The Soft X-ray Spectrum from NGC 1068 Observed with LETGS on Chandra

Using the combined spectral and spatial resolving power of the Low Energy Transmission Grating (LETGS) on board Chandra, we obtain separate spectra from the bright central source of NGC 1068 (Primary region), and from a fainter bright spot 4" to the NE (Secondary region). Both spectra are dominated by line emission from H- and He-like ions of C through S, and from Fe L-shell ions, but also include narrow radiative recombination continua, indicating that most of the soft X-ray emission arises in low-temperature (kT few eV) photoionized plasma. We confirm the conclusions of Kinkhabwala et al. (2002), based on XMM-Newton RGS observations, that the entire nuclear spectrum can be explained by recombination/radiative cascade following photoionization, and radiative decay following photoexcitation, with no evidence for hot, collisionally ionized plasma. In addition, this model also provides an excellent fit to the spectrum of the Secondary region, albeit with radial column densities a factor of three lower, as would be expected given its distance from the source of the ionizing continuum. The remarkable overlap and kinematical agreement of the optical and X-ray line emission, coupled with the need for a distribution of ionization parameter to explain the X-ray spectra, collectively imply the presence of a distribution of densities (over a few orders of magnitude) at each radius in the ionization cone. Relative abundances of all elements are consistent with Solar abundance, except for N, which is 2-3 times Solar. The long wavelength spectrum beyond 30 A is rich of L-shell transitions of Mg, Si, S, and Ar, and M-shell transitions of Fe. The velocity dispersion decreases with increasing ionization parameter, as deduced from these long wavelength lines and the Fe-L shell lines.Comment: 12 pages, 11 figures, accepted for publication in Astronomy and Astrophysic

Dielectronic Recombination (via N=2 --> N'=2 Core Excitations) and Radiative Recombination of Fe XX: Laboratory Measurements and Theoretical Calculations

We have measured the resonance strengths and energies for dielectronic recombination (DR) of Fe XX forming Fe XIX via N=2 --> N'=2 (Delta_N=0) core excitations. We have also calculated the DR resonance strengths and energies using AUTOSTRUCTURE, HULLAC, MCDF, and R-matrix methods, four different state-of-the-art theoretical techniques. On average the theoretical resonance strengths agree to within <~10% with experiment. However, the 1 sigma standard deviation for the ratios of the theoretical-to-experimental resonance strengths is >~30% which is significantly larger than the estimated relative experimental uncertainty of <~10%. This suggests that similar errors exist in the calculated level populations and line emission spectrum of the recombined ion. We confirm that theoretical methods based on inverse-photoionization calculations (e.g., undamped R-matrix methods) will severely overestimate the strength of the DR process unless they include the effects of radiation damping. We also find that the coupling between the DR and radiative recombination (RR) channels is small. We have used our experimental and theoretical results to produce Maxwellian-averaged rate coefficients for Delta_N=0 DR of Fe XX. For kT>~1 eV, which includes the predicted formation temperatures for Fe XX in an optically thin, low-density photoionized plasma with cosmic abundances, our experimental and theoretical results are in good agreement. We have also used our R-matrix results, topped off using AUTOSTRUCTURE for RR into J>=25 levels, to calculate the rate coefficient for RR of Fe XX. Our RR results are in good agreement with previously published calculations.Comment: To be published in ApJS. 65 pages with 4 tables and lots of figure

The role of emotional intelligence training in developing meaningfulness at work

To date, there remains a significant gap in the western management literature in understanding how individuals proactively shape their work environments to create meaningfulness. Equally, little is known about how training and development supports this process. This article shows how emotional intelligence (EI) training in the UK nurtures meaningfulness through the development of EI skills and aptitudes. The article explores how EI skills are then used at work to develop tasks, roles and relationships of worth and value. Data is collected from participant observations and interviews with trainers and managers attending three externally provided, ‘popular’ EI training courses. Interpreting the data through Lips-Wiersma and Morris’s (2009; 2011) model of meaningful work enables a clear articulation of managers’ independent capacity to shape their work environments to create four, interconnected sources of meaningfulness: inner development, expressing one’s full potential, unity with others and serving others. The findings also show the tension between the ‘inspiration’ and ‘reality’ of fulfilling these four existential needs at work through EI skills and aptitudes. Findings also exemplify how this is a constant process of search, balance and struggle which sometimes pivots work against life values and demands. Practically, the study demonstrates the importance of training for meaning making at work and offers recommendations for HRD practitioners. Implications for transferring innovative western management practices such as EI and meaningfulness/engagement processes across national contexts are discussed. Overall, this study provides empirical evidence that sources of meaningfulness are a core ingredient of EI training when popular EI models are used. It points towards future research on meaningfulness training and transfer to new contrasting regional contexts such as the middle east

