A Quantitative method for the characterization of lytic metastases of the bone from radiographic images

The aim of our study was to assess the diagnostic usefulness of the gray level parameters to distinguish osteolytic lesions using radiological images. Materials and Methods: A retrospective study was carried out. A total of 76 skeletal radiographs of osteolytic metastases and 67 radiographs of multiple myeloma were used. The cases were classified into nonflat (MM1 and OL1) and flat bones (MM2 and OL2). These radiological images were analyzed by using a computerized method. The parameters calculated were mean, standard deviation, and coefficient of variation (MGL, SDGL, and CVGL) based on gray level histogram analysis of a region-of-interest.Diagnostic utility was quantified bymeasurement of parameters on osteolyticmetastases andmultiplemyeloma, yielding quantification of area under the receiver operating characteristic (ROC) curve (AUC). Results: Flat bone groups (MM2 and OL2) showed significant differences in mean values of MGL ( = 0.048) and SDGL ( = 0.003). Their corresponding values of AUC were 0.758 for MGL and 0.883 for SDGL in flat bones. In nonflat bones these gray level parameters do not show diagnostic ability. Conclusion: The gray level parametersMGL and SDGL show a good discriminatory diagnostic ability to distinguish between multiple myeloma and lytic metastases in flat bones

Osteolytic metastasis detected in a patient with lung carcinoma by F18-FDG PET

We present a 53-year-old man with a vocal cord paralysis observed as a primary manifestation of lung carcinoma. Tc-99m MDP whole body bone scan was performed and resulted in a normal scintiscan. The bone scan did not reveal any suspicious foci of uptake. The possibility of bone metastasis was taken into consideration. A whole body F18-FDG-PET scan showed intense uptake in the left upper lung corresponding to the primary tumor. A bronchial biopsy confirmed infiltration by small cell lung carcinoma (SCLC). SCLC is composed of poorly differentiated, rapidly growing cells with diseases usually occurring centrally rather than peripherally. It metastasizes early. The whole-body F18-FDG-PET scan clearly demonstrated a focus of increased uptake in the second lumbar vertebral body suspicious for osteolytic metastasis. A lytic bone metastasis was confirmed by MRI. The patient then received therapy and underwent follow up abdominal CT. The scan showed blastic changes in the L2 vertebra suggesting response to treatment

La evolución de la violencia ultra en el fútbol español

En el mundo del deporte existen varios factores que desencadenan en violencia, ya sea entre los propios participantes, entre los clubes, entre el público o al árbitro/s. Pero en el caso del fútbol, esta violencia se produce con mucha más frecuencia e intensidad en algunas ocasiones. Durante la celebración de cualquier evento deportivo con carácter relevante y también en los encuentros de fútbol a nivel profesional o de alto nivel, se congrega gran cantidad de espectadores y aficionados de todo tipo. La gran de esa gente solamente desea pasar un buen rato y animar a su propio equipo. Desgraciadamente, donde hay mucha gente suele haber también gente violenta que no entiende de la nobleza deportiva y que en ocasiones provocan enfrentamientos, destrozos y altercados varios. Todo lo anterior a veces por diversión y en otras porque han hecho de la violencia su modo de vida. Pero ¿realmente estamos ante un fenómeno acorde con su dimensión o magnitud respecto a la violencia extrema en el fútbol? ¿O precisamente es esa cualidad de deporte mayoritario la que provoca que haya más casos de violencia o realmente la prevalencia es inferior a otros deportes? En este trabajo, este alumno va a investigar las causas que motivan la aparición de infracciones tanto administrativas como penales en las celebraciones de partidos de fútbol, sobre todo a nivel profesional, haciendo un estudio de si realmente la promulgación de nuevas leyes o de modificaciones o ampliaciones de las mismas devienen en una disminución de las precitadas infracciones

Academic self-concept: methods of schooling, repeat of courses and sex

Este estudio, de carácter descriptivo, tiene como objetivo analizar la dimensión académica del autoconcepto y buscar relaciones con otras variables (modalidades escolarización, número de repeticiones y sexo). La muestra estuvo formada por 297 estudiantes de ESO, bachillerato y alumnos de diversificación curricular (PDC) y cualificación profesional inicial (PCPI), en edades comprendidas entre 12 y 20 años. Se utilizó la Escala multidimensional de autoconcepto AF5 y entrevistas con padres, profesores y alumnos para detectar posibles necesidades. Los resultados indican que los sujetos que han repetido en alguna ocasión y aquellos que estudian PDC y PCPI obtienen resultados inferiores en autoconcepto. Los que cursan bachillerato alcanzan valores superiores. Se concluyó que existen diferencias significativas en el autoconcepto en función de las variables estudiadas.This study, descriptive, aims to analyze the academic aspects of self-concept and seek relationships with other variables (schooling arrangements, number of repetitions and gender). The sample consisted of 297 secondary school students, high school students and curriculum diversification (CD) and initial vocational qualification (IVQ), aged between 12 and 20 years. Multidimensional scale of self-concept (AF5) was used and interviews with parents, teachers and students to identify possible needs. The results indicate that those who have repeated the year on occasion and those studying IVQ and CD have lower scores on self-concept. The school enrolled reach higher values . It was concluded that there are significant differences in self-concept as a function of the variables studied.peerReviewe

