Bazhenov fm unconventional reservoir 3D geological modeling methodology

The Bazhenov Formation has been studied for more than 50 years, but its petroleum potential, optimal STOIIP or resource estimation approaches, the methodology used to select a reservoir, determine its properties are still unclear. The distinctive features of bituminous shale are specific geochemical properties chosen as basic parameters to perform the geological modeling of the Bazhenov deposits and determine the key areas. The main objective of this paper is to choose an optimal 3D geological modeling algorithm and test conventional (petrophysical) and specific (geochemical) properties

Bazhenov Fm Classification Based on Wireline Logs

This paper considers the main aspects of Bazhenov Formation interpretation and application of machine learning algorithms for the Kolpashev type section of the Bazhenov Formation, application of automatic classification algorithms that would change the scale of research from small to large. Machine learning algorithms help interpret the Bazhenov Formation in a reference well and in other wells. During this study, unsupervised and supervised machine learning algorithms were applied to interpret lithology and reservoir properties. This greatly simplifies the routine problem of manual interpretation and has an economic effect on the cost of laboratory analysis

Ротавирусная инфекция у детей — нерешенная проблема. Обзор рекомендаций по вакцинопрофилактике

These clinical guidelines were developed by the professional association of pediatric specialists «Union of Pediatricians of Russia» and approved by the Association’s Executive Committee at the Congress of Pediatricians of Russia «Actual Problems of Pediatrics». Clinical guidelines are devoted to the problem of rotavirus infection, the relevance of which is determined by the high prevalence level and significant contribution of infectious diarrhea to the mortality pattern of children in the first 5 years of life. We present epidemiological data and detailed information on the infectious agent and pathogenesis of rotavirus infection progression. A detailed picture of clinical manifestations as well as extraintestinal complications is presented. The approach to specific prophylaxis has been reasoned. Practical recommendations for immunization as well as various regimens for administering the vaccine, depending on the age and condition of the patient, are given.Данные клинические рекомендации разработаны профессиональной ассоциацией детских специалистов «Союз педиатров России» и утверждены Исполкомом ассоциации на Съезде педиатров России «Актуальные проблемы педиатрии». Клинические рекомендации посвящены проблеме ротавирусной инфекции, актуальность которой определяется высоким уровнем распространенности и значительным вкладом инфекционной диареи в структуру смертности детей первых 5 лет жизни. Приводятся эпидемиологические данные, подробно описаны особенности возбудителя, патогенез развития ротавирусной инфекции. Представлена развернутая картина клинических проявлений, а также внекишечных осложнений. Обоснована тактика специфической профилактики. Даны практические рекомендации по проведению иммунизации, а также различные схемы введения вакцины в зависимости от возраста и состояния пациента

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Гідрокавітаційна активація у технологіях виробництва і спалювання композиційних палив

Special methods and means for production and use of new types of liquid composite fuels with addition of industrial wastes of various origins were developed and scientifically substantiated.The studies enabled production of composite fuels with improved physical and chemical qualities. For this purpose, a rotary cavitation device for tryout of hydrocavitational activation of fuel components was worked out. The possibility of introduction of various industrial wastes including ecologically hazardous wastes of various origins into production of composite fuels was proved.Comprehensive studies of producing and burning composite fuels with application of methods for activation of physical and chemical processes were carried out. Liquid composite fuels obtained on the basis of “classical” hydrocarbons with addition of various types of waste meet present-day energy, environmental and consumer requirements.The developed technology of burning composite fuels is helpful for solving the environmental problem of recycling industrial waste and the problem of generation of a cheaper thermal energy. The proposed technological approach is universal and applicable for utilization and neutralization of organic and mineral wastes of various origins using hydrocavitational activation methods at the stages of production and combustion of composite fuels.Theoretical studies of hydrodynamics of flow of a viscous incompressible fluid in channels of a complex shape have enabled design of new types of atomizers and hydrocavitational activatorsПредложена гидрокавитационная технология создания композиционных топлив на основе углеводородов и различных отходов. Показано, что применение данной технологии комплексно решает не только энергетическую задачу получения более дешевой тепловой энергии, но и экологическую проблему снижения вредных выбросов в атмосферу при сжигании. Одновременно решается задача по утилизации и обеззараживанию отходов, добавляемых в качестве компонентов в состав композиционных топливЗапропонована гідрокавітаціона технологія створення композиційних палив на основі вуглеводнів та різних відходів. Показано, що застосування даної технології комплексно вирішує не тільки енергетичну задачу отримання більш дешевої теплової енергії, а й екологічну проблему зниження шкідливих викидів в атмосферу при спалюванні. Одночасно вирішується задача по утилізації і знезараженню відходів, що додаються в якості компонентів до складу композиційних пали

Preparation and Hydrolytic Degradation of Hydroxyapatite-Filled PLGA Composite Microspheres