Multi-wavelength study of the Seyfert 1 galaxy NGC 3783 with XMM-Newton

We present the analysis of multi-wavelength XMM-Newton data from the Seyfert galaxy NGC 3783, including UV imaging, X-ray and UV lightcurves, the 0.2-10 keV X-ray continuum, the iron K-alpha emission line, and high-resolution spectroscopy and modelling of the soft X-ray warm absorber. The 0.2-10 keV spectral continuum can be well reproduced by a power-law at higher energies; we detect a prominent Fe K-alpha emission line, with both broad and narrow components, and a weaker emission line at 6.9 keV which is probably a combination of Fe K-beta and Fe XXVI. We interpret the significant deficit of counts in the soft X-ray region as being due to absorption by ionised gas in the line of sight. This is demonstrated by the large number of narrow absorption lines in the RGS spectrum from iron, oxygen, nitrogen, carbon, neon, argon, magnesium, silicon and sulphur. The wide range of iron states present in the spectrum enables us to deduce the ionisation structure of the absorbing medium. We find that our spectrum contains evidence of absorption by at least two phases of gas: a hotter phase containing plasma with a log ionisation parameter xi (where xi is in erg cm/s) of 2.4 and greater, and a cooler phase with log xi centred around 0.3. The gas in both phases is outflowing at speeds of around 800 km/s. The main spectral signature of the cold phase is the Unresolved Transition Array (UTA) of M-shell iron, which is the deepest yet observed; its depth requires either that the abundance of iron, in the cold phase, is several times that of oxygen, with respect to solar abundances, or that the absorption lines associated with this phase are highly saturated. The cold phase is associated with ionisation states that would also absorb in the UV.Comment: 16 pages, 10 figures, accepted by Astronomy & Astrophysics; some measured wavelengths and blueshifts changed to correct a computing erro

Multiwavelength studies of the Seyfert 1 galaxy NGC7469. II - X-ray and UV observations with XMM-Newton

We present an XMM-Newton observation of NGC 7469, including studies of the X-ray and UV variability, 0.2-10 keV spectral continuum, Fe K-alpha emission line and the first-ever high-resolution X-ray spectrum of the soft X-ray warm absorber. We compare the properties of this X-ray warm absorber with the UV warm absorber as seen in a FUSE observation one year previously. The 0.2-10 keV spectral continuum is best fitted by a power-law plus two blackbody model. An Fe K-alpha emission line is visible which consists of a single narrow component and is well-modelled by a simple gaussian. Narrow absorption and emission lines in the soft X-ray RGS spectrum demonstrate the existence of a multi-phase warm absorber with a range in log xi of ~ 2 to ~ -2 where xi is in erg cm s^-1. The warm absorber is blueshifted by several hundred km s^-1. The highest-ionisation phase of the absorber is the best constrained and has an overall equivalent Hydrogen column of order 10^20 cm^-2; we find that its ionisation parameter is consistent with that of the warm emitter which generates the narrow emission lines. We identify this high ionisation absorber with the low-velocity phase of the UV absorber observed by FUSE.Comment: 12 pages, 12 figures, accepted by A&A, a companion paper to "Multiwavelength studies of the Seyfert 1 galaxy NGC7469. I - Far UV observations with FUSE" by Kriss et al., astro-ph/030255

ALIED: Humans as adaptive lie detectors

People make for poor lie detectors. They have accuracy rates comparable to a coin toss, and come with a set of systematic biases that sway the judgment. This pessimistic view stands in contrast to research showing that people make informed decisions that adapt to the context they operate in. The current article proposes a new theoretical direction for lie detection research. I argue that lie detectors make informed, adaptive judgments in a low-diagnostic world. This Adaptive Lie Detector (ALIED) account is outlined by drawing on supporting evidence from across various psychological literatures. The account is contrasted with longstanding and more recent accounts of the judgment process, which propose that people fall back on default ways of thinking. Limitations of the account are considered, and future research directions are outlined

Ectopic PDX-1 Expression Directly Reprograms Human Keratinocytes along Pancreatic Insulin-Producing Cells Fate