Ewing sarcoma of the rib: respiratory tract infection as initial symptoms in a 14-year-old boy. Functional medical imaging findings

Ewing sarcoma or primitive neuroectodermal tumor (PNET) of bone is the second most common pediatric malignant bone tumor. The median age at diagnosis is 15 years and there is a male predilection of 1.5/1. The authors present the case of a 14-year-old boy with Ewing sarcoma situated on the left ninth rib which was being investigated for respiratory tract infection. Pleurisy is the most common misdiagnosis. Our case illustrates the importance of recognizing exceptional features when interpreting FDG PET or scintigraphy to prevent the misinterpretation of metastases as other etiologies, such as infection

Flora and plant communities of the Zone of Special Conservation Sierra de Camarolos (Malaga, Spain)

El objetivo de este trabajo es realizar un catálogo de la flora, de las comunidades vegetales y el estudio del dinamismo sucesional y del paisaje vegetal de la Zona de Especial Conservación (ZEC) Sierra de Camarolos (ES6170012), situada en la provincia de Málaga (Andalucía, España) con una superficie de 8.691 Ha. Presenta macrobioclima de tipo mediterráneo con termotipos meso y supramediterráneo y ombrotipos subhúmedo y húmedo. Está compuesta litológicamente de modo mayoritario por materiales calizo-dolomíticos, arcillosos y margo-yesíferos, con relieve kárstico y ondulado-escarpado y altitudes entre 500 y 1640 m. Se encuentra en la provincia fitogeográfica Bética (región Mediterránea), sector Antequerano, subsector Antequerano (zonas margo-yesíferas)y subsector Torcalense (zonas calizo-dolomíticas). El catálogo florístico se compone de 879 taxones, destacando la presencia de numerosas especies amenazadas y/o legalmente protegidas a nivel autonómico como Narcissus pseudonarcissus subsp. nevadensis, Narcissus assoanus, Festuca elegans, Amelanchier ovalis, Prunus insititia, P. mahaleb, Sorbus aria, Hieracium texedense, Scrophularia viciosoi, Quercus faginea subsp. alpestris, Sarcocapnos baetica y Saxifraga biternata. Otras especies de interés son nuevas citas a nivel fitogeográfico y/o provincial. Se han catalogado 73 comunidades y asociaciones vegetales, entre las que destacan como novedades sintaxonómicas una nueva subalianza( Fumano hispidulae-Hippocrepidenion bourgaei uball. nova) y 5 nuevas asociaciones: la vegetación rupícola orófila sobre dolomías ( Hieracietum baetici-texedensis ass.)nova ),los cardales verticícolas temporihigrófilos ( Eryngio aquifolii-Cynaretum baeticae ass. nova), los majadales basófilos (Thrincio hispidae-Poetum bulbosae ass. nova), los albaidares gipsícolas ( Hippocrepido bourgaei-Anthyllidetum cytisoidis ass.nova) y los piornales xeroacánticos supra-mesomediterráneos (Festuco segimonensis-Erinaceetum anthyllidis ass. nova). También se proponen 3 nuevas subasociaciones: espartal termófilo (Thymo gracilis-Stipetum tenacissimae thymetosum capitati subass. nova), vallicares ( Gaudinio fragilis-Agrostietum castellanae festucetosum amplae subass. nova) y encinares mesomediterráneos termófilos (Paeonio coriaceae-Quercetum rotundifoliae pistacietosum lentisci subass. nova). El dinamismo sucesional se expresa en 8 series de vegetación. 3 series climatófilas: una mesomediterránea de Quercus rotundifolia, y 2 de Quercus faginea, respectivamente antequerana y torcalense. 3 series edafoxerófilas puntuales: una termófila subrupícola de Olea europaea subsp. sylvestris, otra karsticícola más ombrófila de Pistacia terebinthus y una gipsícola de Pinus halepensis. Existen también una serie edafohigrófila de fresnedas (Fraxinus angustifolia ) y otra de adelfar (Nerium oleander). En los frecuentes hábitats rocosos y de gleras se describen 2 geopermaseries: una calcícola caracterizada por Saxifraga biternata,S.reuteriana y S. camposii y otra dolomitícola con Hieracium texedense e H.baeticum y, muy escaso, con Sarcocapnos baetica. Las geopermaseries ulceacuícolas lagunares están caracterizadas por R. peltatus subsp. saniculifolius y subsp.peltatus , Zannichellia palustris y Chara vulgaris subsp. crassicaulis. Finalmente la geopermaserie temporihigrófila de suelos vérticos se caracteriza por Eryngium caespitiferum, Phalaris caerulescens y Festuca ampla. En la ZEC existen 15 grandes unidades de paisaje zonopotencial, caracterizados en gran medida, y en el caso de los bosques, por la presencia de Quercus rotundifolia y Q. faginea, con diferencias entre el paisaje vegetal de los dos subsectores de la ZEC, Torcalense y Antequerano

