Deleterious mutation accumulation and the long-term fate of chromosomal inversions

Chromosomal inversions contribute widely to adaptation and speciation, yet they present a unique evolutionary puzzle as both their allelic content and frequency evolve in a feedback loop. In this simulation study, we quantified the role of the allelic content in determining the long-term fate of the inversion. Recessive deleterious mutations accumulated on both arrangements with most of them being private to a given arrangement. This led to increasing overdominance, allowing for the maintenance of the inversion polymorphism and generating strong non-adaptive divergence between arrangements. The accumulation of mutations was mitigated by gene conversion but nevertheless led to the fitness decline of at least one homokaryotype under all considered conditions. Surprisingly, this fitness degradation could be permanently halted by the branching of an arrangement into multiple highly divergent haplotypes. Our results highlight the dynamic features of inversions by showing how the non-adaptive evolution of allelic content can play a major role in the fate of the inversion

ICZM and WTP of stakeholders for beach conservation: Policymaking suggestions from an Italian case study

In accordance with integrated coastal zone management (ICZM), private stakeholders could be asked to pay for the benefits from beach conservation projects. Since a private contribution is measured by the amount of other goods a person is willing to give up for beach quality, it can be solicited in monetary terms or, when possible, in other forms, such as specific works. In this paper, by analysing the results of two surveys in Italy concerning stakeholders' perceptions of ICZM and their willingness to pay for these benefits, suggestions for beach management are provided to policymakers. One survey focuses on beach visitors who are asked to pay in monetary terms, while the other focuses on sunbathing establishment managers, who are asked to pay not only in monetary terms but also through beach works. The results show that the majority of these stakeholders are fully or partially aware of what ICZM is, and are unwilling to pay. However, regression analysis of those willing to pay suggests that promoting an information and education campaign about ICZM may be important if stakeholders' probability of paying is to be increased

Nonlinear Integer Programming

Research efforts of the past fifty years have led to a development of linear integer programming as a mature discipline of mathematical optimization. Such a level of maturity has not been reached when one considers nonlinear systems subject to integrality requirements for the variables. This chapter is dedicated to this topic. The primary goal is a study of a simple version of general nonlinear integer problems, where all constraints are still linear. Our focus is on the computational complexity of the problem, which varies significantly with the type of nonlinear objective function in combination with the underlying combinatorial structure. Numerous boundary cases of complexity emerge, which sometimes surprisingly lead even to polynomial time algorithms. We also cover recent successful approaches for more general classes of problems. Though no positive theoretical efficiency results are available, nor are they likely to ever be available, these seem to be the currently most successful and interesting approaches for solving practical problems. It is our belief that the study of algorithms motivated by theoretical considerations and those motivated by our desire to solve practical instances should and do inform one another. So it is with this viewpoint that we present the subject, and it is in this direction that we hope to spark further research.Comment: 57 pages. To appear in: M. J\"unger, T. Liebling, D. Naddef, G. Nemhauser, W. Pulleyblank, G. Reinelt, G. Rinaldi, and L. Wolsey (eds.), 50 Years of Integer Programming 1958--2008: The Early Years and State-of-the-Art Surveys, Springer-Verlag, 2009, ISBN 354068274

Improving community health through marketing exchanges: A participatory action research study on water, sanitation, and hygiene in three Melanesian countries

Diseases related to poor water, sanitation and hygiene (WaSH) are major causes of mortality and morbidity. While pursuing marketing approaches to WaSH to improve health outcomes is often narrowly associated with monetary exchange, marketing theory recognises four broad marketing exchange archetypes: market-based, non-market-based, command-based and culturally determined. This diversity reflects the need for parameters broader than monetary exchange when improving WaSH. This study applied a participatory action research process to investigate how impoverished communities in Melanesian urban and peri-urban informal settlements attempt to meet their WaSH needs through marketing exchange. Exchanges of all four archetypes were present, often in combination. Motivations for participating in the marketing exchanges were based on social relationships alongside WaSH needs, health aspirations and financial circumstances. By leveraging these motivations and pre-existing, self-determined marketing exchanges, WaSH practitioners may be able to foster WaSH marketing exchanges consistent with local context and capabilities, in turn improving community physical, mental and social health

Climate Justice and Food Security:Experience from Climate Finance in Bangladesh

Bangladesh has been experiencing frequent climate-induced extreme weather events which cause large-scale damage to agriculture, food security, livelihoods, and social protection. Both government and nongovernment actors are working to secure climate-resilient development across the country in different thematic areas including adaptation, mitigation, disaster management, and capacity building. This chapter synthesizes the climate change policies, strategies, action plans, and climate finance systems in Bangladesh in line with the different resilience paradigms in spatial, racial, ethnic, and social exclusion perspectives and examines climate justice hypothesis in a resilient food security system. The study was conducted using an exploratory methodology, including analysis of grant allocation by different funding entities in Bangladesh that are engaged with climate-resilient development interventions. The study shows that significant gaps are evident in fund allocation from four major funding mechanisms of the government: Bangladesh Climate Change Resilience Fund (BCCRF), Strategic Program for Climate Resilience (SPCR) Bangladesh, Bangladesh Climate Change Trust Fund (BCCTF), and nongovernmental efforts. Moreover, fund allocation and project implementation lack equity and justice in the process, failing to consider vulnerability, ethnic, and social disparities, etc. that result in food insecurity among the most vulnerable communities. The results illustrate that the implemented projects are beyond climate justice