Cavity cooling of an optically trapped nanoparticle

We study the cooling of a dielectric nanoscale particle trapped in an optical cavity. We derive the frictional force for motion in the cavity field, and show that the cooling rate is proportional to the square of oscillation amplitude and frequency. Both the radial and axial centre-of-mass motion of the trapped particle, which are coupled by the cavity field, are cooled. This motion is analogous to two coupled but damped pendulums. Our simulations show that the nanosphere can be cooled to 1/e of its initial momentum over time scales of hundredths of milliseconds.Comment: 11 page

Transition from inspiral to plunge in precessing binaries of spinning black holes

We investigate the non-adiabatic dynamics of spinning black hole binaries by using an analytical Hamiltonian completed with a radiation-reaction force, containing spin couplings, which matches the known rates of energy and angular momentum losses on quasi-circular orbits. We consider both a straightforward post-Newtonian-expanded Hamiltonian (including spin-dependent terms), and a version of the resummed post-Newtonian Hamiltonian defined by the Effective One-Body approach. We focus on the influence of spin terms onto the dynamics and waveforms. We evaluate the energy and angular momentum released during the final stage of inspiral and plunge. For an equal-mass binary the energy released between 40Hz and the frequency beyond which our analytical treatment becomes unreliable is found to be, when using the more reliable Effective One-Body dynamics: 0.6% M for anti-aligned maximally spinning black holes, 5% M for aligned maximally spinning black hole, and 1.8% M for non-spinning configurations. In confirmation of previous results, we find that, for all binaries considered, the dimensionless rotation parameter J/E^2 is always smaller than unity at the end of the inspiral, so that a Kerr black hole can form right after the inspiral phase. By matching a quasi-normal mode ringdown to the last reliable stages of the plunge, we construct complete waveforms approximately describing the gravitational wave signal emitted by the entire process of coalescence of precessing binaries of spinning black holes.Comment: 31 pages, 7 tables, and 13 figure

Animal-Assisted Interventions in Health Care Settings: A Best Practices Manual for Establishing New Programs: Volunteer Manual Template

This document accompanies Animal-Assisted Interventions in Health Care Settings: A Best Practices Manual for Establishing New Programs (Purdue Press, 2019) and serves as a template for readers to personalize for their facility. The generic terms “ABC Health Care Facility” and “AAI Program” are intended to be replaced by the names of the reader\u27s facility and AAI program. The book can be purchased from Purdue University Press

Identification of winter wheat from ERTS-1 imagery

Continuing interpretation of the test area in Finney County, Kansas, has revealed that winter wheat can be successfully identified. This successful identification is based on human recognition of tonal signatures on MSS images. Several different but highly successful interpretation strategies have been employed. These strategies involve the use of both spectral and temporal inputs. Good results have been obtained from a single MSS-5 image acquired at a critical time in the crop cycle (planting). On a test sample of 54,612 acres, 89 percent of the acreage was correctly classified as wheat or non-wheat and the estimated wheat acreage (19,516 acres) was 99 percent of the actual acreage of wheat in the sample area

A content analysis of tobacco content in season 1 of ‘And Just Like That’

Aim: ‘Sex and the City’ regularly featured smoking as a plot device, often linked with sexuality and female empowerment. Eighteen years later, the follow up ‘And Just Like That’ was released. The aim of this paper was to explore the amount of tobacco content in the first series of ‘And Just Like That’. Subject and Methods: A 1-minute content analysis of the 10 episodes from season1 of ‘And Just Like That’. Results: The 10 episodes included 394 one-minute intervals of content, with individual episodes ranging from 35-44 minutes. Tobacco content occurred in 45 intervals (11% of the total) across all 10 episodes. Conclusion: This study demonstrates that, despite the 18-year age gap between the end of the ‘Sex and the City’ TV series and the start of ‘And just like that’, and the declining smoking rates during that time, tobacco content is still regularly featured in these programmes. Whilst viewing figures are not available for this series, we know that this was HBO Max’s most streamed show of all time and was highly popular, it is, therefore, likely that large numbers of people were exposed to tobacco content through this programme

