A tutorial review on time-frequency analysis of non-stationary vibration signals with nonlinear dynamics applications

Time-frequency analysis (TFA) for mechanical vibrations in non-stationary operations is the main subject of this article, concisely written to be an introducing tutorial comparing different time-frequency techniques for non-stationary signals. The theory was carefully exposed and complemented with sample applications on mechanical vibrations and nonlinear dynamics. A particular phenomenon that is also observed in non-stationary systems is the Sommerfeld effect, which occurs due to the interaction between a non-ideal energy source and a mechanical system. An application through TFA for the characterization of the Sommerfeld effect is presented. The techniques presented in this article are applied in synthetic and experimental signals of mechanical systems, but the techniques presented can also be used in the most diverse applications and also in the numerical solution of differential equation

Skin model and some processing properties of a drilling simulation in the abdominal

We know that the skin is a complex organ, and there is a need to measure the complex mechanical properties of the human skin by means of a mathematical representation capable of simulating the deformations that occur during the movements of the body and surgical procedures. We propose for this modeling an analogy between: a) resistance represented by the shock absorber, in this study the modeling will be based on the compression cycle, which occurs once the needle is inserted in the skin, compressing it; b) elasticity given by a spring with a rigidity k; and c) mass, which in turn constitutes the systems inertia resistance to displacement. With the proposed analysis of skin perforation we aim to obtain a model by relating the force applied by the needle to its velocity in the hypodermis. The results shows the steps outlined to convert the analogous system of human skin into a liaison graph, Bond Graph. As discussed by the authors, all data concerning skin are embedded in uncertainty, due especially to the following factors: spatial distribution of the organ, build and dimensions of the individual and lack of specific literature. The skin was thus modeled through a methodology based on the comparison between the real system and a model of the real system. This paper shows the mechanical model that represents skin and the injection in a procedure of abdominal perforation

Genetic polymorphism of the serine rich antigen N-terminal region in Plasmodium falciparum field isolates from Brazil

In this work we investigated the frequency of polymorphism in exon II of the gene encoding most of the amino-terminal region of the serine rich antigen (SERA) in Plasmodium falciparum field samples. The blood samples were colleted from P. falciparum infected individuals in three areas of the Brazilian Amazon. Two fragments have been characterized by polymerase chain reaction: one of 175 bp corresponding to the repeat region with 5 octamer units and one other of 199 bp related to the 6 repeat octamer units of SERA protein. The 199 bp fragment was the predominant one in all the studied areas. The higher frequency of this fragment has not been described before and could be explained by an immunological selection of the plasmodial population in the infected individuals under study. Since repeat motifs in the amino-terminal region of SERA contain epitopes recognized by parasite-inhibitor antibodies, data reported here suggest that the analysis of the polymorphism of P. falciparum isolates in different geographical areas is a preliminary stage before the final drawing of an universal vaccine against malaria can be reached

Poly-lactic acid nanoparticles (PLA-NP) promote physiological modifications in lung epithelial cells and are internalized by clathrin-coated pits and lipid rafts

BackgroundPoly-lactic acid nanoparticles (PLA-NP) are a type of polymeric NP, frequently used as nanomedicines, which have advantages over metallic NP such as the ability to maintain therapeutic drug levels for sustained periods of time. Despite PLA-NP being considered biocompatible, data concerning alterations in cellular physiology are scarce.MethodsWe conducted an extensive evaluation of PLA-NP biocompatibility in human lung epithelial A549 cells using high throughput screening and more complex methodologies. These included measurements of cytotoxicity, cell viability, immunomodulatory potential, and effects upon the cells’ proteome. We used non- and green-fluorescent PLA-NP with 63 and 66 nm diameters, respectively. Cells were exposed with concentrations of 2, 20, 100 and 200 µg/mL, for 24, 48 and 72 h, in most experiments. Moreover, possible endocytic mechanisms of internalization of PLA-NP were investigated, such as those involving caveolae, lipid rafts, macropinocytosis and clathrin-coated pits.ResultsCell viability and proliferation were not altered in response to PLA-NP. Multiplex analysis of secreted mediators revealed a low-level reduction of IL-12p70 and vascular epidermal growth factor (VEGF) in response to PLA-NP, while all other mediators assessed were unaffected. However, changes to the cells’ proteome were observed in response to PLA-NP, and, additionally, the cellular stress marker miR155 was found to reduce. In dual exposures of staurosporine (STS) with PLA-NP, PLA-NP enhanced susceptibility to STS-induced cell death. Finally, PLA-NP were rapidly internalized in association with clathrin-coated pits, and, to a lesser extent, with lipid rafts.ConclusionsThese data demonstrate that PLA-NP are internalized and, in general, tolerated by A549 cells, with no cytotoxicity and no secretion of pro-inflammatory mediators. However, PLA-NP exposure may induce modification of biological functions of A549 cells, which should be considered when designing drug delivery systems. Moreover, the pathways of PLA-NP internalization we detected could contribute to the improvement of selective uptake strategies

Dementia in Latin America : paving the way towards a regional action plan

Regional challenges faced by Latin American and Caribbean countries (LACs) to fight dementia, such as heterogeneity, diversity, political instabilities, and socioeconomic disparities, can be addressed more effectively grounded in a collaborative setting based on the open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking and translational research) and align them to current global strategies to translate regional knowledge into actions with transformative power. Then, by characterizing genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions and mapping these to the above challenges, we provide the basic mosaics of knowledge that will pave the way towards a KtAF. We describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF

A comment on a nonideal centrifugal vibrator machine behavior with soft and hard springs

This paper concerns a type of rotating machine (centrifugal vibrator), which is supported on a nonlinear spring. This is a nonideal kind of mechanical system. The goal of the present work is to show the striking differences between the cases where we take into account soft and hard spring types. For soft spring, we prove the existence of homoclinic chaos. By using the Melnikov's Method, we show the existence of an interval with the following property: if a certain parameter belongs to this interval, then we have chaotic behavior; otherwise, this does not happen. Furthermore, if we use an appropriate damping coefficient, the chaotic behavior can be avoided. For hard spring, we prove the existence of Hopf's Bifurcation, by using reduction to Center Manifolds and the Bezout Theorem (a classical result about algebraic plane curves)

Multi-core and many-core SPMD parallel algorithms for construction of basins of attraction

Construction of basins of attraction, used for the analysis of nonlinear dynamical systems which present multistability, are computationaly very expensive. Because of the long runtime needed, in many cases, the construction of basins does not have any practical use. Numerical time integration is currently the bottleneck of algorithms used for the construction of such basins. The integrations related to each set of initial conditions are independent of each other. The assignment of each integration to a separate thread seems very attractive, and parallel algorithms which use this approach to construct the basins are presented here. Two versions are considered, one for multi-core and another for many-core architectures, both based on a SPMD approach. The algorithm is tested on three systems, the classic nonlinear Duffing system, a non-ideal system exhibiting the Sommerfeld effect and an immunodynamic system. The results for all examples demonstrate the versatility of the proposed parallel algorithm, showing that the multi-core parallel algorithm using MPI has nearly an ideal speedup and efficiency

Synchronization of the unified chaotic system and application in secure communication

This paper Studies the synchronization of the unified chaotic system via optimal linear feedback control and the potential Use of chaos in cryptography, through the presentation of a chaos-based algorithm for encryption. (C) 2008 Elsevier B.V. All rights reserved.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES