Data Portability and Online Platforms The Effects on Competition [Extended Abstract]

This paper examines the potential effects of data portability among online platforms on competition, providing policy recommendations for the preservation of innovative, undistorted competitive markets. Based on a platform-data model, it is illustrated how users, data and the products and services of a platform are related. Platform markets which entail an especially high risk of market power abuse are determined. It is concluded that the right to data portability as in the EU’s General Data Protection Regulation has to be interpreted in a nuanced fashion in order to avoid adverse effects on competition and innovation

Das Portfolio deutscher Biosphärenreservate im Lichte der Sustainable Development Goals

In diesem Beitrag wird die Repräsentativität der deutschen Biosphärenreservate diskutiert. Die Nachhaltigkeitsziele der Vereinten Nationen dienen dafür als theoriegeleiteter Analyserahmen. Deutschland erreicht derzeit einen Anteil von rund 16 Prozent der Landfläche, die unter striktem Naturschutz stehen. Es stellt sich somit kein Mengenproblem, vielmehr steht die Frage der Anzahl, räumlichen Verteilung und inhaltlichen Qualität von Schutzgebieten im Vordergrund - hier der Biosphärenreservate. In bisherigen Arbeiten wurde ausschließlich die naturräumliche Repräsentativität der Biosphärenreservate in Deutschland beleuchtet. Das ist für die Bedeutung dieser Gebiete, die dem Paradigma der nachhaltigen Entwicklung explizit verpflichtet sind, nicht ausreichend. Deshalb zielt der Beitrag darauf ab, raumstrukturelle und sozioökonomische Defizite im Netz der deutschen Biosphärenreservate aufzudecken. Dazu werden zu ausgewählten Nachhaltigkeitszielen aussagekräftige Parameter analysiert und in Form thematischer Karten präsentiert. Weiter wird untersucht, ob und inwieweit die existierenden Biosphärenreservate in der Lage sind, als Modellregionen für nachhaltige Entwicklung ihrer gewünschten Vorbildfunktion für den Rest der Welt nachzukommen.This paper discusses the representativeness of the German Biosphere Reserves. The United Nations Sustainable Development Goals will serve as the theoretical framework of this analysis. Germany currently accounts a share of 16 % of the terrestrial land area under strict nature protection. This means that there is no quantity problem. Rather, the question arises about the number, geographical distribution and quality of protected areas - in this example Biosphere Reserves. So far, scientific papers only focus on the natural landscape representativeness of Biosphere Reserves in Germany. This is not enough for this category of protected areas as it rests on the paradigm of sustainable development. This is why this paper is focusing on possible structural and socioeconomic shortcomings in the network of German Biosphere Reserves. Therefore, precise indicators will be analysed in form of thematical maps to address selected Sustainable Development Goals. Furthermore, the existing Biosphere Reserves will be analysed if and to what extent they are able to reach their intended exemplary function towards "the rest of the world" as models for sustainable development

Class observations from the University of Hawai‘i at Mānoa highlight the need for active learning strategies to support diverse students in large classes

[EN] Compelling evidence indicates that “active learning” (learning by doing) is an effective pedagogy regardless of discipline or class size, and can be particularly effective with diverse students. This study investigated active learning practices in 64 classes at the University of Hawai‘i at Mānoa, a US university with a highly diverse student body, using a “Passivity Indicator” (PI: ratio of class time spent in passive activities to total class time). For all classes, the mean PI was 43%. Statistical analysis reveals no significant differences in the PI of classes taught in STEM vs. non-STEM disciplines, or between upper vs. lower division courses. However, the PI in larger classes was found to be significantly greater than in small classes (64% vs. 39%, respectively; p=0.02). Moreover, classroom activities aligned with an active learning standard in Language and Literacy Development (e.g., students answering questions) occurred twice as often in small (24%) vs. large classes (12%, with p=0.02). Altogether, these findings indicate an opportunity for more active learning in large classes. We present a range of research-based pedagogical strategies that can be readily implemented in large classrooms, and encourage instructors to use their implementation as research opportunities to gather data on student success.This project is supported by the US NSF‟s Research Infrastructure Improvement (RII) Track-1: „Ike Wai: Securing Hawai„i‟s Water Future‟ Award #NSF/OIA-1557349; and by Improving Undergraduate STEM Education (IUSE) Award #NSF/GEO-1565950. The research protocol was approved as exempt the UH Institutional Review Board (#2017- 003518).Engels, J.; Bruno, B.; Dasalla, N.; Böttjer-Wilson, D. (2019). Class observations from the University of Hawai‘i at Mānoa highlight the need for active learning strategies to support diverse students in large classes. En HEAD'19. 5th International Conference on Higher Education Advances. Editorial Universitat Politècnica de València. 539-547. https://doi.org/10.4995/HEAD19.2019.9547OCS53954

Fiddling while the ice melts? How organizational scholars can take a more active role in the climate change debate