Implementation of a local principal curves algorithm for neutrino interaction reconstruction in a liquid argon volume

A local principal curve algorithm has been implemented in three dimensions for automated track and shower reconstruction of neutrino interactions in a liquid argon time projection chamber. We present details of the algorithm and characterise its performance on simulated data sets.Comment: 14 pages, 17 figures; typing correction to Eq 5, the definition of the local covariance matri

Glassy dynamics in granular compaction

Two models are presented to study the influence of slow dynamics on granular compaction. It is found in both cases that high values of packing fraction are achieved only by the slow relaxation of cooperative structures. Ongoing work to study the full implications of these results is discussed.Comment: 12 pages, 9 figures; accepted in J. Phys: Condensed Matter, proceedings of the Trieste workshop on 'Unifying concepts in glass physics

Nature of the Darwin term and (Zα)4m3/M2{(Z\alpha)^4 m^3/M^2} contribution to the Lamb shift for an arbitrary spin of the nucleus

The contact Darwin term is demonstrated to be of the same origin as the spin-orbit interaction. The $(Z\alpha)^4 m^3/M^2$ correction to the Lamb shift, generated by the Darwin term, is found for an arbitrary nonvanishing spin of the nucleus, both half-integer and integer. There is also a contribution of the same nature to the nuclear quadrupole moment.Comment: 9 pages, latex, no figure

Recent developments in the treatment of Parkinson's Disease.

Parkinson's disease (PD) is a common neurodegenerative disease typified by a movement disorder consisting of bradykinesia, rest tremor, rigidity, and postural instability. Treatment options for PD are limited, with most of the current approaches based on restoration of dopaminergic tone in the striatum. However, these do not alter disease course and do not treat the non-dopamine-dependent features of PD such as freezing of gait, cognitive impairment, and other non-motor features of the disorder, which often have the greatest impact on quality of life. As understanding of PD pathogenesis grows, novel therapeutic avenues are emerging. These include treatments that aim to control the symptoms of PD without the problematic side effects seen with currently available treatments and those that are aimed towards slowing pathology, reducing neuronal loss, and attenuating disease course. In this latter regard, there has been much interest in drug repurposing (the use of established drugs for a new indication), with many drugs being reported to affect PD-relevant intracellular processes. This approach offers an expedited route to the clinic, given that pharmacokinetic and safety data are potentially already available. In terms of better symptomatic therapies that are also regenerative, gene therapies and cell-based treatments are beginning to enter clinical trials, and developments in other neurosurgical strategies such as more nuanced deep brain stimulation approaches mean that the landscape of PD treatment is likely to evolve considerably over the coming years. In this review, we provide an overview of the novel therapeutic approaches that are close to, or are already in, clinical trials

Regenerative Therapies for Parkinson's Disease: An Update.

Parkinson's disease is the second most common neurodegenerative disorder. It is characterised by a typical movement disorder that occurs in part because of the selective degeneration of the dopaminergic neurons of the substantia nigra pars compacta. Current treatment for the motor disorder of Parkinson's disease consists of dopaminergic medications, but these come with significant adverse effects, themselves an important part of the clinical course of Parkinson's disease, particularly in advanced stages. Therefore, treatment is needed that can restore dopaminergic tone in the striatum in a physiological and targeted manner to avert these side effects. A number of potential regenerative treatments have been developed with a view to achieving this. Following decades of optimisation and development of stem-cell-based treatments and viral gene delivery, clinical trials are on the horizon. For these treatments to be widely useful, they must be clinically effective, cost efficient and safe, and a number of practical aspects regarding storage and delivery of treatment must be optimised. Many barriers have been overcome, and the field of regenerative medicine for Parkinson's disease is now increasingly focussed on how these treatments will be delivered, demonstrating the significant progress that has been made and the optimism surrounding these approaches.The authors acknowledge financial support from the following organisations: Medical Research Council, Wellcome Trust Stem Cell Institute (Cambridge), National Institute for Health Research Biomedical Research Centre, and the Cure Parkinson’s Trus