Various hydroxyapatite-filled and unfilled microspheres based on lactide and glycolide copolymers were prepared. The synthesized poly(lactic-co-glycolic acid) (PLGA) samples were characterized by GPC and 1H NMR spectroscopy, the morphology was characterized by SEM. It was shown that under the tin (II) 2-ethylhexanoate catalysis the glycolide is highly active in copolymerization as compared with lactide. According to the data on weight loss and the weight average molecular weight shift of PLGA over time (pH = 6.5; t = 25 °C), an increase in the rate of microsphere destruction was noted when macromolecules were enriched with glycolic acid residues, as well as when filled with hydroxyapatite. It was shown that the rate of PLGA degradation was determined by the water-accessible surface of a sample. The rate increase in PLGA hydrolytic degradation both with an increase in glycolic acid residues mole fraction in the chain and upon filling with hydroxyapatite was the result of the microspheres’ surface hydrophilization, an increase in capillary pressure upon filling of the pores as well as of the defects with water, and an increase in the number of structural defects. Approaches to the creation of composite microspheres based on PLGA degrading at a controlled rate were proposed

Hydrocavitational Activation in the Technologies of Production and Combustion of Composite Fuels

Special methods and means for production and use of new types of liquid composite fuels with addition of industrial wastes of various origins were developed and scientifically substantiated.The studies enabled production of composite fuels with improved physical and chemical qualities. For this purpose, a rotary cavitation device for tryout of hydrocavitational activation of fuel components was worked out. The possibility of introduction of various industrial wastes including ecologically hazardous wastes of various origins into production of composite fuels was proved.Comprehensive studies of producing and burning composite fuels with application of methods for activation of physical and chemical processes were carried out. Liquid composite fuels obtained on the basis of “classical” hydrocarbons with addition of various types of waste meet present-day energy, environmental and consumer requirements.The developed technology of burning composite fuels is helpful for solving the environmental problem of recycling industrial waste and the problem of generation of a cheaper thermal energy. The proposed technological approach is universal and applicable for utilization and neutralization of organic and mineral wastes of various origins using hydrocavitational activation methods at the stages of production and combustion of composite fuels.Theoretical studies of hydrodynamics of flow of a viscous incompressible fluid in channels of a complex shape have enabled design of new types of atomizers and hydrocavitational activator

Rotavirus Infection in Children is an Unsolved Problem. Review of Guidelines for Vaccinal Prevention

These clinical guidelines were developed by the professional association of pediatric specialists «Union of Pediatricians of Russia» and approved by the Association’s Executive Committee at the Congress of Pediatricians of Russia «Actual Problems of Pediatrics». Clinical guidelines are devoted to the problem of rotavirus infection, the relevance of which is determined by the high prevalence level and significant contribution of infectious diarrhea to the mortality pattern of children in the first 5 years of life. We present epidemiological data and detailed information on the infectious agent and pathogenesis of rotavirus infection progression. A detailed picture of clinical manifestations as well as extraintestinal complications is presented. The approach to specific prophylaxis has been reasoned. Practical recommendations for immunization as well as various regimens for administering the vaccine, depending on the age and condition of the patient, are given

Современные подходы к ведению пациентов с крапивницей

The Union of Pediatricians of Russia together with the Russian Association of Allergologists and Clinical Immunologists and the Russian Society of Dermatovenerologists and Cosmetologists have developed new clinical guidelines for the urticaria in adults and children. Urticaria is a common disease; its various clinical variants are diagnosed in 15–25% of people in the global population, and a quarter of all cases belongs to chronic urticaria. The prevalence of acute urticaria is 20%, and 2.1–6.7% in child population, whereas acute urticaria is more common in children than in adults. The prevalence of chronic urticaria in adults in the general population is 0.7 and 1.4%, and 1.1% in children under 15 years of age, according to the systematic review and meta-analysis, respectively. This article covers features of epidemiology, etiology, and pathogenesis of the disease with particular focus on differential diagnostic search. Guidelines on treatment and step-by-step therapy scheme (both based on principles of evidencebased medicine) for pediatric patients were presented. Clarification on the analysis of the therapy efficacy and the degree of disease activity was given.Союзом педиатров России совместно с Российской ассоциацией аллергологов и иммунологов и Российским обществом дерматовенерологов и косметологов (РОДВК) разработаны новые клинические рекомендации для диагноза «крапивница» для взрослых и детей. Крапивница является распространенным заболеванием: различные ее клинические варианты диагностируются у 15–25% людей в популяции, при этом четверть случаев приходится на хроническую крапивницу. Распространенность острой крапивницы составляет 20%, среди детского населения — 2,1–6,7%, при этом острая крапивница у детей встречается чаще, чем у взрослых. По данным систематического обзора и мета-анализа, хроническая крапивница у взрослых в общей популяции составляет 0,7 и 1,4% соответственно, у детей до 15 лет — до 1,1%. В статье рассматриваются особенности эпидемиологии, этиологии и патогенеза заболевания, особое внимание уделено вопросам дифференциально-диагностического поиска. Для пациентов детского возраста приведены рекомендации по лечению согласно принципам доказательной медицины и предложена ступенчатая схема терапии. Дано четкое разъяснение к проведению анализа эффективности терапии и оценки степени активности заболевания