The debate over anthropogenic climate change or the idea that human activities are altering the physical climate of the planet continues to rage amid seemingly irreconcilable differences, both within the developed world and between developed and less developed countries. With high uncertainty, rival worldviews, and wide diversity of meaning attached to the expression, climate change has become a key narrative within which local and transnational issues – economic, social, and political – are framed and contested. The field is fraught with controversies regarding causes and consequences, as well as different attitudes toward risks, technologies, and economic and social well-being for different groups. Parties also dispute how to share responsibility for reducing emissions – whether the issue primarily needs market, regulatory, technological, or behavioral solutions. Climate change is many things to many people. Competing interests negotiate over its interpretation and utilize various strategies to promote practices that advance their own understandings regarding climate change and its governance

Extending the Minimum Information About BIobank Data Sharing Terminology to Describe Samples, Sample Donors, and Events

Introduction: The Minimum Information About BIobank data Sharing (MIABIS) was initiated in 2012. MIABIS aims to create a common biobank terminology to facilitate data sharing in biobanks and sample collections. The MIABIS Core terminology consists of three components describing biobanks, sample collections, and studies, in which information on samples and sample donors is provided at aggregated form. However, there is also a need to describe samples and sample donors at an individual level to allow more elaborate queries on available biobank samples and data. Therefore the MIABIS terminology has now been extended with components describing samples and sample donors at an individual level. Materials and Methods: The components were defined according to specific scope and use cases by a large group of experts, and through several cycles of reviews, according to the new MIABIS governance model of BBMRI-ERIC (Biobanking and Biomolecular Resources Research Infrastructure-European Research Infrastructure Consortium). The guiding principles applied in developing these components included the following terms: model should consider only samples of human origin, model should be applicable to all types of samples and all sample donors, and model should describe the current status of samples stored in a given biobank. Results: A minimal set of standard attributes for defining samples and sample donors is presented here. We added an "event" component to describe attributes that are not directly describing samples or sample donors but are tightly related to them. To better utilize the generic data model, we suggest a procedure by which interoperability can be promoted, using specific MIABIS profiles. Discussion: The MIABIS sample and donor component extensions and the new generic data model complement the existing MIABIS Core 2.0 components, and substantially increase the potential usability of this terminology for better describing biobank samples and sample donors. They also support the use of individual level data about samples and sample donors to obtain accurate and detailed biobank availability queries

Analogue peptides for the immunotherapy of human acute myeloid leukemia

Accepted manuscript. The final publication is available at: http://link.springer.com/article/10.1007%2Fs00262-015-1762-9The use of peptide vaccines, enhanced by adjuvants, has shown some efficacy in clinical trials. However, responses are often short-lived and rarely induce notable memory responses. The reason is that self-antigens have already been presented to the immune system as the tumor develops, leading to tolerance or some degree of host tumor cell destruction. To try to break tolerance against self-antigens, one of the methods employed has been to modify peptides at the anchor residues to enhance their ability to bind major histocompatibility complex molecules, extending their exposure to the T-cell receptor. These modified or analogue peptides have been investigated as stimulators of the immune system in patients with different cancers with variable but sometimes notable success. In this review we describe the background and recent developments in the use of analogue peptides for the immunotherapy of acute myeloid leukemia describing knowledge useful for the application of analogue peptide treatments for other malignancies

T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells

Effective cancer immunotherapy requires overcoming immunosuppressive tumor microenvironments. We\ua0found that local nitric oxide (NO) production by tumor-infiltrating myeloid cells is important for adoptively transferred CD8(+) cytotoxic T\ua0cells to destroy tumors. These myeloid cells are phenotypically similar to inducible nitric oxide synthase (NOS2)- and tumor necrosis factor (TNF)-producing dendritic cells (DC), or Tip-DCs. Depletion of immunosuppressive, colony stimulating factor 1 receptor (CSF-1R)-dependent arginase 1(+) myeloid cells enhanced NO-dependent tumor killing. Tumor elimination via NOS2 required the CD40-CD40L pathway. We also uncovered a strong correlation between survival of colorectal cancer patients and NOS2, CD40, and TNF expression in their tumors. Our results identify a network of pro-tumor factors that can be targeted to boost cancer immunotherapies

Constructing a climate change logic: An institutional perspective on the "tragedy of the commons"

Despite increasing interest in transnational fields, transnational commons have received little attention. In contrast to economic models of commons, which argue that commons occur naturally and are prone to collective inaction and tragedy, we introduce a social constructionist account of commons. Specifically, we show that actor-level frame changes can eventually lead to the emergence of an overarching, hybrid "commons logic" at the field level. These frame shifts enable actors with different logics to reach a working consensus and avoid "tragedies of the commons." Using a longitudinal analysis of key actors' logics and frames, we tracked the evolution of the global climate change field over 40 years. We bracketed time periods demarcated by key field-configuring events, documented the different frame shifts in each time period, and identified five mechanisms (collective theorizing, issue linkage, active learning, legitimacy seeking, and catalytic amplification) that underpin how and why actors changed their frames at various points in time-enabling them to move toward greater consensus around a transnational commons logic. In conclusion, the emergence of a commons logic in a transnational field is a nonlinear process and involves satisfying three conditions: (1) key actors view their fates as being interconnected with respect to a problem issue, (2) these actors perceive their own behavior as contributing to the problem, and (3) they take collective action to address the problem. Our findings provide insights for multinational companies, nation-states, nongovernmental organizations, and other stakeholders in both conventional and unconventional commons