Breastfeeding and Immunohistochemical Expression of ki-67, p53 and BCL2 in Infiltrating Lobular Breast Carcinoma

Background/Aim: Invasive lobular breast carcinoma is the second most common type of breast cancer after invasive ductal carcinoma. According to the American Cancer Society, more than 180,000 women in the United States find out they have invasive breast cancer each year. Personal history of breast cancer and certain changes in the breast are correlated with an increased breast cancer risk. The aim of this work was to analyze breastfeeding in patients with infil- trating lobular breast carcinoma, in relation with: 1) clinicopathological parameters, 2) hor- monal receptors and 3) tissue-based tumor markers. Materials and Methods: The study included 80 women with ILC, 46 of which had breastfeed their children. Analyzed parameters were: age, tumor size, axillary lymph node (N), distant metastasis (M), histologi- cal grade (HG), estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR), Ki-67, p53 and BCL2. Results : ILC of non-lactating women showed a larger (p = 0.009), lymph node involvement (p = 0.051) and distant metastasis (p = 0.060). They were also more proliferative tumors mea- sured by Ki-67 (p = 0.053). Breastfeeding history did not influence the subsequent behavior of the tumor regardless of histological subtype. Conclusion: Lactation seems to influence the biological characteristics of ILC defining a subgroup with more tumor size, axillary lymph node involvement, distant metastasis and higher prolifera- tion measured by ki-67 expression

Hoffmannseggia glauca (Ortega) Einfer (Fabaceae, Caesalpinioideae) nuevo metáfito en el Sur de la Península Ibérica (Málaga, España)

Hoffmannseggia glauca (Ortega) Einfer, (Fabaceae, Caesalpinioideae) es una especie originaria del continente americano donde se distribuye de forma más o menos continua desde el suroeste de los Estados Unidos hasta Chile y Argentina. En la Península Ibérica, H .glauca sólo estaba citada en la provincia de Alicante. En la provincia de Málaga, localizamos una pequeña población en la costa oriental en el año 2007, a la que se le ha hecho un seguimiento durante 200

Osteolytic metastasis detected by F18-FDG PET in a patient with lung carcinoma (WP)

This case is described in part in the paragraph of lung carcinoma (chapter 16): Àngel González-Sistal, Alicia Baltasar Sánchez, Michel Herranz Carnero and Álvaro Ruibal Morell (2011). Advances in Medical Imaging Applied to Bone Metastases, Medical Imaging, Dr. Okechukwu Felix Erondu (Ed.), ISBN: 978-953-307-774-1. http://dx.doi.org/10.5772/28519 - http://hdl.handle.net/2445/21498We present a 53-year-old man with a vocal cord paralysis observed as a primary manifestation of lung carcinoma. Tc-99m MDP whole body bone scan were performed and resulted a normal scintiscan. The bone scan does not revealed suspicious foci of uptake. The possibility of bone metastasis was taken into consideration. A whole body F18-FDG-PET scan showed intense uptake in the left upper lung corresponding to the primary tumor. A bronchial biopsy confirmed infiltration by small cell lung carcinoma (SCLC). SCLC is composed of poorly differentiated, rapidly growing cells with disease usually occurring centrally rather than peripherally. It metastasizes early. The whole-body F18-FDG-PET scan clearly demonstrated a focus of increased uptake in the second lumbar vertebral body suspicious for osteolytic metastasis. A lytic bone metastasis was confirmed by MRI. The patient then received therapy and underwent follow up abdominal CT. The scan showed blastic changes in the L2 vertebra suggesting response to treatment

Comparative study between two aerobiological stations situated in the city of Malaga (southern Spain)

An aerobiological sampler covers the pollen information of a determined area, whose extension mainly depends on the topography of the territory but, in a city, buildings are the elements that obstruct and re-distribute winds as well as the particles suspended in the air. This is the reason for what several pollen traps are often needed for covering the information in a big city. Malaga is one of the biggest cities in Spain with a population of more than 600,000 inhabitants. In 1991 a Hirst-type pollen trap was installed in the northwest part of the city (Malaga-Teatinos station), which have been kept operational until nowadays. Additionally, in 2017, a second device (Malaga-Centre station) was installed in the very city centre, 4 km apart from the first. The aim of this work is to search whether or not there are significant differences between the results obtained in the two locations. For that, the samples obtained were mounted and counted following the methodology proposed by the Spanish Aerobiology Network (REA) and the pollen concentrations expressed as number of pollen grains/m3 of air (daily mean). Results indicate that pollen spectra are quite similar in both sampling stations. However, we found important differences in the annual amount of pollen recorded, regarding some of the more abundant pollen types in the city, Amaranthaceae, Olea europaea, Plantago and Quercus being much more abundant in Malaga-Teatinos, with annual pollen indexes that sometimes triple the obtained in Malaga-Centre. On the contrary, Pinus and Parietaria reach higher values in Malaga-Centre, especially the last one, with annual pollen index almost four times highest than the obtained in Malaga-Teatinos. Phenology was quite similar in the case of almost all the pollen types with scarce differences in the case of Olea and Parietaria.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech