for publication in Phys. Rev.

Quark Condensate in the Deuteron

We study the changes produced by the deuteron on the QCD quark condensate by means the Feynman-Hellmann theorem and find that the pion mass dependence of the pion-nucleon coupling could play an important role. We also discuss the relation between the many body effect of the condensate and the meson exchange currents, as seen by photons and pions. For pion probes, the many-body term in the physical amplitude differs significantly from that of soft pions, the one linked to the condensate. Thus no information about the many-body term of the condensate can be extracted from the pion-deuteron scattering length. On the other hand, in the Compton amplitude, the relationship with the condensate is a more direct one.Comment: to appear in Physics Review C (19 pages, 3 figures

What Attracts Men Who Batter to Their Partners? An Exploratory Study

Men who batter, because of particular personality traits and sense of entitlement, may select partners whom they perceive will be dependent on them, meet their emotional needs, or be “objects” of physical attractiveness. During treatment intake, 181 offenders responded to the question, “What attracted you to her (your partner)?” We explored whether men who mentioned their own needs or her physical traits would engage in more frequent and severe violence and would have specific forms of personality disorder dimensions or personality traits. Six categories of attraction, including “her physical traits” and “his needs,” were derived from the men’s responses. The results showed that men who focused on their partners’ physical attractiveness were more likely to be violent after treatment. Men who cited their own needs for their attraction had higher scores on borderline personality, alcohol abuse, and psychotic thinking and lower scores on compulsive-conformingPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/89970/1/Saunders-Kurko-Barlow-Crane 2011 What Attracts Men Who Batter to Their Partners JIV.pd