BACKGROUND: Cellular differentiation and lineage commitment have previously been considered irreversible processes. However, recent studies have indicated that differentiated adult cells can be reprogrammed to pluripotency and, in some cases, directly into alternate committed lineages. However, although pluripotent cells can be induced in numerous somatic cell sources, it was thought that inducing alternate committed lineages is primarily only possible in cells of developmentally related tissues. Here, we challenge this view and analyze whether direct adult cell reprogramming to alternate committed lineages can cross the boundaries of distinct developmental germ layers. METHODOLOGY/PRINCIPAL FINDINGS: We ectopically expressed non-integrating pancreatic differentiation factors in ectoderm-derived human keratinocytes to determine whether these factors could directly induce endoderm-derived pancreatic lineage and β-cell-like function. We found that PDX-1 and to a lesser extent other pancreatic transcription factors, could rapidly and specifically activate pancreatic lineage and β-cell-like functional characteristics in ectoderm-derived human keratinocytes. Human keratinocytes transdifferentiated along the β cell lineage produced processed and secreted insulin in response to elevated glucose concentrations. Using irreversible lineage tracing for KRT-5 promoter activity, we present supporting evidence that insulin-positive cells induced by ectopic PDX-1 expression are generated in ectoderm derived keratinocytes. CONCLUSIONS/SIGNIFICANCE: These findings constitute the first demonstration of human ectoderm cells to endoderm derived pancreatic cells transdifferentiation. The study represents a proof of concept which suggests that transcription factors induced reprogramming is wider and more general developmental process than initially considered. These results expanded the arsenal of adult cells that can be used as a cell source for generating functional endocrine pancreatic cells. Directly reprogramming somatic cells into alternate desired tissues has important implications in developing patient-specific, regenerative medicine approaches

Noise Management by Molecular Networks

Fluctuations in the copy number of key regulatory macromolecules (“noise”) may cause physiological heterogeneity in populations of (isogenic) cells. The kinetics of processes and their wiring in molecular networks can modulate this molecular noise. Here we present a theoretical framework to study the principles of noise management by the molecular networks in living cells. The theory makes use of the natural, hierarchical organization of those networks and makes their noise management more understandable in terms of network structure. Principles governing noise management by ultrasensitive systems, signaling cascades, gene networks and feedback circuitry are discovered using this approach. For a few frequently occurring network motifs we show how they manage noise. We derive simple and intuitive equations for noise in molecule copy numbers as a determinant of physiological heterogeneity. We show how noise levels and signal sensitivity can be set independently in molecular networks, but often changes in signal sensitivity affect noise propagation. Using theory and simulations, we show that negative feedback can both enhance and reduce noise. We identify a trade-off; noise reduction in one molecular intermediate by negative feedback is at the expense of increased noise in the levels of other molecules along the feedback loop. The reactants of the processes that are strongly (cooperatively) regulated, so as to allow for negative feedback with a high strength, will display enhanced noise

In Vivo Quantitative Study of Sized-Dependent Transport and Toxicity of Single Silver Nanoparticles Using Zebrafish Embryos

Nanomaterials possess distinctive physicochemical properties (e.g., small sizes and high surface area-to-volume ratios) and promise a wide variety of applications, ranging from the design of high quality consumer products to effective disease diagnosis and therapy. These properties can lead to toxic effects, potentially hindering advances in nanotechnology. In this study, we have synthesized and characterized purified and stable (nonaggregation) silver nanoparticles (Ag NPs, 41.6 ± 9.1 nm in average diameter) and utilized early developing (cleavage-stage) zebrafish embryos (critical aquatic and eco- species) as in vivo model organisms to probe the diffusion and toxicity of Ag NPs. We found that single Ag NPs (30-72 nm diameters) passively diffused into the embryos through chorionic pores via random Brownian motion and stayed inside the embryos throughout their entire development (120 hours-post-fertilization, hpf). Dose-and size-dependent toxic effects of the NPs on embryonic development were observed, showing the possibility of tuning biocompatibility and toxicity of the NPs. At lower concentrations of the NPs (≤0.02 nM), 75-91% of embryos developed into normal zebrafish. At the higher concentrations of NPs (≥0.20 nM), 100% of embryos became dead. At the concentrations in between (0.02-0.2 nM), embryos developed into various deformed zebrafish. Number and sizes of individual Ag NPs embedded in tissues of normal and deformed zebrafish at 120 hpf were quantitatively analyzed, showing deformed zebrafish with higher number of larger NPs than normal zebrafish and size-dependent nanotoxicity. By comparing with our previous studies of smaller Ag NPs (11.6 ± 3.5 nm), we found striking size-dependent nanotoxicity that, at the same molar concentration, the larger Ag NPs (41.6 ± 9.1 nm) are more toxic than the smaller Ag NPs (11.6 ± 3.5 nm)